NO180232C - Karboksylsyrederivater, legemidler inneholdende disse, og anvendelse av disse for fremstilling av legemidler - Google Patents

Karboksylsyrederivater, legemidler inneholdende disse, og anvendelse av disse for fremstilling av legemidler

Info

Publication number
NO180232C
NO180232C NO933647A NO933647A NO180232C NO 180232 C NO180232 C NO 180232C NO 933647 A NO933647 A NO 933647A NO 933647 A NO933647 A NO 933647A NO 180232 C NO180232 C NO 180232C
Authority
NO
Norway
Prior art keywords
medicaments
manufacture
carboxylic acid
acid derivatives
medicaments containing
Prior art date
Application number
NO933647A
Other languages
English (en)
Norwegian (no)
Other versions
NO180232B (no
NO933647L (no
NO933647D0 (no
Inventor
Helmut Pieper
Guenter Linz
Frank Himmelsbach
Volkhard Austel
Thomas Mueller
Johannes Weisenberger
Brian Guth
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO933647D0 publication Critical patent/NO933647D0/no
Publication of NO933647L publication Critical patent/NO933647L/no
Publication of NO180232B publication Critical patent/NO180232B/no
Publication of NO180232C publication Critical patent/NO180232C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO933647A 1992-10-12 1993-10-11 Karboksylsyrederivater, legemidler inneholdende disse, og anvendelse av disse for fremstilling av legemidler NO180232C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4234295A DE4234295A1 (de) 1992-10-12 1992-10-12 Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (4)

Publication Number Publication Date
NO933647D0 NO933647D0 (no) 1993-10-11
NO933647L NO933647L (no) 1994-04-13
NO180232B NO180232B (no) 1996-12-02
NO180232C true NO180232C (no) 1997-03-12

Family

ID=6470224

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933647A NO180232C (no) 1992-10-12 1993-10-11 Karboksylsyrederivater, legemidler inneholdende disse, og anvendelse av disse for fremstilling av legemidler

Country Status (19)

Country Link
US (1) US5442064A (fr)
EP (1) EP0592949A3 (fr)
JP (1) JPH06199788A (fr)
KR (1) KR940009164A (fr)
CN (1) CN1087904A (fr)
AU (1) AU668765B2 (fr)
CA (1) CA2108093A1 (fr)
CZ (1) CZ212893A3 (fr)
DE (1) DE4234295A1 (fr)
FI (1) FI934460A7 (fr)
HU (1) HU9302875D0 (fr)
IL (1) IL107221A0 (fr)
MX (1) MX9306303A (fr)
NO (1) NO180232C (fr)
NZ (1) NZ248894A (fr)
PL (1) PL300673A1 (fr)
SK (1) SK107293A3 (fr)
TW (1) TW293815B (fr)
ZA (1) ZA937502B (fr)

