NO180375C - Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin

Info

Publication number: NO180375C
Authority: NO; Norway
Prior art keywords: hydrogen; halo; amino; alkyl; propylpiperazin
Prior art date: 1990-06-01

Application number

NO912100A

Other languages

English (en)

Norwegian (no)

Other versions

NO180375B (no

NO912100L (no

NO912100D0 (no

Inventor

Michael John Leach

Malcolm Stuart Nobbs

Ramachandran Iyer

Clive Leonard Yeates

Philip Alan Skone

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-01

Filing date

1991-05-31

Publication date

1997-04-09

1991-05-31 Application filed by Wellcome Found filed Critical Wellcome Found

1991-05-31 Publication of NO912100D0 publication Critical patent/NO912100D0/no

1991-12-02 Publication of NO912100L publication Critical patent/NO912100L/no

1995-10-16 Priority to NO954109A priority Critical patent/NO954109D0/no

1996-12-30 Publication of NO180375B publication Critical patent/NO180375B/no

1997-04-09 Publication of NO180375C publication Critical patent/NO180375C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Liquid Crystal Substances (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Paper (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO912100A 1990-06-01 1991-05-31 Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin NO180375C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO954109A NO954109D0 (no)	1990-06-01	1995-10-16	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909012316A GB9012316D0 (en)	1990-06-01	1990-06-01	Pharmacologically active cns compounds

Publications (4)

Publication Number	Publication Date
NO912100D0 NO912100D0 (no)	1991-05-31
NO912100L NO912100L (no)	1991-12-02
NO180375B NO180375B (no)	1996-12-30
NO180375C true NO180375C (no)	1997-04-09

Family

ID=10676964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO912100A NO180375C (no)	1990-06-01	1991-05-31	Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin

Country Status (25)

Country	Link
EP (2)	EP0679645A1 (de)
JP (1)	JPH06340634A (de)
KR (1)	KR920000733A (de)
AT (1)	ATE141263T1 (de)
AU (2)	AU652753B2 (de)
CA (1)	CA2043640A1 (de)
CZ (1)	CZ281070B6 (de)
DE (1)	DE69121317T2 (de)
DK (1)	DK0459819T3 (de)
ES (1)	ES2093078T3 (de)
FI (1)	FI912623A7 (de)
GB (1)	GB9012316D0 (de)
GR (1)	GR3021237T3 (de)
HU (2)	HUT58707A (de)
IE (1)	IE911861A1 (de)
IL (2)	IL113599A (de)
MY (2)	MY136248A (de)
NO (1)	NO180375C (de)
NZ (3)	NZ272001A (de)
PL (2)	PL170373B1 (de)
PT (1)	PT97827B (de)
RU (1)	RU2091374C1 (de)
SK (1)	SK278444B6 (de)
TW (1)	TW224460B (de)
ZA (1)	ZA914165B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
MY110880A (en) *	1991-01-30	1999-06-30	The Wellcome Foundation Ltd	Water-dispersible tablets
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
GB9226377D0 (en) *	1992-12-18	1993-02-10	Babbedge Rachel C	Pharmaceutical compositions
EP0674627A1 (de) *	1992-12-18	1995-10-04	The Wellcome Foundation Limited	Pyrimidin-, pyridin-, pteridinon- und indazolderivate als enzyminhibitoren
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
GB9319341D0 (en) *	1993-09-17	1993-11-03	Wellcome Found	Novel process
FR2741879A1 (fr) *	1995-12-05	1997-06-06	Esteve Labor Dr	Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) *	1997-10-15	2002-08-27	Krenitsky Pharmaceuticals, Inc.	Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
DE19751949A1 (de) *	1997-11-24	1999-05-27	Bayer Ag	Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9726987D0 (en)	1997-12-22	1998-02-18	Glaxo Group Ltd	Compounds
US6583148B1 (en)	1999-04-08	2003-06-24	Krenitsky Pharmaceuticals, Inc.	Neurotrophic substituted pyrimidines
DE19918325A1 (de) *	1999-04-22	2000-10-26	Euro Celtique Sa	Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
CN1374953A (zh)	1999-09-16	2002-10-16	田边制药株式会社	含氮的6－员芳香环化合物
WO2001062233A2 (en) *	2000-02-25	2001-08-30	F. Hoffmann La Roche Ag	Adenosine receptor modulators
CN1657523A (zh)	2000-04-28	2005-08-24	田边制药株式会社	环状化合物
US7273868B2 (en)	2000-04-28	2007-09-25	Tanabe Seiyaku Co., Ltd.	Pyrazine derivatives
JP5154728B2 (ja) *	2000-07-24	2013-02-27	クレニツキー・ファーマシューティカルズ，インコーポレイテッド	神経栄養活性を有する置換５−アルキニルピリミジン
JP4166991B2 (ja)	2001-02-26	2008-10-15	田辺三菱製薬株式会社	ピリドピリミジンまたはナフチリジン誘導体
EP1474401A2 (de) *	2002-02-05	2004-11-10	Novo Nordisk A/S	Neue aryl- und heteroarylpiperazine
TW200637556A (en) *	2005-01-31	2006-11-01	Basf Ag	Substituted 5-phenyl pyrimidines I in therapy
MX2007015675A (es)	2005-07-04	2008-02-20	Novo Nordisk As	Antagonistas del receptor de histamina h3.
EP2038256A1 (de)	2006-05-23	2009-03-25	TransTech Pharma, Inc	6-(4-cyclopropylpiperazin-1-yl)-2'-methyl-[3,4']-bipyridin und seine verwendung als arzneimittel
EP2402324A1 (de)	2006-05-29	2012-01-04	High Point Pharmaceuticals, LLC	Benzodioxolylcyclopropylpiperazinylpyridazine
EP2014656A3 (de)	2007-06-11	2011-08-24	High Point Pharmaceuticals, LLC	Neue heterocyclische H3-Antagonisten
MX354412B (es)	2011-06-10	2018-03-05	Merck Patent Gmbh	Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton.
ES2699351T3 (es) *	2014-01-17	2019-02-08	Novartis Ag	Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
JO3517B1 (ar)	2014-01-17	2020-07-05	Novartis Ag	ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
WO2017216706A1 (en)	2016-06-14	2017-12-21	Novartis Ag	Compounds and compositions for inhibiting the activity of shp2
CA3048340A1 (en)	2017-01-10	2018-07-19	Novartis Ag	Pharmaceutical combination comprising an alk inhibitor and a shp2 inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE518622A (de) *
FI895821A7 (fi) *	1988-12-07	1990-06-08	The Wellcome Foundation Ltd	Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) *	1989-12-04	1992-08-04	Burroughs Wellcome Co.	Nitrile compounds

