NL8802178A - Prothetische voortbrengsels met botbindende eigenschappen. - Google Patents

Prothetische voortbrengsels met botbindende eigenschappen. Download PDF

Info

Publication number: NL8802178A
Authority: NL; Netherlands
Prior art keywords: molecular weight; article; ester units; chain ester; poly
Prior art date: 1988-09-02

Application number

NL8802178A

Other languages

English (en)

Dutch (nl)

Original Assignee

Stichting Tech Wetenschapp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-02

Filing date

1988-09-02

Publication date

1990-04-02

1988-09-02 Application filed by Stichting Tech Wetenschapp filed Critical Stichting Tech Wetenschapp

1988-09-02 Priority to NL8802178A priority Critical patent/NL8802178A/nl

1988-09-07 Priority to CA000576657A priority patent/CA1341282C/en

1989-09-01 Priority to DE68915229T priority patent/DE68915229T2/de

1989-09-01 Priority to EP89202226A priority patent/EP0357155B1/de

1989-09-01 Priority to AT8989202226T priority patent/ATE105490T1/de

1989-09-01 Priority to ES89202226T priority patent/ES2056195T3/es

1989-09-02 Priority to KR1019890012721A priority patent/KR0140538B1/ko

1990-04-02 Publication of NL8802178A publication Critical patent/NL8802178A/nl

1993-07-12 Priority to US08/089,854 priority patent/US20020095213A1/en

1995-02-16 Priority to US08/389,303 priority patent/US20010051832A1/en

Links

150000002148 esters Chemical group 0.000 claims abstract description 20
-1 poly(oxyethylene) Polymers 0.000 claims abstract description 20
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 12
230000001225 therapeutic effect Effects 0.000 claims abstract description 9
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 8
229920006344 thermoplastic copolyester Polymers 0.000 claims abstract description 8
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 6
229910052799 carbon Inorganic materials 0.000 claims abstract description 6
229920001634 Copolyester Polymers 0.000 claims abstract description 5
150000001408 amides Chemical class 0.000 claims abstract description 4
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 4
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 4
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 3
229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
210000000988 bone and bone Anatomy 0.000 claims description 43
125000003827 glycol group Chemical group 0.000 claims description 9
229920001169 thermoplastic Polymers 0.000 claims description 8
239000004416 thermosoftening plastic Substances 0.000 claims description 8
125000002947 alkylene group Chemical group 0.000 claims description 5
125000000217 alkyl group Chemical group 0.000 claims description 3
KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 claims 4
239000005977 Ethylene Substances 0.000 claims 2
150000001721 carbon Chemical group 0.000 claims 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
235000019256 formaldehyde Nutrition 0.000 claims 1
230000036571 hydration Effects 0.000 claims 1
238000006703 hydration reaction Methods 0.000 claims 1
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 1
210000003454 tympanic membrane Anatomy 0.000 abstract description 6
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical group O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 abstract description 5
150000003949 imides Chemical class 0.000 abstract 1
238000009423 ventilation Methods 0.000 abstract 1
239000007943 implant Substances 0.000 description 26
229920001707 polybutylene terephthalate Polymers 0.000 description 17
239000004721 Polyphenylene oxide Substances 0.000 description 13
229910052588 hydroxylapatite Inorganic materials 0.000 description 13
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 13
229920000728 polyester Polymers 0.000 description 13
229920000570 polyether Polymers 0.000 description 13
229920001577 copolymer Polymers 0.000 description 11
239000011148 porous material Substances 0.000 description 9
210000000959 ear middle Anatomy 0.000 description 8
239000000463 material Substances 0.000 description 7
229920001223 polyethylene glycol Polymers 0.000 description 6
239000013078 crystal Substances 0.000 description 5
238000002513 implantation Methods 0.000 description 5
210000002808 connective tissue Anatomy 0.000 description 4
238000001356 surgical procedure Methods 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
241000197194 Bulla Species 0.000 description 3
208000002352 blister Diseases 0.000 description 3
229910010293 ceramic material Inorganic materials 0.000 description 3
229940091173 hydantoin Drugs 0.000 description 3
238000000034 method Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
229920002379 silicone rubber Polymers 0.000 description 3
