NO20003969L - Antibakterielle midler - Google Patents

Antibakterielle midler

Info

Publication number
NO20003969L
NO20003969L NO20003969A NO20003969A NO20003969L NO 20003969 L NO20003969 L NO 20003969L NO 20003969 A NO20003969 A NO 20003969A NO 20003969 A NO20003969 A NO 20003969A NO 20003969 L NO20003969 L NO 20003969L
Authority
NO
Norway
Prior art keywords
sub
butyl
methyl
hydrogen
antibacterial agents
Prior art date
Application number
NO20003969A
Other languages
English (en)
Norwegian (no)
Other versions
NO20003969D0 (no
Inventor
Michael George Hunter
Raymond Paul Beckett
John Martin Clements
Mark Whittaker
Stephen John Davies
Lisa Marie Pratt
Zoe Marie Spavold
Steven Launchbury
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802549.7A external-priority patent/GB9802549D0/en
Priority claimed from GBGB9806300.1A external-priority patent/GB9806300D0/en
Priority claimed from GBGB9810463.1A external-priority patent/GB9810463D0/en
Priority claimed from GBGB9828318.7A external-priority patent/GB9828318D0/en
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Publication of NO20003969D0 publication Critical patent/NO20003969D0/no
Publication of NO20003969L publication Critical patent/NO20003969L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/14—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO20003969A 1998-02-07 2000-08-04 Antibakterielle midler NO20003969L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9802549.7A GB9802549D0 (en) 1998-02-07 1998-02-07 Antibacterial agents
GBGB9806300.1A GB9806300D0 (en) 1998-03-24 1998-03-24 Antibacterial agents
GBGB9810463.1A GB9810463D0 (en) 1998-05-16 1998-05-16 Antibacterial agents
GBGB9828318.7A GB9828318D0 (en) 1998-12-22 1998-12-22 Antibacterial agents
PCT/GB1999/000386 WO1999039704A1 (en) 1998-02-07 1999-02-05 Antibacterial agents

Publications (2)

Publication Number Publication Date
NO20003969D0 NO20003969D0 (no) 2000-08-04
NO20003969L true NO20003969L (no) 2000-09-28

Family

ID=27451747

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003969A NO20003969L (no) 1998-02-07 2000-08-04 Antibakterielle midler

Country Status (21)

Country Link
US (4) US6423690B1 (de)
EP (1) EP1052984B1 (de)
JP (1) JP2002502815A (de)
KR (1) KR100600518B1 (de)
CN (1) CN1298299A (de)
AT (1) ATE266394T1 (de)
AU (1) AU749699B2 (de)
BR (1) BR9907689A (de)
CA (1) CA2320476A1 (de)
DE (1) DE69917221T2 (de)
DK (1) DK1052984T3 (de)
ES (1) ES2221359T3 (de)
GB (1) GB2349884A (de)
HU (1) HUP0102901A3 (de)
IL (1) IL137312A (de)
NO (1) NO20003969L (de)
NZ (1) NZ505675A (de)
PL (1) PL194240B1 (de)
PT (1) PT1052984E (de)
TR (1) TR200002311T2 (de)
WO (1) WO1999039704A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1052984T3 (da) * 1998-02-07 2004-09-20 Vernalis Oxford Ltd Antibakterielle midler
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
GB9907055D0 (en) * 1999-03-29 1999-05-19 British Biotech Pharm Antibacterial agents
EP1169031A1 (de) 1999-04-09 2002-01-09 British Biotech Pharmaceuticals Limited Antimikrobielles mittel
DE69924887T2 (de) * 1999-08-10 2006-03-09 Vernalis (Oxford) Ltd., Abington Antibakterielle mittel
MXPA02001394A (es) * 1999-08-10 2002-08-12 British Biotech Pharm Agentes antibacterianos.
JP4576649B2 (ja) * 1999-10-29 2010-11-10 東ソー株式会社 新規オキサゾリジノン誘導体及びその用途
EP1237862A1 (de) * 1999-12-17 2002-09-11 Versicor, Inc. Succinat-verbindungen, zusammensetzungen sowie verfahren zur anwendung und herstellung
US6540653B2 (en) 2000-04-04 2003-04-01 Fleetguard, Inc. Unitary spiral vane centrifuge module
AR029916A1 (es) 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
AR028075A1 (es) * 2000-05-05 2003-04-23 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
WO2002028829A2 (en) * 2000-09-25 2002-04-11 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
ATE298565T1 (de) 2000-11-23 2005-07-15 Vernalis Oxford Ltd N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen
EP1363612A4 (de) * 2001-03-01 2006-01-18 Smithkline Beecham Corp Peptid-deformylase-hemmer
JP4220377B2 (ja) * 2001-04-05 2009-02-04 スミスクライン・ビーチャム・コーポレイション ペプチドデホルミラーゼ阻害物質
US7018642B2 (en) 2001-04-27 2006-03-28 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
AU2002256505B2 (en) * 2001-05-11 2008-06-26 Eisai Inc. Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
JP4266815B2 (ja) * 2001-06-05 2009-05-20 スミスクライン・ビーチャム・コーポレイション ペプチドデホルミラーゼ阻害剤
EP1406893B1 (de) 2001-06-15 2007-04-18 Vicuron Pharmaceuticals, Inc. Bicyclische pyrrolidinverbindungen
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
GB0128943D0 (en) 2001-12-04 2002-01-23 Novo Pharmaceuticals De Ltd Bacterial enzyme inhibitors
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
WO2004018453A1 (ja) * 2002-08-23 2004-03-04 Dainippon Pharmaceutical Co., Ltd. プロリン誘導体
ATE417826T1 (de) * 2002-09-19 2009-01-15 Novartis Pharma Gmbh Verfahren zur herstellung von zwischenprodukten
US7442793B2 (en) 2002-12-11 2008-10-28 Smithkline Beecham Corporation Peptide deformylase inhibitors
KR101076018B1 (ko) 2003-01-08 2011-10-21 유니버시티 오브 워싱톤 항균제
MXPA05008842A (es) * 2003-02-21 2005-10-05 Novartis Ag Proceso quimico.
KR100527361B1 (ko) * 2003-04-01 2005-11-09 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
US20070026011A1 (en) * 2003-05-29 2007-02-01 Inhibitex, Inc. Sdr proteins from staphylococcus capitis and their use in preventing and treating infections
WO2005000835A1 (en) * 2003-06-26 2005-01-06 Novartis Ag Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines
KR100750328B1 (ko) * 2004-12-18 2007-08-20 한국생명공학연구원 곰팡이 Ｂｉｏｎｅｃｔｒａ ｂｙｓｓｉｃｏｌａ Ｆ120생산하는 새로운 펩타이드 디포밀레이즈 저해 물질과 그항균활성
KR100648133B1 (ko) * 2005-04-25 2006-11-23 일동제약주식회사 펩티드 데포르밀라제 저해제로서 신규의 히드록사믹 산유도체 및 그 제조방법
GT200600196A (es) 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
PL1951687T3 (pl) * 2005-11-24 2012-01-31 Merck Serono Sa Pochodne N-hydroksyamidu i ich zastosowanie
WO2007067904A2 (en) * 2005-12-06 2007-06-14 Smithkline Beecham Corporation Peptide deformylase inhibitors
KR100878446B1 (ko) * 2007-06-07 2009-01-13 일동제약주식회사 신규 펩티드 데포르밀라제 저해제 화합물 및 그 제조방법
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
WO2009070736A1 (en) 2007-11-29 2009-06-04 Inolex Investment Corporation Preservatives for cosmetic, toiletry and pharmaceutical compositions
JP2011517313A (ja) 2007-12-11 2011-06-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤
JP5524215B2 (ja) * 2008-09-19 2014-06-18 ファイザー・インク 抗菌剤として有用なヒドロキサム酸誘導体
WO2011073845A1 (en) 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
CN102452998B (zh) * 2010-10-20 2014-12-10 天津药物研究院 N-甲酰羟胺类化合物及其制备方法和用途
ES2626457T3 (es) 2011-03-07 2017-07-25 Pfizer Inc. Derivados de fluoro-piridinona útiles como agentes antibacterianos
CA2830866A1 (en) 2011-04-08 2012-10-11 Pfizer Inc. Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
ES2526687T3 (es) 2011-04-08 2015-01-14 Pfizer Inc. Derivados de isoxazol útiles como agentes antibacterianos
EP2847168A1 (de) 2012-05-10 2015-03-18 Achaogen, Inc. Antibakterielle wirkstoffe
FR3098217B1 (fr) * 2019-07-05 2023-04-21 Pharmaleads N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3166587A (en) * 1963-07-29 1965-01-19 Olin Mathieson Alkanoyl, hydroxy-ureas
US3692787A (en) * 1970-02-16 1972-09-19 Burroughs Wellcome Co Substituted 2,4-diamino-5-benzyl pyrimidines
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
DE3320175A1 (de) * 1983-06-03 1984-12-06 Boehringer Mannheim Gmbh, 6800 Mannheim Aminosaeure- bzw. peptidderivate, verfahren zu deren herstellung und verwendung als arzneimittel
DK77487A (da) * 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
DK0485430T3 (da) * 1989-08-01 1999-06-14 Scripps Research Inst Fremgangsmåder og sammensætninger til bedring af symptomer på sepsis
GB9220845D0 (en) 1992-10-03 1992-11-18 British Bio Technology Vasoactive peptide inhibition
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US6028110A (en) * 1994-05-28 2000-02-22 British Biotech Pharmaceuticals Ltd. Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
JP2000511882A (ja) * 1996-04-12 2000-09-12 ブリストル―マイヤーズ・スクイブ・カンパニー Ａｃｅ阻害剤及び／またはｎｅｐ阻害剤として有用なｎ―ホルミルヒドロキシルアミン化合物
EP0863152A3 (de) * 1997-02-10 2000-04-19 Smithkline Beecham Corporation Streptococcus pneumoniae Protein Def1
PL335378A1 (en) * 1997-02-26 2000-04-25 Glaxo Group Ltd Derivatives of inverse hydroxamates as metaloprotease inhibitors
US6586578B1 (en) * 1997-05-21 2003-07-01 Smithkline Beecham Corporation Defl
US5962666A (en) * 1997-09-16 1999-10-05 Smithkline Beecham Corporation Deformylase
DK1052984T3 (da) * 1998-02-07 2004-09-20 Vernalis Oxford Ltd Antibakterielle midler
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
DE69924887T2 (de) * 1999-08-10 2006-03-09 Vernalis (Oxford) Ltd., Abington Antibakterielle mittel

Also Published As

Publication number Publication date
US6423690B1 (en) 2002-07-23
US7148198B2 (en) 2006-12-12
GB2349884A8 (en) 2000-11-20
US20050014702A1 (en) 2005-01-20
AU2529299A (en) 1999-08-23
US20060276409A1 (en) 2006-12-07
ES2221359T3 (es) 2004-12-16
CN1298299A (zh) 2001-06-06
PT1052984E (pt) 2004-09-30
WO1999039704A1 (en) 1999-08-12
WO1999039704A8 (en) 2001-03-08
HUP0102901A2 (hu) 2001-12-28
DE69917221D1 (de) 2004-06-17
AU749699B2 (en) 2002-07-04
ATE266394T1 (de) 2004-05-15
NO20003969D0 (no) 2000-08-04
US20020165167A1 (en) 2002-11-07
IL137312A (en) 2005-12-18
KR20010040621A (ko) 2001-05-15
KR100600518B1 (ko) 2006-07-13
GB0016855D0 (en) 2000-08-30
DK1052984T3 (da) 2004-09-20
US6787522B2 (en) 2004-09-07
NZ505675A (en) 2002-11-26
GB2349884A (en) 2000-11-15
HUP0102901A3 (en) 2002-12-28
TR200002311T2 (tr) 2000-11-21
DE69917221T2 (de) 2005-05-04
US7323448B2 (en) 2008-01-29
PL342296A1 (en) 2001-06-04
JP2002502815A (ja) 2002-01-29
EP1052984B1 (de) 2004-05-12
BR9907689A (pt) 2000-11-14
EP1052984A1 (de) 2000-11-22
CA2320476A1 (en) 1999-08-12
IL137312A0 (en) 2001-07-24
PL194240B1 (pl) 2007-05-31

Similar Documents

Publication Publication Date Title
DK1052984T3 (da) Antibakterielle midler
BR0014651A (pt) Inibidores de adesão de célula mediada por "alfa" l beta2
NO20025725D0 (no) Forbindelse, farmasöytisk preparat inneholdende den samme samt anvendelse derav
AU6613896A (en) Chemical compounds
AU2001266575A1 (en) Chemical compounds
NZ313185A (en) 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
HRP20000585B1 (en) Substituted bisindolymaleimides for the inhibition of cell proliferation
AU9066498A (en) Substituted 6-alkylphenanthridines
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
DE69722031D1 (en) 4- (thien-3-yl)methyl] imidazolderivate mit alpha2-adrenoceptor agonistischer aktivität
AU2001263278A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
DK1204658T3 (da) Benzofurylpiperazin-serotoninagonister
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives
CA2250929A1 (en) 4-[(thien-2-yl)methyl]imidazole derivatives having alpha2-adrenoceptor agonistic activity
UA26459C2 (uk) Іhгібітор впливу амілоїдhих білків
ATE286892T1 (de) Hydroxam- und carbonsäurederivate mit mmp- und tnf-hemmender aktivität
AU5230898A (en) Metalloproteinase inhibitors
YU200791A (sh) Trifluorometil 1-karba (1-detia) cefemi
MX9709468A (es) Composiciones farmaceuticas para minimizar la perdida osea.
GB9723905D0 (en) Heterocyclic compounds having MMP and TNF inhibitory activity
SI0937075T1 (en) New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors.
PT914129E (pt) Utilizacao de aspirocloro ou derivados seus como agentes imunossupresivos
AU3479299A (en) N-aryloxyethyl-indoly-alkylamines for the treatment of depression
CA2250930A1 (en) 4-[(thien-3-yl)methyl] imidazole derivatives having .alpha.2-adrenoceptor agonistic activity

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application