NO178263C - New benzomorphans and their use as a drug - Google Patents

New benzomorphans and their use as a drug

Info

Publication number
NO178263C
NO178263C NO922603A NO922603A NO178263C NO 178263 C NO178263 C NO 178263C NO 922603 A NO922603 A NO 922603A NO 922603 A NO922603 A NO 922603A NO 178263 C NO178263 C NO 178263C
Authority
NO
Norway
Prior art keywords
alkyl
new
benzomorphans
drug
acyl
Prior art date
Application number
NO922603A
Other languages
Norwegian (no)
Other versions
NO178263B (en
NO922603D0 (en
NO922603L (en
Inventor
Adrian Carter
Helmut Ensinger
Matthias Grauert
Franz Josef Kuhn
Herbert Merz
Enzio Muller
Werner Stransky
Ilse Streller
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of NO922603D0 publication Critical patent/NO922603D0/en
Publication of NO922603L publication Critical patent/NO922603L/en
Publication of NO178263B publication Critical patent/NO178263B/en
Publication of NO178263C publication Critical patent/NO178263C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

Benzomorphane derivs. of formula (I) are new. In (I), X = O or S; R1 = 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl or aryl; R2 = H, 1-8C alkyl, 3-6C alkenyl, 3-6C alkynyl, aryl or aralkyl; R3 = H or 1-6C alkyl; R4 and R5 = each 1-8C alkyl; R6 = 1-8C alkyl or aryl; R7 and R8 = each H, 1-8C alkyl, halogen, OH, 1-8C alkoxy, O-Acyl, CN, NO2, NH2, NH(1-8C alkyl), N(1-8C alkyl)2 (n which the alkyl gps. are opt. different), NH-acyl or N-acyl-(1-8C alkyl).
NO922603A 1991-07-02 1992-07-01 New benzomorphans and their use as a drug NO178263C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4121821A DE4121821A1 (en) 1991-07-02 1991-07-02 NEW BENZOMORPHANE AND ITS USE AS A MEDICAMENT

Publications (4)

Publication Number Publication Date
NO922603D0 NO922603D0 (en) 1992-07-01
NO922603L NO922603L (en) 1993-01-04
NO178263B NO178263B (en) 1995-11-13
NO178263C true NO178263C (en) 1996-02-21

Family

ID=6435223

Family Applications (1)

Application Number Title Priority Date Filing Date
NO922603A NO178263C (en) 1991-07-02 1992-07-01 New benzomorphans and their use as a drug

Country Status (23)

Country Link
EP (1) EP0521422B1 (en)
JP (1) JP3324785B2 (en)
KR (1) KR100251256B1 (en)
AT (1) ATE137749T1 (en)
AU (1) AU657330B2 (en)
CA (1) CA2072814C (en)
CZ (1) CZ286949B6 (en)
DE (2) DE4121821A1 (en)
DK (1) DK0521422T3 (en)
ES (1) ES2086585T3 (en)
FI (1) FI105913B (en)
GR (1) GR3020124T3 (en)
HU (1) HU220873B1 (en)
IE (1) IE74400B1 (en)
IL (1) IL102361A (en)
MX (1) MX9203845A (en)
NO (1) NO178263C (en)
NZ (1) NZ243388A (en)
PH (1) PH31430A (en)
SG (1) SG43001A1 (en)
SK (1) SK280776B6 (en)
TW (1) TW214547B (en)
ZA (1) ZA924883B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (en) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan
DE19740110A1 (en) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, process for their preparation and their use as medicaments
JPH1196519A (en) * 1997-09-17 1999-04-09 Alps Electric Co Ltd Spin valve type thin-film element and its production
US6136980A (en) * 1998-05-01 2000-10-24 Boehringer Ingelheim Kg Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
DE19826365A1 (en) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Use of benzomorphan derivatives as an analgesic
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE19957156A1 (en) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma New amino and fluoro substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine derivatives useful in treatment of e.g. arrythmias, spasms, ischaemia, pain and neurodegenerative disorders
DE10204276A1 (en) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceuticals
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
AU2003234621A1 (en) 2002-05-17 2003-12-02 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP2220048B1 (en) * 2007-11-16 2017-01-25 Boehringer Ingelheim International GmbH Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7804509A (en) * 1978-04-26 1979-10-30 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts.
DE2828039A1 (en) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2- (2-ALKOXYETHYL) -2'-HYDROXY-6,7-BENZOMORPHANES THEIR ACID ADDITION SALTS, THESE MEDICINAL PRODUCTS, AND METHOD FOR THE PRODUCTION THEREOF
NL7907800A (en) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Novel 6,7-benzomorphan derivatives and their acid addition salts, pharmaceutical compositions containing such a compound, and process for the preparation of these compounds and their pharmaceutical compositions.

Also Published As

Publication number Publication date
FI105913B (en) 2000-10-31
ES2086585T3 (en) 1996-07-01
DE59206212D1 (en) 1996-06-13
ZA924883B (en) 1993-02-24
HUT66410A (en) 1994-11-28
IE922144A1 (en) 1993-01-13
HK1003111A1 (en) 1998-10-09
NO178263B (en) 1995-11-13
CZ286949B6 (en) 2000-08-16
FI923050L (en) 1993-01-03
HU9202199D0 (en) 1992-10-28
CA2072814A1 (en) 1993-01-03
AU657330B2 (en) 1995-03-09
NZ243388A (en) 1994-11-25
IL102361A0 (en) 1993-01-14
IE74400B1 (en) 1997-07-30
NO922603D0 (en) 1992-07-01
SK280776B6 (en) 2000-07-11
KR930002321A (en) 1993-02-22
IL102361A (en) 1997-02-18
ATE137749T1 (en) 1996-05-15
KR100251256B1 (en) 2000-05-01
CZ207592A3 (en) 1993-08-11
CA2072814C (en) 2003-09-23
SG43001A1 (en) 1997-10-17
JPH05201987A (en) 1993-08-10
AU1868692A (en) 1993-01-07
FI923050A0 (en) 1992-07-01
NO922603L (en) 1993-01-04
DE4121821A1 (en) 1993-01-14
MX9203845A (en) 1993-01-01
EP0521422A1 (en) 1993-01-07
SK207592A3 (en) 1997-01-08
GR3020124T3 (en) 1996-08-31
PH31430A (en) 1998-11-03
HU220873B1 (en) 2002-06-29
EP0521422B1 (en) 1996-05-08
TW214547B (en) 1993-10-11
DK0521422T3 (en) 1996-06-10
JP3324785B2 (en) 2002-09-17

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