239000004945 silicone rubber Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
241000700159 Rattus Species 0.000 description 2
241000700157 Rattus norvegicus Species 0.000 description 2
239000012620 biological material Substances 0.000 description 2
210000002449 bone cell Anatomy 0.000 description 2
230000010256 bone deposition Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000013013 elastic material Substances 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
210000000416 exudates and transudate Anatomy 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000003993 interaction Effects 0.000 description 2
239000010410 layer Substances 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
238000013425 morphometry Methods 0.000 description 2
210000004877 mucosa Anatomy 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
229920000747 poly(lactic acid) Polymers 0.000 description 2
239000004626 polylactic acid Substances 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
230000008569 process Effects 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 2
238000004627 transmission electron microscopy Methods 0.000 description 2
WSQZNZLOZXSBHA-UHFFFAOYSA-N 3,8-dioxabicyclo[8.2.2]tetradeca-1(12),10,13-triene-2,9-dione Chemical compound O=C1OCCCCOC(=O)C2=CC=C1C=C2 WSQZNZLOZXSBHA-UHFFFAOYSA-N 0.000 description 1
VSAWBBYYMBQKIK-UHFFFAOYSA-N 4-[[3,5-bis[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]-2,4,6-trimethylphenyl]methyl]-2,6-ditert-butylphenol Chemical compound CC1=C(CC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)C(C)=C(CC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)C(C)=C1CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 VSAWBBYYMBQKIK-UHFFFAOYSA-N 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
101100042258 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) sem-1 gene Proteins 0.000 description 1
CKUAXEQHGKSLHN-UHFFFAOYSA-N [C].[N] Chemical compound [C].[N] CKUAXEQHGKSLHN-UHFFFAOYSA-N 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
238000000376 autoradiography Methods 0.000 description 1
230000002146 bilateral effect Effects 0.000 description 1
230000000975 bioactive effect Effects 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
QPKOBORKPHRBPS-UHFFFAOYSA-N bis(2-hydroxyethyl) terephthalate Chemical compound OCCOC(=O)C1=CC=C(C(=O)OCCO)C=C1 QPKOBORKPHRBPS-UHFFFAOYSA-N 0.000 description 1
230000037396 body weight Effects 0.000 description 1
230000008468 bone growth Effects 0.000 description 1
230000037118 bone strength Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
210000000845 cartilage Anatomy 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000002316 cosmetic surgery Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
210000003094 ear ossicle Anatomy 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000004744 fabric Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
210000003128 head Anatomy 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
210000002540 macrophage Anatomy 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
239000013642 negative control Substances 0.000 description 1
210000004279 orbit Anatomy 0.000 description 1
230000000399 orthopedic effect Effects 0.000 description 1
210000000963 osteoblast Anatomy 0.000 description 1
210000004409 osteocyte Anatomy 0.000 description 1
235000019629 palatability Nutrition 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
239000013641 positive control Substances 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
238000002601 radiography Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000004626 scanning electron microscopy Methods 0.000 description 1
239000002356 single layer Substances 0.000 description 1
230000000930 thermomechanical effect Effects 0.000 description 1
210000002303 tibia Anatomy 0.000 description 1
210000004746 tooth root Anatomy 0.000 description 1
210000000216 zygoma Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/58—Preparations specially adapted for dental root treatment specially adapted for dental implants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/672—Dicarboxylic acids and dihydroxy compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
- C08G63/6854—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/6856—Dicarboxylic acids and dihydroxy compounds

Landscapes

Health & Medical Sciences (AREA)
Oral & Maxillofacial Surgery (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Transplantation (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Plastic & Reconstructive Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Materials For Medical Uses (AREA)
Dental Preparations (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Polyesters Or Polycarbonates (AREA)
Prostheses (AREA)

NL8802178A 1988-09-02 1988-09-02 Prothetische voortbrengsels met botbindende eigenschappen. NL8802178A (nl)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
NL8802178A NL8802178A (nl)	1988-09-02	1988-09-02	Prothetische voortbrengsels met botbindende eigenschappen.
CA000576657A CA1341282C (en)	1988-09-02	1988-09-07	Prosthetic devices having bone-binding properties as well as the therapeutic use of said devices
DE68915229T DE68915229T2 (de)	1988-09-02	1989-09-01	Prothesen mit knochenbindenden Eigenschaften.
EP89202226A EP0357155B1 (de)	1988-09-02	1989-09-01	Prothesen mit knochenbindenden Eigenschaften
AT8989202226T ATE105490T1 (de)	1988-09-02	1989-09-01	Prothesen mit knochenbindenden eigenschaften.
ES89202226T ES2056195T3 (es)	1988-09-02	1989-09-01	Dispositivo protesico que tiene propiedades de union con los huesos.
KR1019890012721A KR0140538B1 (ko)	1988-09-02	1989-09-02	골-결합 특성을 갖는 보철구 및 그의 치료적 용도
US08/089,854 US20020095213A1 (en)	1988-09-02	1993-07-12	Prosthetic devices formed from materials having bone-bonding properties and uses therefor
US08/389,303 US20010051832A1 (en)	1988-09-02	1995-02-16	Prosthetic devices formed from materials having bone-bonding properties and uses therefor

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8802178A NL8802178A (nl)	1988-09-02	1988-09-02	Prothetische voortbrengsels met botbindende eigenschappen.
NL8802178		1988-09-02

Publications (1)

Publication Number	Publication Date
NL8802178A true NL8802178A (nl)	1990-04-02

Family

ID=19852852

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8802178A NL8802178A (nl)	1988-09-02	1988-09-02	Prothetische voortbrengsels met botbindende eigenschappen.

Country Status (7)

Country	Link
EP (1)	EP0357155B1 (de)
KR (1)	KR0140538B1 (de)
AT (1)	ATE105490T1 (de)
CA (1)	CA1341282C (de)
DE (1)	DE68915229T2 (de)
ES (1)	ES2056195T3 (de)
NL (1)	NL8802178A (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8902237A (nl) *	1989-09-06	1991-04-02	Hc Implants Bv	Kunsthuid.
US5081161A (en) *	1990-06-15	1992-01-14	E. I. Du Pont De Nemours And Company	Process for making shaped articles of a thermoplastic resin having a microcellular structure
EP0464827B1 (de) *	1990-07-05	1995-04-19	Matsushita Electric Industrial Co., Ltd.	Magnetischer Aufzeichnungsträger und dessen Herstellungsverfahren
DE69805920T2 (de)	1997-07-16	2003-01-02	Isotis N.V., Bilthoven	Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen
EP0891783B1 (de) *	1997-07-16	2002-06-12	IsoTis N.V.	Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen
EP1005873B1 (de) *	1998-11-30	2003-04-09	IsoTis N.V.	Kunsthaut
JP2000167039A (ja)	1998-11-30	2000-06-20	Isotis Bv	人造皮膚
US6656489B1 (en) *	1999-02-10	2003-12-02	Isotis N.V.	Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
EP1027897B1 (de) *	1999-02-10	2005-04-13	IsoTis N.V.	Verfahren zur Knorpelgeweberegeneration
EP1038538A1 (de) *	1999-03-19	2000-09-27	IsoTis B.V.	Verfahren zur Regeneration von Muskelgewebe
JP2003506158A (ja) *	1999-08-06	2003-02-18	イソティスエヌ．ブイ．	固定デバイス
DE60238241D1 (de)	2001-01-02	2010-12-23	Advanced Ceramics Res Inc	Zusammensetzungen und verfahren für biomedizinische anwendungen
RU2260402C1 (ru) *	2004-03-25	2005-09-20	Майкл Готесман	Композиционный материал для замещения костной ткани

