NO20002588L - Bifenylamidinderivater - Google Patents

Bifenylamidinderivater

Info

Publication number
NO20002588L
NO20002588L NO20002588A NO20002588A NO20002588L NO 20002588 L NO20002588 L NO 20002588L NO 20002588 A NO20002588 A NO 20002588A NO 20002588 A NO20002588 A NO 20002588A NO 20002588 L NO20002588 L NO 20002588L
Authority
NO
Norway
Prior art keywords
bifenylamidinderivater
formula
pharmaceutically acceptable
provides
present
Prior art date
Application number
NO20002588A
Other languages
English (en)
Other versions
NO20002588D0 (no
Inventor
Yasunobu Takano
Tomohisa Nakada
Takayuki Hara
Satoshi Sugiura
Takaharu Tsutsumi
Reiko Takarada
Yoshiharu Takazawa
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of NO20002588D0 publication Critical patent/NO20002588D0/no
Publication of NO20002588L publication Critical patent/NO20002588L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelse tilveiebringer et bifenylamidinderivat representert ved formelen (1) eller et farmasøytisk akseptabelt derivat derav: CH2-0¿Y (D og bifenylamidinderivatet eller det farmasøytisk akseptable derivat derav, er en ny forbindelse som kan anvendes som en klinisk appliserbar FXa-inhibitor.
NO20002588A 1997-11-20 2000-05-19 Bifenylamidinderivater NO20002588L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP31969697 1997-11-20
PCT/JP1998/005210 WO1999026919A1 (en) 1997-11-20 1998-11-19 Biphenylamidine derivatives

Publications (2)

Publication Number Publication Date
NO20002588D0 NO20002588D0 (no) 2000-05-19
NO20002588L true NO20002588L (no) 2000-06-26

Family

ID=18113172

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002588A NO20002588L (no) 1997-11-20 2000-05-19 Bifenylamidinderivater

Country Status (9)

Country Link
US (1) US6348478B1 (no)
EP (1) EP1043311A4 (no)
KR (1) KR20010032175A (no)
AU (1) AU736112B2 (no)
CA (1) CA2310330A1 (no)
IS (1) IS5476A (no)
NO (1) NO20002588L (no)
NZ (1) NZ504324A (no)
WO (1) WO1999026919A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1043310T3 (da) * 1997-11-20 2004-10-25 Teijin Ltd Biphenylamidinderivater
CA2360686A1 (en) * 1999-01-28 2000-08-03 Teijin Limited Release-regulating preparations
HK1040510A1 (en) * 1999-05-17 2002-06-14 Teijin Limited Cyanobiphenyl derivatives
RU2324686C2 (ru) * 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
US20070004736A1 (en) 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
KR100897642B1 (ko) 2002-12-20 2009-05-14 글락소 그룹 리미티드 신경 장애 치료용 벤즈아제핀 유도체
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
FR2872159B1 (fr) * 2004-06-28 2007-10-05 Merck Sante Soc Par Actions Si Nouveaux derives acides carboxyliques phenyliques et leur utilisation dans le traitement du diabete
EP3190103A1 (en) * 2016-01-08 2017-07-12 Rijksuniversiteit Groningen Inhibitors of the pd-1/pd-l1 protein/protein interaction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ATE140225T1 (de) * 1992-04-28 1996-07-15 Thomae Gmbh Dr K Tritiumarkierte fibrinogen-rezeptor-antagonisten, deren verwendung und verfahren zur ihrer herstellung
JPH101467A (ja) * 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体
JPH101647A (ja) 1996-06-14 1998-01-06 Sekisui Chem Co Ltd 防かび性化粧シート
DK1043310T3 (da) * 1997-11-20 2004-10-25 Teijin Ltd Biphenylamidinderivater

Also Published As

Publication number Publication date
CA2310330A1 (en) 1999-06-03
AU736112B2 (en) 2001-07-26
NZ504324A (en) 2002-02-01
US6348478B1 (en) 2002-02-19
NO20002588D0 (no) 2000-05-19
IS5476A (is) 2000-05-03
WO1999026919A1 (en) 1999-06-03
AU1174199A (en) 1999-06-15
EP1043311A4 (en) 2001-01-24
EP1043311A1 (en) 2000-10-11
KR20010032175A (ko) 2001-04-16

Similar Documents

Publication Publication Date Title
TR199600930A2 (tr) Kristal yapida (R)-(-)-2-{N-£4-(1,1-dioksido-3-okzo-2, 3-dihidrobenzizotiazol-2-il)-butil|- aminometil}-kroman hidroklorür.
NL1002835A1 (nl) Synergistisch stabilisatormengsel.
NO981534D0 (no) 1-(1,2-disubstituert piperidinyl)-4-substituerte piperazinderivater
MY126559A (en) Fungicidal 2-methoxybenzophenones
DK0876359T3 (da) (-)-cis-6(S)-phenyl-5(R)- [4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol-D-tartrat
NO961748D0 (no) Polisykliske antiparasittiske midler, fremgangsmåte og stamme for deres fremstilling, og anvendelse derav
EP0630898A4 (en) MEDICINE FOR THROMBOZYTOPENIA.
CY1113054T1 (el) Παραγωγα διαμινης
TR200000812T2 (tr) 2-metil-tieno- benzodiazepin formülasyonu.
DK0843679T3 (da) 1-(1,2-disubstitueret piperidinyl)-4-(kondenseret midazol)-piperidinderivater
NO20002588L (no) Bifenylamidinderivater
FI923031A7 (fi) Proteiinikinaasi C:tä inhiboivat 1,4-bis(aminohydroksialkyyliamino)ant rakinonit
FI920192L (fi) Substituerade 1,2,3,4-tetrahydro -cyklopent/b/indoler, 1,2,3,3a,4,8a-hexahydrocyklopent/b/indoler och motsvarande foereningar, mellanprodukter och foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FI922592L (fi) (arylalkylpiperidin-4-yl)metyl)-2a,3,4,5-tetra-hydro-1(2h)-acetnaftylen-1-oner och motsvarande foereningar, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
DE69427286D1 (de) 7,42-bis (o-demethyl)rapamycin
PA8465101A1 (es) Compuestos de triazina
KR930702303A (ko) 1,2,5,6-테트라하이드로피리딘 옥심 유도체
WO2001009122A3 (en) Serotonergic benzofurans
NO990914L (no) Amorfe benzotiofener, fremgangsmÕter for fremstilling og fremgangsmÕter for anvendelse
EA200001134A1 (ru) Вакцина
MX9804659A (es) Tiazolinas substituidas y su empleo para la lucha contra las pestes animales.
IT1277329B1 (it) Procedimento per la metilazione del 2,2,6,6-tetrametil-4-piperidone (triacetonammina)
FI962768A7 (fi) N-(2-ftaali-imidoetyyli)substituoituja transpiperidiini-2,5-dikarboksy laatteja
DE69426021D1 (de) Xamonelin-Tartrat
MX9700179A (es) Derivados de triazol y su utilizacion.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application