NL8303673A - Benzodioxinopyrroolderivaten en werkwijzen voor het bereiden daarvan; farmaceutische preparaten. - Google Patents

Benzodioxinopyrroolderivaten en werkwijzen voor het bereiden daarvan; farmaceutische preparaten. Download PDF

Info

Publication number: NL8303673A
Authority: NL; Netherlands
Prior art keywords: compound; general formula; physiologically acceptable; group; trans
Prior art date: 1982-10-25

Application number

NL8303673A

Other languages

English (en)

Dutch (nl)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-25

Filing date

1983-10-25

Publication date

1984-05-16

1983-10-25 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1984-05-16 Publication of NL8303673A publication Critical patent/NL8303673A/nl

Links

238000000034 method Methods 0.000 title claims description 18
239000000825 pharmaceutical preparation Substances 0.000 title description 4
CEOQGBDEHVSEQC-UHFFFAOYSA-N 1h-[1,4]benzodioxino[2,3-b]pyrrole Chemical class O1C2=CC=CC=C2OC2=C1NC=C2 CEOQGBDEHVSEQC-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims description 99
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 50
150000003839 salts Chemical class 0.000 claims description 24
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 11
238000002360 preparation method Methods 0.000 claims description 11
238000006243 chemical reaction Methods 0.000 claims description 9
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 7
230000001430 anti-depressive effect Effects 0.000 claims description 6
239000000935 antidepressant agent Substances 0.000 claims description 6
229940005513 antidepressants Drugs 0.000 claims description 6
125000003342 alkenyl group Chemical group 0.000 claims description 5
150000001412 amines Chemical class 0.000 claims description 5
125000003710 aryl alkyl group Chemical group 0.000 claims description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
230000008569 process Effects 0.000 claims description 5
208000024827 Alzheimer disease Diseases 0.000 claims description 4
206010010774 Constipation Diseases 0.000 claims description 4
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 4
206010020772 Hypertension Diseases 0.000 claims description 4
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206010012601 diabetes mellitus Diseases 0.000 claims description 4
206010027599 migraine Diseases 0.000 claims description 4
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239000008194 pharmaceutical composition Substances 0.000 claims description 4
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125000006239 protecting group Chemical group 0.000 claims description 4
TYUHPIMUSJSGLB-QWRGUYRKSA-N (3as,9as)-2-methyl-1,3,3a,9a-tetrahydro-[1,4]benzodioxino[2,3-c]pyrrole Chemical compound O1C2=CC=CC=C2O[C@@H]2[C@@H]1CN(C)C2 TYUHPIMUSJSGLB-QWRGUYRKSA-N 0.000 claims description 3
125000000753 cycloalkyl group Chemical group 0.000 claims description 3
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FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
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DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 8
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WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 6
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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OPSXVXRECQNWRM-UHFFFAOYSA-N 2,3,3a,9a-tetrahydro-1h-[1,4]benzodioxino[3,2-b]pyrrole Chemical class O1C2=CC=CC=C2OC2C1CCN2 OPSXVXRECQNWRM-UHFFFAOYSA-N 0.000 description 4
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230000029936 alkylation Effects 0.000 description 4
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238000005576 amination reaction Methods 0.000 description 4
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229960002896 clonidine Drugs 0.000 description 4
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Classifications

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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

NL8303673A 1982-10-25 1983-10-25 Benzodioxinopyrroolderivaten en werkwijzen voor het bereiden daarvan; farmaceutische preparaten. NL8303673A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8230379		1982-10-25
GB8230379		1982-10-25

Publications (1)

Publication Number	Publication Date
NL8303673A true NL8303673A (nl)	1984-05-16

Family

ID=10533819

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8303673A NL8303673A (nl)	1982-10-25	1983-10-25	Benzodioxinopyrroolderivaten en werkwijzen voor het bereiden daarvan; farmaceutische preparaten.

Country Status (18)

Country	Link
US (1)	US4496579A (fr)
JP (1)	JPS5998086A (fr)
KR (1)	KR840006486A (fr)
AU (1)	AU2055283A (fr)
BE (1)	BE898072A (fr)
CH (1)	CH661046A5 (fr)
DE (1)	DE3338753A1 (fr)
ES (1)	ES526738A0 (fr)
FI (1)	FI833887A7 (fr)
FR (1)	FR2534921B1 (fr)
GB (1)	GB2129795B (fr)
GR (1)	GR79405B (fr)
IL (1)	IL70034A0 (fr)
IT (1)	IT1212893B (fr)
LU (1)	LU85059A1 (fr)
NL (1)	NL8303673A (fr)
SE (1)	SE8305866L (fr)
ZA (1)	ZA837921B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4769367A (en) *	1984-04-24	1988-09-06	Glaxo Group Limited	Heterocyclic amino compounds
DE3587511T2 (de) *	1984-04-24	1993-11-18	Glaxo Group Ltd	Aromatische Diole.
GB8526210D0 (en) *	1985-10-23	1985-11-27	Glaxo Group Ltd	Chemical compounds
GB8410459D0 (en) *	1984-04-24	1984-05-31	Glaxo Group Ltd	Chemical compounds
GB8526209D0 (en) *	1985-10-23	1985-11-27	Glaxo Group Ltd	Chemical process
US5225431A (en) *	1987-10-23	1993-07-06	Burroughs Wellcome Co.	Therapeutic substituted indole compounds and compositions thereof
GB8828032D0 (en) *	1988-12-01	1989-01-05	Glaxo Group Ltd	Medicaments
DE10107243A1 (de) *	2001-02-16	2002-08-22	Bayer Ag	Benzodioxinopyrrole, deren Herstellung und Verwendung
US8099200B2 (en)	2005-09-30	2012-01-17	Coombs Joshua D	Vehicle interface based on the weight distribution of a user
US20070074922A1 (en) *	2005-09-30	2007-04-05	Coombs Joshua D	Vehicle interface based on a shift of the torso of a user
US20070078569A1 (en) *	2005-09-30	2007-04-05	Jeffrey Schox	Vehicle interface to communicate a safety alert mode command
US20070074921A1 (en) *	2005-09-30	2007-04-05	Coombs Joshua D	Vehicle interface based on a shift of the appendages of a user
US20090076686A1 (en) *	2005-09-30	2009-03-19	Jeffrey Schox	Vehicle interface to communicate a safety alert mode command

1983
- 1983-10-24 IL IL70034A patent/IL70034A0/xx unknown
- 1983-10-25 IT IT8349214A patent/IT1212893B/it active
- 1983-10-25 KR KR1019830005035A patent/KR840006486A/ko not_active Withdrawn
- 1983-10-25 GR GR72780A patent/GR79405B/el unknown
- 1983-10-25 NL NL8303673A patent/NL8303673A/nl not_active Application Discontinuation
- 1983-10-25 CH CH5771/83A patent/CH661046A5/fr not_active IP Right Cessation
- 1983-10-25 BE BE0/211766A patent/BE898072A/fr not_active IP Right Cessation
- 1983-10-25 ES ES526738A patent/ES526738A0/es active Granted
- 1983-10-25 US US06/545,191 patent/US4496579A/en not_active Expired - Fee Related
- 1983-10-25 FI FI833887A patent/FI833887A7/fi not_active Application Discontinuation
- 1983-10-25 LU LU85059A patent/LU85059A1/fr unknown
- 1983-10-25 SE SE8305866A patent/SE8305866L/xx not_active Application Discontinuation
- 1983-10-25 DE DE19833338753 patent/DE3338753A1/de not_active Ceased
- 1983-10-25 GB GB08328468A patent/GB2129795B/en not_active Expired
- 1983-10-25 FR FR8316989A patent/FR2534921B1/fr not_active Expired
- 1983-10-25 AU AU20552/83A patent/AU2055283A/en not_active Abandoned
- 1983-10-25 JP JP58199871A patent/JPS5998086A/ja active Pending
- 1983-10-25 ZA ZA837921A patent/ZA837921B/xx unknown

