NO170430C - Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper - Google Patents

Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper

Info

Publication number
NO170430C
NO170430C NO873859A NO873859A NO170430C NO 170430 C NO170430 C NO 170430C NO 873859 A NO873859 A NO 873859A NO 873859 A NO873859 A NO 873859A NO 170430 C NO170430 C NO 170430C
Authority
NO
Norway
Prior art keywords
anticoagulating
protein
procedure
manufacturing
metastatic properties
Prior art date
Application number
NO873859A
Other languages
English (en)
Norwegian (no)
Other versions
NO170430B (no
NO873859D0 (no
NO873859L (no
Inventor
Gabriel J Gasic
Tatiana B Gasic
George P Tuszynski
Gregory P Gasic
Paul A Friedman
John W Jacobs
Ellen Simpson
Original Assignee
Pennsylvania Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennsylvania Hospital filed Critical Pennsylvania Hospital
Publication of NO873859D0 publication Critical patent/NO873859D0/no
Publication of NO873859L publication Critical patent/NO873859L/no
Publication of NO170430B publication Critical patent/NO170430B/no
Publication of NO170430C publication Critical patent/NO170430C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO873859A 1986-09-18 1987-09-15 Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper NO170430C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90858186A 1986-09-18 1986-09-18
US8843287A 1987-08-26 1987-08-26

Publications (4)

Publication Number Publication Date
NO873859D0 NO873859D0 (no) 1987-09-15
NO873859L NO873859L (no) 1988-03-21
NO170430B NO170430B (no) 1992-07-06
NO170430C true NO170430C (no) 1992-10-14

Family

ID=26778655

Family Applications (1)

Application Number Title Priority Date Filing Date
NO873859A NO170430C (no) 1986-09-18 1987-09-15 Fremgangsmaate for fremstilling av et protein som har antikoagulerende og anti-metastatiske egenskaper

Country Status (9)

Country Link
EP (1) EP0263608A3 (de)
KR (1) KR880003975A (de)
AU (1) AU615635B2 (de)
DK (1) DK489187A (de)
FI (1) FI874055A7 (de)
IL (1) IL83912A (de)
NO (1) NO170430C (de)
NZ (1) NZ221835A (de)
PT (1) PT85746B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
US4832849A (en) * 1988-06-16 1989-05-23 Merrell Dow Pharmaceuticals Inc. Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
AU624962B2 (en) * 1989-06-20 1992-06-25 Merrell Dow Pharmaceuticals Inc. Ghilanten: antimetastatic principle from the south american leech, haementeria ghilanii
US5648461A (en) * 1990-02-22 1997-07-15 W.R. Grace & Co.-Conn Synthetic analogs of thrombospondin and therapeutic use thereof
US5200397A (en) * 1990-02-22 1993-04-06 W. R. Grace & Co.-Conn. Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
US6239110B1 (en) 1990-02-22 2001-05-29 W.R. Grace & Co. -Conn. Synthetic analogs of thrombospondin and therapeutic use thereof
US5190918A (en) * 1990-02-22 1993-03-02 W. R. Grace & Co.-Conn. Peptide fragments and analogs of thrombospondin and methods of use
CA2047527A1 (en) * 1990-07-24 1992-01-25 Christopher Dunwiddie Method for administering a therapeutic anticoagulant
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
AU6630294A (en) * 1993-04-09 1994-11-08 Bio-Technology General Corporation Production of recombinant factor xa inhibitor of leech hirudo medicinalis
US5863534A (en) * 1993-04-09 1999-01-26 Bio-Technology General Corp. Polypeptide having factor Xa inhibitory method of reducing blood coagulation with a novel polypeptide having factor Xa inhibitory activity
US6339062B1 (en) 1998-11-23 2002-01-15 Inkine Pharmaceutical Company, Inc. Retroinverso polypeptides that mimic or inhibit thrombospondin activity
GB9930659D0 (en) * 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
CA2623565A1 (en) 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
CN109620847B (zh) * 2018-12-11 2022-07-26 山东沃华医药科技股份有限公司 一种脑血疏口服液中的水蛭抗凝成分的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis

Also Published As

Publication number Publication date
IL83912A (en) 1993-05-13
FI874055L (fi) 1988-03-19
NO170430B (no) 1992-07-06
NO873859D0 (no) 1987-09-15
PT85746A (en) 1987-10-01
DK489187A (da) 1988-03-19
IL83912A0 (en) 1988-02-29
NO873859L (no) 1988-03-21
DK489187D0 (da) 1987-09-17
EP0263608A3 (de) 1989-06-14
EP0263608A2 (de) 1988-04-13
FI874055A0 (fi) 1987-09-17
PT85746B (pt) 1990-07-31
FI874055A7 (fi) 1988-03-19
AU7862687A (en) 1988-03-24
AU615635B2 (en) 1991-10-10
KR880003975A (ko) 1988-05-31
NZ221835A (en) 1992-03-26

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