NL970043I2 - Esters van hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-on en verwante verbindingen. - Google Patents

Esters van hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-on en verwante verbindingen.

Info

Publication number: NL970043I2
Authority: NL; Netherlands
Prior art keywords: quinolizin; methano; hexahydro; hydroxy; esters
Prior art date: 1986-11-03

Application number

NL970043C

Other languages

English (en)

Other versions

NL970043I1 (nl

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-03

Filing date

1997-12-17

Publication date

1998-10-01

1997-12-17 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1998-03-02 Publication of NL970043I1 publication Critical patent/NL970043I1/nl

1998-10-01 Publication of NL970043I2 publication Critical patent/NL970043I2/nl

Links

NEDMCWSHHDYQAJ-UHFFFAOYSA-N 115956-07-5 Chemical compound C1C2CC(O)CC3N2CC(=O)C1C3 NEDMCWSHHDYQAJ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
150000002148 esters Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NL970043C 1986-11-03 1997-12-17 Esters van hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-on en verwante verbindingen. NL970043I2 (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92661986A	1986-11-03	1986-11-03

Publications (2)

Publication Number	Publication Date
NL970043I1 NL970043I1 (nl)	1998-03-02
NL970043I2 true NL970043I2 (nl)	1998-10-01

Family

ID=25453460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL970043C NL970043I2 (nl)	1986-11-03	1997-12-17	Esters van hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-on en verwante verbindingen.

Country Status (21)

Country	Link
EP (1)	EP0266730B1 (nl)
JP (2)	JP2542225B2 (nl)
KR (1)	KR950011737B1 (nl)
CN (1)	CN1021654C (nl)
AR (1)	AR246264A1 (nl)
AT (1)	ATE109779T1 (nl)
AU (1)	AU600318B2 (nl)
CA (1)	CA1329203C (nl)
DE (2)	DE19775092I2 (nl)
DK (1)	DK171116B1 (nl)
ES (1)	ES2061469T3 (nl)
FI (1)	FI87786C (nl)
HU (1)	HU197008B (nl)
IE (1)	IE63670B1 (nl)
IL (1)	IL84309A (nl)
NL (1)	NL970043I2 (nl)
NO (2)	NO165922C (nl)
NZ (1)	NZ222349A (nl)
PH (2)	PH24664A (nl)
PT (1)	PT86060B (nl)
ZA (1)	ZA878096B (nl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0329903A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of glaucoma
EP0329904A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of anxiety
US5011846A (en) *	1988-02-23	1991-04-30	Merrell Dow Pharmaceuticals Inc.	Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
EP0329902A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizinone and quinolizine derivatives in the manufacture of medicaments for the treatment of psychosis
EP0329932B1 (en) *	1988-02-23	1995-10-18	Merrell Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments
EP0329905A1 (en) *	1988-02-23	1989-08-30	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for increasing gastric motility
EP0330788A1 (en) *	1988-03-01	1989-09-06	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
ZA893008B (en) *	1988-04-29	1989-12-27	Merrell Dow Pharma	Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one
GB8928837D0 (en) *	1989-12-21	1990-02-28	Beecham Group Plc	Pharmaceuticals
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
CA2315262C (en) *	1997-12-17	2009-11-10	Biocryst Pharmaceuticals, Inc.	Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
CN100390172C (zh) *	2004-09-10	2008-05-28	成都欣捷高新技术开发有限公司	一种甲磺酸多拉司琼晶型及其制备方法
EP1819705A1 (de) *	2004-11-25	2007-08-22	Cilag Ltd.	Verfahren zur herstellung von estern von hexahydro-8-hydroxy-2,6-methano-2h-chinolizin-3(4h)-on
ATE411314T1 (de) *	2005-07-06	2008-10-15	Inke Sa	Verfahren zur gewinnung der pharmazeutisch aktiven verbindung dolasetron, synthese- zwischenprodukte davon und verfahren zu deren gewinnung
ES2264901B1 (es)	2005-07-06	2007-12-01	Inke, S.A.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
WO2007081890A2 (en) *	2006-01-05	2007-07-19	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Production of dolasetron
ES2389261T3 (es)	2007-11-13	2012-10-24	Inke, S.A.	Compuestos intermedios útiles para preparar dolasetrón
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
CN102458400B (zh)	2009-05-20	2014-10-08	国立健康与医学研究所	用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂
US20180250270A1 (en)	2015-09-11	2018-09-06	Chase Pharmaceuticals Corporation	Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CN108976230A (zh) *	2018-06-18	2018-12-11	东莞市联洲知识产权运营管理有限公司	一种基于石墨烯活化制备甲磺酸多拉司琼关键中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI74707C (fi) *	1982-06-29	1988-03-10	Sandoz Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
DE3429830A1 (de) *	1983-08-26	1985-03-07	Sandoz-Patent-GmbH, 7850 Lörrach	Automatische carbonsaeure- und sulfonsaeureester oder -amide
EP0189002B1 (en) *	1984-12-20	1993-03-03	Sandoz Ag	Treatment of gastrointestinal disorders using 5-ht3 antagonists

1987
- 1987-10-28 ZA ZA878096A patent/ZA878096B/xx unknown
- 1987-10-29 FI FI874768A patent/FI87786C/fi not_active IP Right Cessation
- 1987-10-29 IL IL84309A patent/IL84309A/xx not_active IP Right Cessation
- 1987-10-29 NZ NZ222349A patent/NZ222349A/xx unknown
- 1987-10-29 CA CA000550612A patent/CA1329203C/en not_active Expired - Lifetime
- 1987-10-30 PH PH36006A patent/PH24664A/en unknown
- 1987-10-30 AR AR87309166A patent/AR246264A1/es active
- 1987-11-02 DE DE1997175092 patent/DE19775092I2/de active Active
- 1987-11-02 AT AT87116119T patent/ATE109779T1/de not_active IP Right Cessation
- 1987-11-02 DE DE3750359T patent/DE3750359T2/de not_active Expired - Lifetime
- 1987-11-02 CN CN87107629A patent/CN1021654C/zh not_active Expired - Lifetime
- 1987-11-02 ES ES87116119T patent/ES2061469T3/es not_active Expired - Lifetime
- 1987-11-02 DK DK572887A patent/DK171116B1/da not_active IP Right Cessation
- 1987-11-02 NO NO874550A patent/NO165922C/no not_active IP Right Cessation
- 1987-11-02 HU HU874918A patent/HU197008B/hu unknown
- 1987-11-02 JP JP62275894A patent/JP2542225B2/ja not_active Expired - Lifetime
- 1987-11-02 PT PT86060A patent/PT86060B/pt unknown
- 1987-11-02 EP EP87116119A patent/EP0266730B1/en not_active Expired - Lifetime
- 1987-11-02 IE IE295587A patent/IE63670B1/en not_active IP Right Cessation
- 1987-11-02 AU AU80596/87A patent/AU600318B2/en not_active Expired
- 1987-11-03 KR KR1019870012286A patent/KR950011737B1/ko not_active Expired - Lifetime
1990
- 1990-01-02 PH PH39830A patent/PH26261A/en unknown
1996
- 1996-02-27 JP JP8065408A patent/JP2657267B2/ja not_active Expired - Lifetime
1997
- 1997-12-17 NL NL970043C patent/NL970043I2/nl unknown
1999
- 1999-08-26 NO NO1999020C patent/NO1999020I1/no unknown

Also Published As

Publication number	Publication date
FI874768A0 (fi)	1987-10-29
EP0266730A1 (en)	1988-05-11
NO1999020I1 (no)	1999-08-26
ATE109779T1 (de)	1994-08-15
DK572887A (da)	1988-05-04
KR950011737B1 (ko)	1995-10-09
FI87786C (fi)	1993-02-25
JPH0977769A (ja)	1997-03-25
NO874550L (no)	1988-05-04
JP2542225B2 (ja)	1996-10-09
NO874550D0 (no)	1987-11-02
IE63670B1 (en)	1995-05-31
EP0266730B1 (en)	1994-08-10
DE3750359D1 (de)	1994-09-15
JP2657267B2 (ja)	1997-09-24
ES2061469T3 (es)	1994-12-16
IE872955L (en)	1988-05-03
DE3750359T2 (de)	1994-12-08
AR246264A1 (es)	1994-07-29
NO165922B (no)	1991-01-21
HU197008B (en)	1989-02-28
PT86060B (pt)	1990-07-31
FI874768A7 (fi)	1988-05-04
HUT45055A (en)	1988-05-30
FI87786B (fi)	1992-11-13
NZ222349A (en)	1990-05-28
CN1021654C (zh)	1993-07-21
PT86060A (en)	1987-12-01
PH24664A (en)	1990-09-07
PH26261A (en)	1992-04-01
AU600318B2 (en)	1990-08-09
IL84309A (en)	1991-09-16
NL970043I1 (nl)	1998-03-02
CN87107629A (zh)	1988-06-15
ZA878096B (en)	1988-04-26
DE19775092I2 (de)	2001-11-22
AU8059687A (en)	1988-05-05
KR880006240A (ko)	1988-07-22
NO165922C (no)	1991-05-02
CA1329203C (en)	1994-05-03
JPS63258476A (ja)	1988-10-25
DK572887D0 (da)	1987-11-02
DK171116B1 (da)	1996-06-17

Publication	Publication Date	Title
NL970043I1 (nl)	1998-03-02	Esters van hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-on en verwante verbindingen.
DE3674906D1 (de)	1990-11-15	Selbstklemmende medizinische prothese und ihre herstellung.
PT85616A (de)	1987-09-01	Aryloxycarbonsaurederivate ihre herstellung und verwendung
DE3885534D1 (de)	1993-12-16	Arylphosphorderivate, ihre Herstellung und Verwendung.
MX9203134A (es)	1992-07-01	Esteres de hexahidro-8-hidroxi-2,6-metano-2h-quinolizin-3-(4h)-ona y compuestos relacionados.
ATE87927T1 (de)	1993-04-15	Demethylavermectine und herstellung dazu.
FI874046L (fi)	1988-03-18	Foerfarande foer framstaellning av en med laonga fibrer armerad polyamidbaserad komposit.
NO882762L (no)	1988-12-27	Fremgangsmaate for fremstilling av antihypertensive og antiarytmiske forbindelser.
FI873398A0 (fi)	1987-08-05	Bestaemning av kliniska parametrar med hjaelp av en enzymatisk immunoprocess.
FI882583L (fi)	1988-12-03	Foerfarande foer tryckning pao plastunderlag med anvaendning av vattenbaserat blaeck.
NO870126D0 (no)	1987-01-13	7-(azabicykloalkyl)-chinolinkarboksylsyre- og naftyri-donkarboksylsyre-derivater.
DE3781574D1 (de)	1992-10-15	Calixaren-derivate und die verwendung dieser verbindungen zur sequestrierung von metallen.
DE3789963D1 (de)	1994-07-07	Menschliche tachykinine und ihre vorläufer.
DE3783751D1 (de)	1993-03-04	Glyzirrhetinsaeure-derivate und ihre anwendung.
FI883867A7 (fi)	1989-02-22	2-pyrimidinyyli-1 -piperatsiinijohdannaisten käyttö.
FI873606A7 (fi)	1988-02-23	Ihmisen glykoalbumiinin määrittämiseen käyttökelpoisia vasta-aineita.
DE3889644D1 (de)	1994-06-23	Pheophorbidderivate.
EP0311634A4 (en)	1989-06-26	6- (6-ALKYLPYRIDONE) -CARBOSTYRILE COMPOUNDS AND THEIR CARDIOTONIC USES.
NO863113D0 (no)	1986-08-01	Fremgangsmaate for fremstilling av heterocyclocarbonyl- og acetyl-thiazoloner.
FI861641A0 (fi)	1986-04-18	Foerfarande foer framstaellning av (-)-1 -etyl-1 -hydroximetyl-1,2,3,4,6,7,12,12b -oktahydroindolo/2,3-a/ -kinolizin.
NO871477D0 (no)	1987-04-08	Fremgangsmaate for fremstilling av human plasminogenaktivator.
DE3689036D1 (de)	1993-10-21	Lankacidinderivate und ihre Herstellung.
TR24449A (tr)	1991-10-10	Tiyazinol tuerevleri hazirlanmalarina mahsus usul v ve fungusid olarak kullanimi
NO870828D0 (no)	1987-02-27	Fremgangsmaate for fremstilling av biskarbamater.
FI900835A0 (fi)	1990-02-20	Taetning med reglerbar diameter.