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US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
DE19743435A1 (de) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
FR2781220B1 (fr) * 1998-07-17 2000-10-13 Lafon Labor Piperazinones substituees en beta
WO2000017163A1 (fr) 1998-09-22 2000-03-30 Yamanouchi Pharmaceutical Co., Ltd. Derives de cyanophenyle
EP1230231B1 (fr) * 1999-11-08 2005-06-22 Schering Corporation Procede servant a preparer n-(4-hydroxyphenyl)-n'-(4'-aminophenyl)-piperazine
US7204981B2 (en) * 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
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US7087578B2 (en) 2000-05-24 2006-08-08 Eli Lilly And Company Formulations and methods for treating hypercoagulable states
IL153884A0 (en) 2000-07-20 2003-07-31 Neurogen Corp Capsaicin receptor ligands
AU2003212882A1 (en) 2002-02-01 2003-09-02 Euro-Celtique S.A. 2 - piperazine - pyridines useful for treating pain
ATE416168T1 (de) 2002-02-15 2008-12-15 Glaxo Group Ltd Modulatoren des vanilloidrezeptors
CA2475738A1 (fr) * 2002-03-08 2003-09-18 Eli Lilly And Company Formulations de proteines c activees
DE60318875T2 (de) * 2002-06-28 2009-01-15 Euro-Celtique S.A. Therapeutische piperazin-derivate für die behandlung von schmerzen
US7262194B2 (en) * 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
ATE556067T1 (de) 2003-05-20 2012-05-15 Ajinomoto Kk Modulatoren des vanilloid rezeptors
AR044688A1 (es) * 2003-06-12 2005-09-21 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor
ES2327684T3 (es) 2003-07-24 2009-11-02 Euro-Celtique S.A. Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor.
SI1664041T1 (sl) 2003-09-22 2008-12-31 Euro Celtique Sa Fenil-karboksamidne spojine, uporabne za tretiranje bolečine
MXPA06003123A (es) * 2003-09-22 2006-05-31 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor.
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
MXPA06014573A (es) * 2004-06-24 2007-03-12 Incyte Corp Compuestos amido y su uso como farmaceuticos.
WO2006012226A2 (fr) * 2004-06-24 2006-02-02 Incyte Corporation Piperidines a substitution n et utilisation de ces dernieres en tant que substances pharmaceutiques
US20060009491A1 (en) * 2004-06-24 2006-01-12 Incyte Corporation Amido compounds and their use as pharmaceuticals
EP1768954A4 (fr) * 2004-06-24 2008-05-28 Incyte Corp 2-methylpropanamides et leur utilisation en tant que pharmaceutiques
EA200700251A1 (ru) * 2004-08-10 2007-08-31 Инсайт Корпорейшн Амидосоединения и их применение в качестве фармацевтических средств
SG161261A1 (en) * 2004-11-10 2010-05-27 Incyte Corp Lactam compounds and their use as pharmaceuticals
US8110581B2 (en) 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
CN101103016A (zh) * 2004-11-18 2008-01-09 因塞特公司 11-β羟基类固醇脱氢酶1型抑制剂及其使用方法
CA2589748C (fr) * 2004-12-24 2013-08-13 Astrazeneca Ab Composes heterocycliques en tant qu'antagonistes de ccr2b
CA2621255A1 (fr) * 2005-09-21 2007-04-05 Incyte Corporation Utilisation pharmaceutique de composes amido
EA200870019A1 (ru) * 2005-12-05 2008-12-30 Инсайт Корпорейшн Лактамовые соединения и способы их применения
GB0525957D0 (en) 2005-12-21 2006-02-01 Astrazeneca Ab Methods
US7998959B2 (en) * 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
BRPI0707408A2 (pt) * 2006-01-31 2011-05-03 Incyte Corp compostos de amido e seu uso como produtos farmacêuticos
WO2007101270A1 (fr) * 2006-03-02 2007-09-07 Incyte Corporation MODULATEURS DE LA 11β-HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1, COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT ET PROCEDE D'UTILISATION DESDITS MODULATEURS
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
JP2009535420A (ja) * 2006-05-01 2009-10-01 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア
JP2009537564A (ja) * 2006-05-17 2009-10-29 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプＩの複素環阻害剤およびそれを用いる方法
ES2293834B1 (es) * 2006-07-20 2009-02-16 Consejo Superior Investig. Cientificas Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas.
EP2142529B1 (fr) * 2007-04-27 2013-12-25 Purdue Pharma LP Antagonistes de trpv1 et utilisations de ceux-ci
AU2011226773C1 (en) * 2007-04-27 2012-07-26 Purdue Pharma L.P. TRPV1 antagonists and uses thereof
CA2685121A1 (fr) * 2007-04-27 2008-11-06 Purdue Pharma L.P. Agents therapeutiques utiles pour traiter la douleur
US8026384B2 (en) * 2007-05-04 2011-09-27 Astrazeneca Ab Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide
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WO2010065668A1 (fr) * 2008-12-03 2010-06-10 Presidio Pharmaceuticals, Inc. Inhibiteurs du virus de l'hépatite c de type ns5a
US20100152197A1 (en) * 2008-12-15 2010-06-17 Astrazeneca Ab (4-tert-butylpiperazin-2-yl)(piperazin-1-yl)methanone-n-carboxamide derivatives
CA2749163A1 (fr) * 2009-01-14 2010-07-22 The Salk Institute For Biological Studies Methodes de criblage et composes utiles dans la protection contre les maladies amyloides
RS55701B1 (sr) 2011-06-22 2017-07-31 Purdue Pharma Lp Trpv1 antagonisti koji uključuju dihidroksi supstituent i njihove upotrebe
WO2013146969A1 (fr) * 2012-03-29 2013-10-03 第一三共株式会社 Nouveau dérivé de cyclohexane disubstitué

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EP0518819B1 (fr) * 1991-06-11 1995-08-02 Ciba-Geigy Ag Dérivés d'amidine, leur préparation et utilisation comme médicament
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CA2150550A1 (fr) * 1992-12-01 1994-06-09 Melissa S. Egbertson Antagonistes du recepteur du fibrinogene

Also Published As

Publication number Publication date
KR940009164A (ko) 1994-05-20
CN1087904A (zh) 1994-06-15
AU668765B2 (en) 1996-05-16
DE4234295A1 (de) 1994-04-14
FI934460A7 (fi) 1994-04-13
EP0592949A3 (en) 1994-08-10
NO180232B (no) 1996-12-02
MX9306303A (es) 1994-04-29
NO933647L (no) 1994-04-13
NO933647D0 (no) 1993-10-11
CZ212893A3 (en) 1994-04-13
TW293815B (fr) 1996-12-21
JPH06199788A (ja) 1994-07-19
IL107221A0 (en) 1994-01-25
PL300673A1 (en) 1994-05-16
CA2108093A1 (fr) 1994-04-13
US5442064A (en) 1995-08-15
FI934460A0 (fi) 1993-10-11
NZ248894A (en) 1996-01-26
HU9302875D0 (en) 1993-12-28
AU4893993A (en) 1994-04-28
ZA937502B (en) 1995-04-11
SK107293A3 (en) 1994-08-10
EP0592949A2 (fr) 1994-04-20

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