NO20003179L - Farmasøytisk sammensetning for Õ antagonisere CCR5 som innbefatter anilid-derivat - Google Patents
Farmasøytisk sammensetning for Õ antagonisere CCR5 som innbefatter anilid-derivatInfo
- Publication number
- NO20003179L NO20003179L NO20003179A NO20003179A NO20003179L NO 20003179 L NO20003179 L NO 20003179L NO 20003179 A NO20003179 A NO 20003179A NO 20003179 A NO20003179 A NO 20003179A NO 20003179 L NO20003179 L NO 20003179L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- pharmaceutical composition
- ring
- anilide derivative
- antagonizing ccr5
- Prior art date
Links
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 title abstract 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 title abstract 2
- 230000003042 antagnostic effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003931 anilides Chemical class 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35148097 | 1997-12-19 | ||
| JP21887598 | 1998-08-03 | ||
| JP23438898 | 1998-08-20 | ||
| PCT/JP1998/005708 WO1999032100A2 (fr) | 1997-12-19 | 1998-12-17 | Composition pharmaceutique antagoniste de ccr5 et contenant un derive d'anilide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003179D0 NO20003179D0 (no) | 2000-06-19 |
| NO20003179L true NO20003179L (no) | 2000-06-19 |
Family
ID=27330200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003179A NO20003179L (no) | 1997-12-19 | 2000-06-19 | Farmasøytisk sammensetning for Õ antagonisere CCR5 som innbefatter anilid-derivat |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6172061B1 (fr) |
| EP (1) | EP1039899A2 (fr) |
| JP (1) | JP2000128782A (fr) |
| KR (1) | KR20010032841A (fr) |
| CN (1) | CN1282243A (fr) |
| AU (1) | AU748064B2 (fr) |
| BR (1) | BR9813691A (fr) |
| CA (1) | CA2304959A1 (fr) |
| HU (1) | HUP0100199A2 (fr) |
| ID (1) | ID29994A (fr) |
| NO (1) | NO20003179L (fr) |
| WO (1) | WO1999032100A2 (fr) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
| FR2746101B1 (fr) * | 1996-03-14 | 1998-04-30 | Composes bicycliques-aromatiques | |
| CA2338804A1 (fr) * | 1998-07-28 | 2000-02-10 | Smithkline Beecham Corporation | Propenamides tenant lieu de modulateurs de ccr5 |
| EP1104416A2 (fr) * | 1998-08-20 | 2001-06-06 | Takeda Chemical Industries, Ltd. | Sels d'ammonium quaternaire et leur utilisation |
| WO2000021916A1 (fr) * | 1998-10-15 | 2000-04-20 | Takeda Chemical Industries, Ltd. | Procede de preparation de derives d'amine |
| US6635278B1 (en) * | 1998-12-15 | 2003-10-21 | Gilead Sciences, Inc. | Pharmaceutical formulations |
| EP1140896A1 (fr) * | 1998-12-21 | 2001-10-10 | Takeda Chemical Industries, Ltd. | Derives de benzothiepin-anilide, production et utilisation comme antagoniste de ccr-5 |
| US6750348B1 (en) | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| IL145401A0 (en) | 1999-03-24 | 2002-06-30 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
| CA2373073A1 (fr) * | 1999-05-07 | 2000-11-16 | Takeda Chemical Industries, Ltd. | Composes cycliques et leurs utilisations |
| WO2000069845A1 (fr) | 1999-05-18 | 2000-11-23 | Takeda Chemical Industries, Ltd. | Procedes de preparation de derives de 2,3-dihydrothiepine |
| AU5426500A (en) | 1999-06-16 | 2001-01-02 | Takeda Chemical Industries Ltd. | Benzazepine derivatives, process for the preparation of the same and uses thereof |
| WO2001017971A1 (fr) * | 1999-09-06 | 2001-03-15 | Takeda Chemical Industries, Ltd. | Procede de preparation de derives 2,3-dihydroazepine |
| CA2384145A1 (fr) * | 1999-09-06 | 2001-03-15 | Takeda Chemical Industries, Ltd. | Procedes de preparation de composes 2,3-dihydroazepine |
