NO176476C - Analogifremgangsmåte for fremstilling av 2-pyridoner samt ketonmellomprodukter til bruk ved fremgangsmåten - Google Patents

Analogifremgangsmåte for fremstilling av 2-pyridoner samt ketonmellomprodukter til bruk ved fremgangsmåten

Info

Publication number: NO176476C
Authority: NO; Norway
Prior art keywords: optionally substituted; pyridones; preparation; analogous; ketone intermediates
Prior art date: 1988-12-14

Application number

NO894814A

Other languages

English (en)

Norwegian (no)

Other versions

NO176476B (no

NO894814D0 (no

NO894814L (no

Inventor

Peter Fey

Rolf Angerbauer

Walter Hubsch

Thomas Philipps

Hilmar Bischoff

Dieter Petzinna

Delf Schmidt

Gunther Thomas

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-14

Filing date

1989-12-01

Publication date

1995-04-12

1988-12-14 Priority claimed from DE3841991A external-priority patent/DE3841991A1/de

1989-06-13 Priority claimed from IT8920861A external-priority patent/IT8920861A0/it

1989-12-01 Application filed by Bayer Ag filed Critical Bayer Ag

1989-12-01 Publication of NO894814D0 publication Critical patent/NO894814D0/no

1990-06-15 Publication of NO894814L publication Critical patent/NO894814L/no

1995-01-02 Publication of NO176476B publication Critical patent/NO176476B/no

1995-04-12 Publication of NO176476C publication Critical patent/NO176476C/no

Links

UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
150000002576 ketones Chemical class 0.000 title 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
-1 imino, amino Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

NO894814A 1988-12-14 1989-12-01 Analogifremgangsmåte for fremstilling av 2-pyridoner samt ketonmellomprodukter til bruk ved fremgangsmåten NO176476C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3841991A DE3841991A1 (de)	1988-12-14	1988-12-14	Substituierte 2-pyridone und pyrid-2-thione, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
IT8920861A IT8920861A0 (it)	1989-06-13	1989-06-13	2 pirodoni e pirid 2 tioni sostituiti, processo per produrli e loro impiego in medicinali.

Publications (4)

Publication Number	Publication Date
NO894814D0 NO894814D0 (no)	1989-12-01
NO894814L NO894814L (no)	1990-06-15
NO176476B NO176476B (no)	1995-01-02
NO176476C true NO176476C (no)	1995-04-12

Family

ID=25875117

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO894814A NO176476C (no)	1988-12-14	1989-12-01	Analogifremgangsmåte for fremstilling av 2-pyridoner samt ketonmellomprodukter til bruk ved fremgangsmåten

Country Status (16)

Country	Link
US (1)	US5032602A (fr)
EP (1)	EP0373423B1 (fr)
JP (1)	JP2954954B2 (fr)
CN (1)	CN1032203C (fr)
AT (1)	ATE100086T1 (fr)
CA (1)	CA2005206A1 (fr)
DE (1)	DE58906708D1 (fr)
DK (1)	DK630489A (fr)
ES (1)	ES2061902T3 (fr)
FI (1)	FI92196C (fr)
HU (2)	HU210056B (fr)
IE (1)	IE63401B1 (fr)
IL (1)	IL92632A0 (fr)
NO (1)	NO176476C (fr)
NZ (1)	NZ231707A (fr)
PT (1)	PT92550B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ238576A (en) *	1990-06-18	1994-12-22	Merck & Co Inc	Pyridinone derivatives, preparation and pharmaceutical compositions thereof
US5308854A (en) *	1990-06-18	1994-05-03	Merck & Co., Inc.	Inhibitors of HIV reverse transcriptase
AU660132B2 (en) *	1992-12-21	1995-06-08	Bayer Aktiengesellschaft	Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridine
AR008789A1 (es)	1996-07-31	2000-02-23	Bayer Corp	Piridinas y bifenilos substituidos
US6867217B1 (en) *	1999-05-19	2005-03-15	Pharmacia Corporation	Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
AP1822A (en) *	2002-02-14	2008-01-30	Pharmacia Corp	Substituted pyridinones as modulators of P38 MAP kinase.
TW200307667A (en) *	2002-05-06	2003-12-16	Bristol Myers Squibb Co	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
GB0420722D0 (en) *	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
AR059898A1 (es)	2006-03-15	2008-05-07	Janssen Pharmaceutica Nv	Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en)	2007-03-07	2009-01-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) *	2007-03-07	2008-12-01	Janssen Pharmaceutica Nv	3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200922566A (en)	2007-09-14	2009-06-01	Ortho Mcneil Janssen Pharm	1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
EA017648B1 (ru) *	2007-09-14	2013-02-28	Орто-Макнейл-Янссен Фармасьютикалз, Инк.	1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны
BRPI0816970A2 (pt) *	2007-09-14	2015-03-24	Ortho Mcneil Janssen Pharm	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
CA2704436C (fr) *	2007-11-14	2016-01-05	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Derives imidazo[1,2-a]pyridine et leur utilisation comme modulateurs allosteriques positifs des recepteurs mglur2
JP5547194B2 (ja)	2008-09-02	2014-07-09	ジャンセンファーマシューティカルズ，インコーポレイテッド．	代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
WO2010043396A1 (fr)	2008-10-16	2010-04-22	Ortho-Mcneil-Janssen Pharmaceuticals, Inc.	Dérivés d’indole et de benzomorpholine en tant que modulateurs des récepteurs métabotropiques du glutamate
JP5690277B2 (ja)	2008-11-28	2015-03-25	ジャンセンファーマシューティカルズ，インコーポレイテッド．	代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
CN102439015B (zh)	2009-05-12	2015-05-13	杨森制药有限公司	1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
MY153913A (en)	2009-05-12	2015-04-15	Janssen Pharmaceuticals Inc	7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
HRP20131122T1 (hr)	2009-05-12	2013-12-20	Janssen Pharmaceuticals, Inc.	Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja
EP2661435B1 (fr)	2010-11-08	2015-08-19	Janssen Pharmaceuticals, Inc.	Dérivés 1,2,4-triazolo[4,3-a]pyridine et leur utilisation en tant que modulateurs allostériques positifs des récepteurs mglur2
ES2536433T3 (es)	2010-11-08	2015-05-25	Janssen Pharmaceuticals, Inc.	Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JP5852664B2 (ja)	2010-11-08	2016-02-03	ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド	１，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
JO3368B1 (ar)	2013-06-04	2019-03-13	Janssen Pharmaceutica Nv	مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar)	2013-09-06	2019-03-13	Janssen Pharmaceutica Nv	مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
PL3096790T3 (pl)	2014-01-21	2020-01-31	Janssen Pharmaceutica, N.V.	Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie
ME03518B (fr)	2014-01-21	2020-04-20	Janssen Pharmaceutica Nv	Combinaisons comprenant des modulateurs allostériques positifs de sous-type 2 de récepteurs glutamatergiques métabotropes et leur utilisation
US10160718B2 (en)	2015-12-22	2018-12-25	Eastman Chemical Company	Methods of making compounds having antidegradant and antifatigue efficacy
US10260017B2 (en)	2015-12-22	2019-04-16	Eastman Chemical Company	Compounds and mixtures with antidegradant and antifatigue efficacy and compositions including said compounds
US10428009B2 (en) *	2015-12-22	2019-10-01	Eastman Chemical Company	Methods of making compounds and mixtures having antidegradant and antifatigue efficacy
US10287418B2 (en)	2015-12-22	2019-05-14	Eastman Chemical Company	Compounds with antidegradant and antifatigue efficacy and compositions including said compounds
US10167252B2 (en)	2015-12-22	2019-01-01	Eastman Chemical Company	Compounds and mixtures with antidegradant and antifatigue efficacy and compositions including such compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE758759A (fr) *	1969-11-12	1971-05-10	Merck & Co Inc	Pyridones anti-inflammatoires

1989
- 1989-11-27 US US07/441,806 patent/US5032602A/en not_active Expired - Fee Related
- 1989-11-29 AT AT89122067T patent/ATE100086T1/de active
- 1989-11-29 EP EP89122067A patent/EP0373423B1/fr not_active Expired - Lifetime
- 1989-11-29 ES ES89122067T patent/ES2061902T3/es not_active Expired - Lifetime
- 1989-11-29 DE DE89122067T patent/DE58906708D1/de not_active Expired - Fee Related
- 1989-12-01 NO NO894814A patent/NO176476C/no unknown
- 1989-12-11 IL IL92632A patent/IL92632A0/xx not_active IP Right Cessation
- 1989-12-11 NZ NZ231707A patent/NZ231707A/en unknown
- 1989-12-12 PT PT92550A patent/PT92550B/pt not_active IP Right Cessation
- 1989-12-12 CA CA002005206A patent/CA2005206A1/fr not_active Abandoned
- 1989-12-12 FI FI895925A patent/FI92196C/fi not_active IP Right Cessation
- 1989-12-13 DK DK630489A patent/DK630489A/da not_active Application Discontinuation
- 1989-12-13 IE IE398789A patent/IE63401B1/en not_active IP Right Cessation
- 1989-12-14 HU HU896603A patent/HU210056B/hu not_active IP Right Cessation
- 1989-12-14 CN CN89109399A patent/CN1032203C/zh not_active Expired - Fee Related
- 1989-12-14 HU HU91647A patent/HUT59907A/hu unknown
- 1989-12-14 JP JP1322771A patent/JP2954954B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL92632A0 (en)	1990-08-31
DE58906708D1 (de)	1994-02-24
FI92196B (fi)	1994-06-30
US5032602A (en)	1991-07-16
DK630489A (da)	1990-06-15
EP0373423B1 (fr)	1994-01-12
HU910647D0 (en)	1991-09-30
FI92196C (fi)	1994-10-10
PT92550B (pt)	1996-06-28
CA2005206A1 (fr)	1990-06-14
IE63401B1 (en)	1995-04-19
EP0373423A1 (fr)	1990-06-20
HU210056B (en)	1995-01-30
CN1032203C (zh)	1996-07-03
DK630489D0 (da)	1989-12-13
NZ231707A (en)	1992-06-25
FI895925A0 (fi)	1989-12-12
HU896603D0 (en)	1990-02-28
JPH02258766A (ja)	1990-10-19
NO176476B (no)	1995-01-02
JP2954954B2 (ja)	1999-09-27
IE893987L (en)	1990-06-14
PT92550A (pt)	1990-06-29
NO894814D0 (no)	1989-12-01
HUT59907A (en)	1992-07-28
CN1043501A (zh)	1990-07-04
NO894814L (no)	1990-06-15
ES2061902T3 (es)	1994-12-16
ATE100086T1 (de)	1994-01-15

