NO20001938L - Fremgangsmate for fremstilling av aryloksy-alkyl-dialkylaminer - Google Patents

Fremgangsmate for fremstilling av aryloksy-alkyl-dialkylaminer

Info

Publication number
NO20001938L
NO20001938L NO20001938A NO20001938A NO20001938L NO 20001938 L NO20001938 L NO 20001938L NO 20001938 A NO20001938 A NO 20001938A NO 20001938 A NO20001938 A NO 20001938A NO 20001938 L NO20001938 L NO 20001938L
Authority
NO
Norway
Prior art keywords
dialkylamines
aryloxyalkyl
preparation
aryloxyalkyl dialkylamines
Prior art date
Application number
NO20001938A
Other languages
English (en)
Norwegian (no)
Other versions
NO20001938D0 (no
Inventor
Panolil Raveendranath
Joseph Zeldis
Galina Vid
John Richard Potoski
Jianxin Ren
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/161,653 external-priority patent/US6005102A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20001938D0 publication Critical patent/NO20001938D0/no
Publication of NO20001938L publication Critical patent/NO20001938L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
  • Indole Compounds (AREA)
NO20001938A 1997-10-15 2000-04-13 Fremgangsmate for fremstilling av aryloksy-alkyl-dialkylaminer NO20001938L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95081897A 1997-10-15 1997-10-15
US09/161,653 US6005102A (en) 1997-10-15 1998-09-28 Aryloxy-alkyl-dialkylamines
PCT/US1998/021609 WO1999019293A1 (en) 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines

Publications (2)

Publication Number Publication Date
NO20001938D0 NO20001938D0 (no) 2000-04-13
NO20001938L true NO20001938L (no) 2000-06-07

Family

ID=26858006

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001938A NO20001938L (no) 1997-10-15 2000-04-13 Fremgangsmate for fremstilling av aryloksy-alkyl-dialkylaminer

Country Status (26)

Country Link
EP (2) EP1025077B1 (de)
JP (1) JP2001519410A (de)
KR (1) KR100669836B1 (de)
CN (1) CN1231458C (de)
AR (1) AR015183A1 (de)
AT (1) ATE355264T1 (de)
AU (1) AU757630C (de)
BR (1) BR9813069A (de)
CA (1) CA2306343C (de)
CY (1) CY1106497T1 (de)
DE (1) DE69837210T2 (de)
DK (1) DK1025077T3 (de)
EA (1) EA003937B1 (de)
EE (1) EE200000225A (de)
ES (1) ES2281937T3 (de)
HU (1) HUP0004419A3 (de)
ID (1) ID24417A (de)
IL (2) IL135343A0 (de)
NO (1) NO20001938L (de)
NZ (1) NZ503793A (de)
PL (1) PL198443B1 (de)
PT (1) PT1025077E (de)
SI (1) SI1025077T1 (de)
SK (1) SK286460B6 (de)
TR (1) TR200001012T2 (de)
WO (1) WO1999019293A1 (de)

