NO20003314L - Nye tetravcykliske analoger av camptotheciner, deres fremstillingsprosesser, anvendelse av dem som medikamenter og farmasøytiske preparater inneholdende dem - Google Patents

Nye tetravcykliske analoger av camptotheciner, deres fremstillingsprosesser, anvendelse av dem som medikamenter og farmasøytiske preparater inneholdende dem

Info

Publication number
NO20003314L
NO20003314L NO20003314A NO20003314A NO20003314L NO 20003314 L NO20003314 L NO 20003314L NO 20003314 A NO20003314 A NO 20003314A NO 20003314 A NO20003314 A NO 20003314A NO 20003314 L NO20003314 L NO 20003314L
Authority
NO
Norway
Prior art keywords
tetravcyclic
camptothecins
medicaments
analogues
new
Prior art date
Application number
NO20003314A
Other languages
English (en)
Other versions
NO316676B1 (no
NO20003314D0 (no
Inventor
Dennis Bigg
Olivier Lavergne
Alain Rolland
Christophe Lanco
Gerard Ulibarri
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NO20003314D0 publication Critical patent/NO20003314D0/no
Publication of NO20003314L publication Critical patent/NO20003314L/no
Publication of NO316676B1 publication Critical patent/NO316676B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
NO20003314A 1997-12-24 2000-06-23 Nye tetravcykliske analoger av camptotheciner, deres fremstillingsprosesser, anvendelse av dem til fremstilling av medikamenter og farmasoytiske preparater inneholdende dem NO316676B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9716461A FR2772763B1 (fr) 1997-12-24 1997-12-24 Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
PCT/FR1998/002751 WO1999033829A1 (fr) 1997-12-24 1998-12-16 Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (3)

Publication Number Publication Date
NO20003314D0 NO20003314D0 (no) 2000-06-23
NO20003314L true NO20003314L (no) 2000-06-30
NO316676B1 NO316676B1 (no) 2004-03-29

Family

ID=9515095

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003314A NO316676B1 (no) 1997-12-24 2000-06-23 Nye tetravcykliske analoger av camptotheciner, deres fremstillingsprosesser, anvendelse av dem til fremstilling av medikamenter og farmasoytiske preparater inneholdende dem

Country Status (22)

Country Link
US (2) US6436951B1 (no)
EP (1) EP1042323B1 (no)
JP (1) JP2001527075A (no)
AR (1) AR016440A1 (no)
AT (1) ATE215951T1 (no)
AU (1) AU749224B2 (no)
CA (1) CA2315897C (no)
DE (1) DE69804856T2 (no)
DK (1) DK1042323T3 (no)
ES (1) ES2175834T3 (no)
FR (1) FR2772763B1 (no)
HU (1) HUP0004628A3 (no)
IL (1) IL136732A0 (no)
MY (1) MY117585A (no)
NO (1) NO316676B1 (no)
NZ (1) NZ505339A (no)
PL (1) PL193468B1 (no)
PT (1) PT1042323E (no)
RU (1) RU2220144C2 (no)
TW (1) TW513429B (no)
WO (1) WO1999033829A1 (no)
ZA (1) ZA9811796B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
AU2002335472B8 (en) * 2002-03-26 2007-12-20 Banyu Pharmaceutical Co., Ltd. Combined use of antitumor indolopyrrolocarbazole derivative and other antitumor agent
EP1558614B1 (en) * 2002-10-30 2010-09-01 Merck Frosst Canada Ltd. Pyridopyrrolizine and pyridoindolizine derivatives
DE112005002757T5 (de) * 2004-12-08 2007-10-25 Fuji Electric Holdings Co., Ltd., Kawasaki Organische EL-Vorrichtung
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
JP5126707B2 (ja) * 2007-04-23 2013-01-23 有機合成薬品工業株式会社 α−ヒドロキシアシルピリジンの製造方法
EA017648B1 (ru) 2007-09-14 2013-02-28 Орто-Макнейл-Янссен Фармасьютикалз, Инк. 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
RU2397984C1 (ru) * 2009-03-05 2010-08-27 Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ БЕНЗО[7,8]АЗОНИНО[5,4-b]ИНДОЛОВ, 7,9-ЭТЕНОАЗЕЦИНО[5,4-b]ИНДОЛОВ И 7,9-ЭТАНОАЗЕЦИНО[5,4-b]ИНДОЛОВ
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
HRP20131122T1 (hr) 2009-05-12 2013-12-20 Janssen Pharmaceuticals, Inc. Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja
ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JP5852664B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
US9353122B2 (en) 2013-02-15 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
US9353123B2 (en) 2013-02-20 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
KR20160099084A (ko) 2013-11-01 2016-08-19 칼라 파마슈티컬스, 인크. 치료 화합물의 결정질 형태 및 그의 용도
CN103588660B (zh) * 2013-11-18 2016-06-01 中国医学科学院生物医学工程研究所 一种新型的酰基苯胺化合物及用途
JP6219523B2 (ja) 2013-12-13 2017-10-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトンチロシンキナーゼの阻害剤
PL3096790T3 (pl) 2014-01-21 2020-01-31 Janssen Pharmaceutica, N.V. Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
US10253036B2 (en) 2016-09-08 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2018048750A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509421A4 (en) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
DE69635560T2 (de) * 1995-06-21 2006-08-17 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Camptothecinanaloge, Verfahren zur ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds

Also Published As

Publication number Publication date
AU749224B2 (en) 2002-06-20
ZA9811796B (en) 1999-06-29
NO316676B1 (no) 2004-03-29
NO20003314D0 (no) 2000-06-23
HUP0004628A1 (hu) 2001-05-28
US20010000521A1 (en) 2001-04-26
DE69804856D1 (de) 2002-05-16
PL193468B1 (pl) 2007-02-28
DK1042323T3 (da) 2002-08-05
WO1999033829A1 (fr) 1999-07-08
HUP0004628A3 (en) 2001-11-28
US6632946B2 (en) 2003-10-14
EP1042323B1 (fr) 2002-04-10
PT1042323E (pt) 2002-09-30
CA2315897A1 (fr) 1999-07-08
JP2001527075A (ja) 2001-12-25
AR016440A1 (es) 2001-07-04
EP1042323A1 (fr) 2000-10-11
FR2772763B1 (fr) 2004-01-23
AU1764599A (en) 1999-07-19
FR2772763A1 (fr) 1999-06-25
DE69804856T2 (de) 2002-11-07
NZ505339A (en) 2003-01-31
ES2175834T3 (es) 2002-11-16
MY117585A (en) 2004-07-31
CA2315897C (fr) 2010-01-19
US6436951B1 (en) 2002-08-20
TW513429B (en) 2002-12-11
ATE215951T1 (de) 2002-04-15
RU2220144C2 (ru) 2003-12-27
IL136732A0 (en) 2001-06-14
PL341288A1 (en) 2001-04-09

Similar Documents

Publication Publication Date Title
NO20003314D0 (no) Nye tetravcykliske analoger av camptotheciner, deres fremstillingsprosesser, anvendelse av dem som medikamenter og farmasøytiske preparater inneholdende dem
NO954942D0 (no) Nye erytromycinderivater, fremgangsmåte for deres fremstilling og anvendelse av derivatene som legemidler
DK1194403T3 (da) Indanylsubstituerede benzencarboxamider, fremgangsmåde til deres fremstilling, deres anvendelse som lægemiddel samt farmaceutiske tilberedninger med indhold deraf
DK0911340T3 (da) Substituerede isoquinolin-3-carboxylsyreamider, deres fremstilling og deres anvendelse som lægemiddel
NO993003L (no) Sulfonamid-derivater, fremgangsmÕte for deres fremstilling og deres anvendelse som medikamenter
NO20000294L (no) Derivater av acylpiperazinylpyrimidiner, deres fremstilling og anvendelse som legemidler
NO20032438L (no) Ortosubstituerte og metasubstituerte bisarylforbindelser, fremgangsmåte forfremstilling derav, deres anvendelse som et medikament samtfarmasöytiske preparater inneholdende forbindelsene
NO20010031D0 (no) Derivater av 2-aminopyridiner, anvendelse av dem som medikamenter og farmasöytiske preparater inneholdende dem
DK1222163T3 (da) 2'-Substituerede 1,1'-biphenyl-2-carboxamider, fremgangsmåder til fremstilling deraf, deres anvendelse som medikament samt farmaceutiske præparater, som indeholder dem
NO20014013D0 (no) 16-halogenepotilonderivater, fremgangsmater for fremstilling av dem og deres farmasoytiske anvendelse
NO305075B1 (no) Glycinamid-derivater, farmas°ytiske medikamenter som inneholder dem og mellomprodukter for fremstilling av dem
NO870666D0 (no) Substituerte thienoinidasolderivater, fremgangsmaate til deres fremstilling og farmasoeytiske tilberedninger inneholdende dem og deres anvendelse som magesyresekresjonshemmer.
DK1210348T3 (da) Naphthyridinderivater, fremgangsmåde til deres fremstilling, deres anvendelse og farmaceutiske præparater omfattende dem
DK0946567T3 (da) Hidtil ukendte camptothecinanaloge forbindelser, deres anvendelse som lægemidler og farmaceutiske præparater, der indeholder dem
NO305286B1 (no) Kinoksalinforbindelser, farmas°ytiske preparater som omfatter dem, og anvendelse derav for fremstilling av medikamenter
DK1015421T3 (da) Nye phenylamidinderivater, fremgangsmåder til deres fremstilling og deres anvendelse som lægemidler
NO983860D0 (no) Nye triazolopuriner, fremgangsmÕte for fremstilling av dem og deres anvendelse som legemidler
NO323466B1 (no) Nye kinolinyl-piperidin-4-yliden-metyl-benzamidderivater, fremgangsmate til fremstilling derav, anvendelse derav i medikamenter til behandling av smerte, samt farmasoytisk sammensetning som innbefatter slike derivater
NO984476L (no) Sulfonamidsubstituerte kromaner, fremgangsmÕte for fremstilling derav, deres anvendelse som medikament samt farmas°ytiske preparater inneholdende forbindelsene
NO304378B1 (no) Nye imidazopyridinderivater som er angiotensin II-antagonister, farmas°ytiske preparater som inneholder dem, og deres anvendelse til fremstilling av medikamenter
NO20002483L (no) Nye 19-norsteroider substituert i posisjon 11B, fremstillingsfremgangsmÕte og intermediater, anvendelse som medisiner og farmasøytiske preparater som inneholder dem
DK0915087T3 (da) Sulfonamid-substituerede anellerede 5-leddede ringforbindelser, deres anvendelse som lægemiddel samt farmaceutiske præparater, som indeholder dem
DK0858459T3 (da) Nye sure pyrazolforbindelser, fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler, deres nye anvendelse og farmaceutiske præparater med indhold deraf
DK0905131T3 (da) Sulfonamidsubstituerede chromaner, fremgangsmåde til fremstilling deraf, anvendelse deraf som lægemidler og farmaceutiske præparater indeholdende dem
NO20002114D0 (no) Bicykliske forbindelser, fremgangsmÕte for deres fremstilling og farmasøytiske sammensetninger inneholdende dem

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees