NO173735C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridyl-1,3-dioksan-5-yl-alkensyrederivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridyl-1,3-dioksan-5-yl-alkensyrederivater

Info

Publication number: NO173735C
Authority: NO; Norway
Prior art keywords: acid derivatives; disease; pyridyl; dioxan; preparation
Prior art date: 1988-10-21

Application number

NO894190A

Other languages

English (en)

Norwegian (no)

Other versions

NO894190D0 (no

NO894190L (no

NO173735B (no

Inventor

Andrew George Brewster

George Robert Brown

Alan Wellington Faull

Reginald Jessup

Michael James Smithers

Original Assignee

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-21

Filing date

1989-10-20

Publication date

1994-01-26

1988-10-21 Priority claimed from GB888824667A external-priority patent/GB8824667D0/en

1988-10-21 Priority claimed from GB888824668A external-priority patent/GB8824668D0/en

1989-08-18 Priority claimed from GB898918937A external-priority patent/GB8918937D0/en

1989-10-20 Application filed by Ici Plc filed Critical Ici Plc

1989-10-20 Publication of NO894190D0 publication Critical patent/NO894190D0/no

1990-04-23 Publication of NO894190L publication Critical patent/NO894190L/no

1993-10-18 Publication of NO173735B publication Critical patent/NO173735B/no

1994-01-26 Publication of NO173735C publication Critical patent/NO173735C/no

Links

239000002253 acid Substances 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
125000000532 dioxanyl group Chemical group 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical compound C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 abstract 1
125000003158 alcohol group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO894190A 1988-10-21 1989-10-20 Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridyl-1,3-dioksan-5-yl-alkensyrederivater NO173735C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888824667A GB8824667D0 (en)	1988-10-21	1988-10-21	Carboxylic acids
GB888824668A GB8824668D0 (en)	1988-10-21	1988-10-21	Alkenoic acids
GB898918937A GB8918937D0 (en)	1989-08-18	1989-08-18	Acid derivatives

Publications (4)

Publication Number	Publication Date
NO894190D0 NO894190D0 (no)	1989-10-20
NO894190L NO894190L (no)	1990-04-23
NO173735B NO173735B (no)	1993-10-18
NO173735C true NO173735C (no)	1994-01-26

Family

ID=27264134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO894190A NO173735C (no)	1988-10-21	1989-10-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridyl-1,3-dioksan-5-yl-alkensyrederivater

Country Status (22)

Country	Link
US (1)	US5053415A (de)
EP (1)	EP0365328B1 (de)
JP (1)	JPH0699426B2 (de)
KR (1)	KR0161260B1 (de)
AT (1)	ATE136304T1 (de)
AU (1)	AU627230B2 (de)
CA (1)	CA2001160C (de)
DE (1)	DE68926144T2 (de)
DK (1)	DK513789A (de)
ES (1)	ES2087868T3 (de)
FI (1)	FI93545C (de)
GR (1)	GR3019550T3 (de)
HU (2)	HU212263B (de)
IE (1)	IE81170B1 (de)
IL (1)	IL92028A (de)
MY (1)	MY104242A (de)
NO (1)	NO173735C (de)
PH (1)	PH27054A (de)
PL (2)	PL163045B1 (de)
PT (1)	PT92035B (de)
RU (1)	RU2045526C1 (de)
ZW (1)	ZW12889A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8901201D0 (en) *	1988-02-16	1989-03-15	Ici Plc	Pyridine derivatives
US5248780A (en) *	1988-02-16	1993-09-28	Imperial Chemical Industries, Plc	Pyridyl substituted alkenoic acid derivatives
IE66512B1 (en) *	1989-02-28	1996-01-10	Ici Plc	Heterocyclic ethers as 5-lipoxygenase inhibitors
GB9021571D0 (en) *	1990-10-04	1990-11-21	Ici Plc	Heterocyclic acids
FR2702213B1 (fr) *	1993-03-02	1995-04-07	Rhone Poulenc Rorer Sa	Procédé de préparation de N-méthyl (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2-oxyde-1-(1R,2R).
US5371096A (en) *	1993-08-27	1994-12-06	Ciba-Geigy Corporation	(3-pyridyl)tetrafuran-2-yl substituted carboxylic acids
DK1976509T3 (en) *	2006-01-18	2015-03-23	Evolva Sa	PPAR modulators
EP2120567A4 (de) *	2007-01-18	2011-11-09	Evolva Sa	Prodrugs von substituierten 1,3-dioxanen und ihre verwendungen
BRPI0806686A2 (pt)	2007-01-18	2014-11-04	Evolva Sa	Compostos e seus usos, métodos de tratamento ou prevenção, composições farmacêuticas e composto e solvato cristalinos
EP2797597B1 (de)	2011-12-28	2020-02-26	Global Blood Therapeutics, Inc.	Substituierte heteroarylaldehydverbindungen und verfahren zu deren verwendung bei der erhöhung einer gewebeoxigenierung
CA2860323C (en) *	2011-12-28	2022-03-08	The Regents Of The University Of California	Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
WO2014145040A1 (en)	2013-03-15	2014-09-18	Global Blood Therapeutics, Inc.	Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
CN111454200A (zh)	2013-03-15	2020-07-28	全球血液疗法股份有限公司	化合物及其用于调节血红蛋白的用途
CA2902711C (en)	2013-03-15	2021-07-06	Global Blood Therapeutics, Inc.	Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin
EA034922B1 (ru)	2013-03-15	2020-04-07	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en)	2013-03-15	2016-10-04	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru)	2013-11-18	2021-09-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
EP3868745A1 (de)	2014-02-07	2021-08-25	Global Blood Therapeutics, Inc.	Kristalline polymorphe der freien base von 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
SG10201912511WA (en)	2015-12-04	2020-02-27	Global Blood Therapeutics Inc	Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AR108435A1 (es)	2016-05-12	2018-08-22	Global Blood Therapeutics Inc	Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
CN106700129B (zh) *	2016-10-20	2018-11-23	北京吉海川科技发展有限公司	一种位阻酚的酯类抗氧化剂及其制备方法和应用
EP3860975B1 (de)	2018-10-01	2023-10-18	Global Blood Therapeutics, Inc.	Modulatoren von hämoglobin zur behandlung von sichelzellenanämie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8310407D0 (en) *	1982-05-12	1983-05-25	Ici Plc	1 3 - dioxan -5- ylalkenoic acids
GB8330099D0 (en) *	1983-11-11	1983-12-21	Ici Plc	Cycloalkane derivatives
US4554011A (en) *	1984-08-24	1985-11-19	Chevron Research Company	Herbicidal 2S-(2β,4β,5β)-5-Arylmethoxy-4-substituted 2-alkyl-1,3-dioxane derivatives
GB8511894D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Phenol derivatives
GB8511895D0 (en) *	1985-05-10	1985-06-19	Ici Plc	Heterocyclic compounds
GR861209B (en) *	1985-05-10	1986-08-29	Ici Plc	Process for preparing novel alkene derivatives
AT387860B (de) *	1985-09-16	1989-03-28	Optical Sensing Technology	Verfahren und vorrichtung zur tumordiagnose mittels sera
GB8709794D0 (en) *	1987-04-24	1987-05-28	Ici Plc	Heterocyclic acids
GB8901201D0 (en) *	1988-02-16	1989-03-15	Ici Plc	Pyridine derivatives

1989
- 1989-10-12 IE IE330089A patent/IE81170B1/en not_active IP Right Cessation
- 1989-10-15 ZW ZW128/89A patent/ZW12889A1/xx unknown
- 1989-10-16 HU HU895320A patent/HU212263B/hu not_active IP Right Cessation
- 1989-10-16 AU AU42936/89A patent/AU627230B2/en not_active Ceased
- 1989-10-16 DK DK513789A patent/DK513789A/da not_active Application Discontinuation
- 1989-10-17 MY MYPI89001432A patent/MY104242A/en unknown
- 1989-10-17 IL IL9202889A patent/IL92028A/en not_active IP Right Cessation
- 1989-10-18 PH PH39377A patent/PH27054A/en unknown
- 1989-10-19 ES ES89310772T patent/ES2087868T3/es not_active Expired - Lifetime
- 1989-10-19 AT AT89310772T patent/ATE136304T1/de not_active IP Right Cessation
- 1989-10-19 DE DE68926144T patent/DE68926144T2/de not_active Expired - Fee Related
- 1989-10-19 PT PT92035A patent/PT92035B/pt not_active IP Right Cessation
- 1989-10-19 EP EP89310772A patent/EP0365328B1/de not_active Expired - Lifetime
- 1989-10-20 PL PL89281921A patent/PL163045B1/pl unknown
- 1989-10-20 JP JP1271923A patent/JPH0699426B2/ja not_active Expired - Lifetime
- 1989-10-20 US US07/424,611 patent/US5053415A/en not_active Expired - Fee Related
- 1989-10-20 RU SU894742319A patent/RU2045526C1/ru active
- 1989-10-20 PL PL89286429A patent/PL163178B1/pl unknown
- 1989-10-20 NO NO894190A patent/NO173735C/no not_active IP Right Cessation
- 1989-10-20 KR KR1019890015088A patent/KR0161260B1/ko not_active Expired - Fee Related
- 1989-10-20 FI FI895007A patent/FI93545C/fi not_active IP Right Cessation
- 1989-10-20 CA CA002001160A patent/CA2001160C/en not_active Expired - Fee Related
1995
- 1995-06-16 HU HU95P/P00227P patent/HU211522A9/hu unknown
1996
- 1996-04-04 GR GR960400645T patent/GR3019550T3/el unknown

