NO20003514L - Hypolipidemiske benzothiazepin-forbindelser - Google Patents

Hypolipidemiske benzothiazepin-forbindelser

Info

Publication number
NO20003514L
NO20003514L NO20003514A NO20003514A NO20003514L NO 20003514 L NO20003514 L NO 20003514L NO 20003514 A NO20003514 A NO 20003514A NO 20003514 A NO20003514 A NO 20003514A NO 20003514 L NO20003514 L NO 20003514L
Authority
NO
Norway
Prior art keywords
benzothiazepine compounds
hypolipidemic benzothiazepine
compounds
hypolipidemic
solvates
Prior art date
Application number
NO20003514A
Other languages
English (en)
Other versions
NO20003514D0 (no
Inventor
Anthony Louis Handlon
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20003514D0 publication Critical patent/NO20003514D0/no
Publication of NO20003514L publication Critical patent/NO20003514L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Det er beskrevet nye hypolipidemiske forbindelser ifølge formel (I), hvori R1 er H eller metyl og salter, solvater eller fysiologiske funksjonelle derivater derav, frem- gangsmåter og nye mellomprodukter for fremstilling derav, farmasøytiske sammen- setninger som inneholder disse og anvendelse i medisin, spesielt ved profylakse og behandling av hyperlipidemiske tilstander og assosierte sykdommer, så som athero- sklerose.
NO20003514A 1998-01-10 2000-07-07 Hypolipidemiske benzothiazepin-forbindelser NO20003514L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9800428.6A GB9800428D0 (en) 1998-01-10 1998-01-10 Chemical compounds
PCT/EP1999/000021 WO1999035135A1 (en) 1998-01-10 1999-01-07 Hypolipidemic benzothiazepine compounds

Publications (2)

Publication Number Publication Date
NO20003514D0 NO20003514D0 (no) 2000-07-07
NO20003514L true NO20003514L (no) 2000-09-07

Family

ID=10825042

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003514A NO20003514L (no) 1998-01-10 2000-07-07 Hypolipidemiske benzothiazepin-forbindelser

Country Status (27)

Country Link
US (1) US6465451B1 (no)
EP (1) EP1045840A1 (no)
JP (1) JP2002500220A (no)
KR (1) KR20010033988A (no)
CN (1) CN1292785A (no)
AP (1) AP2000001860A0 (no)
AR (1) AR014261A1 (no)
AU (1) AU2515599A (no)
BR (1) BR9906799A (no)
CA (1) CA2317651A1 (no)
CO (1) CO4820391A1 (no)
EA (1) EA200000623A1 (no)
GB (1) GB9800428D0 (no)
HR (1) HRP20000468A2 (no)
HU (1) HUP0201343A3 (no)
ID (1) ID25495A (no)
IL (1) IL137040A0 (no)
IS (1) IS5551A (no)
MA (1) MA26595A1 (no)
NO (1) NO20003514L (no)
NZ (1) NZ505453A (no)
PE (1) PE20000179A1 (no)
PL (1) PL341672A1 (no)
SK (1) SK10242000A3 (no)
TR (1) TR200001816T2 (no)
WO (1) WO1999035135A1 (no)
ZA (1) ZA9981B (no)

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SE0000772D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
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GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
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FR2849024B1 (fr) * 2002-12-20 2007-11-02 Aventis Pharma Sa Nouveaux composes chiraux derives d'esters de l'acide hexanoique, procede et intermediaires de preparation, utilisation a la synthese de l'acide 2-(bromomethyl)2-ethyl hexanoique chiral
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
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EP2367554A4 (en) * 2008-11-26 2020-03-25 Satiogen Pharmaceuticals, Inc. Bile acid reflux inhibitor for the treatment of obesity and diabetes
EP4137137A1 (en) 2010-05-26 2023-02-22 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
PL3400944T3 (pl) 2010-11-04 2020-11-16 Albireo Ab Inhibitory ibat w leczeniu chorób wątroby
PT2637646T (pt) 2010-11-08 2016-08-17 Albireo Ab Uma combinação farmacêutica que compreende um inibidor do ibat e um sequestrador de ácido biliar
US20140323412A1 (en) 2011-10-28 2014-10-30 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
SG10201909122QA (en) 2011-10-28 2019-11-28 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
CA2907230A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
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KR102560954B1 (ko) 2014-06-25 2023-07-31 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
ES2874669T3 (es) 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
CN108601745B (zh) 2016-02-09 2021-12-07 阿尔比里奥公司 口服考来烯胺制剂及其用途
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CN111032019B (zh) 2017-08-09 2022-07-05 阿尔比里奥公司 考来烯胺颗粒、口服考来烯胺制剂及其用途
WO2019032027A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
EP3802504B1 (en) 2018-06-05 2023-01-18 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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EP3810084A1 (en) 2018-06-20 2021-04-28 Albireo AB Pharmaceutical formulation of odevixibat
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US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
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JP7562546B2 (ja) 2019-02-12 2024-10-07 ミルム ファーマシューティカルズ インコーポレイテッド 胆汁うっ滞性肝疾患を有する小児対象の成長を増加させる方法
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ES2972045T3 (es) * 2019-12-04 2024-06-10 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CN114761018B (zh) 2019-12-04 2025-12-02 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
CA3158175A1 (en) * 2019-12-04 2021-06-10 Per-Goran Gillberg Benzothiazepine compounds and their use as bile acid modulators
AR120674A1 (es) * 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzotiazepina y su uso como ácido biliar
DK4069360T3 (da) * 2019-12-04 2024-02-26 Albireo Ab Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer
PT4069360T (pt) 2019-12-04 2024-03-06 Albireo Ab Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar
WO2021110886A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TWI877263B (zh) 2019-12-04 2025-03-21 瑞典商艾爾比瑞歐公司 苯并噻二氮呯化合物及其作為膽酸調節劑之用途
JP7696897B2 (ja) * 2019-12-04 2025-06-23 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
CN116157389B (zh) 2020-08-03 2026-02-10 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
WO2022117778A1 (en) * 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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Also Published As

Publication number Publication date
US6465451B1 (en) 2002-10-15
NZ505453A (en) 2002-11-26
MA26595A1 (fr) 2004-12-20
ZA9981B (en) 2000-07-06
HRP20000468A2 (en) 2000-10-31
CO4820391A1 (es) 1999-07-28
IS5551A (is) 2000-06-27
CA2317651A1 (en) 1999-07-15
WO1999035135A1 (en) 1999-07-15
SK10242000A3 (sk) 2001-02-12
KR20010033988A (ko) 2001-04-25
PE20000179A1 (es) 2000-03-16
JP2002500220A (ja) 2002-01-08
EA200000623A1 (ru) 2001-04-23
AU2515599A (en) 1999-07-26
HUP0201343A2 (hu) 2003-06-28
CN1292785A (zh) 2001-04-25
GB9800428D0 (en) 1998-03-04
ID25495A (id) 2000-10-05
AP2000001860A0 (en) 2000-09-30
BR9906799A (pt) 2000-10-10
PL341672A1 (en) 2001-04-23
AR014261A1 (es) 2001-02-07
HUP0201343A3 (en) 2003-08-28
NO20003514D0 (no) 2000-07-07
EP1045840A1 (en) 2000-10-25
TR200001816T2 (tr) 2000-11-21
IL137040A0 (en) 2001-06-14

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