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ID26890A (id) * 1998-05-15 2001-02-15 American Home Prod 2-fenil-1-(4-(2-aminoetoksi) -benzil)-indol dalam kombinasinya dengan estrogen
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
HK1044777B (en) * 1999-09-13 2006-04-13 Wyeth Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols
US6358991B2 (en) 2000-07-06 2002-03-19 American Home Products Corporation Methods of treating neuropeptide Y-related conditions
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
EP1990051A1 (de) 2000-07-06 2008-11-12 Wyeth Kombinationen aus SSRI und Östrogenmitteln
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AU2001271782A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted insole compounds for treating excessive intraocular pressure
EP1656938A1 (de) 2000-07-06 2006-05-17 Wyeth Kombinationen aus SSRI und Oestrogenmitteln
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
JP2004532834A (ja) * 2001-03-23 2004-10-28 イーライ・リリー・アンド・カンパニー ヒスタミンｈ３受容体アンタゴニストである非イミダゾール系アリールアルキルアミン化合物、その製造および治療的使用
ES2236536T3 (es) 2001-05-22 2005-07-16 Eli Lilly And Company Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos.
ATE321754T1 (de) 2001-05-22 2006-04-15 Lilly Co Eli 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
US7098241B2 (en) 2002-12-16 2006-08-29 Hoffmann-La Roche Inc. Thiophene hydroxamic acid derivatives
PE20060676A1 (es) * 2004-04-07 2006-07-24 Wyeth Corp Polimorfo cristalino de acetato de bazedoxifeno
GT200500080A (es) * 2004-04-07 2005-10-31 Polimorfo cristalino de acetato de bazedoxifeno
CN1946689A (zh) 2004-04-08 2007-04-11 惠氏公司 作为选择性雌激素受体调节剂的巴西多昔芬抗坏血酸盐
MX2007001506A (es) * 2004-08-05 2007-03-27 Wyeth Corp Polimorfo cristalino del clorhidrato de pipindoxifeno monohidratado.
AR055837A1 (es) * 2005-01-13 2007-09-12 Wyeth Corp Procedimientos para la preparacion de alc0holes aminoetoxibencilicos
US20100087661A1 (en) * 2007-02-12 2010-04-08 Josef Jirman Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole
US20100016582A1 (en) * 2008-02-11 2010-01-21 Wyeth Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate
US20120253038A1 (en) * 2009-04-13 2012-10-04 Sandoz Ag Processes for the synthesis of bazedoxifene acetate and intermediates thereof
US8569483B2 (en) 2011-06-21 2013-10-29 Divi's Laboratories, Ltd. Process for the preparation of bazedoxifene acetate and intermediates thereof
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
US9751835B2 (en) 2013-05-15 2017-09-05 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH448121A (de) 1963-03-13 1967-12-15 Hoffmann La Roche Verfahren zur Herstellung substituierter Hydrazinverbindungen
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9326332D0 (en) 1993-12-23 1994-02-23 Karo Bio Indole derivatives
JP2000515133A (ja) * 1996-07-01 2000-11-14 イーライ・リリー・アンド・カンパニー 血糖降下性および脂質低下性の化合物
PT973512E (pt) * 1997-02-27 2004-07-30 Wyeth Corp N-hidroxi-2-(alquil, aril ou heteroaril sulfanil, sulfinilou sulfonil)-alquil, aril ou heteroarilamidas substituidas na posicao 3 como inibidores de metaloproteinases da matriz
US6172100B1 (en) * 1997-04-30 2001-01-09 Eli Lilly And Company Antithrombotic agents

Also Published As

Publication number Publication date
KR100669836B1 (ko) 2007-01-18
PL198443B1 (pl) 2008-06-30
EE200000225A (et) 2001-06-15
JP2001519410A (ja) 2001-10-23
CA2306343C (en) 2010-08-03
PT1025077E (pt) 2007-05-31
CA2306343A1 (en) 1999-04-22
AU1083199A (en) 1999-05-03
KR20010024505A (ko) 2001-03-26
IL135343A0 (en) 2001-05-20
DE69837210T2 (de) 2007-12-27
DK1025077T3 (da) 2007-05-07
EA200000416A1 (ru) 2000-10-30
IL135343A (en) 2007-12-03
EP1025077B1 (de) 2007-02-28
NO20001938D0 (no) 2000-04-13
HUP0004419A3 (en) 2002-01-28
AR015183A1 (es) 2001-04-18
WO1999019293A1 (en) 1999-04-22
PL339908A1 (en) 2001-01-15
EA003937B1 (ru) 2003-10-30
SK286460B6 (sk) 2008-10-07
CN1281429A (zh) 2001-01-24
NZ503793A (en) 2002-10-25
EP1777214A2 (de) 2007-04-25
EP1025077A1 (de) 2000-08-09
DE69837210D1 (de) 2007-04-12
SI1025077T1 (sl) 2007-06-30
CY1106497T1 (el) 2012-01-25
AU757630C (en) 2006-10-26
EP1777214A3 (de) 2007-05-09
TR200001012T2 (tr) 2000-09-21
HUP0004419A2 (hu) 2001-07-30
BR9813069A (pt) 2000-08-22
ID24417A (id) 2000-07-20
HK1026889A1 (en) 2000-12-29
AU757630B2 (en) 2003-02-27
ATE355264T1 (de) 2006-03-15
SK5372000A3 (en) 2000-11-07
CN1231458C (zh) 2005-12-14
ES2281937T3 (es) 2007-10-01

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