NO20003199L - Benzo[c]kinolizinderivater og deres anvendelse som 5<alfa>-reduktaseinhibitorer - Google Patents

Benzo[c]kinolizinderivater og deres anvendelse som 5<alfa>-reduktaseinhibitorer Download PDF

Info

Publication number
NO20003199L
NO20003199L NO20003199A NO20003199A NO20003199L NO 20003199 L NO20003199 L NO 20003199L NO 20003199 A NO20003199 A NO 20003199A NO 20003199 A NO20003199 A NO 20003199A NO 20003199 L NO20003199 L NO 20003199L
Authority
NO
Norway
Prior art keywords
alfa
benzo
reductase inhibitors
quinolizine derivatives
quinolizine
Prior art date
Application number
NO20003199A
Other languages
English (en)
Other versions
NO326034B1 (no
NO20003199D0 (no
Inventor
Antonio Guarna
Mario Serio
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20003199D0 publication Critical patent/NO20003199D0/no
Publication of NO20003199L publication Critical patent/NO20003199L/no
Publication of NO326034B1 publication Critical patent/NO326034B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Description

Q er valgt i gruppen som består av; enkeltbinding, C,.g alkyl, C2.8alkenyl, C2.8alkynyl, syklopropan, syklobutan, syklopentan, sykloheksan, sykloheptan, syklooktan, norbornan, kanfan, adamantan, CO, CONR, NR, hvori R er som definert over;
W er valgt i gruppen som består av: H, CU8 alkyl, C2.8alkenyl, C2.3alkynyl, syklopropan, syklobutan, syklopentan, sykloheksan, sykloheptan, syklooktan,
NO20003199A 1997-12-23 2000-06-20 Benzo[c]kinolizinderivater, fremgangsmate for fremstilling og anvendelse derav som 5<alfa>-reduktaseinhibitorer NO326034B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97122733A EP0926148A1 (en) 1997-12-23 1997-12-23 Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
PCT/EP1998/008582 WO1999033828A1 (en) 1997-12-23 1998-12-21 Benzo[c]quinolizine derivatives and their use as 5 alpha-reductases inhibitors

Publications (3)

Publication Number Publication Date
NO20003199D0 NO20003199D0 (no) 2000-06-20
NO20003199L true NO20003199L (no) 2000-08-23
NO326034B1 NO326034B1 (no) 2008-09-01

Family

ID=8227866

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003199A NO326034B1 (no) 1997-12-23 2000-06-20 Benzo[c]kinolizinderivater, fremgangsmate for fremstilling og anvendelse derav som 5<alfa>-reduktaseinhibitorer

Country Status (21)

Country Link
US (1) US6962925B1 (no)
EP (2) EP0926148A1 (no)
JP (1) JP2001527074A (no)
KR (1) KR100580742B1 (no)
CN (1) CN1144804C (no)
AR (1) AR017964A1 (no)
AT (1) ATE303382T1 (no)
AU (1) AU744105B2 (no)
BR (1) BR9813836A (no)
CA (1) CA2315055A1 (no)
DE (1) DE69831427T2 (no)
EA (1) EA002831B1 (no)
EE (1) EE04615B1 (no)
ES (1) ES2245053T3 (no)
IL (1) IL136919A0 (no)
NO (1) NO326034B1 (no)
PT (1) PT1066284E (no)
SI (1) SI1066284T1 (no)
UA (1) UA66371C2 (no)
WO (1) WO1999033828A1 (no)
ZA (1) ZA9811762B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
US6048869A (en) * 1998-07-29 2000-04-11 Merck & Co., Inc. Tricyclic compounds
KR100785088B1 (ko) 2006-05-23 2007-12-12 한국과학기술연구원 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
WO2008007778A1 (fr) * 2006-07-13 2008-01-17 Nihon Nohyaku Co., Ltd. agent de RÉGULATION de plante parasite et son emploi
GB201506894D0 (en) * 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN106008423B (zh) * 2016-06-24 2018-02-02 云南民族大学 一种苯丙素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2125884T3 (es) * 1991-08-21 1999-03-16 Lilly Co Eli Hexahidrobenzo(f)quinolinonas como inhibidores de la 5-alfa-reductasa.
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
EP0591583B1 (en) * 1991-08-21 2001-12-19 Eli Lilly And Company Benzo (f) quinolinones as 5-alpha-reductase inhibitors
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones
WO1994021614A1 (en) * 1993-03-24 1994-09-29 Merck & Co., Inc. SUBSTITUTED 3-PHENANTHRIDINONE DERIVATIVES AS 5α-REDUCTASE INHIBITORS
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
IT1286545B1 (it) * 1996-02-09 1998-07-15 Antonio Guarna Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
ITFI970193A1 (it) * 1997-08-01 1999-02-01 Applied Research Systems Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) * 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors

Also Published As

Publication number Publication date
EP1066284A1 (en) 2001-01-10
NO326034B1 (no) 2008-09-01
IL136919A0 (en) 2001-06-14
PT1066284E (pt) 2005-11-30
AU2419499A (en) 1999-07-19
UA66371C2 (en) 2004-05-17
NO20003199D0 (no) 2000-06-20
CA2315055A1 (en) 1999-07-08
WO1999033828A1 (en) 1999-07-08
DE69831427T2 (de) 2006-06-08
BR9813836A (pt) 2000-10-10
DE69831427D1 (de) 2005-10-06
EP0926148A1 (en) 1999-06-30
ZA9811762B (en) 1999-06-23
CN1284954A (zh) 2001-02-21
CN1144804C (zh) 2004-04-07
KR20010033432A (ko) 2001-04-25
JP2001527074A (ja) 2001-12-25
AR017964A1 (es) 2001-10-24
KR100580742B1 (ko) 2006-05-15
AU744105B2 (en) 2002-02-14
ES2245053T3 (es) 2005-12-16
EE04615B1 (et) 2006-04-17
EA002831B1 (ru) 2002-10-31
EA200000697A1 (ru) 2000-12-25
US6962925B1 (en) 2005-11-08
SI1066284T1 (sl) 2005-12-31
EE200000387A (et) 2001-12-17
HK1033128A1 (en) 2001-08-17
EP1066284B1 (en) 2005-08-31
ATE303382T1 (de) 2005-09-15

Similar Documents

Publication Publication Date Title
NO20012977L (no) N-ureidoalkylpiperidiner som modulatorer av chemokinreseptoraktivitet
WO2003068750A1 (en) Jnk inhibitor
HK1054032A1 (zh) N-酰脲异环烷-六氢吡啶作为化学增活受者活动的抑扬调节剂
ATE302606T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
NO20043098L (no) Alfa-(N-sulfonamido) acetamidderivater som beta-amyloidinhibitorer
NO20083684L (no) Laktam-inneholdende forbindelser og derivater derav som faktor XA-inhibitorer
WO2003024401A3 (en) Piperizinones as modulators of chemokine receptor activity
DK1131315T3 (da) Polyhydroxylerede heterocykliske derivater som antikoagulanter
WO2001098268A3 (en) Piperidine amides as modulators of chemokine receptor activity
EP1889842A4 (en) HETEROCYCLIC CONNECTION
DE122008000021I2 (de) Sulfonamidderivate als Wirkstoff-Vorläufer vom Inhibitoren der Aspartyl-Protease
DK1040094T3 (da) Substitueret cyklopentan og cyklopenten-forbindelser anvendelige som neuraminidase-inhibitorer
HRP20030472B1 (en) Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
MXPA03010630A (es) Nuevos derivados de pirrol como agentes farmaceuticos.
CA2427338A1 (en) Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
NO20024627D0 (no) Inhibering av cyklooksygenase-1-aktivitet
WO2001028987A8 (en) Benzylcycloalkyl amines as modulators of chemokine receptor activity
WO2001007049A3 (en) Ophthalmic composition comprising ketotifen
WO2001098270A3 (en) N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
DK0746979T3 (da) Anvendelse af pyrrolforbindelser som antibegroningsmidler
EP1667976A4 (en) Isoquinolinone POTASSIUM CHANNEL INHIBITORS
DK0734380T3 (da) 4-Benzoylisoxazoler samt deres anvendelse som herbicider
BR9812085A (pt) &#34;método para a sìntese de derivados de quinolina&#34;
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
CA2423286A1 (en) Amorphous form of cell cycle inhibitor

Legal Events

Date Code Title Description
CREP Change of representative

Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS

MM1K Lapsed by not paying the annual fees