NO157329C - Analogifremgangsmaate for fremstilling av 5-fluor pgi-forbindelser. - Google Patents

Analogifremgangsmaate for fremstilling av 5-fluor pgi-forbindelser.

Info

Publication number
NO157329C
NO157329C NO821108A NO821108A NO157329C NO 157329 C NO157329 C NO 157329C NO 821108 A NO821108 A NO 821108A NO 821108 A NO821108 A NO 821108A NO 157329 C NO157329 C NO 157329C
Authority
NO
Norway
Prior art keywords
fluor
preparation
analogy procedure
pgi
compounds
Prior art date
Application number
NO821108A
Other languages
English (en)
Norwegian (no)
Other versions
NO821108L (no
NO157329B (no
Inventor
Leonard Norman Nysted
Raphael Pappo
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO821108L publication Critical patent/NO821108L/no
Publication of NO157329B publication Critical patent/NO157329B/no
Publication of NO157329C publication Critical patent/NO157329C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Furan Compounds (AREA)
NO821108A 1981-04-02 1982-04-01 Analogifremgangsmaate for fremstilling av 5-fluor pgi-forbindelser. NO157329C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25053081A 1981-04-02 1981-04-02

Publications (3)

Publication Number Publication Date
NO821108L NO821108L (no) 1982-10-04
NO157329B NO157329B (no) 1987-11-23
NO157329C true NO157329C (no) 1988-03-02

Family

ID=22948130

Family Applications (2)

Application Number Title Priority Date Filing Date
NO821108A NO157329C (no) 1981-04-02 1982-04-01 Analogifremgangsmaate for fremstilling av 5-fluor pgi-forbindelser.
NO854442A NO854442L (no) 1981-04-02 1985-11-07 Fremgangsmaate til fremstilling av mellomprodukt for syntese av farmakologisk aktive 5-flour-pgi2 derivater.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO854442A NO854442L (no) 1981-04-02 1985-11-07 Fremgangsmaate til fremstilling av mellomprodukt for syntese av farmakologisk aktive 5-flour-pgi2 derivater.

Country Status (12)

Country Link
EP (1) EP0062303B1 (da)
JP (1) JPS57176978A (da)
AU (1) AU549367B2 (da)
CA (1) CA1215973A (da)
DE (1) DE3267651D1 (da)
DK (1) DK149682A (da)
ES (1) ES8306997A1 (da)
IE (1) IE52937B1 (da)
NO (2) NO157329C (da)
NZ (1) NZ200210A (da)
PT (1) PT74691B (da)
ZA (1) ZA822297B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57200378A (en) * 1981-06-02 1982-12-08 Teijin Ltd Halogenated pgi2 and its preparation
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation
US4670569A (en) * 1981-04-02 1987-06-02 G. D. Searle & Co. 5-fluoro-PGI2 compounds
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
US4579958A (en) * 1983-12-23 1986-04-01 G. D. Searle & Co. 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds
US4611065A (en) * 1985-01-25 1986-09-09 G. D. Searle & Co. Method for preparing 5-fluoroprostacyclins
US4616034A (en) * 1985-02-28 1986-10-07 G. D. Searle & Co. 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097489A (en) * 1977-06-17 1978-06-27 The Upjohn Company 9-Deoxy-9α,6-nitrilo or 6,9α-imino-PGF compounds
WO1981001002A1 (en) * 1979-10-10 1981-04-16 Univ Chicago Fluoro-substituted prostaglandins and prostacyclins
EP0054795B1 (en) * 1980-12-09 1987-07-15 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
IE52937B1 (en) 1988-04-13
AU549367B2 (en) 1986-01-23
DK149682A (da) 1982-10-03
EP0062303B1 (en) 1985-11-27
ES511067A0 (es) 1983-06-16
AU8225882A (en) 1982-10-07
EP0062303A3 (en) 1982-11-10
NO821108L (no) 1982-10-04
PT74691B (en) 1983-10-26
ES8306997A1 (es) 1983-06-16
NO157329B (no) 1987-11-23
NO854442L (no) 1982-10-04
PT74691A (en) 1982-05-01
EP0062303A2 (en) 1982-10-13
NZ200210A (en) 1985-10-11
JPS57176978A (en) 1982-10-30
CA1215973A (en) 1986-12-30
DE3267651D1 (en) 1986-01-09
ZA822297B (en) 1983-04-27
IE820773L (en) 1982-10-02

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