1990
- 1990-06-01 GB GB909012316A patent/GB9012316D0/en active Pending
1991
- 1991-05-30 ZA ZA914165A patent/ZA914165B/xx unknown
- 1991-05-31 TW TW080104285A patent/TW224460B/zh active
- 1991-05-31 PL PL91305331A patent/PL170373B1/pl unknown
- 1991-05-31 DK DK91304935.9T patent/DK0459819T3/da active
- 1991-05-31 MY MYPI95001459A patent/MY136248A/en unknown
- 1991-05-31 PT PT97827A patent/PT97827B/pt not_active IP Right Cessation
- 1991-05-31 FI FI912623A patent/FI912623A7/fi not_active Application Discontinuation
- 1991-05-31 NZ NZ272001A patent/NZ272001A/en unknown
- 1991-05-31 PL PL91290496A patent/PL166656B1/pl unknown
- 1991-05-31 NO NO912100A patent/NO180375C/no unknown
- 1991-05-31 ES ES91304935T patent/ES2093078T3/es not_active Expired - Lifetime
- 1991-05-31 IL IL113599A patent/IL113599A/xx not_active IP Right Cessation
- 1991-05-31 HU HU911826A patent/HUT58707A/hu unknown
- 1991-05-31 DE DE69121317T patent/DE69121317T2/de not_active Expired - Fee Related
- 1991-05-31 JP JP3235334A patent/JPH06340634A/ja active Pending
- 1991-05-31 NZ NZ238360A patent/NZ238360A/en unknown
- 1991-05-31 EP EP95111314A patent/EP0679645A1/de not_active Withdrawn
- 1991-05-31 CA CA002043640A patent/CA2043640A1/en not_active Abandoned
- 1991-05-31 IE IE186191A patent/IE911861A1/en unknown
- 1991-05-31 MY MYPI91000962A patent/MY109958A/en unknown
- 1991-05-31 CZ CS911643A patent/CZ281070B6/cs unknown
- 1991-05-31 IL IL9833091A patent/IL98330A/en active IP Right Grant
- 1991-05-31 EP EP91304935A patent/EP0459819B1/de not_active Expired - Lifetime
- 1991-05-31 KR KR1019910009010A patent/KR920000733A/ko not_active Ceased
- 1991-05-31 AU AU78097/91A patent/AU652753B2/en not_active Ceased
- 1991-05-31 RU SU914895583A patent/RU2091374C1/ru active
- 1991-05-31 AT AT91304935T patent/ATE141263T1/de not_active IP Right Cessation
- 1991-05-31 SK SK1643-91A patent/SK278444B6/sk unknown
- 1991-05-31 NZ NZ248501A patent/NZ248501A/en unknown
1994
- 1994-07-13 AU AU67455/94A patent/AU680252B2/en not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00669P patent/HU211649A9/hu unknown
1996
- 1996-10-03 GR GR960402585T patent/GR3021237T3/el unknown

