NO170938C - Analogifremgangsmaate for fremstilling av terapeutisk virksomme fosfonosubstituerte aminoalkensyrer - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk virksomme fosfonosubstituerte aminoalkensyrer

Info

Publication number: NO170938C
Authority: NO; Norway
Prior art keywords: alkyl; amino; acids; phosphonosubstituted; aminoalky
Prior art date: 1986-02-13

Application number

NO870577A

Other languages

English (en)

Norwegian (no)

Other versions

NO870577D0 (no

NO870577L (no

NO170938B (no

Inventor

Christof Angst

Derek Edward Brundisch

John Grey Dingwall

Graham Eric Fagg

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-13

Filing date

1987-02-13

Publication date

1992-12-30

1987-02-13 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1987-02-13 Publication of NO870577D0 publication Critical patent/NO870577D0/no

1987-08-14 Publication of NO870577L publication Critical patent/NO870577L/no

1992-09-21 Publication of NO170938B publication Critical patent/NO170938B/no

1992-12-30 Publication of NO170938C publication Critical patent/NO170938C/no

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
BDYHNCZIGYIOGJ-DUXPYHPUSA-N (e)-2-amino-4-methyl-5-phosphonopent-3-enoic acid Chemical compound OP(=O)(O)CC(/C)=C/C(N)C(O)=O BDYHNCZIGYIOGJ-DUXPYHPUSA-N 0.000 abstract 1
TUMOUMLCWZEIRK-OWOJBTEDSA-N (e)-2-amino-5-phosphonopent-3-enoic acid Chemical compound OC(=O)C(N)\C=C\CP(O)(O)=O TUMOUMLCWZEIRK-OWOJBTEDSA-N 0.000 abstract 1
OKDOWCKDTWNRCB-GQCTYLIASA-N [(e)-4-amino-5-ethoxy-2-methyl-5-oxopent-2-enyl]phosphonic acid Chemical compound CCOC(=O)C(N)\C=C(/C)CP(O)(O)=O OKDOWCKDTWNRCB-GQCTYLIASA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/302—Acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3217—Esters of acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO870577A 1986-02-13 1987-02-13 Analogifremgangsmaate for fremstilling av terapeutisk virksomme fosfonosubstituerte aminoalkensyrer NO170938C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH57886		1986-02-13

Publications (4)

Publication Number	Publication Date
NO870577D0 NO870577D0 (no)	1987-02-13
NO870577L NO870577L (no)	1987-08-14
NO170938B NO170938B (no)	1992-09-21
NO170938C true NO170938C (no)	1992-12-30

Family

ID=4190244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO870577A NO170938C (no)	1986-02-13	1987-02-13	Analogifremgangsmaate for fremstilling av terapeutisk virksomme fosfonosubstituerte aminoalkensyrer

Country Status (23)

Country	Link
EP (1)	EP0233154B1 (es)
JP (2)	JPH0717665B2 (es)
KR (1)	KR900003533B1 (es)
AT (1)	ATE70535T1 (es)
AU (1)	AU610493B2 (es)
CA (1)	CA1331625C (es)
CY (1)	CY1821A (es)
DD (1)	DD263775A5 (es)
DE (1)	DE3775229D1 (es)
DK (1)	DK169341B1 (es)
ES (1)	ES2038690T3 (es)
FI (1)	FI85144C (es)
GR (1)	GR3003526T3 (es)
HK (1)	HK95594A (es)
HU (1)	HU204532B (es)
IE (1)	IE59417B1 (es)
IL (1)	IL81543A0 (es)
NO (1)	NO170938C (es)
NZ (1)	NZ219255A (es)
PH (1)	PH23762A (es)
PT (1)	PT84270B (es)
SG (1)	SG92294G (es)
ZA (1)	ZA871022B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175344A (en) *	1986-02-13	1992-12-29	Ciba-Geigy Corporation	Unsaturated amino acids
EP0263502A3 (de) *	1986-10-09	1990-05-02	Ciba-Geigy Ag	Oligopeptid-Antibiotika
EP0302826A3 (de) *	1987-08-04	1991-04-03	Ciba-Geigy Ag	Verfahren zur Herstellung neuer ungesättigter Aminosäureverbindungen
US5175153A (en) *	1987-11-30	1992-12-29	Warner-Lambert Company	Substituted alpha-amino acids having pharmaceutical activity
US5179085A (en) *	1989-03-15	1993-01-12	Warner-Lambert Company	N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
ES2060122T3 (es) *	1989-04-07	1994-11-16	Ciba Geigy Ag	Derivados insaturados de acidos aminodicarboxilicos.
US5500419A (en) *	1989-09-19	1996-03-19	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
US5294734A (en) *	1989-09-26	1994-03-15	Ciba-Geigy Corp.	4-substituted 2-aminoalk-3-enoic acids
DE59009368D1 (de) *	1989-09-26	1995-08-10	Ciba Geigy Ag	Phosphonsäure, Verfahren zur Herstellung und Verwendung als Arzneimittelwirkstoff.
US5488140A (en) *	1989-09-26	1996-01-30	Ciba-Geigy Corporation	4-substituted 2-aminoalk-3-enoic
US5238958A (en) *	1990-02-26	1993-08-24	Warner-Lambert Company	Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
JPH07505908A (ja) *	1992-09-28	1995-06-29	マックセチーニ、マリア　ルイザ	Ｎｍｄａ受容体のアロステリックモジュレーター
US20090170813A1 (en) *	2005-10-18	2009-07-02	Francine Acher	Hypophosphorous Acid Derivatives and their Therapeutical Applications
DE102007032669A1 (de)	2007-07-13	2009-01-15	Clariant International Limited	Alkylphosphonigsäuren, -salze und -ester, Verfahren zu deren Herstellung und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4477391A (en) *	1981-08-14	1984-10-16	Collins James F	Amino acid isomers, their production and their medicinal use
GB2104079B (en) *	1981-08-14	1985-08-21	London Polytech	New aminoacid isomers, their production and their medicinal use

1987
- 1987-02-10 DE DE8787810080T patent/DE3775229D1/de not_active Expired - Lifetime
- 1987-02-10 AT AT87810080T patent/ATE70535T1/de not_active IP Right Cessation
- 1987-02-10 EP EP87810080A patent/EP0233154B1/de not_active Expired - Lifetime
- 1987-02-10 ES ES198787810080T patent/ES2038690T3/es not_active Expired - Lifetime
- 1987-02-11 DD DD87299843A patent/DD263775A5/de not_active IP Right Cessation
- 1987-02-11 FI FI870558A patent/FI85144C/fi not_active IP Right Cessation
- 1987-02-11 KR KR1019870001107A patent/KR900003533B1/ko not_active Expired
- 1987-02-11 IL IL81543A patent/IL81543A0/xx not_active IP Right Cessation
- 1987-02-11 CA CA000529448A patent/CA1331625C/en not_active Expired - Fee Related
- 1987-02-11 PT PT84270A patent/PT84270B/pt not_active IP Right Cessation
- 1987-02-12 HU HU87554A patent/HU204532B/hu not_active IP Right Cessation
- 1987-02-12 JP JP62028375A patent/JPH0717665B2/ja not_active Expired - Lifetime
- 1987-02-12 NZ NZ219255A patent/NZ219255A/xx unknown
- 1987-02-12 IE IE36587A patent/IE59417B1/en not_active IP Right Cessation
- 1987-02-12 AU AU68726/87A patent/AU610493B2/en not_active Ceased
- 1987-02-12 ZA ZA871022A patent/ZA871022B/xx unknown
- 1987-02-12 DK DK070787A patent/DK169341B1/da not_active IP Right Cessation
- 1987-02-13 PH PH34860A patent/PH23762A/en unknown
- 1987-02-13 NO NO870577A patent/NO170938C/no unknown
1992
- 1992-01-08 GR GR910402040T patent/GR3003526T3/el unknown
1994
- 1994-07-11 SG SG92294A patent/SG92294G/en unknown
- 1994-09-01 JP JP6208837A patent/JP2509465B2/ja not_active Expired - Lifetime
- 1994-09-08 HK HK95594A patent/HK95594A/xx not_active IP Right Cessation
1995
- 1995-10-20 CY CY182195A patent/CY1821A/xx unknown

Also Published As

Publication number	Publication date
PH23762A (en)	1989-11-03
FI85144C (fi)	1992-03-10
FI85144B (fi)	1991-11-29
IE59417B1 (en)	1994-02-23
ES2038690T3 (es)	1993-08-01
AU6872687A (en)	1987-08-20
CA1331625C (en)	1994-08-23
PT84270A (en)	1987-03-01
ZA871022B (en)	1987-09-30
JPS62246586A (ja)	1987-10-27
FI870558A7 (fi)	1987-08-14
JP2509465B2 (ja)	1996-06-19
HK95594A (en)	1994-09-16
SG92294G (en)	1995-04-28
EP0233154A2 (de)	1987-08-19
NO870577D0 (no)	1987-02-13
NZ219255A (en)	1989-08-29
KR870007942A (ko)	1987-09-23
PT84270B (pt)	1989-09-14
JPH0717665B2 (ja)	1995-03-01
HU204532B (en)	1992-01-28
IE870365L (en)	1987-08-13
DD263775A5 (de)	1989-01-11
NO870577L (no)	1987-08-14
ATE70535T1 (de)	1992-01-15
GR3003526T3 (es)	1993-03-16
EP0233154A3 (en)	1989-06-14
DK169341B1 (da)	1994-10-10
KR900003533B1 (ko)	1990-05-21
DE3775229D1 (de)	1992-01-30
JPH07206683A (ja)	1995-08-08
HUT43863A (en)	1987-12-28
DK70787D0 (da)	1987-02-12
IL81543A0 (en)	1987-09-16
AU610493B2 (en)	1991-05-23
EP0233154B1 (de)	1991-12-18
CY1821A (en)	1995-10-20
FI870558A0 (fi)	1987-02-11
NO170938B (no)	1992-09-21
DK70787A (da)	1987-08-14

Publication	Publication Date	Title
ATE70535T1 (de)	1992-01-15	Ungesaettigte aminosaeuren.
AR034556A1 (es)	2004-03-03	Un derivado de fenilalanina, una composicion farmaceutica que comprende al derivado de fenilalanina, el uso del derivado y proceso para preparar dicho derivado
NO932614L (no)	1994-01-24	Heteroeddiksyrederivater
DE69633398D1 (de)	2004-10-21	Betulinsäure-derivate und ihre verwendungen
HUP9701540A1 (hu)	2000-08-28	A gasztrointesztinális keringést elősegítő gyógyászati készítmény
ES2057126T3 (es)	1994-10-16	Metodo de tratamiento de la caquexia y algunos nuevos compuestos para utilizar en este metodo.
ES8606394A1 (es)	1986-04-01	Procedimiento para la obtencion de tetrapeptidos sustituidos
ES2058173T3 (es)	1994-11-01	Dioxialquilenaril-dihidropiridinas, productos intermedios para su fabricacion, procedimientos para su fabricacion y su utilizacion.
DK132188A (da)	1988-09-13	Anvendelse af tetrahydrobenz(c,d)indol-6-carboxamider som anxiolytika
DK0552060T3 (da)	1999-08-02	Imidazolderivater med anti-HIV-virkning
PT88383A (pt)	1989-07-31	Verfahren fuer die herstellung von 2-[4-<2-(4-chlorbenzamido)-ethyl-phenoxy]-2-methylpropionsaeure enthaltenden pharmazeutischen zusammensetzungen zur behandlung von diabetes geeignet
DE3787796D1 (de)	1993-11-18	Anwendung heterozyklischer Derivate zur Herstellung von Arzneimitteln.
ATE32715T1 (de)	1988-03-15	Verfahren zur herstellung von b-((2methylpropoxy)-methyl>-n-phenyl-n-(phenylmethyl - 1-pyrrolidinethanamin.
FI925546A7 (fi)	1992-12-07	Amidiliittyneitä pyridyylihappojohdannaisia leukotrieeniin liittyvien sairauksien hoitamiseksi
GB1369577A (en)	1974-10-09	Indole-carboxylic acid derivatives
ATE62684T1 (de)	1991-05-15	Hydroxyindolester.
FI870057A0 (fi)	1987-01-07	Nya tyroninderivat.
ES8602815A1 (es)	1985-12-01	Un derivado de cefalosporina
FR2244489A1 (en)	1975-04-18	3-Halo-4-heterocyclic substd.-phenylalkanoic acids - their esters and salts with antiinflammatory activity
SE8204641L (sv)	1983-02-15	Aminosyraderivat
FR2043463A1 (en)	1971-02-19	Benzoxazines and benzothiazines having c n s and
SU681818A1 (ru)	2006-12-20	Эфиры α-триалкилсилоксикарбоновых кислот, проявляющие анальгетическую или пролонгирующую гексеналовый наркоз активность
ES2095831T3 (es)	1997-03-01	Acidos tetrahidro-4-fenilimino-3-tiofeno-aceticos.
DE58909563D1 (de)	1996-02-22	3-Anilino-2-hydroxycarbonyl-4-thiophenessigsäuren
PT80187A (en)	1985-04-01	A process for the preparation of quinoline carboxylic acid derivatives