NL8320153A - Werkwijze voor het bereiden van 26,26,26,27,27,27,hexafluor-1alfa,25-dihydroxycholesterol. - Google Patents

Werkwijze voor het bereiden van 26,26,26,27,27,27,hexafluor-1alfa,25-dihydroxycholesterol. Download PDF

Info

Publication number
NL8320153A
NL8320153A NL8320153A NL8320153A NL8320153A NL 8320153 A NL8320153 A NL 8320153A NL 8320153 A NL8320153 A NL 8320153A NL 8320153 A NL8320153 A NL 8320153A NL 8320153 A NL8320153 A NL 8320153A
Authority
NL
Netherlands
Prior art keywords
diacetate
trinorcholest
triol
acyl
trinor
Prior art date
Application number
NL8320153A
Other languages
English (en)
Dutch (nl)
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of NL8320153A publication Critical patent/NL8320153A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8320153A 1982-05-26 1983-04-18 Werkwijze voor het bereiden van 26,26,26,27,27,27,hexafluor-1alfa,25-dihydroxycholesterol. NL8320153A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/382,055 US4411833A (en) 1982-05-26 1982-05-26 Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US38205582 1982-05-26

Publications (1)

Publication Number Publication Date
NL8320153A true NL8320153A (nl) 1984-04-02

Family

ID=23507359

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8320153A NL8320153A (nl) 1982-05-26 1983-04-18 Werkwijze voor het bereiden van 26,26,26,27,27,27,hexafluor-1alfa,25-dihydroxycholesterol.

Country Status (14)

Country Link
US (1) US4411833A (fr)
JP (2) JPH0742306B2 (fr)
AU (1) AU561182B2 (fr)
BE (1) BE896830A (fr)
CH (2) CH663212A5 (fr)
DE (1) DE3390016C2 (fr)
DK (1) DK168539B1 (fr)
FR (2) FR2527615B1 (fr)
GB (2) GB2121044B (fr)
IE (1) IE55022B1 (fr)
IL (1) IL68537A (fr)
IT (1) IT1203706B (fr)
NL (1) NL8320153A (fr)
WO (1) WO1983004256A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
WO1990009179A1 (fr) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Traitement de la dyschondroplasie tibiale d'allien
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5571802A (en) * 1993-02-19 1996-11-05 Wisconsin Alumni Research Foundation Method of treating post menopausal osteoporosis with hexafluro-vitamin D
WO2008035207A2 (fr) * 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation Composés analogues à la 2-méthylène-1alpha-hydroxy-19,21-dinorvitamine d3 et leurs utilisations
MX2008012912A (es) * 2006-04-06 2008-11-26 Wisconsin Alumni Res Found Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos.
EP2001860A2 (fr) * 2006-04-06 2008-12-17 Wisconsin Alumni Research Foundation Analogues de la 19-nor-vitamine d présentant un noyau 1,2, ou 3,2 hétérocyclique
EP2021321B1 (fr) * 2006-04-06 2012-06-20 Wisconsin Alumni Research Foundation 2-méthylène-1-alpha,25-dihydroxy-18,19,21-trinorvitamine d3 et ses utilisations
NZ570712A (en) * 2006-04-06 2011-11-25 Wisconsin Alumni Res Found 2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof
NZ570711A (en) 2006-04-06 2012-10-26 Wisconsin Alumni Res Found 2-Substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
EP2004597B1 (fr) * 2006-04-10 2011-01-26 Wisconsin Alumni Research Foundation Composés de la 1-alpha-hydroxy-2-(3'-hydroxypropylidène)-19-nor-vitamine d ayant une chaîne latérale 1,1-diméthylpropyle
EA201691980A1 (ru) 2009-01-27 2017-07-31 БЕРГ ЭлЭлСи Способы уменьшения побочных эффектов, связанных с химиотерапией
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
WO2014194133A1 (fr) 2013-05-29 2014-12-04 Berg Llc Prévention ou atténuation de l'alopécie induite par la chimiothérapie au moyen de vitamine d
CN113968888B (zh) * 2020-07-24 2023-06-27 上海医药工业研究院 一种胆甾衍生物的制备方法、其中间体及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183852A (en) * 1977-07-18 1980-01-15 Kaiser Emil T Process for preparing 25-hydroxycholesterol
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
JPS5598199A (en) * 1979-01-17 1980-07-25 Eisai Co Ltd Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
IL60270A0 (en) * 1979-06-14 1980-09-16 Diamond Shamrock Corp Preparation of 25-ydroxycholesterol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Also Published As