Also Published As

Publication number	Publication date
PT97827A (pt)	1992-03-31
PT97827B (pt)	1998-10-30
RU2091374C1 (ru)	1997-09-27
EP0459819A3 (en)	1992-03-11
HU211649A9 (en)	1995-12-28
DE69121317T2 (de)	1997-01-02
NZ272001A (en)	1997-03-24
EP0459819B1 (de)	1996-08-14
FI912623A7 (fi)	1991-12-02
CZ281070B6 (cs)	1996-06-12
IE911861A1 (en)	1991-12-04
MY136248A (en)	2008-08-29
MY109958A (en)	1997-10-31
HU911826D0 (en)	1991-12-30
NZ248501A (en)	1997-03-24
AU6745594A (en)	1994-09-15
JPH06340634A (ja)	1994-12-13
EP0459819A2 (de)	1991-12-04
EP0679645A1 (de)	1995-11-02
IL98330A0 (en)	1992-06-21
AU680252B2 (en)	1997-07-24
AU652753B2 (en)	1994-09-08
IL98330A (en)	1996-10-31
SK278444B6 (en)	1997-05-07
GB9012316D0 (en)	1990-07-18
AU7809791A (en)	1991-12-05
IL113599A (en)	1997-09-30
PL170373B1 (pl)	1996-12-31
ZA914165B (en)	1993-03-01
DE69121317D1 (de)	1996-09-19
ES2093078T3 (es)	1996-12-16
IL113599A0 (en)	1995-08-31
ATE141263T1 (de)	1996-08-15
NO180375B (no)	1996-12-30
NO912100L (no)	1991-12-02
FI912623A0 (fi)	1991-05-31
CS164391A3 (en)	1992-02-19
NZ238360A (en)	1997-03-24
CA2043640A1 (en)	1991-12-02
TW224460B (de)	1994-06-01
DK0459819T3 (da)	1996-09-02
HUT58707A (en)	1992-03-30
NO912100D0 (no)	1991-05-31
PL166656B1 (pl)	1995-06-30
KR920000733A (ko)	1992-01-29
GR3021237T3 (en)	1997-01-31

Publication	Publication Date	Title
NO180375C (no)	1997-04-09	Analogifremgangsmåte for fremstilling av terapeutisk aktivt 4-amino-2-(4-n-propylpiperazin-1-yl)-5-(2,3,5-triklorfenyl)pyrimidin
MD960225A (ro)	1997-11-30	Compuşi noi cu activitate erbicidă, acaricidă şi insecticidă
BR8500720A (pt)	1985-10-08	Amina contendo carbamato de hidroalquila,composicao de revestimento termo-fixavel;polimero auto-reticulavel,catodicamente eletropepositavel,composicao para revestimento catodico;polimero hidrofilico;polimero acricilo auto-reticulavel;e sistema de ligacao para ligar superficies de objetos
YU53700A (sh)	2002-11-15	Biciklo(2.2.1.) heptani i srodna jedinjenja
FI901982A0 (fi)	1990-04-20	Menetelmä terapeuttisesti aktiivisten piperatsiniijohdannaisten valmistamiseksi
GR3033519T3 (en)	2000-09-29	Substituted pyridinesulfonamide compounds, herbicidal compositions containing them, and process for their production.
ES8801639A1 (es)	1988-02-16	Procedimiento para la obtencion de derivados del acido barbiturico
DE3852008D1 (de)	1994-12-08	Verbindungen.
ATE84028T1 (de)	1993-01-15	Biologisch aktive verbindungen.
ES2001781A6 (es)	1988-06-16	Procedimiento para la obtencion de heterociclialquilesteres de acidos 2-imidazolinon-nicotinicos
ES8703861A1 (es)	1987-03-01	Un procedimiento para preparar nuevas 1,2,4-tiadiazinas
ES2034642T3 (es)	1993-04-01	Un procedimiento para preparar derivados de 1,5-benzotiazepina y su utilizacion en el tratamiento de las alteraciones cardiovasculares.
HK74287A (en)	1987-10-23	Imidazolylphenyl amidines
DK0451626T3 (da)	1998-04-20	Anvendelse af benzodiazepinforbindelser til fremstilling af et farmaceutisk præparat mod med excitatoriske aminosyrer forbundne forstyrrelser i centralnervesystemet
BR8603928A (pt)	1987-03-24	Compostos de hidrazino-eteres difenilicos,processo para sua preparacao,composicao herbicida e processo para combater o crescimento de plantas indesejaveis
NO954109L (no)	1991-12-02	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner
GR3015529T3 (en)	1995-06-30	Heterocyclic amide derivatives and their use as pesticides.