NO170018C - Analogifremgangsmaate for fremstilling av terapeutisk virksomme substituerte imidazolyl-alkyl-piperazin- og -diazepinderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk virksomme substituerte imidazolyl-alkyl-piperazin- og -diazepinderivater

Info

Publication number: NO170018C
Authority: NO; Norway
Prior art keywords: alkyl; aryl; piperazine; substituted imidazolyl; preparation
Prior art date: 1987-04-24

Application number

NO881789A

Other languages

English (en)

Norwegian (no)

Other versions

NO170018B (no

NO881789L (no

NO881789D0 (no

Inventor

Jean-Claude Pascal

Chi-Ho Lee

Brian J Alps

Henri Pinhas

Roger L Whiting

Original Assignee

Syntex Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-24

Filing date

1988-04-22

Publication date

1992-09-02

1988-04-22 Application filed by Syntex Pharma Ltd filed Critical Syntex Pharma Ltd

1988-04-22 Publication of NO881789D0 publication Critical patent/NO881789D0/no

1988-10-25 Publication of NO881789L publication Critical patent/NO881789L/no

1992-05-25 Publication of NO170018B publication Critical patent/NO170018B/no

1992-09-02 Publication of NO170018C publication Critical patent/NO170018C/no

Links

150000004908 diazepines Chemical class 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
208000028867 ischemia Diseases 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 1
201000006474 Brain Ischemia Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
206010013654 Drug abuse Diseases 0.000 abstract 1
208000005189 Embolism Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
208000023105 Huntington disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000004880 Polyuria Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
208000020339 Spinal injury Diseases 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
206010003119 arrhythmia Diseases 0.000 abstract 1
230000006793 arrhythmia Effects 0.000 abstract 1
201000001272 cocaine abuse Diseases 0.000 abstract 1
125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000035619 diuresis Effects 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
230000001037 epileptic effect Effects 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Epoxy Resins (AREA)

NO881789A 1987-04-24 1988-04-22 Analogifremgangsmaate for fremstilling av terapeutisk virksomme substituerte imidazolyl-alkyl-piperazin- og -diazepinderivater NO170018C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/042,181 US4829065A (en)	1987-04-24	1987-04-24	Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

Publications (4)

Publication Number	Publication Date
NO881789D0 NO881789D0 (no)	1988-04-22
NO881789L NO881789L (no)	1988-10-25
NO170018B NO170018B (no)	1992-05-25
NO170018C true NO170018C (no)	1992-09-02

Family

ID=21920487

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO881789A NO170018C (no)	1987-04-24	1988-04-22	Analogifremgangsmaate for fremstilling av terapeutisk virksomme substituerte imidazolyl-alkyl-piperazin- og -diazepinderivater

Country Status (20)