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4340091A (en) *	1975-05-07	1982-07-20	Albany International Corp.	Elastomeric sheet materials for heart valve and other prosthetic implants
US4164794A (en) *	1977-04-14	1979-08-21	Union Carbide Corporation	Prosthetic devices having coatings of selected porous bioengineering thermoplastics
US4350806A (en) *	1981-09-28	1982-09-21	Akzona Incorporated	Biocompatible copolymers
JPS62295666A (ja) *	1986-06-16	1987-12-23	呉羽化学工業株式会社	連続二次元多孔型インプラント材及びその製造法
DE3644588C1 (de) *	1986-12-27	1988-03-10	Ethicon Gmbh	Implantat und Verfahren zu seiner Herstellung

1988
- 1988-09-02 NL NL8802178A patent/NL8802178A/nl not_active Application Discontinuation
- 1988-09-07 CA CA000576657A patent/CA1341282C/en not_active Expired - Fee Related
1989
- 1989-09-01 ES ES89202226T patent/ES2056195T3/es not_active Expired - Lifetime
- 1989-09-01 DE DE68915229T patent/DE68915229T2/de not_active Expired - Lifetime
- 1989-09-01 AT AT8989202226T patent/ATE105490T1/de not_active IP Right Cessation
- 1989-09-01 EP EP89202226A patent/EP0357155B1/de not_active Expired - Lifetime
- 1989-09-02 KR KR1019890012721A patent/KR0140538B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR900004311A (ko)	1990-04-12
EP0357155B1 (de)	1994-05-11
CA1341282C (en)	2001-08-07
KR0140538B1 (ko)	1998-06-15
ATE105490T1 (de)	1994-05-15
DE68915229T2 (de)	1994-11-17
ES2056195T3 (es)	1994-10-01
EP0357155A1 (de)	1990-03-07
DE68915229D1 (de)	1994-06-16

Legal Events

Date	Code	Title	Description
1990-04-02	A1B	A search report has been drawn up
1991-01-16	CNR	Transfer of rights (patent application after its laying open for public inspection)	Free format text: HC IMPLANTS B.V.
1991-05-01	BV	The patent application has lapsed

Publication	Publication Date	Title
DE69805920T2 (de)	2003-01-02	Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen
Panduranga Rao	1996	Recent developments of collagen-based materials for medical applications and drug delivery systems
Venugopal et al.	2005	Applications of polymer nanofibers in biomedicine and biotechnology
US6656489B1 (en)	2003-12-02	Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
EP1027897B1 (de)	2005-04-13	Verfahren zur Knorpelgeweberegeneration
JP4934279B2 (ja)	2012-05-16	生物医用接着剤
JP5514441B2 (ja)	2014-06-04	ケラチンバイオセラミック組成物
Takatsuka et al.	1995	Bone‐bonding behavior of titanium alloy evaluated mechanically with detaching failure load
NL8802178A (nl)	1990-04-02	Prothetische voortbrengsels met botbindende eigenschappen.
Kumbar et al.	2006	In vitro and in vivo characterization of biodegradable poly (organophosphazenes) for biomedical applications
US9364587B2 (en)	2016-06-14	Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
ES2350708T3 (es)	2011-01-26	Material de soporte de implante médico.
Scott et al.	2013	Advances in bionanomaterials for bone tissue engineering
EP1594423A2 (de)	2005-11-16	In-situ hergestellte intervertebrale fusionsvorrichtung
NZ528749A (en)	2006-06-30	Implantable prosthetic or tissue expanding device
EP0891783B1 (de)	2002-06-12	Vorrichtung zur Knochenbehandlung bestehend aus abbaubarem thermoplastischen Copolyester und kultivierten Zellen
US20010051832A1 (en)	2001-12-13	Prosthetic devices formed from materials having bone-bonding properties and uses therefor
WO2012113812A1 (en)	2012-08-30	Nano-reservoirs technology for use in bone and/or cartilage regeneration
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