NO174506B - Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser Download PDF

Info

Publication number
NO174506B
NO174506B NO854321A NO854321A NO174506B NO 174506 B NO174506 B NO 174506B NO 854321 A NO854321 A NO 854321A NO 854321 A NO854321 A NO 854321A NO 174506 B NO174506 B NO 174506B
Authority
NO
Norway
Prior art keywords
hal
solution
compound
formula
quinoline
Prior art date
Application number
NO854321A
Other languages
English (en)
Norwegian (no)
Other versions
NO174506C (da
NO854321L (no
Inventor
John H Musser
Utpal Ranjan Chakraborty
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of NO854321L publication Critical patent/NO854321L/no
Publication of NO174506B publication Critical patent/NO174506B/no
Publication of NO174506C publication Critical patent/NO174506C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO854321A 1984-10-30 1985-10-29 Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser NO174506B (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66643084A 1984-10-30 1984-10-30
US73679585A 1985-05-22 1985-05-22

Publications (3)

Publication Number Publication Date
NO854321L NO854321L (no) 1986-05-02
NO174506B true NO174506B (no) 1994-02-07
NO174506C NO174506C (da) 1994-05-18

Family

ID=27099462

Family Applications (1)

Application Number Title Priority Date Filing Date
NO854321A NO174506B (no) 1984-10-30 1985-10-29 Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser

Country Status (10)

Country Link
EP (1) EP0181568A3 (da)
KR (1) KR860003226A (da)
AR (1) AR243870A1 (da)
AU (1) AU595489B2 (da)
CA (1) CA1304088C (da)
DK (1) DK497885A (da)
ES (1) ES8704461A1 (da)
FI (1) FI854259A7 (da)
NO (1) NO174506B (da)
NZ (1) NZ213986A (da)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547509A (en) * 1983-01-03 1985-10-15 Usv Pharmaceutical Corp. 5,6,7-Quinoline carbanilates and method of treating ischemic heart disease therewith
CA1261835A (en) * 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
IE861607L (en) * 1985-06-18 1986-12-18 Bunce Roger A 2-substituted quinolines
US5237070A (en) * 1985-07-22 1993-08-17 Riker Laboratories, Inc. Substituted DI-t-butylphenols
ZA865090B (en) * 1985-07-22 1988-02-24 Riker Laboratories Inc Substituted di-t-butylphenols
US4716178A (en) * 1985-07-22 1987-12-29 Riker Laboratories, Inc. Substituted di-t-butylphenols
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
EP0219307A3 (en) * 1985-10-16 1987-10-14 Merck Frosst Canada Inc. 2-substituted quinolines
ATE68789T1 (de) * 1985-10-16 1991-11-15 Merck Frosst Canada Inc 2-substituierte chinoline.
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
CA1297109C (en) * 1986-01-17 1992-03-10 Dieter Binder 2-pyridinyl or 2-quinolinyl-methoxy-thiophene derivatives
GB2185741B (en) * 1986-01-27 1989-10-25 American Home Prod Heterocyclic sulphonamides
AU6907687A (en) * 1986-02-18 1987-08-20 Rorer Pharmaceutical Corporation Composition for treatment of asthmatic conditions using phenoxymethyl quinolines
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
US5202336A (en) * 1986-09-24 1993-04-13 Bayer Aktiengesellschaft Antiflammatory quinolin methoxy phenylsulphonamides
EP0273678B1 (en) * 1986-12-26 1994-02-16 Teijin Limited Aromatic derivative and preparation method thereof
JPH01502755A (ja) * 1987-03-18 1989-09-21 アメリカン・ホーム・プロダクツ・コーポレイション スルホニルカルボキシアミド
US5103037A (en) * 1987-04-06 1992-04-07 Riker Laboratories, Inc. Substituted di-t-butylphenols
US5049572A (en) * 1987-04-06 1991-09-17 Riker Laboratories, Inc. Substituted di-t-butylphenols and anti-allergic use thereof
JPS63258854A (ja) * 1987-04-16 1988-10-26 Mitsubishi Kasei Corp カルボキシスチレン誘導体およびそれを有効成分とする薬剤
DK196688A (da) * 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
US4980372A (en) * 1987-05-11 1990-12-25 Ono Pharmaceutical Co., Ltd. Benzoylaminophenoxybutanoic acid derivatives
GB8711802D0 (en) * 1987-05-19 1987-06-24 Fujisawa Pharmaceutical Co Dithioacetal compounds
US4968710A (en) * 1987-11-13 1990-11-06 Riker Laboratories, Inc. Substituted di-t-butylphenols and anti-allergic use thereof
US5066822A (en) * 1987-11-13 1991-11-19 Riker Laboratories, Inc Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group
US5204358A (en) * 1987-11-25 1993-04-20 Merck Frosst Canada, Inc. Hetaryl styryl quinolines as leukotriene inhibitors
US5104882A (en) * 1987-11-25 1992-04-14 Merck Frosst Canada, Inc. Diarylstrylquinoline diacids and pharmaceutical compositions thereof
DE3814504A1 (de) * 1988-04-29 1989-11-09 Bayer Ag (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
NZ229761A (en) * 1988-07-12 1991-10-25 Ici Pharma Substituted thiazole derivatives for use as inhibitors of enzyme 5-lipoxygenase; pharmaceutical compositions and preparatory processes
US5214069A (en) * 1988-12-23 1993-05-25 Imperial Chemical Industries Plc Alcohol and ether derivatives
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
GB8927287D0 (en) * 1988-12-23 1990-01-31 Ici Plc Cyclic ether derivatives
IL92620A0 (en) * 1988-12-23 1990-08-31 Ici Pharma Cycloalkane derivatives
NZ231735A (en) * 1988-12-23 1992-04-28 Ici Plc Alcohol/ether derivatives, preparation and pharmaceutical compositions thereof
US5219881A (en) * 1988-12-23 1993-06-15 Imperial Chemical Industries Plc Cyclic ether derivatives
US5089495A (en) * 1989-01-30 1992-02-18 Imperial Chemical Industries Plc Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes
IE66512B1 (en) * 1989-02-28 1996-01-10 Ici Plc Heterocyclic ethers as 5-lipoxygenase inhibitors
US5236919A (en) * 1989-02-28 1993-08-17 Imperial Chemical Industries Plc Quinoxalinyl derivatives suitable for use in leukotriene mediated disease
US5196419A (en) * 1989-02-28 1993-03-23 Imperial Chemical Industries Plc Heterocyclic cyclic ethers
US5217977A (en) * 1989-02-28 1993-06-08 Imperial Chemical Industries Plc Heterocyclic cycloalkanes
US5134148A (en) * 1989-02-28 1992-07-28 Imperial Chemical Industries Plc Heterocycles for use as inhibitors of leukotrienes
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
US5202326A (en) * 1989-02-28 1993-04-13 Imperial Chemical Industries Plc Heterocyclic ethers
WO1990012006A1 (en) * 1989-04-07 1990-10-18 Pfizer Inc. Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma, arthritis and related diseases
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof
US5214070A (en) * 1989-07-18 1993-05-25 Imperial Chemical Industries Plc Diaryl ether cycloalkanes
IE902113A1 (en) * 1989-07-18 1991-06-19 Ici Plc Diaryl ether cyclic ethers
IE64358B1 (en) * 1989-07-18 1995-07-26 Ici Plc Diaryl ether heterocycles
EP0410661B1 (en) * 1989-07-26 1994-06-15 Imperial Chemical Industries Plc Bicyclic derivatives
US4904674A (en) * 1989-08-16 1990-02-27 Hoechst-Roussel Pharmaceuticals Inc. 1-(Benzo[b]thienyl)-2-(thienyl)ethenes and related compounds useful as anti-inflammatory agents
US5204344A (en) * 1989-08-22 1993-04-20 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5272145A (en) * 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
DE3927931A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate
DE3927930A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate
GB9018134D0 (en) * 1989-09-29 1990-10-03 Ici Plc Heterocyclic derivatives
US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
ES2083526T3 (es) * 1990-06-21 1996-04-16 Zeneca Ltd Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa.
AU637500B2 (en) * 1990-06-21 1993-05-27 Zeneca Limited Bicyclic heterocyclic compounds
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
US4996214A (en) * 1990-06-28 1991-02-26 Smithkline Beecham Corporation Quinolinyl substituted phenyl/thioalkanoic acid substituted propionic acids and leucotriene antagonist use thereof
GB9113137D0 (en) * 1990-07-13 1991-08-07 Ici Plc Thioxo heterocycles
US5272173A (en) * 1990-11-28 1993-12-21 Imperial Chemical Industries Plc 5-lipoxygenase inhibitors
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
CA2058254A1 (en) * 1991-01-15 1992-07-16 John Francis Kingston Benzodioxole derivatives
AU645159B2 (en) * 1991-01-17 1994-01-06 Ici Pharma Sulphonamide derivatives
US5258399A (en) * 1991-01-17 1993-11-02 Imperial Chemical Industries Plc Sulphonamide derivatives
EP0505122A1 (en) * 1991-03-21 1992-09-23 Zeneca Limited Alpha, alpha-dialkylbenzyl derivatives
GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
EP0540165A1 (en) * 1991-10-03 1993-05-05 Zeneca Limited Alkanoic acid derivatives
WO1993010780A1 (en) * 1991-12-06 1993-06-10 Smithkline Beecham Corporation Heterocyclic-substituted pyridine compounds and uses
GB9127252D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
GB9300894D0 (en) * 1992-02-07 1993-03-10 Zeneca Ltd Oxime derivatives
WO1993016069A1 (en) * 1992-02-13 1993-08-19 Merck Frosst Canada Inc. (azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
US5506227A (en) * 1992-04-13 1996-04-09 Merck Frosst Canada, Inc. Pyridine-substituted benzyl alcohols as leukotriene antagonists
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
TW232013B (da) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
IL105558A (en) * 1992-05-18 1998-04-05 Zeneca Ltd Tertiary carbinols having potassium channel activity, process for their preparation and pharmaceutical compositions containing them
DE4219765A1 (de) * 1992-06-17 1993-12-23 Bayer Ag Substituierte (Benzothiazolyl- und Chinoxalyl-methoxy)phenylessigsäurederivate
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
GB9305295D0 (en) * 1993-03-15 1993-05-05 Zeneca Ltd Therapeutic compounds
US5374635A (en) * 1993-03-29 1994-12-20 Merck Frosst Canada, Inc. Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
GB9310095D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Therapeutic compounds
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
RU2164224C2 (ru) * 1995-03-14 2001-03-20 Новартис Аг Трехзамещенные фенильные производные и фармацевтическая композиция
US6197993B1 (en) 1996-07-02 2001-03-06 Ono Pharmaceutical Co., Ltd. Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient
EP0845451A4 (en) * 1995-07-26 1999-10-13 Ono Pharmaceutical Co NAPHTHYLOXYACETIC ACID DERIVATIVES AND MEDICINAL PRODUCTS INTEGRATING THESE DERIVATIVES AS ACTIVE INGREDIENTS
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
US7067539B2 (en) 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
CN100567266C (zh) 2001-11-14 2009-12-09 先灵公司 类大麻苷受体配体
DE60319714T2 (de) 2002-06-19 2009-04-02 Schering Corp. Agonisten des cannabinoidrezeptors
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
SE0400234D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New compounds, methods for their preparation and use thereof
JP5349332B2 (ja) 2007-02-06 2013-11-20 チェルシー・セラピューティクス，インコーポレイテッド 新規化合物、その調製方法、およびその使用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754405A (fr) * 1969-08-05 1971-02-04 Thomae Gmbh Dr K Nouveaux beta-aryl-2-aminoalcoxystyrenes
US3793328A (en) * 1969-11-03 1974-02-19 Upjohn Co 8benzoyl 1,2,3,4 tetrahydroquinoline
GB1357212A (en) * 1971-06-25 1974-06-19 Labaz Benzothiophene derivatives and process for preparing the same
US4053607A (en) * 1972-04-04 1977-10-11 Beecham Group Limited Aryloxypyridine for treating hyperglycaemia
FR2201883B1 (da) * 1972-10-05 1975-10-31 Roussel Uclaf
CH603638A5 (en) * 1973-03-02 1978-08-31 Ciba Geigy Ag 2-(piperidino or tetrahydropyrido) benzofurans
DE2415867A1 (de) * 1974-04-02 1975-10-09 Merck Patent Gmbh Phenoxyalkanolderivate und verfahren zu ihrer herstellung
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4024273A (en) * 1974-06-20 1977-05-17 Smithkline Corporation Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity
US3989838A (en) * 1975-09-22 1976-11-02 Smithkline Corporation Uricosuric compositions and method of producing uricosuria and hypouricemia
US4017632A (en) * 1975-10-22 1977-04-12 Centre European De Recherches Pharmacologiques C.E.R.P.H.A. Phenoxyacetic acid derivatives
US4255585A (en) * 1975-10-22 1981-03-10 Centre European De Recherches Pharmacologique Benzoheterocyclic derivatives of phenoxyacetic acid
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
ZA775350B (en) * 1976-12-23 1978-07-26 Ciba Geigy Ag Substituted 5-amino-2-pyridinecarboxylic acids
US4092334A (en) * 1977-07-28 1978-05-30 International Flavors & Fragrances Inc. 5-Acyl-2-(furfurylthio)dihydro-2,5-dialkyl-3-[2H]furanones
EP0002408A1 (fr) * 1977-11-26 1979-06-13 SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: Nouveaux composés phénoxy-alcanols substitués, leur procédé de préparation et leur application en thérapeutique
US4325729A (en) * 1977-12-13 1982-04-20 Ciba-Geigy Corporation Herbicidal and plant growth regulating pyridyloxy-phenoxy-propionic acid derivatives
LU79008A1 (de) * 1978-02-03 1979-09-06 Byk Gulden Lomberg Chem Fab W-(n-alkyl-n-benzoyl-amino)-phenylalkansaeuren,ihre verwendung und herstellung sowie sie enthaltende arzneimittel
US4263040A (en) * 1978-02-18 1981-04-21 Kumiai Chemical Industry Co., Ltd. Phenoxyphenoxy unsaturated derivatives and herbicidal composition
FR2426045A2 (fr) * 1978-05-19 1979-12-14 Meiji Seika Kaisha Esters d'acide 5-alkoxy-picoliniques, procede pour leur preparation et composition anti-hypertensive contenant ces esters
GB2030131B (en) * 1978-09-12 1982-12-22 Taiyo Pharma Ind Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
JPS6033389B2 (ja) * 1979-02-22 1985-08-02 日産化学工業株式会社 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤
US4236912A (en) * 1979-03-05 1980-12-02 The Dow Chemical Company Quinolinyloxyphenoxy and quinolyinylthiophenoxy alkanoic acids and derivatives thereof and methods of herbicidal use
JPS584712B2 (ja) * 1979-07-04 1983-01-27 工業技術院長 アセタ−ル基をもつ含窒素複素環化合物及びその製造方法
AU541697B2 (en) * 1979-11-19 1985-01-17 Ici Australia Limited Quinoline derivatives
USRE31624E (en) * 1979-11-26 1984-07-03 Forsyth Dental Infirmary For Children Method of treating inflammation
JPS56115784A (en) * 1980-02-15 1981-09-11 Tanabe Seiyaku Co Ltd Novel pyridinecarboxamide derivative and its preparation
DE3006351A1 (de) * 1980-02-20 1981-09-17 Basf Ag, 6700 Ludwigshafen 2- ((3-amino-2- hydroxy-propoxy)-styryl )-verbindungen
US4412856A (en) * 1980-05-31 1983-11-01 Ciba-Geigy Corporation Herbicidal heterocyclic and substituted phenyl phenylacetylene amines
DE3101544A1 (de) * 1981-01-20 1982-08-19 Hoechst Ag, 6000 Frankfurt "chinolinoxy-phenoxypropionsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide"
DE3260868D1 (en) * 1981-04-16 1984-11-08 Ici Plc Indanyloxy- and tetralinyloxy-phenoxypropionic acid derivatives, processes for preparing them, and herbicidal processes and compositions utilising them
DE3120099A1 (de) * 1981-05-20 1982-12-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neues arzneimittel mit wirkung auf das zentralnervensystem
DE3205150A1 (de) * 1982-02-13 1983-08-18 Celamerck Gmbh & Co Kg, 6507 Ingelheim Pyridinderivate, ihre herstellung und verwendung
CH651034A5 (de) * 1982-05-12 1985-08-30 Hoffmann La Roche Chroman-, thiochroman- oder 1,2,3,4-tetrahydrochinolinderivate und ihre verwendung als arzneimittel-wirkstoffe.
US4522647A (en) * 1982-07-30 1985-06-11 Zoecon Corporation Substituted phenoxyalkanediones and their herbicidal method of use
US4520199A (en) * 1982-08-13 1985-05-28 Zoecon Corporation Alkoxy substituted phenoxy alkanoic acid esters
US4469872A (en) * 1982-08-20 1984-09-04 Zoecon Corporation Substituted pyridyloxyphenoxyhydroxyketones
JPS5973579A (ja) * 1982-10-19 1984-04-25 Kotobuki Seiyaku Kk ベンゾフラン又はベンゾチオフェン誘導体，この化合物を有効成分とする尿酸排泄剤及びその製造方法
US4464533A (en) * 1982-11-08 1984-08-07 Ppg Industries, Inc. Herbicidally active quinoline or quinoxaline benzoate derivatives
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
JPS59152891A (ja) * 1983-02-18 1984-08-31 Yamada Kagaku Kogyo Kk 発色性記録材料
ZA848416B (en) * 1983-11-10 1986-06-25 Dow Chemical Co Fluorophenoxy compounds,herbicidal compositions and methods
JPS60110887A (ja) * 1983-11-18 1985-06-17 Shiyouno Tamie α−アルキル化酢酸誘導体の製造方法
JPS60172964A (ja) * 1984-02-15 1985-09-06 Tanabe Seiyaku Co Ltd 桂皮酸誘導体及びその製法
HU195492B (en) * 1984-07-27 1988-05-30 Boehringer Biochemia Srl Process for producing 2-substituted thiazolidine derivatives with antitussive and mucus regulating action and pharmaceuticals comprising these compounds as active ingredient
DE3431004A1 (de) * 1984-08-23 1986-03-06 Hoechst Ag, 6230 Frankfurt Neue 3-pyridylverbindungen und verfahren zu ihrer herstellung
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
DE3508903A1 (de) * 1985-03-13 1986-09-18 Hoechst Ag, 6230 Frankfurt Neue 3-pyridylmethylnaphtylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
IE861607L (en) * 1985-06-18 1986-12-18 Bunce Roger A 2-substituted quinolines
EP0206772A3 (en) * 1985-06-20 1988-05-11 E.I. Du Pont De Nemours And Company Herbicidal aryloxybenzeneacetic acid derivatives
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
EP0219307A3 (en) * 1985-10-16 1987-10-14 Merck Frosst Canada Inc. 2-substituted quinolines