Publication	Publication Date	Title
FI895925A0 (fi)	1989-12-12	Menetelmä terapeuttisesti käyttökelpoisten 2-pyridonien valmistamiseksi
AU673111B2 (en)	1996-10-24	Compounds containing a fused multiple ring lactam
ES2101960T3 (es)	1997-07-16	Lactamas benzo-condensadas.
ES2167371T3 (es)	2002-05-16	Derivados de 1h-3-aril-pirrolidin-2,4-diona espirociclicos substituidos.
DE69528000D1 (de)	2002-10-02	Zwischenprodukte zur Hertellung von Oxazolidindion- und Thiazolidindionderivate
NO2003005I2 (no)	2007-12-11	Substituerte isoxazoler, farmasoytisk preparat inneholdende slike forbindelser, fremgangsmâte for deres fremstilling og anvendelse derav, samt mellomprodukter
DK175689A (da)	1989-10-14	4-acylcephemsulfon- eller 3-acylpenamsulfonforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
NO823836L (no)	1983-05-18	Fremgangsmaate ved fremstilling av antifibrinolytisk aktive forbindelser.
ES2185634T3 (es)	2003-05-01	Derivados de cefalosporina.
EA200000551A1 (ru)	2000-10-30	α-ГИДРОКСИ, -АМИНО И ГАЛОИДНЫЕ ПРОИЗВОДНЫЕ β-СУЛЬФОНИЛГИДРОКСАМОВЫХ КИСЛОТ В КАЧЕСТВЕ ИНГИБИТОРОВ МАТРИКСНЫХ МЕТАЛЛОПРОТЕИНАЗ
AU539028B2 (en)	1984-09-06	Indolobenzoxazines
ATE14880T1 (de)	1985-08-15	Cephalosporinverbindungen und ihre herstellung.
FI940306L (fi)	1994-01-21	Menetelmä kiraalisten tiatsolidiini-2,4-dionijohdannaisten synteesissä tarvittavien välituotteiden valmistamiseksi
SE9202476D0 (sv)	1992-08-28	Mellanprodukter foer framstaellning av epipodofyllotoxin och beslaektade foereningar och foerfaranden foer framstaellning och anvaendning daerav
ES2065478T3 (es)	1995-02-16	2-amino-1,2,3,4-tetrahidronaftalenos y 3-aminocromanos sustituidos en el anillo.
ES555820A0 (es)	1987-08-16	Procedimiento para la obtencion de 1-aril-5-alcoxiiminoalquilamino-pirazoles
NO306297B1 (no)	1999-10-18	FremgangsmÕte for fremstilling av HIV-proteaseinhibitorer
DK369289A (da)	1990-01-27	Anvendelse af imidazopyrazolderivater som analgetica og antiinflammatoriske midler
SE8704792D0 (sv)	1987-12-01	Azole derivatives
SE8000298L (sv)	1980-07-16	Karbamatderivat av merkaptoacylhydroxiproliner
IE43116L (en)	1976-12-09	Oxadiazolidine derivatives
NO940226D0 (no)	1994-01-21	Chirale mellomprodukter for fremstilling av antidiabetiske tiazol er
TH33561A (th)	1999-07-02	กระบวนการเตรียมอนุพันธ์ 1,5-เบนโซไธอะเซพีน
EP0569139A3 (fr)	1993-12-08	Dérivés du nitrotoluène substitué par alkyle
IL80525A (en)	1991-12-12	Preparation of indolines by cyclodehydrating 2-(2'-aminoethylphenyl)-ethanol in the presence of amorphous aluminium silicate catalyst