DK70787A - Umaettede aminosyrer og salte deraf samt deres fremstilling og anvendelse - Google Patents

Umaettede aminosyrer og salte deraf samt deres fremstilling og anvendelse

Info

Publication number: DK70787A
Authority: DK; Denmark
Prior art keywords: alkyl; amino; hydroxy; salts; phosphono
Prior art date: 1986-02-13

Application number

DK070787A

Other languages

English (en)

Other versions

DK70787D0 (da

DK169341B1 (da

Inventor

Christof Angst

Derek Edward Brundish

John Grey Dingwall

Graham Eric Fagg

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-13

Filing date

1987-02-12

Publication date

1987-08-14

1987-02-12 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1987-02-12 Publication of DK70787D0 publication Critical patent/DK70787D0/da

1987-08-14 Publication of DK70787A publication Critical patent/DK70787A/da

1994-10-10 Application granted granted Critical

1994-10-10 Publication of DK169341B1 publication Critical patent/DK169341B1/da

Links

150000001413 amino acids Chemical class 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 5
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
BDYHNCZIGYIOGJ-DUXPYHPUSA-N (e)-2-amino-4-methyl-5-phosphonopent-3-enoic acid Chemical compound OP(=O)(O)CC(/C)=C/C(N)C(O)=O BDYHNCZIGYIOGJ-DUXPYHPUSA-N 0.000 abstract 1
TUMOUMLCWZEIRK-OWOJBTEDSA-N (e)-2-amino-5-phosphonopent-3-enoic acid Chemical compound OC(=O)C(N)\C=C\CP(O)(O)=O TUMOUMLCWZEIRK-OWOJBTEDSA-N 0.000 abstract 1
OKDOWCKDTWNRCB-GQCTYLIASA-N [(e)-4-amino-5-ethoxy-2-methyl-5-oxopent-2-enyl]phosphonic acid Chemical compound CCOC(=O)C(N)\C=C(/C)CP(O)(O)=O OKDOWCKDTWNRCB-GQCTYLIASA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/302—Acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3217—Esters of acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)

DK070787A 1986-02-13 1987-02-12 2-Amino-omega-phospono-alk-3-ensyreforbindelser og salte deraf, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf, deres anvendelse til fremstilling af farmaceutiske præparater samt forbindelserne til anvendelse ved en fremgangsmåde til terapeutisk behandling af humane eller animalske legemer DK169341B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH57886		1986-02-13
CH57886		1986-02-13

Publications (3)

Publication Number	Publication Date
DK70787D0 DK70787D0 (da)	1987-02-12
DK70787A true DK70787A (da)	1987-08-14
DK169341B1 DK169341B1 (da)	1994-10-10

Family

ID=4190244

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK070787A DK169341B1 (da)	1986-02-13	1987-02-12	2-Amino-omega-phospono-alk-3-ensyreforbindelser og salte deraf, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf, deres anvendelse til fremstilling af farmaceutiske præparater samt forbindelserne til anvendelse ved en fremgangsmåde til terapeutisk behandling af humane eller animalske legemer

Country Status (23)

Country	Link
EP (1)	EP0233154B1 (da)
JP (2)	JPH0717665B2 (da)
KR (1)	KR900003533B1 (da)
AT (1)	ATE70535T1 (da)
AU (1)	AU610493B2 (da)
CA (1)	CA1331625C (da)
CY (1)	CY1821A (da)
DD (1)	DD263775A5 (da)
DE (1)	DE3775229D1 (da)
DK (1)	DK169341B1 (da)
ES (1)	ES2038690T3 (da)
FI (1)	FI85144C (da)
GR (1)	GR3003526T3 (da)
HK (1)	HK95594A (da)
HU (1)	HU204532B (da)
IE (1)	IE59417B1 (da)
IL (1)	IL81543A0 (da)
NO (1)	NO170938C (da)
NZ (1)	NZ219255A (da)
PH (1)	PH23762A (da)
PT (1)	PT84270B (da)
SG (1)	SG92294G (da)
ZA (1)	ZA871022B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175344A (en) *	1986-02-13	1992-12-29	Ciba-Geigy Corporation	Unsaturated amino acids
PT85874B (pt) *	1986-10-09	1990-07-31	Ciba Geigy Ag	Processo para a preparacao de oligo-peptidos com accao antibiotica
EP0302826A3 (de) *	1987-08-04	1991-04-03	Ciba-Geigy Ag	Verfahren zur Herstellung neuer ungesättigter Aminosäureverbindungen
US5175153A (en) *	1987-11-30	1992-12-29	Warner-Lambert Company	Substituted alpha-amino acids having pharmaceutical activity
US5179085A (en) *	1989-03-15	1993-01-12	Warner-Lambert Company	N-substituted α-amino acids and derivatives thereof having pharmaceutical activity
DE59007300D1 (de) *	1989-04-07	1994-11-03	Ciba Geigy Ag	Ungesättigte Aminodicarbonsäurederivate.
US5500419A (en) *	1989-09-19	1996-03-19	Merrell Dow Pharmaceuticals Inc.	NMDA antagonists
EP0420806B1 (de) *	1989-09-26	1995-07-05	Ciba-Geigy Ag	Phosphonsäure, Verfahren zur Herstellung und Verwendung als Arzneimittelwirkstoff
US5294734A (en) *	1989-09-26	1994-03-15	Ciba-Geigy Corp.	4-substituted 2-aminoalk-3-enoic acids
US5488140A (en) *	1989-09-26	1996-01-30	Ciba-Geigy Corporation	4-substituted 2-aminoalk-3-enoic
US5238958A (en) *	1990-02-26	1993-08-24	Warner-Lambert Company	Substituted α-amino acids having selected acidic moieties for use as excitatory amino acid antagonists in pharmaceuticals
JPH07505908A (ja) *	1992-09-28	1995-06-29	マックセチーニ、マリア　ルイザ	Ｎｍｄａ受容体のアロステリックモジュレーター
CA2626435A1 (en) *	2005-10-18	2007-05-10	Centre National De La Recherche Scientifique (Cnrs)	Hypophosphorous acid derivatives and their therapeutical applications
DE102007032669A1 (de) *	2007-07-13	2009-01-15	Clariant International Limited	Alkylphosphonigsäuren, -salze und -ester, Verfahren zu deren Herstellung und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4477391A (en)	1981-08-14	1984-10-16	Collins James F	Amino acid isomers, their production and their medicinal use
GB2104079B (en) *	1981-08-14	1985-08-21	London Polytech	New aminoacid isomers, their production and their medicinal use

1987
- 1987-02-10 AT AT87810080T patent/ATE70535T1/de not_active IP Right Cessation
- 1987-02-10 DE DE8787810080T patent/DE3775229D1/de not_active Expired - Lifetime
- 1987-02-10 EP EP87810080A patent/EP0233154B1/de not_active Expired - Lifetime
- 1987-02-10 ES ES198787810080T patent/ES2038690T3/es not_active Expired - Lifetime
- 1987-02-11 PT PT84270A patent/PT84270B/pt not_active IP Right Cessation
- 1987-02-11 FI FI870558A patent/FI85144C/fi not_active IP Right Cessation
- 1987-02-11 KR KR1019870001107A patent/KR900003533B1/ko not_active Expired
- 1987-02-11 DD DD87299843A patent/DD263775A5/de not_active IP Right Cessation
- 1987-02-11 CA CA000529448A patent/CA1331625C/en not_active Expired - Fee Related
- 1987-02-11 IL IL81543A patent/IL81543A0/xx not_active IP Right Cessation
- 1987-02-12 HU HU87554A patent/HU204532B/hu not_active IP Right Cessation
- 1987-02-12 AU AU68726/87A patent/AU610493B2/en not_active Ceased
- 1987-02-12 ZA ZA871022A patent/ZA871022B/xx unknown
- 1987-02-12 IE IE36587A patent/IE59417B1/en not_active IP Right Cessation
- 1987-02-12 JP JP62028375A patent/JPH0717665B2/ja not_active Expired - Lifetime
- 1987-02-12 DK DK070787A patent/DK169341B1/da not_active IP Right Cessation
- 1987-02-12 NZ NZ219255A patent/NZ219255A/xx unknown
- 1987-02-13 NO NO870577A patent/NO170938C/no unknown
- 1987-02-13 PH PH34860A patent/PH23762A/en unknown
1992
- 1992-01-08 GR GR910402040T patent/GR3003526T3/el unknown
1994
- 1994-07-11 SG SG92294A patent/SG92294G/en unknown
- 1994-09-01 JP JP6208837A patent/JP2509465B2/ja not_active Expired - Lifetime
- 1994-09-08 HK HK95594A patent/HK95594A/xx not_active IP Right Cessation
1995
- 1995-10-20 CY CY182195A patent/CY1821A/xx unknown

Also Published As

Publication number	Publication date
NO170938B (no)	1992-09-21
HK95594A (en)	1994-09-16
HU204532B (en)	1992-01-28
IL81543A0 (en)	1987-09-16
ES2038690T3 (es)	1993-08-01
KR870007942A (ko)	1987-09-23
PH23762A (en)	1989-11-03
DK70787D0 (da)	1987-02-12
NO170938C (no)	1992-12-30
FI85144B (fi)	1991-11-29
FI85144C (fi)	1992-03-10
NO870577L (no)	1987-08-14
HUT43863A (en)	1987-12-28
FI870558A0 (fi)	1987-02-11
EP0233154A3 (en)	1989-06-14
FI870558A7 (fi)	1987-08-14
DE3775229D1 (de)	1992-01-30
NO870577D0 (no)	1987-02-13
IE870365L (en)	1987-08-13
PT84270B (pt)	1989-09-14
JPH07206683A (ja)	1995-08-08
GR3003526T3 (da)	1993-03-16
JPH0717665B2 (ja)	1995-03-01
CY1821A (en)	1995-10-20
DK169341B1 (da)	1994-10-10
EP0233154B1 (de)	1991-12-18
IE59417B1 (en)	1994-02-23
JPS62246586A (ja)	1987-10-27
SG92294G (en)	1995-04-28
EP0233154A2 (de)	1987-08-19
ZA871022B (en)	1987-09-30
CA1331625C (en)	1994-08-23
NZ219255A (en)	1989-08-29
AU6872687A (en)	1987-08-20
JP2509465B2 (ja)	1996-06-19
KR900003533B1 (ko)	1990-05-21
PT84270A (en)	1987-03-01
ATE70535T1 (de)	1992-01-15
AU610493B2 (en)	1991-05-23
DD263775A5 (de)	1989-01-11

Legal Events

Date	Code	Title
1993-01-25	AHB	Application shelved due to non-payment
1994-10-10	B1	Patent granted (law 1993)
1999-09-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK70787D0 (da)	1987-02-12	Umaettede aminosyrer og salte deraf samt deres fremstilling og anvendelse
ES8606394A1 (es)	1986-04-01	Procedimiento para la obtencion de tetrapeptidos sustituidos
ES8507135A1 (es)	1985-09-01	Procedimiento de preparar derivados benzofuran- o benzopirancar-boxamidicos
NO20002440L (no)	2000-05-11	Hydroksam- og karboksylsyrederivater med MMP- og TNF- inhiberende aktivitet
ES2040879T3 (es)	1993-11-01	Procedimiento de preparacion de derivados pirimidinilaminicos de piperidina.
FR2390959A1 (fr)	1978-12-15	Association therapeutique a visee anti-agregante et regularisatrice de la duree de vie plaquettaire a base de pyrimido-pyrimidine et d'acide acetyl salycilique
DK0891340T3 (da)	2003-03-10	Oxazolderivater samt fremstilling og anvendelse deraf
FI971711A0 (fi)	1997-04-22	Levobupivakaiinin ja sen analogien kiteyttäminen
ES8600243A1 (es)	1985-10-01	Procedimiento para la obtencion de compuestos de 2-hidroximetil-3-carbamoil-1,4-dihidropiridina
ES8601328A1 (es)	1985-10-16	Procedimiento para la obtencion de derivados de acido aroilcarboxilicos de efecto inhibidor de la corrosion
DK382185D0 (da)	1985-08-23	Umaettede 10-substituerede steroider samt fremgangsmaade til deres fremstilling
FI870057A0 (fi)	1987-01-07	Nya tyroninderivat.
DE3683836D1 (de)	1992-03-19	Glucopyranose-derivate.
ES2038260T3 (es)	1993-07-16	Procedimiento para la preparacion de derivados del acido fenoxialquilcarboxilico.
ES8703457A1 (es)	1987-02-16	Un procedimiento para la preparacion de nuevos derivados de tiacetona.
ES469206A1 (es)	1979-09-16	Un procedimiento para preparar acido 7 b-haloarilmalonamido-7-metoxi-3-tiometil heterociclico-1-destia-1-oxa-3-cefem-4- carboxilico
FR2043463A1 (en)	1971-02-19	Benzoxazines and benzothiazines having c n s and
SE8204641D0 (sv)	1982-08-10	Aminosyraderivat
ES476031A1 (es)	1979-06-16	Procedimiento para la preparacion de semiamidas de acidos dicarboxilicos alifaticos no saturados.
FR2387958A2 (fr)	1978-11-17	Nouveau procede de preparation du disulfure de bis-n ((methyl-2 hydroxy-3 hydroxymethyl-5 pyridyl-4) methyl) thiocarbamoyle
FR2426045A2 (fr)	1979-12-14	Esters d'acide 5-alkoxy-picoliniques, procede pour leur preparation et composition anti-hypertensive contenant ces esters
DE3586795D1 (de)	1992-12-10	Absorptionsverbesserer fuer proteine.
CO4700458A1 (es)	1998-12-29	Nuevas feniliminomidazolidinas como agonistas de alfa[1]l para el tratamiento de la incontinencia urinaria
NL6906967A (en)	1970-11-10	Phthalimidine derivs tumour-inhibiting etc
NL7410333A (en)	1976-02-03	2'-Aminoethyl 3,5'-dimethyl (thio)benzoates - as anti-ulcerogenic agents