ATE303382T1 - Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer - Google Patents

Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer

Info

Publication number: ATE303382T1
Authority: AT; Austria
Prior art keywords: benzo; alpha; reductase inhibitors; quinolizine derivatives; quinolizine
Prior art date: 1997-12-23

Application number

AT98966711T

Other languages

English (en)

Inventor

Antonio Guarna

Mario Serio

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-23

Filing date

1998-12-21

Publication date

2005-09-15

1998-12-21 Application filed by Applied Research Systems filed Critical Applied Research Systems

2005-09-15 Application granted granted Critical

2005-09-15 Publication of ATE303382T1 publication Critical patent/ATE303382T1/de

Links

UOGFZJRMCBHRQU-UHFFFAOYSA-N 10ah-benzo[c]quinolizine Chemical class N12C=CC=CC2=CC=C2C1C=CC=C2 UOGFZJRMCBHRQU-UHFFFAOYSA-N 0.000 title 1
239000002677 5-alpha reductase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Dermatology (AREA)
Environmental Sciences (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Zoology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Steroid Compounds (AREA)

AT98966711T 1997-12-23 1998-12-21 Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer ATE303382T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97122733A EP0926148A1 (de)	1997-12-23	1997-12-23	Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer
PCT/EP1998/008582 WO1999033828A1 (en)	1997-12-23	1998-12-21	Benzo[c]quinolizine derivatives and their use as 5 alpha-reductases inhibitors

Publications (1)

Publication Number	Publication Date
ATE303382T1 true ATE303382T1 (de)	2005-09-15

Family

ID=8227866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98966711T ATE303382T1 (de)	1997-12-23	1998-12-21	Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer

Country Status (21)

Country	Link
US (1)	US6962925B1 (de)
EP (2)	EP0926148A1 (de)
JP (1)	JP2001527074A (de)
KR (1)	KR100580742B1 (de)
CN (1)	CN1144804C (de)
AR (1)	AR017964A1 (de)
AT (1)	ATE303382T1 (de)
AU (1)	AU744105B2 (de)
BR (1)	BR9813836A (de)
CA (1)	CA2315055A1 (de)
DE (1)	DE69831427T2 (de)
EA (1)	EA002831B1 (de)
EE (1)	EE04615B1 (de)
ES (1)	ES2245053T3 (de)
IL (1)	IL136919A0 (de)
NO (1)	NO326034B1 (de)
PT (1)	PT1066284E (de)
SI (1)	SI1066284T1 (de)
UA (1)	UA66371C2 (de)
WO (1)	WO1999033828A1 (de)
ZA (1)	ZA9811762B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0926148A1 (de) *	1997-12-23	1999-06-30	Applied Research Systems Ars Holding N.V.	Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer
EP1105133A4 (de) *	1998-07-29	2002-03-27	Merck & Co Inc	Tricyclische verbindungen
KR100785088B1 (ko)	2006-05-23	2007-12-12	한국과학기술연구원	두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법
WO2008007778A1 (fr) *	2006-07-13	2008-01-17	Nihon Nohyaku Co., Ltd.	agent de RÉGULATION de plante parasite et son emploi
GB201506894D0 (en) *	2015-04-23	2015-06-10	Galapagos Nv	Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
CN106008423B (zh) *	2016-06-24	2018-02-02	云南民族大学	一种苯丙素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5239075A (en) *	1991-08-21	1993-08-24	Eli Lilly And Company	Process for the preparation of benzo (f) quinolinones
EP0591583B1 (de) *	1991-08-21	2001-12-19	Eli Lilly And Company	Benzo(f)quinolinone als 5-Alpha-reduktase Inhibitoren
ES2125884T3 (es) *	1991-08-21	1999-03-16	Lilly Co Eli	Hexahidrobenzo(f)quinolinonas como inhibidores de la 5-alfa-reductasa.
US5250539A (en) *	1991-08-21	1993-10-05	Eli Lilly And Company	Hexahydrobenzo[f]quinolinones
AU6413594A (en) *	1993-03-24	1994-10-11	Merck & Co., Inc.	Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors
US5578724A (en) *	1994-09-20	1996-11-26	Eli Lilly And Company	Process for preparation of benzo[f]quinolinones
IT1286545B1 (it) *	1996-02-09	1998-07-15	Antonio Guarna	Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
ITFI970193A1 (it) *	1997-08-01	1999-02-01	Applied Research Systems	Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (de) *	1997-12-23	1999-06-30	Applied Research Systems Ars Holding N.V.	Benzo (c)quinolizine-derivate,deren herstellung und verwendung als 5-alpha-reduktase-hemmer

