NO176606C - Analogifremgangsmåte for fremstilling av terapeutisk aktive (kinolin-2-ylmetoksy)-indoler - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive (kinolin-2-ylmetoksy)-indoler

Info

Publication number: NO176606C
Authority: NO; Norway
Prior art keywords: ylmethoxy; indoles; quinolin; preparation; therapeutically active
Prior art date: 1989-08-22

Application number

NO903678A

Other languages

English (en)

Norwegian (no)

Other versions

NO903678D0 (no

NO176606B (no

NO903678L (no

Inventor

Petpiboon Prasit

Rejean Fortin

John H Hutchinson

Michell L Belley

Serge Leger

John Gillard

Richard Frenette

Original Assignee

Merck Frosst Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-22

Filing date

1990-08-21

Publication date

1995-05-03

1990-08-21 Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc

1990-08-21 Publication of NO903678D0 publication Critical patent/NO903678D0/no

1991-03-21 Publication of NO903678L publication Critical patent/NO903678L/no

1995-01-23 Publication of NO176606B publication Critical patent/NO176606B/no

1995-05-03 Publication of NO176606C publication Critical patent/NO176606C/no

Links

DKKCAHNTVNRXAN-UHFFFAOYSA-N 2-(1h-indol-2-yloxymethyl)quinoline Chemical class C1=CC=CC2=NC(COC=3NC4=CC=CC=C4C=3)=CC=C21 DKKCAHNTVNRXAN-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
206010000234 Abortion spontaneous Diseases 0.000 abstract 1
206010002383 Angina Pectoris Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
206010036600 Premature labour Diseases 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001088 anti-asthma Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000924 antiasthmatic agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001120 cytoprotective effect Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000002617 leukotrienes Chemical class 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
208000026440 premature labor Diseases 0.000 abstract 1
208000000995 spontaneous abortion Diseases 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO903678A 1989-08-22 1990-08-21 Analogifremgangsmåte for fremstilling av terapeutisk aktive (kinolin-2-ylmetoksy)-indoler NO176606C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39714489A	1989-08-22	1989-08-22
US55230090A	1990-07-18	1990-07-18

Publications (4)

Publication Number	Publication Date
NO903678D0 NO903678D0 (no)	1990-08-21
NO903678L NO903678L (no)	1991-03-21
NO176606B NO176606B (no)	1995-01-23
NO176606C true NO176606C (no)	1995-05-03

Family

ID=27015763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903678A NO176606C (no)	1989-08-22	1990-08-21	Analogifremgangsmåte for fremstilling av terapeutisk aktive (kinolin-2-ylmetoksy)-indoler

Country Status (13)

Country	Link
EP (1)	EP0419049B1 (de)
JP (1)	JPH0786101B2 (de)
KR (1)	KR910004600A (de)
AT (1)	ATE121085T1 (de)
AU (1)	AU650185B2 (de)
CA (1)	CA2023340C (de)
DE (1)	DE69018553T2 (de)
FI (1)	FI904132A7 (de)
IE (1)	IE903022A1 (de)
IL (1)	IL95371A (de)
NO (1)	NO176606C (de)
NZ (1)	NZ234883A (de)
PT (1)	PT95055A (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5272145A (en) *	1989-08-22	1993-12-21	Merck Frosst Canada, Inc.	(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5204344A (en) *	1989-08-22	1993-04-20	Merck Frosst Canada, Inc.	(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5252585A (en) *	1992-02-03	1993-10-12	Merck Frosst Canada, Inc.	Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes
US5095031A (en) *	1990-08-20	1992-03-10	Abbott Laboratories	Indole derivatives which inhibit leukotriene biosynthesis
JPH0764841B2 (ja) *	1990-10-03	1995-07-12	ファイザー製薬株式会社	インドール誘導体およびその用途
US5202321A (en) *	1991-06-13	1993-04-13	Merck Frosst Canada, Inc.	Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) *	1991-09-30	1995-02-14	Merck Frosst Canada, Inc.	(Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
CA2079374C (en) *	1991-09-30	2003-08-05	Merck Frosst Canada Incorporated	(bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) *	1991-09-30	1994-05-03	Merck Frosst Canada, Inc.	(Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) *	1991-09-30	1994-03-01	Merck Frosst Canada, Inc.	(hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) *	1991-09-30	1993-03-02	Merck Frosst Canada, Inc.	(Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5254541A (en) *	1991-11-15	1993-10-19	Merck Frosst Canada, Inc.	(Quinolin-2-ylmethoxy)indole/cyclodextrin complex
US5321033A (en) *	1991-11-15	1994-06-14	Merck Frosst Canada, Inc.	Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases
US5254567A (en) *	1991-11-15	1993-10-19	Merck Frosst Canada, Inc.	Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility
EP0542355A1 (de) *	1991-11-15	1993-05-19	Merck Frosst Canada Inc.	Amorphe (Chinolin-2-ylmethoxy)Indole als Leukotrien-Antagonisten
WO1993016069A1 (en) *	1992-02-13	1993-08-19	Merck Frosst Canada Inc.	(azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
US5274096A (en) *	1992-03-17	1993-12-28	Merck & Co., Inc.	Hydrazine synthesis
US5334719A (en) *	1992-06-17	1994-08-02	Merck Frosst Canada, Inc.	Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
WO1994000446A1 (en) *	1992-06-22	1994-01-06	Merck Frosst Canada Inc.	Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes
US5314900A (en) *	1992-11-19	1994-05-24	Merck Frosst Canada, Inc.	Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis
US5288743A (en) *	1992-11-20	1994-02-22	Abbott Laboratories	Indole carboxylate derivatives which inhibit leukotriene biosynthesis
US5374635A (en) *	1993-03-29	1994-12-20	Merck Frosst Canada, Inc.	Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
US5399699A (en) *	1994-01-24	1995-03-21	Abbott Laboratories	Indole iminooxy derivatives which inhibit leukotriene biosynthesis
MX9501608A (es)	1994-04-01	1997-02-28	Lilly Co Eli	1h-indol-3-glioxilamidas inhibidoras de spla2.
US5859031A (en) *	1995-06-07	1999-01-12	Gpi Nil Holdings, Inc.	Small molecule inhibitors of rotamase enzyme activity
US5801197A (en) *	1995-10-31	1998-09-01	Gpi Nil Holdings, Inc.	Rotamase enzyme activity inhibitors
US5786378A (en) *	1996-09-25	1998-07-28	Gpi Nil Holdings, Inc.	Heterocyclic thioesters
US5801187A (en)	1996-09-25	1998-09-01	Gpi-Nil Holdings, Inc.	Heterocyclic esters and amides
US6218424B1 (en)	1996-09-25	2001-04-17	Gpi Nil Holdings, Inc.	Heterocyclic ketone and thioester compounds and uses
US6274602B1 (en)	1998-06-03	2001-08-14	Gpi Nil Holdings, Inc.	Heterocyclic thioester and ketone hair growth compositions and uses
US6187796B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Sulfone hair growth compositions and uses
US6187784B1 (en)	1998-06-03	2001-02-13	Gpi Nil Holdings, Inc.	Pipecolic acid derivative hair growth compositions and uses
US20010049381A1 (en)	1997-06-04	2001-12-06	Gpl Nil Holdings, Inc.,	Pyrrolidine derivative hair growth compositions and uses
US5945441A (en)	1997-06-04	1999-08-31	Gpi Nil Holdings, Inc.	Pyrrolidine carboxylate hair revitalizing agents
US6271244B1 (en)	1998-06-03	2001-08-07	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
GB9716657D0 (en)	1997-08-07	1997-10-15	Zeneca Ltd	Chemical compounds
GB9803226D0 (en)	1998-02-17	1998-04-08	Zeneca Ltd	Chemical compounds
AU1708099A (en)	1998-06-03	1999-12-20	Amgen, Inc.	N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
US6429215B1 (en)	1998-06-03	2002-08-06	Gpi Nil Holdings, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
CA2334204A1 (en)	1998-06-03	1999-12-09	Gpi Nil Holdings, Inc.	Heterocyclic ester and amide hair growth compositions and uses
US6172087B1 (en)	1998-06-03	2001-01-09	Gpi Nil Holding, Inc.	N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6333340B1 (en)	1998-08-14	2001-12-25	Gpi Nil Holdings, Inc.	Small molecule sulfonamides for vision and memory disorders
US6384056B1 (en)	1998-08-14	2002-05-07	Gpi Nil Holdings, Inc.	Heterocyclic thioesters or ketones for vision and memory disorders
US6395758B1 (en)	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
US7338976B1 (en)	1998-08-14	2008-03-04	Gpi Nil Holdings, Inc.	Heterocyclic esters or amides for vision and memory disorders
US6506788B1 (en)	1998-08-14	2003-01-14	Gpi Nil Holdings, Inc.	N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6335348B1 (en)	1998-08-14	2002-01-01	Gpi Nil Holdings, Inc.	Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6337340B1 (en)	1998-08-14	2002-01-08	Gpi Nil Holdings, Inc.	Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6399648B1 (en)	1998-08-14	2002-06-04	Gpi Nil Holdings, Inc.	N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6376517B1 (en)	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US6339101B1 (en)	1998-08-14	2002-01-15	Gpi Nil Holdings, Inc.	N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6218423B1 (en)	1998-08-14	2001-04-17	Gpi Nil Holdings, Inc.	Pyrrolidine derivatives for vision and memory disorders
US6462072B1 (en)	1998-09-21	2002-10-08	Gpi Nil Holdings, Inc.	Cyclic ester or amide derivatives
GB9902461D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902452D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902459D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902455D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902453D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB0000625D0 (en)	2000-01-13	2000-03-01	Zeneca Ltd	Chemical compounds
ES2211315B1 (es) *	2002-11-12	2005-10-16	Almirall Prodesfarma, S.A.	Nuevos compuestos triciclicos.
NZ577031A (en)	2003-05-30	2010-09-30	Ranbaxy Lab Ltd	Substituted pyrrole derivatives and their use as HMG-CO inhibitors
AR045536A1 (es)	2003-08-29	2005-11-02	Ranbaxy Lab Ltd	Inhibidores de la fosfodiesterasa tipo -iv
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US7915286B2 (en)	2005-09-16	2011-03-29	Ranbaxy Laboratories Limited	Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
US7405302B2 (en) *	2005-10-11	2008-07-29	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en)	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
WO2007054896A1 (en)	2005-11-08	2007-05-18	Ranbaxy Laboratories Limited	Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
AU2007316736A1 (en)	2006-11-09	2008-05-15	F. Hoffmann-La Roche Ag	Indole and benzofuran 2-carboxamide derivatives
US20080207659A1 (en)	2007-02-15	2008-08-28	Asit Kumar Chakraborti	Inhibitors of phosphodiesterase type 4
SI2124944T1 (sl)	2007-03-14	2012-05-31	Ranbaxy Lab Ltd	Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze
TW200920369A (en)	2007-10-26	2009-05-16	Amira Pharmaceuticals Inc	5-lipoxygenase activating protein (flap) inhibitor
BRPI0912267A2 (pt)	2008-05-23	2015-10-13	Amira Pharmaceuticals Inc	sal farmaceuticamente aceitável, composição farmacêutica, artigo de fabricação, métodos para tratar asma, rinite alérgica, doença, lesões gástricas e dor, métodos para prevenir broncoconstrição e rinite alérgica, uso de um sal farmaceuticamente aceitável, e, processo para a preparação de um sal farmaceuticamente aceitável.
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
EP3268085A4 (de)	2015-03-13	2018-10-31	The Board of Trustees of The Leland Stanford Junior University	Ltb4-hemmung zur vorbeugung und behandlung von lymphödem beim menschen
CN109535060B (zh) *	2018-12-20	2022-03-25	苏州麦迪耐斯医药科技有限公司	一种刺猬通路抑制剂及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA824343B (en) *	1981-07-01	1983-04-27	Upjohn Co	Pyridinyl- and imidazolyl-benzofurane and benzothiophenes
CA1241660A (en) *	1984-06-25	1988-09-06	Yvan Guindon	Indole-2-alkanoic acids
EP0247089A1 (de) *	1985-10-30	1987-12-02	The Upjohn Company	3-pyridinylalkyliden- und 3'-pyridinylalkylindol-2-carbonsäuren und analoge
IL84796A (en) *	1986-12-17	1992-03-29	Merck Frosst Canada Inc	Substituted n-benzyl-indoles and pharmaceutical compositions containing them

1990
- 1990-08-13 NZ NZ234883A patent/NZ234883A/en unknown
- 1990-08-14 IL IL9537190A patent/IL95371A/en not_active IP Right Cessation
- 1990-08-15 CA CA002023340A patent/CA2023340C/en not_active Expired - Fee Related
- 1990-08-21 PT PT95055A patent/PT95055A/pt not_active Application Discontinuation
- 1990-08-21 DE DE69018553T patent/DE69018553T2/de not_active Expired - Fee Related
- 1990-08-21 EP EP90309149A patent/EP0419049B1/de not_active Expired - Lifetime
- 1990-08-21 NO NO903678A patent/NO176606C/no not_active IP Right Cessation
- 1990-08-21 FI FI904132A patent/FI904132A7/fi not_active Application Discontinuation
- 1990-08-21 AT AT90309149T patent/ATE121085T1/de not_active IP Right Cessation
- 1990-08-21 IE IE302290A patent/IE903022A1/en unknown
- 1990-08-21 KR KR1019900012848A patent/KR910004600A/ko not_active Withdrawn
- 1990-08-22 JP JP2219134A patent/JPH0786101B2/ja not_active Expired - Fee Related
1992
- 1992-12-11 AU AU30126/92A patent/AU650185B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0419049B1 (de)	1995-04-12
NO903678D0 (no)	1990-08-21
FI904132A7 (fi)	1991-02-23
IL95371A (en)	1994-08-26
JPH0786101B2 (ja)	1995-09-20
NO176606B (no)	1995-01-23
FI904132A0 (fi)	1990-08-21
IL95371A0 (en)	1991-06-30
JPH03163075A (ja)	1991-07-15
CA2023340C (en)	2000-07-11
KR910004600A (ko)	1991-03-29
DE69018553T2 (de)	1995-10-19
EP0419049A1 (de)	1991-03-27
PT95055A (pt)	1991-04-18
AU6121190A (en)	1991-02-28
ATE121085T1 (de)	1995-04-15
AU628212B2 (en)	1992-09-10
NO903678L (no)	1991-03-21
AU3012692A (en)	1993-02-11
NZ234883A (en)	1995-01-27
DE69018553D1 (de)	1995-05-18
AU650185B2 (en)	1994-06-09
IE903022A1 (en)	1991-02-27
CA2023340A1 (en)	1991-02-23

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO176606C (no)	1995-05-03	Analogifremgangsmåte for fremstilling av terapeutisk aktive (kinolin-2-ylmetoksy)-indoler
AU8260387A (en)	1988-06-23	3-hetero-substituted-n-benzyl-indoles
IE892065L (en)	1989-12-27	Quinoline Ether Alkanoic Acid
ES2087456T3 (es)	1996-07-16	(biciclo-hetero-arilmetoxi)indoles como inhibidores de la biosintesis de leucotrienos.
CA2079374A1 (en)	1993-03-31	(bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
WO1994013293A3 (en)	1994-08-18	(quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
CA2047858A1 (en)	1992-01-27	(quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
NO914004D0 (no)	1991-10-11	Fremgangsmaate for fremstilling av umettede hydroxyalkylkinolinsyrer
NO943792D0 (no)	1994-10-07	Kinolinderivater som leukotrienantagonister
CA2079375A1 (en)	1993-03-31	(hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
NO902301D0 (no)	1990-05-23	Fremgangsmaate for fremstilling av diarylstyrylkinolin-disyrer.
CA2047857A1 (en)	1992-01-27	(quinolin-2-ylmethoxy)heterotetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
NO914003L (no)	1992-04-13	Fremgangsmaate for fremstilling av hydroxyalkylkinolinethersyrer som leukotrienantagonister
CA2136241A1 (en)	1994-01-06	Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes
CA2079373A1 (en)	1993-03-31	(azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
CA2007786A1 (en)	1991-07-15	Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
CA2012137A1 (en)	1991-09-14	Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase