NO178028C - Fremgangsmåte ved fremstilling av 3-(L-pyroglutamyl)-L-tiazolidin-4-karboksylsyre samt derivater derav - Google Patents

Fremgangsmåte ved fremstilling av 3-(L-pyroglutamyl)-L-tiazolidin-4-karboksylsyre samt derivater derav

Info

Publication number: NO178028C
Authority: NO; Norway
Prior art keywords: derivatives; thiazolidine; carboxylic acid; pyroglutamyl; preparation
Prior art date: 1989-10-12

Application number

NO904404A

Other languages

English (en)

Norwegian (no)

Other versions

NO904404L (no

NO178028B (no

NO904404D0 (no

Inventor

Stefano Poli

Lucio Del Corona

Original Assignee

Poli Ind Chimica Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-12

Filing date

1990-10-11

Publication date

1996-01-10

1990-10-11 Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa

1990-10-11 Publication of NO904404D0 publication Critical patent/NO904404D0/no

1991-04-15 Publication of NO904404L publication Critical patent/NO904404L/no

1995-10-02 Publication of NO178028B publication Critical patent/NO178028B/no

1996-01-10 Publication of NO178028C publication Critical patent/NO178028C/no

Links

-1 L-pyroglutamyl Chemical group 0.000 title 1
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 2
ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical class OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Thiazole And Isothizaole Compounds (AREA)

NO904404A 1989-10-12 1990-10-11 Fremgangsmåte ved fremstilling av 3-(L-pyroglutamyl)-L-tiazolidin-4-karboksylsyre samt derivater derav NO178028C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT22003A IT1239029B (it)	1989-10-12	1989-10-12	Processo per la preparazione dell'acido 3-(l-piroglutamil)-l- tiazolidin-4-carbossilico e suoi derivati.

Publications (4)

Publication Number	Publication Date
NO904404D0 NO904404D0 (no)	1990-10-11
NO904404L NO904404L (no)	1991-04-15
NO178028B NO178028B (no)	1995-10-02
NO178028C true NO178028C (no)	1996-01-10

Family

ID=11190043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO904404A NO178028C (no)	1989-10-12	1990-10-11	Fremgangsmåte ved fremstilling av 3-(L-pyroglutamyl)-L-tiazolidin-4-karboksylsyre samt derivater derav

Country Status (18)

Country	Link
US (1)	US5110936A (de)
EP (1)	EP0422566B1 (de)
JP (1)	JP2813450B2 (de)
KR (1)	KR100195895B1 (de)
AT (1)	ATE121420T1 (de)
AU (1)	AU644379B2 (de)
CA (1)	CA2027341C (de)
DE (2)	DE422566T1 (de)
DK (1)	DK0422566T3 (de)
ES (1)	ES2028766T3 (de)
FI (1)	FI95271C (de)
GR (1)	GR910300072T1 (de)
HU (1)	HU210213B (de)
IE (1)	IE67047B1 (de)
IL (1)	IL95949A (de)
IT (1)	IT1239029B (de)
NO (1)	NO178028C (de)
ZA (1)	ZA908097B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1230706B (it) *	1989-02-10	1991-10-29	Poli Ind Chimica Spa	Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
IT1237998B (it) *	1990-01-23	1993-06-21	Poli Ind Chimica Spa	Acido 3-l-(5-tioxo-l-prolil)tiazolidin-4-carbossilico e derivati, loro preparazione e composizioni farmaceutiche che li contengono
IT1270017B (it) *	1994-09-27	1997-04-16	Poli Ind Chimica Spa	"sintesi quantitativa dell'acido 3-(l-piroglutamil)-l-tiazolidin-4- carbossilico e suoi derivati"
EP0929535A4 (de) *	1996-09-06	2001-05-23	Lilly Co Eli	Verfahren und neue zwischenprodukte
US8404804B2 (en) *	2007-08-28	2013-03-26	Ipsen Pharma S.A.S.	Methods and intermediates for chemical synthesis of polypeptides and proteins
CN102167727B (zh) *	2011-01-29	2013-05-15	浙江金立源药业有限公司	一种匹多莫德的合成方法
WO2016112977A1 (en)	2015-01-15	2016-07-21	Polichem S.A.	Di-pidotimod benzathine and solid forms thereof
KR101642445B1 (ko) *	2016-01-11	2016-07-26	(주)남양통신	수상태양광 발전장치용 계류장치
CN107383162A (zh) *	2017-07-06	2017-11-24	成都美域高制药有限公司	一种匹多莫德的制备方法
CN108640912A (zh) *	2018-06-19	2018-10-12	广州大光制药有限公司	一种匹多莫德的工业化规模制备方法
CN111233854A (zh) *	2019-12-30	2020-06-05	常州寅盛药业有限公司	一种匹多莫德杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1202426B (it) *	1987-01-26	1989-02-09	Poli Ind Chimica Spa	Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono

1989
- 1989-10-12 IT IT22003A patent/IT1239029B/it active IP Right Grant
1990
- 1990-10-08 DE DE199090119271T patent/DE422566T1/de active Pending
- 1990-10-08 DE DE69018755T patent/DE69018755T2/de not_active Expired - Fee Related
- 1990-10-08 IE IE359990A patent/IE67047B1/en not_active IP Right Cessation
- 1990-10-08 DK DK90119271.6T patent/DK0422566T3/da active
- 1990-10-08 ES ES90119271T patent/ES2028766T3/es not_active Expired - Lifetime
- 1990-10-08 EP EP90119271A patent/EP0422566B1/de not_active Expired - Lifetime
- 1990-10-08 AT AT90119271T patent/ATE121420T1/de not_active IP Right Cessation
- 1990-10-09 ZA ZA908097A patent/ZA908097B/xx unknown
- 1990-10-09 US US07/594,313 patent/US5110936A/en not_active Expired - Lifetime
- 1990-10-10 KR KR1019900015999A patent/KR100195895B1/ko not_active Expired - Lifetime
- 1990-10-10 IL IL9594990A patent/IL95949A/en not_active IP Right Cessation
- 1990-10-11 CA CA002027341A patent/CA2027341C/en not_active Expired - Fee Related
- 1990-10-11 HU HU906417A patent/HU210213B/hu not_active IP Right Cessation
- 1990-10-11 AU AU64521/90A patent/AU644379B2/en not_active Ceased
- 1990-10-11 NO NO904404A patent/NO178028C/no unknown
- 1990-10-11 FI FI905011A patent/FI95271C/fi active IP Right Grant
- 1990-10-12 JP JP2275100A patent/JP2813450B2/ja not_active Expired - Fee Related
1991
- 1991-11-15 GR GR91300072T patent/GR910300072T1/el unknown

Also Published As

Publication number	Publication date
AU644379B2 (en)	1993-12-09
DE69018755D1 (de)	1995-05-24
JP2813450B2 (ja)	1998-10-22
EP0422566A1 (de)	1991-04-17
IL95949A0 (en)	1991-07-18
DE422566T1 (de)	1991-09-05
GR910300072T1 (en)	1991-11-15
FI95271B (fi)	1995-09-29
DK0422566T3 (da)	1995-06-26
ES2028766T1 (es)	1992-07-16
HU906417D0 (en)	1991-04-29
HU210213B (en)	1995-02-28
IT8922003A0 (it)	1989-10-12
NO904404L (no)	1991-04-15
JPH03193799A (ja)	1991-08-23
ATE121420T1 (de)	1995-05-15
NO178028B (no)	1995-10-02
IT8922003A1 (it)	1991-04-12
US5110936A (en)	1992-05-05
CA2027341A1 (en)	1991-04-13
IL95949A (en)	1995-10-31
ZA908097B (en)	1991-08-28
IT1239029B (it)	1993-09-20
DE69018755T2 (de)	1995-08-24
NO904404D0 (no)	1990-10-11
ES2028766T3 (es)	1995-07-01
KR910007923A (ko)	1991-05-30
HUT59136A (en)	1992-04-28
AU6452190A (en)	1991-04-18
EP0422566B1 (de)	1995-04-19
IE903599A1 (en)	1991-04-24
KR100195895B1 (ko)	1999-06-15
IE67047B1 (en)	1996-02-21
FI905011A0 (fi)	1990-10-11
FI95271C (fi)	1996-01-10
CA2027341C (en)	2007-10-02