1997
- 1997-12-23 EP EP97122733A patent/EP0926148A1/de not_active Withdrawn
1998
- 1998-12-21 AU AU24194/99A patent/AU744105B2/en not_active Ceased
- 1998-12-21 DE DE69831427T patent/DE69831427T2/de not_active Expired - Fee Related
- 1998-12-21 IL IL13691998A patent/IL136919A0/xx unknown
- 1998-12-21 CN CNB98813702XA patent/CN1144804C/zh not_active Expired - Fee Related
- 1998-12-21 JP JP2000526509A patent/JP2001527074A/ja active Pending
- 1998-12-21 EP EP98966711A patent/EP1066284B1/de not_active Expired - Lifetime
- 1998-12-21 WO PCT/EP1998/008582 patent/WO1999033828A1/en not_active Ceased
- 1998-12-21 CA CA002315055A patent/CA2315055A1/en not_active Abandoned
- 1998-12-21 PT PT98966711T patent/PT1066284E/pt unknown
- 1998-12-21 BR BR9813836-7A patent/BR9813836A/pt not_active Application Discontinuation
- 1998-12-21 KR KR1020007006912A patent/KR100580742B1/ko not_active Expired - Fee Related
- 1998-12-21 EE EEP200000387A patent/EE04615B1/xx not_active IP Right Cessation
- 1998-12-21 EA EA200000697A patent/EA002831B1/ru not_active IP Right Cessation
- 1998-12-21 AT AT98966711T patent/ATE303382T1/de not_active IP Right Cessation
- 1998-12-21 ES ES98966711T patent/ES2245053T3/es not_active Expired - Lifetime
- 1998-12-21 SI SI9830791T patent/SI1066284T1/sl unknown
- 1998-12-21 UA UA2000063687A patent/UA66371C2/uk unknown
- 1998-12-22 ZA ZA9811762A patent/ZA9811762B/xx unknown
- 1998-12-23 AR ARP980106662A patent/AR017964A1/es active IP Right Grant
2000
- 2000-06-12 US US09/593,173 patent/US6962925B1/en not_active Expired - Fee Related
- 2000-06-20 NO NO20003199A patent/NO326034B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA002831B1 (ru)	2002-10-31
EP1066284A1 (de)	2001-01-10
AU744105B2 (en)	2002-02-14
UA66371C2 (en)	2004-05-17
NO20003199D0 (no)	2000-06-20
JP2001527074A (ja)	2001-12-25
KR100580742B1 (ko)	2006-05-15
NO20003199L (no)	2000-08-23
EP0926148A1 (de)	1999-06-30
AR017964A1 (es)	2001-10-24
DE69831427T2 (de)	2006-06-08
BR9813836A (pt)	2000-10-10
IL136919A0 (en)	2001-06-14
EA200000697A1 (ru)	2000-12-25
AU2419499A (en)	1999-07-19
CN1284954A (zh)	2001-02-21
ZA9811762B (en)	1999-06-23
DE69831427D1 (de)	2005-10-06
WO1999033828A1 (en)	1999-07-08
PT1066284E (pt)	2005-11-30
CN1144804C (zh)	2004-04-07
ES2245053T3 (es)	2005-12-16
EE200000387A (et)	2001-12-17
US6962925B1 (en)	2005-11-08
EE04615B1 (et)	2006-04-17
SI1066284T1 (sl)	2005-12-31
EP1066284B1 (de)	2005-08-31
NO326034B1 (no)	2008-09-01
KR20010033432A (ko)	2001-04-25
HK1033128A1 (en)	2001-08-17
CA2315055A1 (en)	1999-07-08

Legal Events

Date

Code

Title

Description

2006-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1066284

Country of ref document: EP

2010-09-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE330955T1 (de)	2006-07-15	Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4.
DE59803292D1 (de)	2002-04-11	Triazolverbindungen und deren verwendung als dopamin-d 3-liganden
DE69636801D1 (de)	2007-02-08	Dioxinoderivate und ihre Verwendung als Dopamine Agonisten
ATE375987T1 (de)	2007-11-15	Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
DE69332898T2 (de)	2004-01-15	4-Carboxamidopiperidinderivate und ihre Verwendung als Neurokinin Antagonisten
ATE277895T1 (de)	2004-10-15	4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
DE69836346D1 (de)	2006-12-14	Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer
DE59908600D1 (de)	2004-03-25	Substituierte benzimidazole und ihre verwendung als parp inhibitoren
DE59710422D1 (de)	2003-08-14	Acylmercapto-triazolyl-derivate und ihre verwendung als mikrobizide
DE69715448D1 (de)	2002-10-17	Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten
DE59703869D1 (de)	2001-07-26	Aminothiophencarbonsäureamide und ihre verwendung als phosphodiesterase inhibitoren
DE59710580D1 (de)	2003-09-18	Thiocyano-triazolyl-derivate und ihre verwendung als mikrobizide
DE69716062D1 (de)	2002-11-07	Benzofuran-derivate und deren verwendung
DE69826693D1 (de)	2004-11-04	Amidinoderivate und ihre verwendung als thrombininhibitoren
DE69717647D1 (de)	2003-01-16	3-mercaptoacetylamino-1,5-substituierte-2-oxo-azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen
DE69613805D1 (de)	2001-08-16	Diiminoquinonderivate und ihre Verwendung als Elektronübertragungsmittel
DE69510228D1 (de)	1999-07-15	Piperidinessigsäurederivate und ihre verwendung als fibrinogenantagonistmittel
DE69917777D1 (de)	2004-07-08	Benzazol-verbindungen und ihre verwendung
DE69708629D1 (de)	2002-01-10	Alkyloxyamin-substituierte fluorenonderivate und ihre verwendung als proteinkinase-c-inhibitoren
DE69811018D1 (de)	2003-03-06	Triazol-Derivate und ihre Verwendung als antimykotische Mittel
ATE253059T1 (de)	2003-11-15	Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2- one und ihre verwendung als lipase-hemmer
ATE229016T1 (de)	2002-12-15	Substituierte heterocyclische benzocycloalkene und ihre verwendung als analgetisch wirksame substanzen
ATE260258T1 (de)	2004-03-15	Substituierte isochinoline derivate und ihre verwendung als anticonvulsiva
ATE303382T1 (de)	2005-09-15	Benzo(c)quinolizinderivative und deren verwendung als 5 alpha-reduktase-hemmer
ATE252079T1 (de)	2003-11-15	Indolderivate und deren verwendung als 5ht2a liganden