NO20002943L - Anvendelse av substituerte amidinoforbindelser ved behandling av kronisk obstruktiv pulmonal sykdom - Google Patents
Anvendelse av substituerte amidinoforbindelser ved behandling av kronisk obstruktiv pulmonal sykdomInfo
- Publication number
- NO20002943L NO20002943L NO20002943A NO20002943A NO20002943L NO 20002943 L NO20002943 L NO 20002943L NO 20002943 A NO20002943 A NO 20002943A NO 20002943 A NO20002943 A NO 20002943A NO 20002943 L NO20002943 L NO 20002943L
- Authority
- NO
- Norway
- Prior art keywords
- aliphatic
- hydrocarbon radical
- radical
- hydroxy
- araliphatic
- Prior art date
Links
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 title abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical group C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 3
- -1 aliphatic hydrocarbon radical Chemical class 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229930195733 hydrocarbon Natural products 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Anvendelse av medikament for behandling av kronisk obstruktiv pulmonal sykdom av forbindelser med formel CO-R, hvori C(=NH)-NHR3 gruppen kan være i tautomer eller isomer form, eller et farmasøytisk akseptabelt salt derav, hvori: RI er amino som er mono- eller disubstituert med en substituent utvalgt fra et alifatisk hydrokarbonradikal, et aralifatisk hydrokarbonradikal, et aromatisk radikal og et cykloalifatisk hydrokarbonradikal eller er amino som er disubstituert med et divalent alifatisk hydrokarbonradikal eller et nevnte radikal avbrutt med oksygen; R2 er hydrogen, halogen, trifluormetyl, et alifatisk hydrokarbonradikal, hydroksy eller er hydroksy som er foretret med en alifatisk, aralifatisk eller aromatisk alkohol eller med en alifatisk alkohol som er substituert med karboksy, med forestret karboksy eller med amidert karboksy eller som er forestret med en alifatisk eller aralifatisk karboksylsyre; RS er hydrogen eller et acylradikal som er avledet fra en organisk karbonsyre, en organisk karboksylsyre, en sulfonsyre eller en karbaminsyre; Xi og Xs, uavhengig av hverandre, er oksygen (-O-) eller svovel (-S-); og Xj er et divalent alifatisk hydrokarbonradikal som kan være avbrutt med et aromatisk radikal; hvori fenylringene med formel I kan være, uavhengig av hverandre, ytterligere substituert med en eller flere substituenter utvalgt fra halogen, trifluormetyl, et alifatisk hydrokarbonradikal, hydroksy og hydroksy som er foretret med en alifatisk alkohol eller som er forestret med en alifatisk eller aralifatisk karboksylsyre; hvori aryl i definisjonene ovenfor kan være, uavhengig av hverandre, ytterligere substituert med en eller flere substituenter utvalgt fra halogen, trifluormetyl, et alifatisk hydrokarbonradikal, hydroksy og hydroksy som er foretret med en alifatisk alkohol eller som er forestret med en alifatisk eller aralifatisk karboksylsyre; hvori et cykloalifatisk hydrokarbonradikal kan være substituert med et alifatisk radikal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11200297P | 1997-12-12 | 1997-12-12 | |
| PCT/EP1998/008066 WO1999030695A1 (en) | 1997-12-12 | 1998-12-10 | Substituted amidino compounds in the treatment of chronic obstructive pulmonary disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20002943L true NO20002943L (no) | 2000-06-08 |
| NO20002943D0 NO20002943D0 (no) | 2000-06-08 |
Family
ID=22341609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002943A NO20002943D0 (no) | 1997-12-12 | 2000-06-08 | Anvendelse av substituerte amidinoforbindelser ved behandling av kronisk obstruktiv pulmonal sykdom |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6380259B2 (no) |
| EP (1) | EP1037617A1 (no) |
| JP (1) | JP2002508313A (no) |
| KR (1) | KR20010033018A (no) |
| CN (1) | CN1281360A (no) |
| AU (1) | AU2270399A (no) |
| BR (1) | BR9813538A (no) |
| CA (1) | CA2314395A1 (no) |
| HU (1) | HUP0100733A3 (no) |
| ID (1) | ID24720A (no) |
| IL (1) | IL136663A0 (no) |
| NO (1) | NO20002943D0 (no) |
| PL (1) | PL340910A1 (no) |
| SK (1) | SK8812000A3 (no) |
| WO (1) | WO1999030695A1 (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1450787A4 (en) | 2001-11-15 | 2006-01-25 | Galileo Pharmaceuticals Inc | FORMULATIONS AND METHODS FOR THE TREATMENT OR AMELIORATION OF INFLAMMATORY CONDITIONS |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| US10328045B2 (en) | 2014-09-12 | 2019-06-25 | Children's Medical Center Corporation, Inc. | Dietary emulsion formulations and methods for using the same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246965A (en) | 1991-06-11 | 1993-09-21 | Ciba-Geigy | Arylethers, their manufacture and methods of treatment |
| US5488160A (en) * | 1991-06-11 | 1996-01-30 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and method of treatment |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| RU2124002C1 (ru) | 1992-02-05 | 1998-12-27 | Берингер Ингельхейм КГ | Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция, обладающая антагонистическим действием в отношении лейкотриена b4 |
| US5455274A (en) * | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
| US5846963A (en) * | 1995-06-07 | 1998-12-08 | University Of Utah Research Foundation | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome |
| DE4309285A1 (de) | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
| DE4424714A1 (de) | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff |
| DE4424713A1 (de) | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
| DE19546452A1 (de) | 1995-12-13 | 1997-06-19 | Boehringer Ingelheim Kg | Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel |
-
1997
- 1997-12-10 ID IDW20001093A patent/ID24720A/id unknown
-
1998
- 1998-12-10 IL IL13666398A patent/IL136663A0/xx unknown
- 1998-12-10 EP EP98966292A patent/EP1037617A1/en not_active Withdrawn
- 1998-12-10 PL PL98340910A patent/PL340910A1/xx unknown
- 1998-12-10 CN CN98812122A patent/CN1281360A/zh active Pending
- 1998-12-10 SK SK881-2000A patent/SK8812000A3/sk unknown
- 1998-12-10 AU AU22703/99A patent/AU2270399A/en not_active Abandoned
- 1998-12-10 JP JP2000538678A patent/JP2002508313A/ja active Pending
- 1998-12-10 BR BR9813538-4A patent/BR9813538A/pt not_active Application Discontinuation
- 1998-12-10 CA CA002314395A patent/CA2314395A1/en not_active Abandoned
- 1998-12-10 HU HU0100733A patent/HUP0100733A3/hu unknown
- 1998-12-10 WO PCT/EP1998/008066 patent/WO1999030695A1/en not_active Ceased
- 1998-12-10 KR KR1020007006371A patent/KR20010033018A/ko not_active Withdrawn
-
2000
- 2000-06-08 NO NO20002943A patent/NO20002943D0/no not_active Application Discontinuation
- 2000-12-07 US US09/732,453 patent/US6380259B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999030695A8 (en) | 1999-07-29 |
| SK8812000A3 (en) | 2000-12-11 |
| BR9813538A (pt) | 2000-10-10 |
| US6380259B2 (en) | 2002-04-30 |
| WO1999030695A1 (en) | 1999-06-24 |
| CA2314395A1 (en) | 1999-06-24 |
| ID24720A (id) | 2000-08-03 |
| CN1281360A (zh) | 2001-01-24 |
| HUP0100733A2 (hu) | 2001-08-28 |
| EP1037617A1 (en) | 2000-09-27 |
| AU2270399A (en) | 1999-07-05 |
| IL136663A0 (en) | 2001-06-14 |
| NO20002943D0 (no) | 2000-06-08 |
| PL340910A1 (en) | 2001-03-12 |
| JP2002508313A (ja) | 2002-03-19 |
| KR20010033018A (ko) | 2001-04-25 |
| HUP0100733A3 (en) | 2003-07-28 |
| US20010000341A1 (en) | 2001-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |