NO172580C - Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte n-(1-alkyl-3-hydroksy-4-piperidinyl)benzamider - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte n-(1-alkyl-3-hydroksy-4-piperidinyl)benzamider

Info

Publication number: NO172580C
Authority: NO; Norway
Prior art keywords: benzamides; piperidinyl; hydroxy; alkyl; preparation
Prior art date: 1987-09-25

Application number

NO884208A

Other languages

English (en)

Norwegian (no)

Other versions

NO884208L (no

NO172580B (no

NO884208D0 (no

Inventor

Georges Henri Paul Van Daele

Freddy Francois Vlaeminck

Michel Anna Jozef De Cleyn

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-25

Filing date

1988-09-22

Publication date

1993-08-11

1988-09-22 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1988-09-22 Publication of NO884208D0 publication Critical patent/NO884208D0/no

1989-03-28 Publication of NO884208L publication Critical patent/NO884208L/no

1993-05-03 Publication of NO172580B publication Critical patent/NO172580B/no

1993-08-11 Publication of NO172580C publication Critical patent/NO172580C/no

Links

229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
150000003936 benzamides Chemical class 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000002269 analeptic agent Substances 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nutrition Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

NO884208A 1987-09-25 1988-09-22 Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte n-(1-alkyl-3-hydroksy-4-piperidinyl)benzamider NO172580C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10111587A	1987-09-25	1987-09-25

Publications (4)

Publication Number	Publication Date
NO884208D0 NO884208D0 (no)	1988-09-22
NO884208L NO884208L (no)	1989-03-28
NO172580B NO172580B (no)	1993-05-03
NO172580C true NO172580C (no)	1993-08-11

Family

ID=22283104

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO884208A NO172580C (no)	1987-09-25	1988-09-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte n-(1-alkyl-3-hydroksy-4-piperidinyl)benzamider

Country Status (24)

Country	Link
EP (1)	EP0309043B1 (de)
JP (1)	JP2830936B2 (de)
KR (1)	KR0124054B1 (de)
CN (2)	CN1021652C (de)
AT (1)	ATE113936T1 (de)
AU (1)	AU610241B2 (de)
BG (1)	BG60560B1 (de)
CA (1)	CA1317940C (de)
DE (1)	DE3852085T2 (de)
DK (1)	DK529888A (de)
ES (1)	ES2066781T3 (de)
FI (1)	FI94129C (de)
GR (1)	GR3014972T3 (de)
HU (1)	HU203724B (de)
IE (1)	IE64980B1 (de)
IL (1)	IL87847A0 (de)
MA (1)	MA21381A1 (de)
NO (1)	NO172580C (de)
NZ (1)	NZ226125A (de)
PH (1)	PH25504A (de)
PT (1)	PT88577B (de)
SU (1)	SU1625331A3 (de)
TN (1)	TNSN88096A1 (de)
ZA (1)	ZA887157B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ225152A (en) *	1987-07-17	1990-04-26	Janssen Pharmaceutica Nv	Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US5019583A (en) *	1989-02-15	1991-05-28	Glaxo Inc.	N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en)	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5438064A (en) *	1991-12-23	1995-08-01	American Home Products Corporation	Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents
TW294595B (de) *	1992-11-20	1997-01-01	Janssen Pharmaceutica Nv
JP3719612B2 (ja) *	1993-06-14	2005-11-24	塩野義製薬株式会社	ヘテロ環を含有する尿素誘導体
HU218698B (hu) *	1994-09-27	2000-11-28	Janssen Pharmaceutica N.V.	Gyógyászati hatású N-szubsztituált piperidinil-(biciklusos benzoát)-származékok, intermedierjeik, előállításuk és alkalmazásuk
WO1996010026A1 (en) *	1994-09-27	1996-04-04	Janssen Pharmaceutica N.V.	Phenyl-oxo-alkyl-(4-piperidinyl)benzoate derivatives
US6096761A (en) *	1996-02-15	2000-08-01	Janssen Pharmaceutica N.V.	Esters of 3-hydroxy-piperidinemethanol derivatives
NZ330263A (en) *	1996-02-15	1999-06-29	Janssen Pharmaceutica Nv	Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
TW402591B (en)	1997-07-11	2000-08-21	Janssen Pharmaceutica Nv	Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CN1076173C (zh) *	1998-05-29	2001-12-19	孙国文	香身茶剂
TW570920B (en) *	1998-12-22	2004-01-11	Janssen Pharmaceutica Nv	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US6552046B2 (en) *	2000-06-07	2003-04-22	Aryx Therapeutics	Materials and methods for the treatment of gastroesophageal reflux disease
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
CA2551686C (en)	2004-01-07	2014-09-23	Ian Irwin	Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8138204B2 (en)	2004-01-07	2012-03-20	Aryx Therapeutics, Inc.	Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8524736B2 (en)	2004-01-07	2013-09-03	Armetheon, Inc.	Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
MY150958A (en) *	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
EP1919909B1 (de)	2005-08-31	2013-08-21	Armetheon, Inc.	Synthetische verfahren und zwischenprodukte für stereoisomere verbindungen, die sich für die behandlung von erkrankungen des magen-darm-trakts und des zentralen nervensystems eignen
WO2007149929A1 (en) *	2006-06-23	2007-12-27	Aryx Therapeutics, Inc.	Piperidine derivatives for the treatment of gastrointestinal and cns disorders
KR100976063B1 (ko) *	2007-03-16	2010-08-17	동아제약주식회사	신규한 벤즈아미드 유도체 화합물 및 그의 제조방법
EP2414361A1 (de)	2009-03-31	2012-02-08	ArQule, Inc.	Substituierte heterocyclische verbindungen
ES2525515T3 (es) *	2010-09-01	2014-12-23	Janssen Pharmaceutica, N.V.	Antagonistas del receptor 5-HT2B

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1183847A (en) *	1981-10-01	1985-03-12	Georges Van Daele	N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
ZW12187A1 (en) *	1986-07-03	1989-02-01	Janssen Pharmaceutica Nv	4-(aroylamino)piperidinebutanamide derivatives
NZ225152A (en) *	1987-07-17	1990-04-26	Janssen Pharmaceutica Nv	Heterocyclically substituted piperidinyl benzamides as pharmaceuticals

1988
- 1988-09-06 CA CA000576546A patent/CA1317940C/en not_active Expired - Fee Related
- 1988-09-09 NZ NZ226125A patent/NZ226125A/xx unknown
- 1988-09-15 DE DE3852085T patent/DE3852085T2/de not_active Expired - Fee Related
- 1988-09-15 ES ES88202011T patent/ES2066781T3/es not_active Expired - Lifetime
- 1988-09-15 AT AT88202011T patent/ATE113936T1/de not_active IP Right Cessation
- 1988-09-15 EP EP88202011A patent/EP0309043B1/de not_active Expired - Lifetime
- 1988-09-19 AU AU22322/88A patent/AU610241B2/en not_active Ceased
- 1988-09-21 MA MA21626A patent/MA21381A1/fr unknown
- 1988-09-22 NO NO884208A patent/NO172580C/no unknown
- 1988-09-23 DK DK529888A patent/DK529888A/da not_active Application Discontinuation
- 1988-09-23 SU SU884356607A patent/SU1625331A3/ru active
- 1988-09-23 TN TNTNSN88096A patent/TNSN88096A1/fr unknown
- 1988-09-23 PH PH37582A patent/PH25504A/en unknown
- 1988-09-23 IL IL87847A patent/IL87847A0/xx not_active IP Right Cessation
- 1988-09-23 IE IE288988A patent/IE64980B1/en not_active IP Right Cessation
- 1988-09-23 BG BG85500A patent/BG60560B1/bg unknown
- 1988-09-23 ZA ZA887157A patent/ZA887157B/xx unknown
- 1988-09-23 PT PT88577A patent/PT88577B/pt not_active IP Right Cessation
- 1988-09-23 FI FI884375A patent/FI94129C/fi not_active IP Right Cessation
- 1988-09-23 HU HU884991A patent/HU203724B/hu not_active IP Right Cessation
- 1988-09-24 CN CN88106959A patent/CN1021652C/zh not_active Expired - Fee Related
- 1988-09-24 JP JP63237547A patent/JP2830936B2/ja not_active Expired - Lifetime
- 1988-09-27 KR KR1019880012475A patent/KR0124054B1/ko not_active Expired - Fee Related
1992
- 1992-07-10 CN CN92105871A patent/CN1067889A/zh active Pending
1995
- 1995-02-08 GR GR940403606T patent/GR3014972T3/el unknown

Also Published As

Publication number	Publication date
TNSN88096A1 (fr)	1990-07-10
FI94129C (fi)	1995-07-25
IE64980B1 (en)	1995-09-20
EP0309043B1 (de)	1994-11-09
ATE113936T1 (de)	1994-11-15
CN1032438A (zh)	1989-04-19
DE3852085T2 (de)	1995-04-06
CN1021652C (zh)	1993-07-21
SU1625331A3 (ru)	1991-01-30
ZA887157B (en)	1990-05-30
EP0309043A3 (en)	1990-08-08
PT88577A (pt)	1988-10-01
CA1317940C (en)	1993-05-18
BG85500A (bg)	1993-12-24
JP2830936B2 (ja)	1998-12-02
AU2232288A (en)	1989-04-06
KR890005053A (ko)	1989-05-11
NZ226125A (en)	1990-05-28
NO884208L (no)	1989-03-28
NO172580B (no)	1993-05-03
CN1067889A (zh)	1993-01-13
DK529888A (da)	1989-03-26
GR3014972T3 (en)	1995-05-31
IL87847A0 (en)	1989-03-31
NO884208D0 (no)	1988-09-22
PH25504A (en)	1991-07-24
EP0309043A2 (de)	1989-03-29
HU203724B (en)	1991-09-30
ES2066781T3 (es)	1995-03-16
PT88577B (pt)	1992-11-30
BG60560B1 (bg)	1995-08-28
MA21381A1 (fr)	1989-04-01
FI884375A7 (fi)	1989-03-26
DE3852085D1 (de)	1994-12-15
AU610241B2 (en)	1991-05-16
KR0124054B1 (ko)	1997-11-27
FI94129B (fi)	1995-04-13
HUT48589A (en)	1989-06-28
DK529888D0 (da)	1988-09-23
JPH01128968A (ja)	1989-05-22
IE882889L (en)	1989-03-25
FI884375A0 (fi)	1988-09-23

Publication	Publication Date	Title
AU616838B2 (en)	1991-11-07	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro- 2h-benzopyran or dihydrobenzodioxin)carboxamide derivatives
FI884375A0 (fi)	1988-09-23	Menetelmä terapeuttisesti käyttökelpoisten N-(1-alkyyli-3-hydroksi-4-piperidinyyli)bentsamidien valmistamiseksi
NO160076C (no)	1989-03-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzoksazol- og benzotianolaminderivater.
NO163818C (no)	1990-07-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte n-((4-piperidinyl)alkyl) bicykliske kondenserte oksazol- og tiazolaminer.