NL8502929A - Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. - Google Patents

Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. Download PDF

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Publication number
NL8502929A
NL8502929A NL8502929A NL8502929A NL8502929A NL 8502929 A NL8502929 A NL 8502929A NL 8502929 A NL8502929 A NL 8502929A NL 8502929 A NL8502929 A NL 8502929A NL 8502929 A NL8502929 A NL 8502929A
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NL
Netherlands
Prior art keywords
formula
sub
transition metal
group viii
preparing
Prior art date
Application number
NL8502929A
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English (en)
Dutch (nl)
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Tno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tno filed Critical Tno
Priority to NL8502929A priority Critical patent/NL8502929A/nl
Priority to DE8686201853T priority patent/DE3679045D1/de
Priority to AT86201853T priority patent/ATE63122T1/de
Priority to ES198686201853T priority patent/ES2039199T3/es
Priority to EP86201853A priority patent/EP0227127B1/en
Priority to FI864327A priority patent/FI85861C/fi
Priority to NO864270A priority patent/NO172585B/no
Priority to DK511786A priority patent/DK511786A/da
Priority to PT83612A priority patent/PT83612B/pt
Priority to US06/922,655 priority patent/US4831170A/en
Priority to HU864487A priority patent/HU200609B/hu
Priority to CA000521403A priority patent/CA1269395A/en
Priority to HU903471A priority patent/HU203557B/hu
Priority to YU181786A priority patent/YU45802B/sh
Priority to IL80416A priority patent/IL80416A0/xx
Priority to KR1019860008963A priority patent/KR870003787A/ko
Priority to CN86107219A priority patent/CN86107219A/zh
Priority to JP61252843A priority patent/JPS62161795A/ja
Priority to AU64413/86A priority patent/AU601954B2/en
Priority to ZA868162A priority patent/ZA868162B/xx
Priority to NZ218072A priority patent/NZ218072A/en
Publication of NL8502929A publication Critical patent/NL8502929A/nl
Priority to CN91101598A priority patent/CN1057962A/zh
Priority to GR91400587T priority patent/GR3001910T3/el
Priority to CN 92104055 priority patent/CN1068573A/zh
Priority to CN 92104056 priority patent/CN1069275A/zh
Priority to CN92104058A priority patent/CN1067430A/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0033—Iridium compounds
    • C07F15/004—Iridium compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C07F15/008—Rhodium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • C07F15/065—Cobalt compounds without a metal-carbon linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NL8502929A 1985-10-25 1985-10-25 Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. NL8502929A (nl)

Priority Applications (26)