Similar Documents

Publication	Publication Date	Title
FI904419A7 (fi)	1991-03-12	3-(1-substituoituja-4-piperatsinyyli)-1H-indatsoleja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä
NO903607L (no)	1991-02-19	Blokkpolymerer med snever molekylvekt fordeling, samt fremgangsmaate for fremstilling av slike.
NO178028C (no)	1996-01-10	Fremgangsmåte ved fremstilling av 3-(L-pyroglutamyl)-L-tiazolidin-4-karboksylsyre samt derivater derav
DE3877428D1 (de)	1993-02-25	Kondensationsprodukte von silanol, deren herstellung und verwendungen.
MA21790A1 (fr)	1990-10-01	Derives de la thieno - triazolo - diazepine ainsi que leur procede de preparation .
FI875684A7 (fi)	1988-06-23	1,1,2,2-tetrahydroperfluorialkanolien ja niiden estereiden valmistusmenetelmä.
NO893623L (no)	1990-03-12	Mikrobiologisk fremgangsmaate ved fremstilling av agrarkjemisk anvendelige virkestoffer.
FR2670206B1 (fr)	1993-01-22	Procede de preparation de derives de l'acide dihydroxy-3,5 pentanouique.
IT8919524A0 (it)	1989-02-22	Derivati dal 1 arilsolfonil 2 piperidone, loro procedimento di preparazione e loro impiego come farmaci.
NO903338D0 (no)	1990-07-27	Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
FI890864A0 (fi)	1989-02-23	Anvaendning av 1,4-dihydropyridinderivat.
DK610388A (da)	1989-05-04	(6-(hetero) aryloxy-naphthalin-2-yl-oxy)-alkancarboxylsyrederivater, deres fremstilling og anvendelse samt ved fremgangsmaaden anvendelige mellemprodukter og disses fremstilling
FI875685A7 (fi)	1988-06-23	1,1,2,2-tetrahydroperfluorialkanolien ja niiden estereiden valmistusmenetelmä.
FI853164A7 (fi)	1986-02-25	Menetelmä optisesti aktiivisten, substituoitujen 1,4-dihydropyridiinien valmistamiseksi ja niiden käyttö lääkeaineina.
NO890428L (no)	1989-08-04	Fremgangsmaate for fremstilling av sulfaterte alkanol- eller alkylfenol-oksetylater med redusert innhold av 1,4-dioksan.
NO992209L (no)	1999-07-01	Nye Knoevenagel-kondensasjonsprodukter, fremgangsmÕte for deres fremstilling samt anvendelse derav
NO900219D0 (no)	1990-01-16	Dihydroksybenzofenon-oksim, samt fremgangsmaate for fremstilling av slike oksimer.
AU1627088A (en)	1988-12-02	Condensation products of 2,2,4-trimethyl -1,2-dihydro-quinoline and oxo compounds and derivatives thereof
DE69009651D1 (de)	1994-07-14	Verfahren zur Herstellung von 3,4-Dihydrocumarinderivaten.
ATE80873T1 (de)	1992-10-15	Tetrahydropyridin-derivate.
DE58906998D1 (de)	1994-03-24	Verfahren zur Herstellung von 4,5,6-Trichlorpyrimidin.
DE68910806D1 (de)	1993-12-23	Verfahren zur Herstellung von 4,4'''-Dihydroxyquaterphenyl oder deren Derivaten.
ATE99693T1 (de)	1994-01-15	Platin-verbindungen, geeignet zur verwendung als arzneimittel.
ATE80151T1 (de)	1992-09-15	2-(3-4-dihydroxyphenyl)-aethylamine, ihre herstellung und ihre verwendung als arzneimittel.
FI874249A7 (fi)	1987-09-28	Menetelmä 3-dimetyyliamino-7-metyyli -1,2,4-bentsotriatsiini-1-oksidi n ja atsapropatsonin valmistamiseksi.