NL8701048A - Glucose-sensor. - Google Patents

Glucose-sensor. Download PDF

Info

Publication number: NL8701048A
Authority: NL; Netherlands
Prior art keywords: film; glucose; iridium; silanized; blood
Prior art date: 1986-05-09

Application number

NL8701048A

Other languages

English (en)

Dutch (nl)

Original Assignee

Cardiac Pacemakers Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-09

Filing date

1987-05-04

Publication date

1987-12-01

1987-05-04 Application filed by Cardiac Pacemakers Inc filed Critical Cardiac Pacemakers Inc

1987-12-01 Publication of NL8701048A publication Critical patent/NL8701048A/nl

Links

239000008103 glucose Substances 0.000 title claims description 56
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims description 55
239000008280 blood Substances 0.000 claims description 25
210000004369 blood Anatomy 0.000 claims description 25
108010015776 Glucose oxidase Proteins 0.000 claims description 16
239000004366 Glucose oxidase Substances 0.000 claims description 16
229940116332 glucose oxidase Drugs 0.000 claims description 16
235000019420 glucose oxidase Nutrition 0.000 claims description 16
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 15
HTXDPTMKBJXEOW-UHFFFAOYSA-N dioxoiridium Chemical compound O=[Ir]=O HTXDPTMKBJXEOW-UHFFFAOYSA-N 0.000 claims description 14
229910000457 iridium oxide Inorganic materials 0.000 claims description 14
239000000758 substrate Substances 0.000 claims description 12
229910052741 iridium Inorganic materials 0.000 claims description 11
230000004044 response Effects 0.000 claims description 10
239000000243 solution Substances 0.000 claims description 10
238000000034 method Methods 0.000 claims description 9
WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims description 6
229920002379 silicone rubber Polymers 0.000 claims description 6
239000004945 silicone rubber Substances 0.000 claims description 6
238000011065 in-situ storage Methods 0.000 claims description 5
239000007864 aqueous solution Substances 0.000 claims description 4
238000010438 heat treatment Methods 0.000 claims description 4
238000001727 in vivo Methods 0.000 claims description 4
238000001816 cooling Methods 0.000 claims description 3
238000007598 dipping method Methods 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
239000002131 composite material Substances 0.000 claims description 2
230000008569 process Effects 0.000 claims description 2
239000011248 coating agent Substances 0.000 claims 2
238000000576 coating method Methods 0.000 claims 2
239000010410 layer Substances 0.000 claims 1
239000002344 surface layer Substances 0.000 claims 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 38
102000004877 Insulin Human genes 0.000 description 19
108090001061 Insulin Proteins 0.000 description 19
229940125396 insulin Drugs 0.000 description 19
238000001802 infusion Methods 0.000 description 12
230000000694 effects Effects 0.000 description 6
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
108090000790 Enzymes Proteins 0.000 description 5
102000004190 Enzymes Human genes 0.000 description 5
239000000306 component Substances 0.000 description 5
229940088598 enzyme Drugs 0.000 description 5
239000008363 phosphate buffer Substances 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
239000000463 material Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000008367 deionised water Substances 0.000 description 3
229910021641 deionized water Inorganic materials 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
108090000854 Oxidoreductases Proteins 0.000 description 2
102000004316 Oxidoreductases Human genes 0.000 description 2
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
230000001070 adhesive effect Effects 0.000 description 2
238000003556 assay Methods 0.000 description 2
230000008859 change Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical class Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 2
239000011888 foil Substances 0.000 description 2
235000013305 food Nutrition 0.000 description 2
238000007654 immersion Methods 0.000 description 2
238000000099 in vitro assay Methods 0.000 description 2
238000005462 in vivo assay Methods 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
230000037081 physical activity Effects 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
229910000077 silane Inorganic materials 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
235000009421 Myristica fragrans Nutrition 0.000 description 1
230000010718 Oxidation Activity Effects 0.000 description 1
230000010757 Reduction Activity Effects 0.000 description 1
229910021607 Silver chloride Inorganic materials 0.000 description 1
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
230000006399 behavior Effects 0.000 description 1
235000013361 beverage Nutrition 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000012503 blood component Substances 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
229940075397 calomel Drugs 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
238000002716 delivery method Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
229940061607 dibasic sodium phosphate Drugs 0.000 description 1
230000037213 diet Effects 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000007812 electrochemical assay Methods 0.000 description 1
230000004190 glucose uptake Effects 0.000 description 1
239000004519 grease Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000001115 mace Substances 0.000 description 1
230000007102 metabolic function Effects 0.000 description 1
230000037323 metabolic rate Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
229940045641 monobasic sodium phosphate Drugs 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
239000008055 phosphate buffer solution Substances 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000000047 product Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
230000003979 response to food Effects 0.000 description 1
229920000260 silastic Polymers 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000007669 thermal treatment Methods 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
230000007723 transport mechanism Effects 0.000 description 1
238000003466 welding Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Optics & Photonics (AREA)
Immunology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Pathology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Medical Informatics (AREA)
Surgery (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Investigating Or Analysing Biological Materials (AREA)

NL8701048A 1986-05-09 1987-05-04 Glucose-sensor. NL8701048A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86134786		1986-05-09
US06/861,347 US4679562A (en)	1983-02-16	1986-05-09	Glucose sensor

Publications (1)

Publication Number	Publication Date
NL8701048A true NL8701048A (nl)	1987-12-01

Family

ID=25335552

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8701048A NL8701048A (nl)	1986-05-09	1987-05-04	Glucose-sensor.

Country Status (6)

Country	Link
US (1)	US4679562A (fr)
JP (1)	JPS6324150A (fr)
DE (1)	DE3714840A1 (fr)
FR (1)	FR2598511B1 (fr)
GB (1)	GB2190504B (fr)
NL (1)	NL8701048A (fr)

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1987
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- 1987-05-06 FR FR878706384A patent/FR2598511B1/fr not_active Expired - Fee Related
- 1987-05-08 JP JP62112238A patent/JPS6324150A/ja active Pending

Also Published As

Publication number	Publication date
FR2598511B1 (fr)	1990-08-03
GB2190504B (en)	1989-12-13
JPS6324150A (ja)	1988-02-01
GB8708834D0 (en)	1987-05-20
GB2190504A (en)	1987-11-18
DE3714840C2 (fr)	1991-05-23
DE3714840A1 (de)	1987-11-12
US4679562A (en)	1987-07-14
FR2598511A1 (fr)	1987-11-13

Legal Events

Date	Code	Title
1989-07-03	BA	A request for search or an international-type search has been filed
1989-11-01	BB	A search report has been drawn up
1991-01-02	BC	A request for examination has been filed
1992-01-02	BV	The patent application has lapsed

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