NO20003451L - 2,3-substituerte indolforbindelser som cox-2 inhibitorer - Google Patents

2,3-substituerte indolforbindelser som cox-2 inhibitorer

Info

Publication number: NO20003451L
Authority: NO; Norway
Prior art keywords: halogen; alkyl; optionally substituted; alkoxy; substituted
Prior art date: 1998-01-05

Application number

NO20003451A

Other languages

English (en)

Norwegian (no)

Other versions

NO20003451D0 (no

Inventor

Kazunari Nakao

Rodney William Stevens

Kiyoshi Kawamura

Chikara Uchida

Hiroki Koike

Stephane Caron

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-05

Filing date

2000-07-04

Publication date

2000-09-01

2000-07-04 Application filed by Pfizer filed Critical Pfizer

2000-07-04 Publication of NO20003451D0 publication Critical patent/NO20003451D0/no

2000-09-01 Publication of NO20003451L publication Critical patent/NO20003451L/no

Links

229940111134 coxibs Drugs 0.000 title 1
239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052736 halogen Chemical group 0.000 abstract 3
150000002367 halogens Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000005605 benzo group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
244000052769 pathogen Species 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003180 prostaglandins Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20003451A 1998-01-05 2000-07-04 2,3-substituerte indolforbindelser som cox-2 inhibitorer NO20003451L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB9800003		1998-01-05
PCT/IB1998/002065 WO1999035130A1 (en)	1998-01-05	1998-12-18	2,3-substituted indole compounds as cox-2 inhibitors

Publications (2)

Publication Number	Publication Date
NO20003451D0 NO20003451D0 (no)	2000-07-04
NO20003451L true NO20003451L (no)	2000-09-01

Family

ID=11004645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20003451A NO20003451L (no)	1998-01-05	2000-07-04	2,3-substituerte indolforbindelser som cox-2 inhibitorer

Country Status (39)

Country	Link
US (1)	US6608070B1 (is)
EP (1)	EP1045833B1 (is)
JP (1)	JP3347136B2 (is)
KR (1)	KR100404054B1 (is)
CN (1)	CN1284064A (is)
AP (1)	AP869A (is)
AR (1)	AR016977A1 (is)
AT (1)	ATE308519T1 (is)
AU (1)	AU748107B2 (is)
BG (1)	BG104643A (is)
BR (1)	BR9813124A (is)
CA (1)	CA2316863A1 (is)
CO (1)	CO4970807A1 (is)
DE (1)	DE69832200T2 (is)
DZ (1)	DZ2700A1 (is)
EA (1)	EA200000614A1 (is)
ES (1)	ES2255190T3 (is)
GT (1)	GT199800205A (is)
HN (1)	HN1997000098A (is)
HR (1)	HRP20000454A2 (is)
HU (1)	HUP0102922A3 (is)
ID (1)	ID24876A (is)
IL (1)	IL136885A0 (is)
IS (1)	IS5532A (is)
MA (1)	MA24736A1 (is)
NO (1)	NO20003451L (is)
OA (1)	OA11441A (is)
PA (1)	PA8466201A1 (is)
PE (1)	PE20000055A1 (is)
PL (1)	PL341696A1 (is)
SA (1)	SA99191299A (is)
SK (1)	SK9912000A3 (is)
TN (1)	TNSN99001A1 (is)
TR (1)	TR200001906T2 (is)
TW (1)	TW436482B (is)
UY (2)	UY25332A1 (is)
WO (1)	WO1999035130A1 (is)
YU (1)	YU41600A (is)
ZA (1)	ZA9911B (is)

Families Citing this family (25)

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US6555540B1 (en) *	1999-06-30	2003-04-29	Pfizer Inc	Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors
MXPA00006605A (es) *	1999-07-02	2004-12-09	Pfizer	Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
DE60000556T2 (de) *	1999-07-02	2003-02-13	Pfizer Inc., New York	Tetrazolylalkyl-Indolderivate als entzündungshemmende und analgetische Mittel
CO5261556A1 (es)	1999-12-08	2003-03-31	Pharmacia Corp	Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
CA2509881A1 (en) *	2002-12-19	2004-07-08	Elan Pharmaceuticals, Inc.	Substituted n-phenyl sulfonamide bradykinin antagonists
US7223785B2 (en)	2003-01-22	2007-05-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
US7098231B2 (en) *	2003-01-22	2006-08-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
PT1534305E (pt)	2003-05-07	2007-02-28	Osteologix As	Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis
KR100795462B1 (ko) *	2006-09-27	2008-01-16	한국생명공학연구원	인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물
CN101611016B (zh) *	2006-10-17	2012-01-25	斯蒂菲尔实验室公司	他拉罗唑代谢物
US20120022121A1 (en) *	2007-11-29	2012-01-26	Dalton James T	Indoles, derivatives and analogs thereof and uses therefor
PL2560956T3 (pl)	2010-04-19	2017-03-31	Octeta Therapeutics, Llc	Nowa synteza związków tiazolidynodionowych
JP5827326B2 (ja) *	2010-07-07	2015-12-02	アーデリクス，インコーポレーテッド	リン酸輸送を阻害する化合物及び方法
EP2590656B1 (en)	2010-07-07	2017-11-15	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
JP5827328B2 (ja)	2010-07-07	2015-12-02	アーデリクス，インコーポレーテッド	リン酸輸送を阻害する化合物及び方法
EP2590965B1 (en)	2010-07-07	2016-04-20	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
KR101857307B1 (ko)	2010-08-10	2018-05-11	메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨	티아졸리딘디온 화합물의 합성법
CA2807662C (en)	2010-08-10	2019-10-08	Metabolic Solutions Development Company, Llc	Synthesis for thiazolidinedione compounds
US10266490B2 (en) *	2012-03-16	2019-04-23	Georgetown University	Radioprotector compounds
US9808443B1 (en)	2016-11-28	2017-11-07	King Saud University	Cyclooxygenase inhibitors
CN111004121A (zh) *	2019-12-09	2020-04-14	南京杰运医药科技有限公司	一种4-烷氧基乙酰乙酸酯类化合物的制备方法
CN112409281B (zh) *	2020-08-20	2022-11-18	上海大学	(e)-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的合成方法
IL305573A (en)	2021-03-15	2023-10-01	Saul Yedgar	HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES
KR102967967B1 (ko) *	2021-06-10	2026-05-21	연세대학교 산학협력단	펜드린 억제 활성을 갖는 신규 화합물 및 이의 의약 용도
CN116262721B (zh) *	2023-01-12	2026-03-13	浙江师范大学	一种二氢吲哚衍生物及吲哚衍生物的制备方法及产品

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US5604253A (en) *	1995-05-22	1997-02-18	Merck Frosst Canada, Inc.	N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5510368A (en) *	1995-05-22	1996-04-23	Merck Frosst Canada, Inc.	N-benzyl-3-indoleacetic acids as antiinflammatory drugs
CO5190664A1 (es) *	1999-06-30	2002-08-29	Pfizer Prod Inc	Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2

1998
- 1998-12-17 AP APAP/P/1998/001423A patent/AP869A/en active
- 1998-12-18 AT AT98959082T patent/ATE308519T1/de not_active IP Right Cessation
- 1998-12-18 HU HU0102922A patent/HUP0102922A3/hu unknown
- 1998-12-18 BR BR9813124-9A patent/BR9813124A/pt not_active IP Right Cessation
- 1998-12-18 YU YU41600A patent/YU41600A/sh unknown
- 1998-12-18 EA EA200000614A patent/EA200000614A1/ru unknown
- 1998-12-18 JP JP2000527531A patent/JP3347136B2/ja not_active Expired - Fee Related
- 1998-12-18 AU AU15005/99A patent/AU748107B2/en not_active Ceased
- 1998-12-18 KR KR10-2000-7007419A patent/KR100404054B1/ko not_active Expired - Fee Related
- 1998-12-18 IL IL13688598A patent/IL136885A0/xx unknown
- 1998-12-18 US US09/355,494 patent/US6608070B1/en not_active Expired - Fee Related
- 1998-12-18 WO PCT/IB1998/002065 patent/WO1999035130A1/en not_active Ceased
- 1998-12-18 SK SK991-2000A patent/SK9912000A3/sk unknown
- 1998-12-18 ID IDW20001286A patent/ID24876A/id unknown
- 1998-12-18 DE DE69832200T patent/DE69832200T2/de not_active Expired - Fee Related
- 1998-12-18 ES ES98959082T patent/ES2255190T3/es not_active Expired - Lifetime
- 1998-12-18 CN CN98813530A patent/CN1284064A/zh active Pending
- 1998-12-18 EP EP98959082A patent/EP1045833B1/en not_active Expired - Lifetime
- 1998-12-18 TR TR2000/01906T patent/TR200001906T2/xx unknown
- 1998-12-18 CA CA002316863A patent/CA2316863A1/en not_active Abandoned
- 1998-12-18 PL PL98341696A patent/PL341696A1/xx unknown
- 1998-12-18 HR HR20000454A patent/HRP20000454A2/hr not_active Application Discontinuation
- 1998-12-22 TW TW087120865A patent/TW436482B/zh active
- 1998-12-28 PE PE1998001288A patent/PE20000055A1/es not_active Application Discontinuation
- 1998-12-28 HN HN1997000098A patent/HN1997000098A/es unknown
- 1998-12-29 GT GT199800205A patent/GT199800205A/es unknown
- 1998-12-30 CO CO98077588A patent/CO4970807A1/es unknown
- 1998-12-31 UY UY25332A patent/UY25332A1/es not_active IP Right Cessation
1999
- 1999-01-04 TN TNTNSN99001A patent/TNSN99001A1/fr unknown
- 1999-01-04 ZA ZA9900011A patent/ZA9911B/xx unknown
- 1999-01-04 AR ARP990100010A patent/AR016977A1/es not_active Application Discontinuation
- 1999-01-04 MA MA25414A patent/MA24736A1/fr unknown
- 1999-01-04 DZ DZ990001A patent/DZ2700A1/xx active
- 1999-01-05 PA PA19998466201A patent/PA8466201A1/es unknown
- 1999-04-13 SA SA99191299A patent/SA99191299A/ar unknown
- 1999-06-28 UY UY25590A patent/UY25590A1/es not_active Application Discontinuation
2000
- 2000-06-13 IS IS5532A patent/IS5532A/is unknown
- 2000-06-30 OA OA1200000195A patent/OA11441A/en unknown
- 2000-07-04 NO NO20003451A patent/NO20003451L/no unknown
- 2000-07-28 BG BG104643A patent/BG104643A/bg unknown

Also Published As

Publication number	Publication date
CO4970807A1 (es)	2000-11-07
DZ2700A1 (fr)	2003-09-01
AP9801423A0 (en)	1998-12-31
CN1284064A (zh)	2001-02-14
WO1999035130A1 (en)	1999-07-15
NO20003451D0 (no)	2000-07-04
BR9813124A (pt)	2000-10-10
JP2002500217A (ja)	2002-01-08
BG104643A (bg)	2001-02-28
ZA9911B (en)	2000-07-04
HUP0102922A2 (hu)	2001-12-28
US6608070B1 (en)	2003-08-19
JP3347136B2 (ja)	2002-11-20
IL136885A0 (en)	2001-06-14
AP869A (en)	2000-09-04
TR200001906T2 (tr)	2001-01-22
ES2255190T3 (es)	2006-06-16
KR100404054B1 (ko)	2003-11-01
PE20000055A1 (es)	2000-02-08
PA8466201A1 (es)	2000-09-29
SK9912000A3 (en)	2001-11-06
TW436482B (en)	2001-05-28
AU1500599A (en)	1999-07-26
SA99191299A (ar)	2005-12-03
IS5532A (is)	2000-06-13
CA2316863A1 (en)	1999-07-15
AR016977A1 (es)	2001-08-01
ID24876A (id)	2000-08-31
YU41600A (sh)	2003-08-29
DE69832200T2 (de)	2006-04-20
AU748107B2 (en)	2002-05-30
OA11441A (en)	2004-04-27
KR20010033859A (ko)	2001-04-25
HUP0102922A3 (en)	2003-06-30
HRP20000454A2 (en)	2001-04-30
HN1997000098A (es)	1998-12-28
TNSN99001A1 (fr)	2005-11-10
UY25332A1 (es)	2001-01-31
ATE308519T1 (de)	2005-11-15
GT199800205A (es)	2000-06-21
EA200000614A1 (ru)	2001-02-26
DE69832200D1 (de)	2005-12-08
EP1045833B1 (en)	2005-11-02
UY25590A1 (es)	1999-09-27
PL341696A1 (en)	2001-04-23
EP1045833A1 (en)	2000-10-25
MA24736A1 (fr)	1999-10-01

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