Application Number Priority Date Filing Date Title
NL8502929A NL8502929A (nl) 1985-10-25 1985-10-25 Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
DE8686201853T DE3679045D1 (de) 1985-10-25 1986-10-23 Pharmazeutisch aktive phosphinohydrocarbongruppe-viii-metallkomplexe, diese komplexe enthaltende antitumorpraeparate und verfahren zur herstellung dieser verbindungen oder antitumorpraeparate.
AT86201853T ATE63122T1 (de) 1985-10-25 1986-10-23 Pharmazeutisch aktive phosphinohydrocarbongruppeviii-metallkomplexe, diese komplexe enthaltende antitumorpraeparate und verfahren zur herstellung dieser verbindungen oder antitumorpraeparate.
ES198686201853T ES2039199T3 (es) 1985-10-25 1986-10-23 Complejos de fosfino-hidrocarburo-metal del grupo viii farmaceuticamente activos, composiciones antitumorales a base de estos complejos y procedimiento para la preparacion de dichos compuestos o composiciones antitumorales.
EP86201853A EP0227127B1 (en) 1985-10-25 1986-10-23 Pharmaceutically active phosphino-hydrocarbon-group viii-metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
YU181786A YU45802B (sh) 1985-10-25 1986-10-24 Postupak za dobijanje farmaceutski aktivnih fosfino-ugljovodoničnih kompleksnih jedinjenja metala viii grupe
NO864270A NO172585B (no) 1985-10-25 1986-10-24 Analogifremgangsmaate for fremstilling av farmasoeytisk aktive fosfino-hydrocarbon-gruppe viii-metallkomplekser
DK511786A DK511786A (da) 1985-10-25 1986-10-24 Phosphino-carbonhydrid-gruppe viii-metalkomplekser, antitumorpraeparater indeholdende disse komplekser og en fremgangsmaade til fremstillingaf komplekserne eller antitumorpraeparaterne
PT83612A PT83612B (pt) 1985-10-25 1986-10-24 Processo para a preparacao de complexos de fosfino-hidrocarbonetos e metais do grupo viii, uteis como agentes antitumorais
US06/922,655 US4831170A (en) 1985-10-25 1986-10-24 Pharmaceutically active phospino-hydrocarbon-group VIII-metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
HU864487A HU200609B (en) 1985-10-25 1986-10-24 Process for producing complexes of pharmaceutically active phosphino hydrocarbon group with metals belonging to group (viii) and antitumour compositions comprising such compounds
CA000521403A CA1269395A (en) 1985-10-25 1986-10-24 Pharmaceutically active phosphino-hydrocarbon-group viii-metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
HU903471A HU203557B (en) 1985-10-25 1986-10-24 Process for producing pharmaceutical compositions of antitumor activity containing complexes of the metals of the (viii) group and pharmaceutically active phosphino-hydrocarbon groups
FI864327A FI85861C (fi) 1985-10-25 1986-10-24 Foerfarande foer framstaellning av terapeutiskt anvaendbara komplexfoereningar.
IL80416A IL80416A0 (en) 1985-10-25 1986-10-24 Phosphino-hydrocarbon-group viii metal complexes,their preparation and pharmaceutical compositions containing them
CN86107219A CN86107219A (zh) 1985-10-25 1986-10-25 药物活性的膦基-烃基ⅷ族金属络合物，含有这些络合物的抗肿瘤组合物和制备这些络合物或抗肿瘤组合物的方法
KR1019860008963A KR870003787A (ko) 1985-10-25 1986-10-25 포스피노-탄화수소-8족 금속복합체 화합물을 함유하는 약학적 조성물
JP61252843A JPS62161795A (ja) 1985-10-25 1986-10-25 薬物として活性なホスフイノ−炭化水素−５１１１族金属錯体、これらの錯体を含有する抗腫瘍組成物、及び該化合物又は抗腫瘍組成物の製造方法
AU64413/86A AU601954B2 (en) 1985-10-25 1986-10-27 Pharmaceutically active phosphino-hydrocarbon-group V111- metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
ZA868162A ZA868162B (en) 1985-10-25 1986-10-27 Pharmaceutically active phosphino-hydrocarbon-group viii-metal complexes,antitumor compositions containing these complexes,and a process for preparing said compounds or antitumor compositions
NZ218072A NZ218072A (en) 1985-10-25 1986-10-28 Phosphino-hydrocarbon-group viii metal complexes and pharmaceutical compositions
CN91101598A CN1057962A (zh) 1985-10-25 1991-03-16 制备含膦基-烃基viii族金属络合物的抗肿瘤组合物的方法
GR91400587T GR3001910T3 (en) 1985-10-25 1991-05-03 Pharmaceutically active phosphino-hydrocarbon-group viii-metal complexes, antitumor compositions containing these complexes, and a process for preparing said compounds or antitumor compositions
CN 92104055 CN1068573A (zh) 1985-10-25 1992-05-25 制备膦基-烃基ⅷ族金属络合物及含有这些络合物的抗肿瘤组合物方法
CN 92104056 CN1069275A (zh) 1985-10-25 1992-05-28 制备膦基-烃基viii族金属络合物及含有这些络合物的抗肿瘤组合物方法
CN92104058A CN1067430A (zh) 1985-10-25 1992-05-28 制备膦基-烃基ⅷ族金属络合物及含有这些络合物的抗肿瘤组合物方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8502929A NL8502929A (nl) 1985-10-25 1985-10-25 Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.
NL8502929 1985-10-25

Publications (1)

Publication Number Publication Date
NL8502929A true NL8502929A (nl) 1987-05-18

Family

ID=19846766

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8502929A NL8502929A (nl) 1985-10-25 1985-10-25 Groep viii-overgangsmetaal-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijke groep viii-overgangsmetaal-complex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.

