NO20002129L - Indazol-bioisoster erstatning av catechol i terapeutiske aktive forbindelser - Google Patents

Indazol-bioisoster erstatning av catechol i terapeutiske aktive forbindelser

Info

Publication number
NO20002129L
NO20002129L NO20002129A NO20002129A NO20002129L NO 20002129 L NO20002129 L NO 20002129L NO 20002129 A NO20002129 A NO 20002129A NO 20002129 A NO20002129 A NO 20002129A NO 20002129 L NO20002129 L NO 20002129L
Authority
NO
Norway
Prior art keywords
bioisosterone
indazole
catechol
replacing
active compounds
Prior art date
Application number
NO20002129A
Other languages
English (en)
Norwegian (no)
Other versions
NO20002129D0 (no
Inventor
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20002129D0 publication Critical patent/NO20002129D0/no
Publication of NO20002129L publication Critical patent/NO20002129L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20002129A 1997-11-04 2000-04-26 Indazol-bioisoster erstatning av catechol i terapeutiske aktive forbindelser NO20002129L (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US6402497P 1997-11-04 1997-11-04
US6422997P 1997-11-04 1997-11-04
US6418797P 1997-11-04 1997-11-04
US6422897P 1997-11-04 1997-11-04
US6419897P 1997-11-04 1997-11-04
PCT/IB1998/001710 WO1999023077A1 (fr) 1997-11-04 1998-10-26 Remplacement bioisosthere du catechol par l'indazole dans des composes therapeutiquement actifs

Publications (2)

Publication Number Publication Date
NO20002129D0 NO20002129D0 (no) 2000-04-26
NO20002129L true NO20002129L (no) 2000-07-03

Family

ID=27535645

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002129A NO20002129L (no) 1997-11-04 2000-04-26 Indazol-bioisoster erstatning av catechol i terapeutiske aktive forbindelser

Country Status (29)

Country Link
US (1) US6391872B1 (fr)
EP (1) EP1028946A1 (fr)
JP (1) JP2001521926A (fr)
CN (1) CN1284948A (fr)
AP (1) AP910A (fr)
AR (1) AR013746A1 (fr)
AU (1) AU754734B2 (fr)
BG (1) BG104450A (fr)
BR (1) BR9813926A (fr)
CA (1) CA2309150A1 (fr)
CZ (1) CZ20001621A3 (fr)
DZ (1) DZ2640A1 (fr)
EA (1) EA200000488A1 (fr)
HR (1) HRP20000253A2 (fr)
HU (1) HUP0004150A3 (fr)
ID (1) ID23921A (fr)
IL (1) IL135900A0 (fr)
IS (1) IS5465A (fr)
MA (1) MA26563A1 (fr)
NO (1) NO20002129L (fr)
NZ (1) NZ503918A (fr)
OA (1) OA11354A (fr)
PE (1) PE129199A1 (fr)
PL (1) PL340753A1 (fr)
SK (1) SK6252000A3 (fr)
TN (1) TNSN98200A1 (fr)
TR (1) TR200001234T2 (fr)
WO (1) WO1999023077A1 (fr)
YU (1) YU25000A (fr)

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IL135714A0 (en) * 1997-11-04 2001-05-20 Pfizer Prod Inc Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors
UA71971C2 (en) 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US7141581B2 (en) 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
JP2001031549A (ja) * 1999-07-14 2001-02-06 Pola Chem Ind Inc 真皮コラーゲン線維束再構築剤及びそれを含有する化粧料
US6432979B1 (en) 1999-08-12 2002-08-13 American Cyanamid Company Method of treating or inhibiting colonic polyps and colorectal cancer
HUP0203162A3 (en) * 1999-08-12 2006-07-28 Wyeth Holdings Corp Madison Nsaid and efgr kinase inhibitor containing composition for the treatment or inhibition of colonic polyps and colorectal cancer
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US7005443B1 (en) * 2000-03-17 2006-02-28 Alcon, Inc. 5-Hydroxy indazole derivatives for treating glaucoma
MXPA02010222A (es) 2000-04-18 2003-05-23 Agouron Pharma Pirazoles para inhibir proteina cinasa.
CN1300116C (zh) * 2001-04-16 2007-02-14 卫材株式会社 1h-吲唑化合物
US20040242597A1 (en) 2001-09-19 2004-12-02 Thomas Klein Combination
WO2003024456A1 (fr) * 2001-09-20 2003-03-27 Eisai Co., Ltd. Methodes de traitement et de prevention des migraines
KR20040085179A (ko) * 2002-02-13 2004-10-07 코닌클리케 필립스 일렉트로닉스 엔.브이. 통합된 반도체 광학 디바이스, 이러한 디바이스를제조하는 방법 및 장치
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
BRPI0309689B1 (pt) * 2002-04-30 2021-06-29 Unigen, Inc Composições compreendendo uma mistura de flavonóides de anel-b-livre e flavanos e usos das mesmas
BR0316950A (pt) 2002-12-02 2006-01-17 Hoffmann La Roche Derivados de indazol como antagonistas de crf
EP1592683A2 (fr) 2003-02-14 2005-11-09 Wyeth Heterocyclyl-3-sulfonylindazoles utilises comme ligands de la 5-hydroxytryptamine-6
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
US20040220119A1 (en) * 2003-04-04 2004-11-04 Unigen Pharmaceuticals, Inc. Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care
US6984652B2 (en) 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
RU2006134022A (ru) 2004-02-27 2008-04-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные индазола и содержащие их фармацевтические композиции
CN1934111A (zh) 2004-02-27 2007-03-21 霍夫曼-拉罗奇有限公司 杂芳基稠合的吡唑并衍生物
WO2005085249A1 (fr) 2004-02-27 2005-09-15 F. Hoffmann-La Roche Ag Derives fusionnes de pyrazole
US7844309B2 (en) * 2004-02-27 2010-11-30 Nokia Corporation Exchangeable keymat
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
KR20070094747A (ko) * 2004-11-29 2007-09-21 워너-램버트 캄파니 엘엘씨 치료용 피라졸로[3,4-b]피리딘 및 인다졸
RU2008103700A (ru) * 2005-08-15 2009-09-27 Вайет (Us) Производные азинил-3-сульфонилиндазола в качестве лиганд 5ов 5-гидрокситриптамина-6
RU2429231C2 (ru) * 2005-08-15 2011-09-20 Вайет Производные замещенного-3-сульфонилиндазола в качестве лигандов 5-гидрокситриптамина-6
KR101011956B1 (ko) 2005-08-25 2011-01-31 에프. 호프만-라 로슈 아게 P38 mαp 키나아제 저해제 및 이의 사용 방법
US7781460B2 (en) 2005-09-05 2010-08-24 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-IV
WO2007031838A1 (fr) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase
WO2007056087A1 (fr) * 2005-11-03 2007-05-18 Allergan, Inc. Prostaglandines et analogues utilises en tant qu'agents pour abaisser la pression intraoculaire
US7645752B2 (en) 2006-01-13 2010-01-12 Wyeth Llc Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors
RS52298B (sr) 2006-01-31 2012-12-31 Array Biopharma Inc. Inhibitori kinaze i postupak njihove upotrebe
BRPI0708337A2 (pt) 2006-02-28 2011-05-24 Helicon Therapeutics Inc pipirazinas terapêutica como inibidores pde4
US8084485B2 (en) 2006-03-31 2011-12-27 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
JP2009532471A (ja) * 2006-04-05 2009-09-10 ワイス 5−ヒドロキシトリプタミン−6リガンドとしてのスルホニル−3−ヘテロシクリルインダゾール誘導体
WO2007120596A1 (fr) * 2006-04-12 2007-10-25 Wyeth DÉRIVÉS DE DIHYDRO[1,4]DIOXINO[2,3-e]INDAZOLE EN TANT QUE LIGANDS DE 5-HYDROXYTRYPTAMINE-6
US8012886B2 (en) * 2007-03-07 2011-09-06 Asm Assembly Materials Ltd Leadframe treatment for enhancing adhesion of encapsulant thereto
NZ579645A (en) 2007-03-14 2012-01-12 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
WO2011034217A1 (fr) * 2009-09-18 2011-03-24 株式会社Riverson Dérivé de polyphénol et son procédé de production
MX2012013197A (es) 2010-05-12 2013-04-03 Abbvie Inc Inhibidores de indazol de cinasa.
CN103709146B (zh) * 2014-01-15 2015-11-25 中国药科大学 一类含苯并咪唑结构的喹啉-4-胺衍生物、其制法及医药用途
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
KR20230152654A (ko) 2020-12-30 2023-11-03 타이라 바이오사이언시스, 인크. 키나아제 억제제로서의 인다졸 화합물

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US5006520A (en) * 1987-10-13 1991-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds and pharmaceutical use thereof
EP0338087A4 (en) * 1987-10-13 1991-07-24 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
SI0912558T1 (en) * 1996-06-25 2003-10-31 Pfizer Inc. Substituted indazole derivatives and their use as phosphodiesterase (pde) type iv and tumor necrosis factor (tnf) inhibitors
EP0816357B1 (fr) * 1996-06-27 2002-01-09 Pfizer Inc. Dérivés d'indazole substitués
EA002113B1 (ru) * 1996-09-04 2001-12-24 Пфайзер Инк. Производные индазола и их использование в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и продуцирования фактора некроза опухоли (фно)
IL135714A0 (en) * 1997-11-04 2001-05-20 Pfizer Prod Inc Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors

Also Published As

Publication number Publication date
HRP20000253A2 (en) 2001-06-30
MA26563A1 (fr) 2004-12-20
NO20002129D0 (no) 2000-04-26
HUP0004150A3 (en) 2001-08-28
DZ2640A1 (fr) 2003-03-08
WO1999023077A1 (fr) 1999-05-14
BR9813926A (pt) 2000-09-19
AR013746A1 (es) 2001-01-10
EP1028946A1 (fr) 2000-08-23
PL340753A1 (en) 2001-02-26
CZ20001621A3 (cs) 2001-08-15
CA2309150A1 (fr) 1999-05-14
ID23921A (id) 2000-05-25
YU25000A (sh) 2003-12-31
NZ503918A (en) 2002-03-28
SK6252000A3 (en) 2001-11-06
US6391872B1 (en) 2002-05-21
AP9801375A0 (en) 1998-12-31
IS5465A (is) 2000-04-19
IL135900A0 (en) 2001-05-20
BG104450A (en) 2000-12-29
TR200001234T2 (tr) 2000-08-21
JP2001521926A (ja) 2001-11-13
AU9455298A (en) 1999-05-24
TNSN98200A1 (fr) 2005-03-15
CN1284948A (zh) 2001-02-21
HUP0004150A2 (hu) 2001-05-28
EA200000488A1 (ru) 2000-10-30
PE129199A1 (es) 1999-12-16
AP910A (en) 2000-12-05
AU754734B2 (en) 2002-11-21
OA11354A (en) 2003-12-23

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