Also Published As

Publication number	Publication date
BE898072A (fr)	1984-04-25
US4496579A (en)	1985-01-29
IT1212893B (it)	1989-11-30
IT8349214A0 (it)	1983-10-25
CH661046A5 (fr)	1987-06-30
SE8305866D0 (sv)	1983-10-25
SE8305866L (sv)	1984-04-26
FR2534921B1 (fr)	1987-01-16
FI833887A0 (fi)	1983-10-25
GB8328468D0 (en)	1983-11-23
FR2534921A1 (fr)	1984-04-27
GB2129795A (en)	1984-05-23
JPS5998086A (ja)	1984-06-06
ES8504200A1 (es)	1985-04-16
GB2129795B (en)	1986-02-12
AU2055283A (en)	1984-05-03
DE3338753A1 (de)	1984-04-26
IL70034A0 (en)	1984-01-31
ES526738A0 (es)	1985-04-16
LU85059A1 (fr)	1985-06-19
GR79405B (fr)	1984-10-22
FI833887A7 (fi)	1984-04-26
KR840006486A (ko)	1984-11-30
ZA837921B (en)	1985-04-24

Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1986-06-02	BV	The patent application has lapsed

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US4496579A (en)	1985-01-29	Benzodioxinopyrrole derivatives and processes for their preparation
US5053521A (en)	1991-10-01	Various n-substituted 3-piperidine carboxylic acids or n-substituted 3-pyridinecarboxylic acids and derivatives thereof
RU2116072C1 (ru)	1998-07-27	Диметилбензофураны и диметилбензопираны, их применение в качестве 5-нт3-антагонистов, способы их получения и фармацевтическая композиция
KR101072796B1 (ko)	2011-10-14	치환된 페닐 메탄온 유도체
AU736710B2 (en)	2001-08-02	New indanol compounds, a process for their preparation and pharmaceutical compositions containing them
FI84069C (fi)	1991-10-10	Foerfarande foer framstaellning av en terapeutiskt aktiv heterocyklisk aminofoerening.
SK289692A3 (en)	1998-08-05	Imidazolylmethyl-pyridine, method of preparation thereof, medicament and pharmaceutical composition containing this pyridine
DK167974B1 (da)	1994-01-10	1-(phenylalkyl)-3-(3-hydroxyphenyl)piperidin-forbindelser fremgangsmaade til fremstilling deraf og 3-(3-methoxyphenylpiperidin-forbindelser til anvendelse som mellemprodukter ved deres fremstilling samt farmaceutiske praeparater indeholdende de foerstnaevnte forbindelser
US5519023A (en)	1996-05-21	New aminoalkylchromones, processes for the preparation thereof
HRP970451A2 (en)	1998-08-31	Quaternary ammonium compounds
AU8818298A (en)	1999-03-01	1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors
GB2174087A (en)	1986-10-29	Heterocyclic amino compounds
EP0162592B1 (fr)	1989-03-22	Composés hétérocycliques de groupe amine
US5994374A (en)	1999-11-30	Substituted 1-indolylpropyl-4-benzyl-tetrahydropyridine derivatives
KR830001667B1 (ko)	1983-08-23	페닐 퀴놀리지딘의 제조방법
EP0097628B1 (fr)	1990-09-19	Dérivés de pipéridine, procédés pour leur préparation et préparations pharmaceutiques les contenant
EP0224332B1 (fr)	1990-08-08	Composés hétérocycliques de groupe amine
AU745808B2 (en)	2002-04-11	New benzocyclobutane compounds, a process for their preparation and pharmaceutical compositions containing them
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WO2003106443A1 (fr)	2003-12-24	1-phenylalkylpiperazines
KR100222238B1 (ko)	1999-10-01	스피로 교상 및 비교상 헤테로고리 화합물