| GB2371622A (en) * | 1999-09-23 | 2002-07-31 | Isis Innovation | Susceptibility gene for inflammatory bowel disease |
| CA2393530A1 (fr) * | 1999-12-10 | 2001-06-14 | Takeda Chemical Industries, Ltd. | Compositions pharmaceutiques a usage par voie orale |
| AU2001232347A1 (en) * | 2000-02-21 | 2001-08-27 | Takeda Chemical Industries Ltd. | Process for producing cyclic compound |
| CA2404687A1 (fr) | 2000-03-30 | 2001-10-11 | Nemichand B. Jain | Granules a liberation lente contenant de la stavudine |
| NZ524421A (en) * | 2000-09-15 | 2005-02-25 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
| AU2002235277A1 (en) * | 2000-10-23 | 2002-05-06 | Smith Kline Beecham Corporation | Compounds and methods |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| WO2002066454A1 (fr) * | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Derives de chromene |
| EP1422228A1 (fr) | 2001-08-08 | 2004-05-26 | Takeda Chemical Industries, Ltd. | Derive de benzazepine, son procede de preparation et d'utilisation |
| US7371772B2 (en) | 2001-08-08 | 2008-05-13 | Takeda Pharmaceutical Company Limited | Bicyclic compound, production and use thereof |
| EP1487795B1 (fr) | 2001-09-12 | 2010-11-03 | Anormed Inc. | Synthese de noyaux bicycliques fusionnes amino-substitues enantiomeriquement purs |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| US20050245537A1 (en) * | 2002-04-24 | 2005-11-03 | Noboru Tsuchimori | Use of compounds having ccr antagonism |
| JP4896518B2 (ja) * | 2002-12-13 | 2012-03-14 | ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド | ニコチンアミド系キナーゼ阻害薬 |
| US20060160864A1 (en) * | 2003-02-07 | 2006-07-20 | Mitsuru Shiraishi | Acrylamide derivative, process for producing the same, and use |
| EP1593680A4 (fr) * | 2003-02-07 | 2008-05-07 | Takeda Pharmaceutical | Derive de la pyridine a cycle fuse, son procede d'obtention et ses utilisations |
| CN101333186A (zh) * | 2003-03-14 | 2008-12-31 | 小野药品工业株式会社 | 含氮杂环衍生物以及包含所述化合物作为活性成分的药物 |
| JP4736043B2 (ja) * | 2003-03-14 | 2011-07-27 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| EP1619193A4 (fr) | 2003-04-18 | 2010-08-11 | Ono Pharmaceutical Co | Compose de spiropiperidine et son utilisation medicinale |
| GB0403038D0 (en) | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
| WO2005105841A2 (fr) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Récepteur humain (ccr5) hdgnr10 de chimiokine de la protéine g |
| ES2573845T3 (es) * | 2004-06-25 | 2016-06-10 | Janssen Pharmaceutica Nv | Antagonistas de CCR2 de sales cuaternarias |
| AU2005283326B2 (en) | 2004-09-13 | 2011-07-21 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient |
| EP1889622A4 (fr) | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | Compose de spiropiperidine et son utilisation medicinale |
| WO2007049771A1 (fr) | 2005-10-28 | 2007-05-03 | Ono Pharmaceutical Co., Ltd. | Compose contenant un groupe basique et son utilisation |
| PT1961744E (pt) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Composto que contém um grupo básico e sua utilização |
| RU2008140144A (ru) | 2006-03-10 | 2010-04-20 | Оно Фармасьютикал Ко., Лтд. (Jp) | Азотосодержащее гетероциклическое производное и фармацевтическое средство, включающее такое производное в качестве активного ингредиента |
| AU2007227202B2 (en) * | 2006-03-21 | 2013-08-22 | Amylin Pharmaceuticals, Llc | Peptide-peptidase inhibitor conjugates and methods of using same |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| WO2008016006A1 (fr) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Composé auquel un groupe cyclique est lié par une liaison spiro et son utilisation |