Publication number Publication date
GB2140016B (en) 1986-01-02
IT1203706B (it) 1989-02-15
DK32684D0 (da) 1984-01-25
DK32684A (da) 1984-01-25
IE55022B1 (en) 1990-04-25
CH663212A5 (de) 1987-11-30
JPH0742306B2 (ja) 1995-05-10
IL68537A0 (en) 1983-07-31
FR2533929A1 (fr) 1984-04-06
AU561182B2 (en) 1987-04-30
GB2121044A (en) 1983-12-14
GB8415630D0 (en) 1984-07-25
GB2121044B (en) 1986-01-02
JPH0578388A (ja) 1993-03-30
IT8321261A0 (it) 1983-05-24
DE3390016C2 (de) 1989-08-10
AU1554283A (en) 1983-12-16
IE831226L (en) 1983-11-26
JPH0578387A (ja) 1993-03-30
DK168539B1 (da) 1994-04-18
IL68537A (en) 1986-07-31
GB8314612D0 (en) 1983-06-29
DE3390016T1 (de) 1984-05-17
US4411833A (en) 1983-10-25
FR2533929B1 (fr) 1986-10-31
FR2527615A1 (fr) 1983-12-02
WO1983004256A1 (fr) 1983-12-08
CH662572A5 (de) 1987-10-15
BE896830A (fr) 1983-09-16
GB2140016A (en) 1984-11-21
JPH0742305B2 (ja) 1995-05-10
FR2527615B1 (fr) 1986-05-23

Similar Documents

Publication Publication Date Title
NL8320153A (nl) Werkwijze voor het bereiden van 26,26,26,27,27,27,hexafluor-1alfa,25-dihydroxycholesterol.
US4183852A (en) Process for preparing 25-hydroxycholesterol
RU2065851C1 (ru) СПОСОБ ПОЛУЧЕНИЯ α -ГИДРОКСИ-24-ЭПИВИТАМИНА D2
US4554105A (en) Process for the preparation of 1-hydroxylated vitamin D compounds
JPS5841900A (ja) ケトアンドロステン類
US5089641A (en) Synthesis of 1α-hydroxy-secosterol compounds
EP0125909B1 (fr) Dérivés de la vitamine D modifiés dans le cycle A et dans le système triénique
DK158990B (da) Cholestadienderivat, der kan anvendes som mellemprodukt til brug ved fremstillingen af homovitamin-d3-derivater
US5248773A (en) 16-methyl-Δ1,4-pregnadiene-3,20-diones
Huffman et al. Synthesis of (.+-.)-isocelorbicol
CS200538B2 (en) Method of producing derivatives of oleandomycin
JPS59500864A (ja) ２６，２６．２６，２７．２７，２７―ヘキサフルオロ―１α，２５―ジヒドロキシコレステロール化合物及びその製造方法
WO1991002741A1 (fr) Derives d'alcool de sucre et procede de preparation de composes et derives d'acide 3-deoxy-2-octulosonique et d'acide 3-deoxy-2-heptulosonique
EP1688409B1 (fr) Derive de composes monohalogenovinyl de vitamine d
JP2953665B2 (ja) ステロイド誘導体の製造方法
JP3483155B2 (ja) １α，２５−ジヒドロキシビタミンＤ４およびＤ７の製造法
JP3429341B2 (ja) 活性型ビタミンｄ中間体
Komeno et al. Thiosteroid—XXVIII: Steroidal transannular 2α, 5α-episulphide—2. Synthesis of 17β-hydroxy-3-oxo-5α-androstan-2α, 5-episulphide and its 19-nor derivative
WO2007076655A1 (fr) Procede de synthese de cholest-3?,5?,6?,19-tetrahydroxy-24-one et ses derives
JP2750175B2 (ja) ステロイド誘導体の製造方法
JPH0413694A (ja) ステロイド誘導体の製造方法
JPS6039279B2 (ja) エピデスモステロ−ル誘導体
Ghaffari et al. Reaction of thiol nucleophiles with 1, 2-epoxy-and 4, 5-epoxy-estrene-3-one-17β-ols
JPH0499763A (ja) ビタミンｄ２およびｄ３又は活性型ビタミンｄ２およびｄ３の製造方法，並びにその中間体
Ignatov et al. Palmitates of Isomeric 15-Oxygenated Δ8 (14)-Sterols

Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BI The patent application has been withdrawn