NL9001865A - Nieuwe aminopropanolderivaten, werkwijze voor de bereiding ervan en farmaceutische samenstellingen, die deze omvatten. - Google Patents

Nieuwe aminopropanolderivaten, werkwijze voor de bereiding ervan en farmaceutische samenstellingen, die deze omvatten. Download PDF

Info

Publication number
NL9001865A
NL9001865A NL9001865A NL9001865A NL9001865A NL 9001865 A NL9001865 A NL 9001865A NL 9001865 A NL9001865 A NL 9001865A NL 9001865 A NL9001865 A NL 9001865A NL 9001865 A NL9001865 A NL 9001865A
Authority
NL
Netherlands
Prior art keywords
formula
group
defined above
process according
procedure
Prior art date
Application number
NL9001865A
Other languages
English (en)
Dutch (nl)
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of NL9001865A publication Critical patent/NL9001865A/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/20—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
NL9001865A 1989-08-25 1990-08-24 Nieuwe aminopropanolderivaten, werkwijze voor de bereiding ervan en farmaceutische samenstellingen, die deze omvatten. NL9001865A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU894401A HU212415B (en) 1989-08-25 1989-08-25 Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components
HU440189 1989-08-25

Publications (1)

Publication Number Publication Date
NL9001865A true NL9001865A (nl) 1991-03-18

Family

ID=10967860

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001865A NL9001865A (nl) 1989-08-25 1990-08-24 Nieuwe aminopropanolderivaten, werkwijze voor de bereiding ervan en farmaceutische samenstellingen, die deze omvatten.

Country Status (24)

Country Link
US (1) US5130487A (2)
JP (1) JPH03169841A (2)
KR (1) KR910004547A (2)
AT (1) AT399504B (2)
BE (1) BE1004530A3 (2)
BG (1) BG92749A (2)
CA (1) CA2023957A1 (2)
CH (1) CH681369A5 (2)
DD (1) DD297402A5 (2)
DE (1) DE4027052A1 (2)
DK (1) DK203290A (2)
ES (1) ES2021261A6 (2)
FI (1) FI904191A7 (2)
FR (1) FR2651227B1 (2)
GB (1) GB2235198B (2)
GR (1) GR1000740B (2)
HU (1) HU212415B (2)
IT (1) IT1243203B (2)
NL (1) NL9001865A (2)
PL (1) PL163028B1 (2)
RU (1) RU2066310C1 (2)
SE (1) SE9002727L (2)
YU (1) YU48372B (2)
ZA (1) ZA906744B (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212262B (en) * 1992-10-30 1996-04-29 Egyt Gyogyszervegyeszeti Gyar Process to prepare benz /e/ indene derivs. and the pharmaceutical compns. contg. them
HU213421B (en) * 1993-04-09 1997-06-30 Egyt Gyogyszervegyeszeti Gyar New basic ethers, pharmaceutical compns. containing the said compds. and process for prepg. them
HUT67314A (en) * 1993-04-09 1995-03-28 Egyt Gyogyszervegyeszeti Gyar Process for prepg. new trisubstituted cykloalkane deriv.s and pharmaceutical compn.s contg. them
HU213472B (en) * 1993-07-20 1997-06-30 Egyt Gyogyszervegyeszeti Gyar Process to preparare pharmaceutical compns. with gastroprotective and anti helicobacter pylori activity
US5597822A (en) * 1993-07-20 1997-01-28 Egis Pharmaceutical Pharmaceutical compositions for the prevention and/or treatment a gastrointestinal diseases
DE19722848A1 (de) * 1997-05-23 1998-11-26 Schering Ag Leukotrien-B¶4¶-Derivate, insbesondere Oximo-LTB¶4¶-Antagonisten
RU2330839C2 (ru) * 2002-01-11 2008-08-10 Санкио Компани, Лимитед Производные аминоспиртов или производные фосфорных кислот и фармацевтические композиции, содержащие указанные производные
TWI355934B (en) 2004-02-24 2012-01-11 Sankyo Co Pharmaceutical composition for treatment or prophy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1474316A (en) * 1975-02-12 1977-05-25 Seperic O-aminoalkyl oximes
DK149043C (da) * 1976-01-27 1986-05-26 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmaade til fremstilling af 2-benzal- eller 2-benzyl-1-(aminoalkoxyimino)-cykloalkaner eller salte eller kvaternaere ammoniumderivater deraf
AT339276B (de) * 1976-01-27 1977-10-10 Egyt Gyogyszervegyeszeti Gyar Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
DE2658938A1 (de) * 1976-12-24 1978-07-06 Hoechst Ag Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4308399A (en) * 1977-08-30 1981-12-29 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. O-(3-Amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
US4652586A (en) * 1980-11-07 1987-03-24 The General Hospital Corporation Selective beta-2 adrenergic antagonists for the treatment of glaucoma
FR2521856A1 (fr) * 1982-02-19 1983-08-26 Pos Lab Medicament ophtalmique pour le traitement des glaucomes, a base d'ethers-oxydes ou d'ether-oximes de derives alcoylamines
HU189227B (en) * 1983-02-08 1986-06-30 Egyt Gyogyszervegyeszeti Gyar,Hu Process for preparing basic oxime-ethers
HU189226B (en) * 1983-02-08 1986-06-30 Egyt Gyogyszervegyeszeti Gyar,Hu Process for producing basic oxime-ethers
HU197205B (en) * 1984-07-10 1989-03-28 Egyt Gyogyszervegyeszeti Gyar Process for production of medical compositions against angine
US4803286A (en) * 1987-08-19 1989-02-07 Merck & Co., Inc. Amino-2-hydroxypropyloximinoheterocycle α-blockers