| WO2008030853A2 (fr) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Thérapie de combinaison contre l'infection par le virus de l'immunodéficience humaine |
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| US8168829B2 (en) * | 2007-10-26 | 2012-05-01 | Janssen Pharmaceutica N.V. | Synthesis of quaternary salt compounds |
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| CN102796075B (zh) * | 2008-01-11 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯并环庚烯类衍生物、其制备方法及医药用途 |
| CN101481323B (zh) * | 2008-01-11 | 2013-11-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 苯并环庚烯类衍生物、其制备方法及医药用途 |
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| WO2010129351A1 (fr) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Procédé pour identifier et pour traiter une dégénérescence maculaire liée à l'âge |
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| BR112018076449A2 (pt) | 2016-06-21 | 2019-04-09 | Tobira Therapeutics, Inc. | cenicriviroc purificado e intermediários purificados para fazer cenicriviroc |
| EP3808748B1 (fr) | 2016-06-21 | 2026-05-20 | X4 Pharmaceuticals, Inc. | Piperidines substutues comme inhibiteurs de cxcr4 |
| JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| JP2019526628A (ja) | 2016-08-31 | 2019-09-19 | トビラ セラピューティクス， インコーポレイテッド | セニクリビロクメシレートの固体形態及びセニクリビロクメシレートの固体形態を製造するプロセス |
| JP7086075B2 (ja) * | 2016-12-09 | 2022-06-17 | 南京明徳新薬研発有限公司 | Ｃｃｒ２／ｃｃｒ５受容体拮抗剤としてのビフェニル化合物 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| AU2021222441B2 (en) | 2020-02-19 | 2026-05-28 | Ichilov Tech Ltd. | Improved antidepressant therapy |
| CN115515585A (zh) | 2020-03-10 | 2022-12-23 | X4 制药有限公司 | 用于治疗中性粒细胞减少症的方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
| CN113735904B (zh) * | 2021-09-17 | 2023-10-24 | 南京自一界科技研发有限公司 | 一种润滑添加剂的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2808495A (en) | 1994-07-04 | 1996-01-25 | Takeda Chemical Industries Ltd. | Phosphonic acid compounds, their production and use |
| WO1999032468A1 (fr) * | 1997-12-19 | 1999-07-01 | Takeda Chemical Industries, Ltd. | Derive d'anilide, sa preparation et son utilisation |
-
1998
- 1998-12-17 WO PCT/JP1998/005708 patent/WO1999032100A2/fr not_active Ceased
- 1998-12-17 EP EP98961384A patent/EP1039899A2/fr not_active Withdrawn
- 1998-12-17 US US09/213,377 patent/US6172061B1/en not_active Expired - Fee Related
- 1998-12-17 AU AU16831/99A patent/AU748064B2/en not_active Withdrawn - After Issue
- 1998-12-17 BR BR9813691-7A patent/BR9813691A/pt not_active IP Right Cessation
- 1998-12-17 CN CN98811942A patent/CN1282243A/zh active Pending
- 1998-12-17 KR KR1020007006167A patent/KR20010032841A/ko not_active Withdrawn
- 1998-12-17 CA CA002304959A patent/CA2304959A1/fr not_active Abandoned
- 1998-12-17 ID IDP981644A patent/ID29994A/id unknown
- 1998-12-17 HU HU0100199A patent/HUP0100199A2/hu unknown
- 1998-12-18 JP JP10360820A patent/JP2000128782A/ja not_active Withdrawn
-
2000
- 2000-06-19 NO NO20003179A patent/NO20003179L/no not_active Application Discontinuation
- 2000-09-13 US US09/661,320 patent/US6268354B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU1683199A (en) | 1999-07-12 |
| WO1999032100A3 (fr) | 1999-09-10 |
| WO1999032100A2 (fr) | 1999-07-01 |
| JP2000128782A (ja) | 2000-05-09 |
| US6172061B1 (en) | 2001-01-09 |
| BR9813691A (pt) | 2000-10-10 |
| KR20010032841A (ko) | 2001-04-25 |
| NO20003179D0 (no) | 2000-06-19 |
| US6268354B1 (en) | 2001-07-31 |
| CN1282243A (zh) | 2001-01-31 |
| CA2304959A1 (fr) | 1999-07-01 |
| ID29994A (id) | 2001-10-25 |
| EP1039899A2 (fr) | 2000-10-04 |
| AU748064B2 (en) | 2002-05-30 |
| HUP0100199A2 (hu) | 2001-04-28 |
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