Also Published As

Publication number	Publication date
RU2045526C1 (ru)	1995-10-10
HU212263B (en)	1996-04-29
IE893300L (en)	1990-04-21
CA2001160A1 (en)	1990-04-21
ZW12889A1 (en)	1989-12-06
IE81170B1 (en)	2000-05-31
NO894190D0 (no)	1989-10-20
US5053415A (en)	1991-10-01
FI895007A0 (fi)	1989-10-20
KR900006324A (ko)	1990-05-07
NO894190L (no)	1990-04-23
HUT58075A (en)	1992-01-28
PT92035A (pt)	1990-04-30
CA2001160C (en)	2000-09-05
AU627230B2 (en)	1992-08-20
DK513789A (da)	1990-04-22
IL92028A (en)	1994-06-24
GR3019550T3 (en)	1996-07-31
EP0365328A2 (de)	1990-04-25
PL163178B1 (pl)	1994-02-28
DE68926144T2 (de)	1996-10-17
AU4293689A (en)	1990-04-26
EP0365328B1 (de)	1996-04-03
PH27054A (en)	1993-02-01
JPH02164877A (ja)	1990-06-25
EP0365328A3 (en)	1990-11-28
DE68926144D1 (de)	1996-05-09
FI93545C (fi)	1995-04-25
PL286429A1 (en)	1991-04-22
DK513789D0 (da)	1989-10-16
ATE136304T1 (de)	1996-04-15
KR0161260B1 (ko)	1998-12-01
JPH0699426B2 (ja)	1994-12-07
HU895320D0 (en)	1990-01-28
MY104242A (en)	1994-02-28
PT92035B (pt)	1995-05-31
IL92028A0 (en)	1990-07-12
ES2087868T3 (es)	1996-08-01
PL163045B1 (pl)	1994-02-28
FI93545B (fi)	1995-01-13
NO173735B (no)	1993-10-18
HU211522A9 (en)	1995-11-28

Legal Events

Date	Code	Title	Description
2001-05-28	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN APRIL 2001

Publication	Publication Date	Title
NO173735C (no)	1994-01-26	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridyl-1,3-dioksan-5-yl-alkensyrederivater
NO174044C (no)	1994-03-09	Analogifremgangsmåte for fremstilling av et terapeutisk aktivt amid-derivat
LU91362I2 (fr)	2007-11-12	Palipéridone et ses dérivés pharmaceutiquement acceptables (INVEGA)
DE3271269D1 (en)	1986-06-26	Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
CA2203274A1 (en)	1996-05-09	Apolipoprotein-b synthesis inhibitors
KR960704890A (ko)	1996-10-09	이미다조[1,2-a] 피리딘의 알콕시알킬 카르바메이트 (ALKOXY ALKYL CARBAMATES FROM IMIDAZO [1,2-a] PYRIDINES)
MY132062A (en)	2007-09-28	Apolipoprotein-b synthesis inhibitors
HUT46536A (en)	1988-11-28	Process for producing antianxietive pharmaceutical compositions
NO881835D0 (no)	1988-04-27	Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
NO172893C (no)	1993-09-22	Analogifremgangsmaate for fremstilling av nye terapeutisk aktive cefem-forbindelser
MY103699A (en)	1993-08-28	Pyridine derivatives.
IE791861L (en)	1980-04-02	Lysosomotrophic formulation
MY103368A (en)	1993-06-30	1,3-dioxanes
NO175679C (no)	1994-11-16	Analogifremgangsmåte for fremstilling av en terapeutisk aktiv, substituert aminforbindelse
NO172541C (no)	1993-08-04	Fremgangsmaate for fremstilling av terapeutisk aktive pyridoindol-derivater
DE3162053D1 (en)	1984-03-01	N-acyl peptide compounds, processes for the preparation thereof and pharmaceutical compositions containing them
JO1604B1 (en)	1990-07-01	Pyridine derivatives
NO173278C (no)	1993-12-01	Analogifremgangsm}te for fremstilling av terapeutisk aktive 5-androsten-17-on-derivater
JPH01308227A (ja)	1989-12-12	プロテアーゼ阻害剤