Country	Link
US (1)	US4829065A (fr)
EP (1)	EP0289227B1 (fr)
JP (1)	JPH0737451B2 (fr)
KR (1)	KR960007524B1 (fr)
AT (1)	ATE74594T1 (fr)
AU (1)	AU614282B2 (fr)
CA (1)	CA1320199C (fr)
DE (1)	DE3869821D1 (fr)
DK (1)	DK220488A (fr)
ES (1)	ES2038288T3 (fr)
FI (1)	FI93104C (fr)
GR (1)	GR3004317T3 (fr)
HU (2)	HU199456B (fr)
IE (1)	IE62106B1 (fr)
IL (1)	IL86149A (fr)
MX (1)	MX9203595A (fr)
NO (1)	NO170018C (fr)
NZ (1)	NZ224344A (fr)
PH (1)	PH27325A (fr)
ZA (1)	ZA882878B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5043447A (en) *	1987-04-24	1991-08-27	Syntex Pharmaceuticals, Ltd.	Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5091428A (en) *	1987-04-24	1992-02-25	Syntex Pharmaceuticals, Ltd.	Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US4973591A (en) *	1988-10-21	1990-11-27	Syntex Pharmaceuticals, Ltd.	Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine
US5106845A (en) *	1990-01-10	1992-04-21	Merrell Dow Pharmaceuticals Inc.	Calcium antagonists
US5159083A (en) *	1990-12-28	1992-10-27	Neurogen Corporation	Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
US5681956A (en) *	1990-12-28	1997-10-28	Neurogen Corporation	4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en)	1990-12-28	1997-05-27	Neurogen Corporation	4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
WO1992018089A2 (fr) *	1991-04-09	1992-10-29	The Upjohn Company	Utilisation d'amines steroides et non steroides pour sensibiliser des cellules resistant a plusieurs medicaments
US5633250A (en) *	1991-12-18	1997-05-27	Schering Corporation	Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
DK0618905T3 (da) *	1991-12-18	1995-12-04	Schering Corp	Imidazolyl-alkyl-piperazin- og -diazepinderivater som histamin H3-agonister/antagonister
US5296609A (en) *	1993-04-09	1994-03-22	Syntex Pharmaceuticals, Ltd.	Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives
US5428037A (en) *	1993-04-09	1995-06-27	Syntex Pharmaceuticals, Ltd.	Heterocyclic derivatives in the treatment of Ischaemia and related diseases
US5478934A (en) *	1994-11-23	1995-12-26	Yuan; Jun	Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
SE9504661D0 (sv) *	1995-12-22	1995-12-22	Astra Pharma Inc	New compounds
SE9504662D0 (sv) *	1995-12-22	1995-12-22	Astra Pharma Inc	New compounds
JP2000507579A (ja) *	1996-04-03	2000-06-20	メルクエンドカンパニーインコーポレーテッド	ファルネシル―タンパク質トランスフェラーゼ阻害剤
US5885995A (en) *	1996-04-03	1999-03-23	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5869682A (en) *	1996-04-03	1999-02-09	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5972942A (en) *	1997-03-27	1999-10-26	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US6166205A (en) *	1998-09-02	2000-12-26	Neurogen Corporation	2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
JP2002540072A (ja)	1999-03-03	2002-11-26	メルクエンドカムパニーインコーポレーテッド	プレニル蛋白トランスフェラーゼの阻害剤
EP1158983A4 (fr)	1999-03-03	2003-05-21	Merck & Co Inc	Inhibiteurs de prenyl-proteine transferases
EP1165013A4 (fr)	1999-03-03	2002-08-07	Merck & Co Inc	Inhibiteurs de prenyle proteine transferase
AU3386600A (en)	1999-03-03	2000-09-21	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
JP2003503482A (ja) *	1999-07-06	2003-01-28	バーテックスファーマシューティカルズインコーポレイテッド	環化アミノ酸誘導体
SE9904674D0 (sv)	1999-12-20	1999-12-20	Astra Pharma Inc	Novel compounds
SE9904673D0 (sv)	1999-12-20	1999-12-20	Astra Pharma Inc	Novel compounds
SE0001209D0 (sv)	2000-04-04	2000-04-04	Astrazeneca Canada Inc	Novel compounds
CA2422729A1 (fr) *	2000-09-20	2002-06-06	Schering Corporation	Imidazoles substituees utilisees comme agonistes ou antagonistes doubles d'histamine h1 et h3
PT1395567E (pt)	2001-05-18	2009-03-26	Astrazeneca Ab	Derivados de 4(fenil-piperazinil-metil)benzamida e sua utilização para o tratamento da ansiedade da dor ou de distúrbios gastrointestinais
SE0203300D0 (sv)	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0203302D0 (sv)	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
SE0203303D0 (sv)	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
KR101234421B1 (ko)	2004-08-02	2013-02-18	아스트라제네카 아베	디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
CN114349745B (zh) *	2022-01-14	2023-12-08	黑龙江中医药大学	一种用于治疗心肌缺血的药物及其制备方法