Also Published As

Publication number Publication date
FI904191A7 (fi) 1991-02-26
BG92749A (bg) 1993-12-24
IT9021305A1 (it) 1992-02-24
CA2023957A1 (en) 1991-02-26
RU2066310C1 (ru) 1996-09-10
ATA174290A (de) 1994-10-15
US5130487A (en) 1992-07-14
FI904191A0 (fi) 1990-08-24
DE4027052A1 (de) 1991-03-07
DK203290D0 (da) 1990-08-24
HU212415B (en) 1996-06-28
FR2651227B1 (fr) 1992-07-31
PL286613A1 (en) 1991-05-06
SE9002727D0 (sv) 1990-08-24
ZA906744B (en) 1991-06-26
DD297402A5 (de) 1992-01-09
PL163028B1 (pl) 1994-02-28
HUT58282A (en) 1992-02-28
GR900100627A (en) 1991-12-30
DK203290A (da) 1991-02-26
KR910004547A (ko) 1991-03-28
IT1243203B (it) 1994-05-24
YU160990A (sh) 1992-12-21
GB2235198B (en) 1993-06-02
CH681369A5 (2) 1993-03-15
JPH03169841A (ja) 1991-07-23
GB9018583D0 (en) 1990-10-10
ES2021261A6 (es) 1991-10-16
YU48372B (sh) 1998-07-10
SE9002727L (sv) 1991-02-26
AT399504B (de) 1995-05-26
IT9021305A0 (it) 1990-08-24
DE4027052C2 (2) 1993-09-09
GR1000740B (el) 1992-12-30
FR2651227A1 (fr) 1991-03-01
GB2235198A (en) 1991-02-27
BE1004530A3 (fr) 1992-12-08

Similar Documents

Publication Publication Date Title
DE69525355T2 (de) 1-acyl-4-aliphatische aminopiperidin verbindungen
NZ202728A (en) 2-(phenylmethylene)-cycloalkylamine and-azetidine derivatives
FI101301B (fi) Menetelmä terapeuttisesti käyttökelpoisten, N-substituoitujen heksahyd roatsepiinijohdannaisten valmistamiseksi
US5130487A (en) Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
DE2609017C3 (de) Basische Oximäther, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzeimittel
WO2001021604A1 (de) Substituierte piperazinderivate, ihre herstellung und ihre verwendung als inhibitoren des mikrosomalen triglyzerid-transferproteins (mtp)
FR2460294A1 (fr) Nouveaux oxime-ethers, leur procede de preparation et compositions pharmaceutiques les contenant
US5234934A (en) Aminopropanol derivatives, process for their preparation and pharmaceutical compositions comprising the same
US3565955A (en) Meta-methoxy-alpha-methyl-phenethyl-amino-diphenylmethyl ethers
CZ173294A3 (en) Alkyl derivatives of trazodone, process of their preparation and pharmaceutical composition containing thereof and its use
DE3404481A1 (de) Basische cycloalkanonoximaether, verfahren zur herstellung derselben und ihre verwendung
HU211858A9 (hu) Új aminopropanolszármazékok, eljárás ezek előállítására és ilyen hatóanyagot tartalmazó gyógyszerkészítmények
AU592358B2 (en) Derivatives of diphenoxyethylamine, a process for their production and the pharmaceutical compositions containing the same
US5439940A (en) Benz[e]indene derivatives
US5486528A (en) Basic ethers and process for the preparation thereof
DE2749214C2 (2)
EP0297435B1 (de) Aminopropanolderivate von 3-(3'-Hydroxyphenyl)-1-propanon-Verbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL95465A (en) Derivatives of aminopropanol, the process for their preparation and pharmaceutical preparations containing them
HU199792B (en) Process for producing new indolecarboxamide derivatives and pharmaceutical compositions comprising such compounds
EP0619298A2 (en) (Phenylmethylene)-2-(alkyl)-1- omega-(amino)-alkoxyimino -cycloalkane derivatives, a process for preparing them as well as medicaments containing them and the use of them
HU180644B (en) Process for preparing 1-/2-propynyl-oxy-/2-amino-3-propanol esters
HK1000598B (en) Derivatives of hexahydroazepines, procedure for their preparation and pharmaceutical compositions containing same
JPH0320382B2 (2)
JPH0288548A (ja) Ｐ−ヒドロキシフエノン誘導体及びこれを含有する抗不整脈剤
CH572044A5 (en) 1,4-disubstd piperazines - as hypoglycaemic agents

Legal Events

Date Code Title Description
BA A request for search or an international-type search has been filed
BC A request for examination has been filed
BV The patent application has lapsed