Country Status (21)

Country Link
US (1) US4831170A (da)
EP (1) EP0227127B1 (da)
JP (1) JPS62161795A (da)
KR (1) KR870003787A (da)
CN (3) CN86107219A (da)
AT (1) ATE63122T1 (da)
AU (1) AU601954B2 (da)
CA (1) CA1269395A (da)
DE (1) DE3679045D1 (da)
DK (1) DK511786A (da)
ES (1) ES2039199T3 (da)
FI (1) FI85861C (da)
GR (1) GR3001910T3 (da)
HU (2) HU203557B (da)
IL (1) IL80416A0 (da)
NL (1) NL8502929A (da)
NO (1) NO172585B (da)
NZ (1) NZ218072A (da)
PT (1) PT83612B (da)
YU (1) YU45802B (da)
ZA (1) ZA868162B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1282218A (zh) * 1997-10-15 2001-01-31 波拉克斯生物药品 使用砷化合物治疗原发性及转移性肿瘤疾病的组合物及方法
JP5015451B2 (ja) * 2005-04-18 2012-08-29 日本化学工業株式会社 ホスフィン遷移金属錯体、その製造方法およびそれを含有する抗癌剤
WO2009081366A1 (en) * 2007-12-20 2009-07-02 Richard John Bowen Palladium and platinum phosphine complexes and their use as anti-tumour agents
WO2009104167A1 (en) * 2008-02-22 2009-08-27 Mintek A substance or composition for the treatment of cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3084179A (en) * 1959-02-27 1963-04-02 Ici Ltd Phosphorous-containing-ligand stabilized transition metal compounds
US3345392A (en) * 1964-03-24 1967-10-03 American Cyanamid Co Organophosphorus-copper complex compounds
GB1085762A (en) * 1965-04-30 1967-10-04 Ici Ltd Complex organic iridium compounds and their use as catalysts
FR2116905A5 (fr) * 1970-12-10 1972-07-21 Inst Francais Du Petrole Nouveaux coordinats bidentes,leur fabrication et leurs applications
US3939188A (en) * 1972-03-24 1976-02-17 Exxon Research And Engineering Company Preparation of zerovalent phosphine substituted rhodium compounds and their use in the selective carbonylation of olefins
US3954821A (en) * 1975-06-30 1976-05-04 E. I. Du Pont De Nemours And Company Carbon dioxide complexes of Rh, Ir, Ni, Pd, and Pt
US4268454A (en) * 1978-12-21 1981-05-19 Allied Chemical Corporation Anionic group VIII metal hydride catalysts
US4302401A (en) * 1980-01-23 1981-11-24 Exxon Research & Engineering Co. Tetraalkyl phosphonium substituted phosphine and amine transition metal complexes
US4331818A (en) * 1980-03-19 1982-05-25 The Procter & Gamble Company Chiral phospine ligand
CA1238854A (en) * 1984-02-01 1988-07-05 David T. Hill ANTITUMOR PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING TUMORS EMPLOYING ¬.alpha.,W- BIS(DISUBSTITUTEDPHOSPHINO)HYDROCARBON| DIGOLD (I) DIGOLD (III), DISILVER (I) AND DICOPPER (I) DERIVATIVES
CA1244764A (en) * 1984-06-04 1988-11-15 Randall K. Johnson Tumor cell growth-inhibiting pharmaceutical compositions containing phosphino-hydrocarbon-gold, silver or copper complexes

Also Published As

Publication number Publication date
DK511786D0 (da) 1986-10-24
NO172585B (no) 1993-05-03
EP0227127A2 (en) 1987-07-01
HU200609B (en) 1990-07-28
FI85861B (fi) 1992-02-28
AU601954B2 (en) 1990-09-27
JPS62161795A (ja) 1987-07-17
HUT44263A (en) 1988-02-29
NO864270D0 (no) 1986-10-24
CN86107219A (zh) 1987-05-27
FI85861C (fi) 1992-06-10
HU203557B (en) 1991-08-28
NZ218072A (en) 1990-12-21
US4831170A (en) 1989-05-16
DE3679045D1 (de) 1991-06-06
KR870003787A (ko) 1987-05-04
EP0227127A3 (en) 1988-09-07
AU6441386A (en) 1987-05-21
YU45802B (sh) 1992-07-20
NO864270L (no) 1987-04-27
IL80416A0 (en) 1987-01-30
FI864327A7 (fi) 1987-04-26
PT83612A (en) 1986-11-01
PT83612B (pt) 1989-05-31
EP0227127B1 (en) 1991-05-02
ATE63122T1 (de) 1991-05-15
CN1057962A (zh) 1992-01-22
FI864327A0 (fi) 1986-10-24
CA1269395A (en) 1990-05-22
CN1067430A (zh) 1992-12-30
YU181786A (en) 1988-02-29
HU903471D0 (en) 1990-12-28
DK511786A (da) 1987-04-26
GR3001910T3 (en) 1992-11-23
ES2039199T3 (es) 1993-09-16
ZA868162B (en) 1987-06-24

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