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Publication number	Priority date	Publication date	Assignee	Title
US3362956A (en) *	1965-08-19	1968-01-09	Sterling Drug Inc	1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
GB1184714A (en) *	1965-12-16	1970-03-18	Science Union & Cie	Di- and Tri-Phenylpropyl Piperazine Derivatives
US3491098A (en) *	1967-05-29	1970-01-20	Sterling Drug Inc	1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
DE1795314A1 (de) *	1968-09-11	1972-01-05	Merck Patent Gmbh	N-(Thiazolyl-2)-piperazine
US3927011A (en) *	1973-05-10	1975-12-16	Yoshitomi Pharmaceutical	2-Aminoalkyl-1-(pyridylcarbonylphenyl)imidazole compounds
IT1056055B (it) *	1974-03-01	1982-01-30	Malesci Sas Inst Farmaco Bilog	Derivati eterocicli della 4 fenil riperazina i alchil sostituita ad azione farmacologica e relativo procedimento di preparazione
US4022783A (en) *	1975-10-29	1977-05-10	Usv Pharmaceutical Corporation	Piperazinyl-imidazolines
GB1551993A (en) *	1976-09-21	1979-09-05	Malesci Sas	Pharmacologiclly active derivatives of 1 alkyl 4-phenylpiperazines and the preparation thereof
IT1159698B (it) *	1978-05-29	1987-03-04	Rotta Research Lab	Derivati 5-nitro-imidazolici della piperazina ad attivita' antiprotozoica
US4243806A (en) *	1979-06-13	1981-01-06	Janssen Pharmaceutica N.V.	5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives
US4404382A (en) *	1980-09-17	1983-09-13	The Upjohn Company	Piperazinyl-substituted imidazoles
CA1162540A (fr) *	1980-12-24	1984-02-21	Ikutaro Saji	Imidazolylpropanols et leurs sels d'addition acide; preparation et applications
US4435399A (en) *	1981-07-18	1984-03-06	Pfizer Inc.	2-Aryl-1-(imidazol-1-yl)-8-(4-piperazin-1-ylphenoxy) octan-2-ol antifungal agents

1987
- 1987-04-24 US US07/042,181 patent/US4829065A/en not_active Expired - Fee Related
1988
- 1988-04-22 FI FI881900A patent/FI93104C/fi not_active IP Right Cessation
- 1988-04-22 IL IL86149A patent/IL86149A/xx not_active IP Right Cessation
- 1988-04-22 ZA ZA882878A patent/ZA882878B/xx unknown
- 1988-04-22 PH PH36835A patent/PH27325A/en unknown
- 1988-04-22 ES ES198888303646T patent/ES2038288T3/es not_active Expired - Lifetime
- 1988-04-22 NZ NZ224344A patent/NZ224344A/xx unknown
- 1988-04-22 HU HU882048A patent/HU199456B/hu not_active IP Right Cessation
- 1988-04-22 JP JP63101194A patent/JPH0737451B2/ja not_active Expired - Lifetime
- 1988-04-22 KR KR1019880004550A patent/KR960007524B1/ko not_active Expired - Fee Related
- 1988-04-22 CA CA000564939A patent/CA1320199C/fr not_active Expired - Fee Related
- 1988-04-22 AT AT88303646T patent/ATE74594T1/de active
- 1988-04-22 NO NO881789A patent/NO170018C/no unknown
- 1988-04-22 DK DK220488A patent/DK220488A/da not_active Application Discontinuation
- 1988-04-22 IE IE120988A patent/IE62106B1/en not_active IP Right Cessation
- 1988-04-22 AU AU15102/88A patent/AU614282B2/en not_active Ceased
- 1988-04-22 EP EP88303646A patent/EP0289227B1/fr not_active Expired - Lifetime
- 1988-04-22 DE DE8888303646T patent/DE3869821D1/de not_active Expired - Lifetime
1992
- 1992-04-09 GR GR910401975T patent/GR3004317T3/el unknown
- 1992-06-26 MX MX9203595A patent/MX9203595A/es unknown
1995
- 1995-02-17 HU HU95P/P00079P patent/HU210720A9/hu unknown

Also Published As

Publication number	Publication date
FI93104B (fi)	1994-11-15
NO170018B (no)	1992-05-25
HUT46690A (en)	1988-11-28
DK220488A (da)	1988-10-25
ATE74594T1 (de)	1992-04-15
EP0289227B1 (fr)	1992-04-08
FI881900A0 (fi)	1988-04-22
FI881900A7 (fi)	1988-10-25
JPS63280081A (ja)	1988-11-17
KR880012589A (ko)	1988-11-28
HU210720A9 (en)	1995-06-28
IE881209L (en)	1988-10-24
KR960007524B1 (ko)	1996-06-05
ZA882878B (en)	1989-12-27
GR3004317T3 (fr)	1993-03-31
EP0289227A1 (fr)	1988-11-02
NO881789L (no)	1988-10-25
JPH0737451B2 (ja)	1995-04-26
ES2038288T3 (es)	1993-07-16
PH27325A (en)	1993-06-08
HU199456B (en)	1990-02-28
AU1510288A (en)	1988-10-27
CA1320199C (fr)	1993-07-13
AU614282B2 (en)	1991-08-29
IL86149A (en)	1993-01-14
NZ224344A (en)	1991-01-29
IL86149A0 (en)	1988-11-15
IE62106B1 (en)	1994-12-14
US4829065A (en)	1989-05-09
DK220488D0 (da)	1988-04-22
MX9203595A (es)	1992-09-01
FI93104C (fi)	1995-02-27
NO881789D0 (no)	1988-04-22
DE3869821D1 (de)	1992-05-14

Publication	Publication Date	Title
NO170018C (no)	1992-09-02	Analogifremgangsmaate for fremstilling av terapeutisk virksomme substituerte imidazolyl-alkyl-piperazin- og -diazepinderivater
NO173651C (no)	1994-01-12	Analogifremgnagsmaate ved fremstilling av terapeutisk aktive benzodiazepinanaloger
EP1016664A4 (fr)	2001-01-24	Composes thiophene condenses et leur utilisation en medecine
IL96498A0 (en)	1991-08-16	Aminocarbonylcarbamates related to physostigmine,a process for their preparation and their use as medicaments
ATE167861T1 (de)	1998-07-15	1,2,4-oxadiazolyl oder 1,2,4-thiadiazolyl- derivate als angiotensin ii antagonisten
ATE101147T1 (de)	1994-02-15	Pharmazeutisch verwendbare polymorphe modifikation von buspiron.
PT98773A (pt)	1992-07-31	Processo para a preparacao de di-hidropirido/4,3-d/pirimidinas substituidas na posicao 4 e de composicoes farmaceuticas analgesicas e antiinflamatorias que as contem
PT92234A (pt)	1990-05-31	Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas
NO180303C (no)	1997-03-26	Kondenserte diazepinoner, og midler som inneholder disse forbindelser
NO892152D0 (no)	1989-05-29	Kondenserte diazepinoner, fremstilling derav og legemidler som inneholder dem.
FI96308C (fi)	1996-06-10	Menetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinien ja niiden johdannaisten valmistamiseksi
ATE113950T1 (de)	1994-11-15	4,5,6,11-tetrahydrobenzo(6,7>-cycloocta(1,2- b>thiophen-6,11-imine und 6,11-dihydrobenzo(6,7>- cycloocta(1,2-b>thiophen-6,11-imine.
ES501744A0 (es)	1982-04-01	Procedimiento para la obtencion de bis (fenoxiacetatos sus- tituidos)de n-alcohil-dialcanolaminas
MX9100640A (es)	1992-04-01	Carbamoil-1-(piridinilalquil)-1h-indoles,indolinas y analogos a fines