Also Published As

Publication number Publication date
FI854259L (fi) 1986-05-01
FI854259A0 (fi) 1985-10-30
ES8704461A1 (es) 1987-04-16
AR243870A1 (es) 1993-09-30
ES549012A0 (es) 1987-04-16
NO174506C (da) 1994-05-18
FI854259A7 (fi) 1986-05-01
DK497885A (da) 1986-05-01
NZ213986A (en) 1989-07-27
EP0181568A2 (en) 1986-05-21
AU4926485A (en) 1986-05-08
CA1304088C (en) 1992-06-23
KR860003226A (ko) 1986-05-21
EP0181568A3 (en) 1989-04-26
DK497885D0 (da) 1985-10-30
AU595489B2 (en) 1990-04-05
NO854321L (no) 1986-05-02

Similar Documents

Publication Publication Date Title
NO174506B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US3931205A (en) Substituted alkanoic acids and derivatives
Boekelheide et al. Syntheses of pyrrocolines unsubstituted in the five-membered ring1
US4259338A (en) Benzofuranyl-tetrahydropyridines and -piperidines, their acid addition salts and antidepressant preparations thereof
NO760993L (da)
NO145657B (no) Analogifremgangsmaate for fremstilling av fysiologisk aktive alkenderivater.
Sundberg et al. o-Styrylnitrene route to 2-substituted indoles. Pyrolysis of o-azidostyrenes
NO137440B (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive pleuromutiliner
NO163552B (no) Sammensatt understell.
NO142865B (no) Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive karbazoler
HU185133B (en) Process for producing 1-hydroxy-octahydro-benzo-bracket-c-bracket closed-quinolines and derivatives
NO803453L (no) Fremgangsmaate ved fremstilling av piperidylbenzimidazolonderivater
NO163597B (no) Styreinnretning for et ett-eller tosporet kjoeretoey.
JPS584781A (ja) テトラヒドロピリジン及びピペリジン誘導体の製法
CS207619B2 (en) Method of making the new derivatives of 5,11-dihydro-6h-pyrido 2,3-b 1,4 benzodiazepin-6-on
NO172643B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive benzopyranolderivater
GB2056435A (en) Novel Tetrahydropyridine and Piperidine Substituted Benzofuranes and Related Compounds
CA2179634C (en) 4-arylisoindole analgesics
US3316272A (en) Heterocyclic derivatives of triphenyl-ethylenes, triphenylethanes and triphenylethanols
NO121212B (da)
US5175297A (en) Methyl-quinoline derivatives as mefloquin intermediates and process for preparation thereof
NO149353B (no) Fremgangsmaate ved fremstilling av 6-klor-alfa-metylkarbazol-2-eddiksyre
SU1017167A3 (ru) Способ получени @ -5-ацетамидо-4,5,6,7-тетрагидро-2н-бензо/с/пиррола
NO133448B (da)
NO144099B (no) Dyse for maskinell flammehoevling av enkelte defekter paa overflaten til et metallegeme