NO20002702L - Tienopyrimidiner - Google Patents

Tienopyrimidiner

Info

Publication number
NO20002702L
NO20002702L NO20002702A NO20002702A NO20002702L NO 20002702 L NO20002702 L NO 20002702L NO 20002702 A NO20002702 A NO 20002702A NO 20002702 A NO20002702 A NO 20002702A NO 20002702 L NO20002702 L NO 20002702L
Authority
NO
Norway
Prior art keywords
thienopyrimidine
tienopyrimidines
phosphodiesterase
inhibition
therapy
Prior art date
Application number
NO20002702A
Other languages
English (en)
Other versions
NO20002702D0 (no
Inventor
Rochus Jonas
Franz-Werner Kluxen
Pierre Schelling
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20002702D0 publication Critical patent/NO20002702D0/no
Publication of NO20002702L publication Critical patent/NO20002702L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Tienopyrimidiner med formel (l) (l) samt deres fysiologisk akseptable salter,, hvor R1, R2, R3, R4, X og n har de i krav l angitte betydninger, utviser en fosfodiesterase V-hemming og kan anvendes til behandling av sykdom- mer i hjerte- og blodomløpssystemet, og til behandling og/eller terapi av potensforstyrrelser.
NO20002702A 1997-11-28 2000-05-26 Tienopyrimidiner NO20002702L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752952A DE19752952A1 (de) 1997-11-28 1997-11-28 Thienopyrimidine
PCT/EP1998/007436 WO1999028325A1 (de) 1997-11-28 1998-11-19 Thienopyrimidine

Publications (2)

Publication Number Publication Date
NO20002702D0 NO20002702D0 (no) 2000-05-26
NO20002702L true NO20002702L (no) 2000-05-26

Family

ID=7850200

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002702A NO20002702L (no) 1997-11-28 2000-05-26 Tienopyrimidiner

Country Status (24)

Country Link
US (2) US6420368B1 (no)
EP (1) EP1036078B1 (no)
JP (1) JP4314341B2 (no)
KR (1) KR20010032445A (no)
CN (1) CN1138780C (no)
AR (1) AR010962A1 (no)
AT (1) ATE361926T1 (no)
AU (1) AU742433B2 (no)
BR (1) BR9815409A (no)
CA (1) CA2311922C (no)
CO (1) CO4980884A1 (no)
CZ (1) CZ291068B6 (no)
DE (2) DE19752952A1 (no)
ES (1) ES2285796T3 (no)
HK (1) HK1038924A1 (no)
HU (1) HUP0100488A3 (no)
ID (1) ID24571A (no)
NO (1) NO20002702L (no)
PL (1) PL341156A1 (no)
RU (1) RU2217431C2 (no)
SK (1) SK7772000A3 (no)
TW (1) TW472059B (no)
WO (1) WO1999028325A1 (no)
ZA (1) ZA9810845B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19819023A1 (de) * 1998-04-29 1999-11-04 Merck Patent Gmbh Thienopyrimidine
EP1167367A4 (en) * 1999-03-30 2002-04-24 Nippon Soda Co THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
CA2407031A1 (en) 2000-04-19 2001-10-25 Lilly Icos Llc Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
DE10042997A1 (de) * 2000-09-01 2002-03-14 Merck Patent Gmbh Thienopyrimidine
EP1329454A1 (en) * 2000-09-29 2003-07-23 Nippon Soda Co., Ltd. Thienopyrimidine compounds and their salts and process for preparation of both
DE10058663A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Thienopyrimidinen
KR20030059351A (ko) * 2000-12-19 2003-07-07 메르크 파텐트 게엠베하 티에노피리미딘 및 항혈전제, 칼슘 길항제,프로스타글란딘 또는 프로스타글란딘 유도체를 포함하여이루어지는 약제학적 조성물
DE10064994A1 (de) * 2000-12-23 2002-07-04 Merck Patent Gmbh Sulfamidothienopyrimidine
DE10103647A1 (de) 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
MXPA03006717A (es) * 2001-01-31 2003-10-24 Merck Patent Gmbh Formulacion farmaceutica que comprende pirazolo (4,3-d) pirimidinas y nitratos o tienopirimidinas y nitratos.
CN101100472A (zh) * 2001-04-30 2008-01-09 美国拜尔公司 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
DE10148883A1 (de) * 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
WO2003035653A1 (en) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Pyridothienopyrimidine compound and salt thereof
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
DK1742950T3 (da) 2004-04-07 2009-03-16 Pfizer Ltd Pyrazolo-[4,3-D]-pyrimidiner
GB0420719D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
ES2259891B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
ES2259892B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109297923A (zh) * 2018-09-19 2019-02-01 南通出入境检验检疫局检验检疫综合技术中心 纺织品中微量含氟整理剂的测定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE245666C (no)
DD245666A1 (de) * 1985-09-20 1987-05-13 Univ Halle Wittenberg Verfahren zur herstellung von 4-aminosubstituierten thieno 2,3-d-pyrimidin-2-ylessigsaeureestern
GB9301192D0 (en) 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
US5869486A (en) 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine

Also Published As

Publication number Publication date
US6495554B2 (en) 2002-12-17
CN1138780C (zh) 2004-02-18
NO20002702D0 (no) 2000-05-26
SK7772000A3 (en) 2000-12-11
JP4314341B2 (ja) 2009-08-12
CA2311922A1 (en) 1999-06-10
EP1036078B1 (de) 2007-05-09
CN1306534A (zh) 2001-08-01
TW472059B (en) 2002-01-11
EP1036078A1 (de) 2000-09-20
ATE361926T1 (de) 2007-06-15
RU2217431C2 (ru) 2003-11-27
DE59814003D1 (en) 2007-06-21
US6420368B1 (en) 2002-07-16
WO1999028325A1 (de) 1999-06-10
AU742433B2 (en) 2002-01-03
KR20010032445A (ko) 2001-04-25
BR9815409A (pt) 2000-10-24
ES2285796T3 (es) 2007-11-16
PL341156A1 (en) 2001-03-26
CZ291068B6 (cs) 2002-12-11
DE19752952A1 (de) 1999-06-02
US20020132818A1 (en) 2002-09-19
CO4980884A1 (es) 2000-11-27
HK1038924A1 (zh) 2002-04-04
ID24571A (id) 2000-07-27
CA2311922C (en) 2009-09-29
AR010962A1 (es) 2000-07-12
CZ20001962A3 (cs) 2002-01-16
AU1962599A (en) 1999-06-16
JP2001525325A (ja) 2001-12-11
HUP0100488A3 (en) 2003-03-28
ZA9810845B (en) 1999-05-26
HUP0100488A2 (hu) 2001-09-28

Similar Documents

Publication Publication Date Title
NO991951L (no) Tienopyrimidiner med fosfodiesterase V-inhiberende virkning
GEP20043303B (en) Polycycloalkylpurines as Adenosine Receptor Antagonists
CA2263561A1 (en) Thienopyrimidines
UA48946C2 (uk) Арилалкілдіазинони, спосіб їх одержання (варіанти), фармацевтичний склад, спосіб його одержання та спосіб лікування
NO20021083L (no) Pyrazolo[4,3-d]pyrimidiner
NO992821L (no) Ketobenzamider som calpain-inhibitorer
NO20016201L (no) Tienopyrimidiner som fosfodiesteraseinhibitorer
MY107157A (en) Quinuclidine derivatives.
CA2268886A1 (en) Aminothiophenecarboxamides
NO307833B1 (no) Pyrimido[5,4-d]pyrimidiner, fysiologisk aksepterbare salter, legemidler inneholdende disse forbindelser og deres anvendelse
GEP20063920B (en) Alpha-(n-sulphonamido) acetamide derivatives as beta-amyloid inhibitors
MX9803753A (es) Acidos alfa-iminohidroxamicos y -carboxilicos n-sustituidos ciclicos y heterociclicos.
CA2311922A1 (en) Thienopyrimidines
IL104154A0 (en) Saccharin derivatives,their preparation and pharmaceutical compositions containing them
NO990433L (no) Nye forbindelser og blandinger for behandling av sykdommer i forbindelse med tryptase-aktivitet
DK1107973T3 (da) Hidtil ukendte thieno(2,3-D)pyrimidindioner, fremgangsmåde til deres fremstilling og anvendelse deraf i terapi
MY115211A (en) Novel amino acid derivatives, their preparation and use
NZ332096A (en) Alpha-hydroxylic acid derivatives their production and use in treating conditions requiring endothelin inhibition
DE50211929D1 (en) Pyrimidinderivate
GEP20043267B (en) Adenosine Receptor Antagonists, Methods of Making and Using the Same
MY121864A (en) Condensed thienopyrimidines with phosphodiesterase-v inhibiting action.
RU94039284A (ru) Производные пиперазина, способ их получения, фармкомпозиция и ее использование
MX9701187A (es) Nuevas lactamas naftofusionadas n-substituidas.
MY103210A (en) Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds.
UA42731C2 (uk) Арилалкілтіадіазинони, спосіб їх отримання, фармацевтична композиція, спосіб її отримання, спосіб лікування

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application