NO20004261L - 2-aryletyl-(piperidin-4-ylmetyl)aminderivater som muscarin- reseptor antagonister - Google Patents
2-aryletyl-(piperidin-4-ylmetyl)aminderivater som muscarin- reseptor antagonisterInfo
- Publication number
- NO20004261L NO20004261L NO20004261A NO20004261A NO20004261L NO 20004261 L NO20004261 L NO 20004261L NO 20004261 A NO20004261 A NO 20004261A NO 20004261 A NO20004261 A NO 20004261A NO 20004261 L NO20004261 L NO 20004261L
- Authority
- NO
- Norway
- Prior art keywords
- arylethyl
- piperidin
- ylmethyl
- receptor antagonists
- muscarinic receptor
- Prior art date
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 150000001412 amines Chemical class 0.000 title 1
- -1 piperidin-4-ylmethyl Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/08—Mydriatics or cycloplegics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7611398P | 1998-02-27 | 1998-02-27 | |
| US10909798P | 1998-11-19 | 1998-11-19 | |
| PCT/EP1999/001102 WO1999043657A1 (en) | 1998-02-27 | 1999-02-19 | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives as muscarinic receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004261D0 NO20004261D0 (no) | 2000-08-25 |
| NO20004261L true NO20004261L (no) | 2000-08-25 |
| NO317106B1 NO317106B1 (no) | 2004-08-09 |
Family
ID=26757679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004261A NO317106B1 (no) | 1998-02-27 | 2000-08-25 | 2-aryletyl-(piperidin-4-ylmetyl)aminderivater som muscarin-reseptor antagonister |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6319920B1 (no) |
| EP (1) | EP1058680B1 (no) |
| JP (1) | JP3523198B2 (no) |
| KR (1) | KR100384906B1 (no) |
| CN (1) | CN1143848C (no) |
| AR (1) | AR015523A1 (no) |
| AT (1) | ATE400554T1 (no) |
| AU (1) | AU753255B2 (no) |
| BR (1) | BR9909253A (no) |
| CA (1) | CA2321198C (no) |
| CO (1) | CO4990939A1 (no) |
| DE (1) | DE69939053D1 (no) |
| ES (1) | ES2310032T3 (no) |
| HR (1) | HRP20000544A2 (no) |
| HU (1) | HUP0100760A3 (no) |
| IL (1) | IL137936A0 (no) |
| MA (1) | MA26610A1 (no) |
| MY (1) | MY133445A (no) |
| NO (1) | NO317106B1 (no) |
| NZ (1) | NZ506317A (no) |
| PE (1) | PE20000325A1 (no) |
| PL (1) | PL194037B1 (no) |
| RU (1) | RU2220138C2 (no) |
| TR (1) | TR200002481T2 (no) |
| WO (1) | WO1999043657A1 (no) |
| YU (1) | YU53100A (no) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2302438A1 (en) * | 1997-05-19 | 1998-11-26 | Sugen, Inc. | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
| AU782191B2 (en) | 2000-05-25 | 2005-07-07 | F. Hoffmann-La Roche Ag | Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists |
| BR0111019A (pt) * | 2000-05-25 | 2003-06-17 | Hoffmann La Roche | 1-aminoalquil-lactamas substituìdas e seu uso como antagonistas de receptores muscarìnicos |
| EP1453806B1 (en) | 2001-12-03 | 2007-12-19 | F. Hoffmann-La Roche Ag | Aminotetralin derivatives as muscarinic receptor antagonist |
| WO2003048124A1 (en) * | 2001-12-03 | 2003-06-12 | F. Hoffmann-La Roche Ag | 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists |
| KR20050008795A (ko) * | 2002-06-07 | 2005-01-21 | 야마노우치세이야쿠 가부시키가이샤 | 과활동 방광 치료제 |
| DE60230683D1 (de) | 2002-07-08 | 2009-02-12 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat |
| CN100364990C (zh) * | 2002-10-30 | 2008-01-30 | 施万制药 | 取代的4-氨基-1-(吡啶甲基)哌啶和相关化合物 |
| TW200800953A (en) * | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| EP1424079A1 (en) * | 2002-11-27 | 2004-06-02 | Boehringer Ingelheim International GmbH | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
| ES2288641T3 (es) * | 2002-12-20 | 2008-01-16 | Dynogen Pharmaceuticals Inc. | Metodo para tratar trastornos indoloros de la vejiga usando moduladores de canales del calcio de la subunidad alfa2-delta. |
| EP1721607A1 (en) * | 2003-03-21 | 2006-11-15 | Dynogen Pharmaceuticals, Inc. | Methods for treating lower urinary tract disorders using smooth muscle modulators and alpha-2-delta subunit calcium channel modulators |
| US7517905B2 (en) | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| CA2522071A1 (en) | 2003-04-11 | 2004-10-21 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
| EP1644356A1 (en) * | 2003-07-11 | 2006-04-12 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| US7214439B2 (en) * | 2003-12-19 | 2007-05-08 | Millennium Cell, Inc. | Triborohydride salts as hydrogen storage materials and preparation thereof |
| WO2008133900A1 (en) | 2007-04-24 | 2008-11-06 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
| DE102007020492A1 (de) * | 2007-04-30 | 2008-11-06 | Grünenthal GmbH | Substituierte Sulfonamid-Derivate |
| EP3170807B1 (en) * | 2015-11-23 | 2019-12-11 | Frau Pharma S.r.l. | New method for synthesis of fenfluramine |
| SI25272A (sl) | 2016-09-23 | 2018-03-30 | Univerza V Ljubljani | Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni |
| CN112824378A (zh) * | 2019-11-20 | 2021-05-21 | 珠海润都制药股份有限公司 | 一种盐酸坦索罗辛的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0361791B1 (en) | 1988-09-26 | 1995-11-08 | Smithkline Beecham Farmaceutici S.p.A. | Azacyclic derivatives useful as medicaments |
| SU1829346A1 (ru) * | 1991-04-01 | 1996-01-10 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | ДИГИДРОХЛОРИДЫ N-[β-(1,2,5-ТРИМЕТИЛ-4-АРИЛПИПЕРИДИН-4-ИЛ)ЭТИЛ]-N-АЛКИЛ-N-(3,4-ДИМЕТОКСИБЕНЗИЛ)АМИНОВ, ЯВЛЯЮЩИЕСЯ ИНГИБИТОРАМИ КАЛЬЦИЙ-КАЛЬМОДУЛИНЗАВИСИМЫХ ПРОЦЕССОВ |
| MY110227A (en) | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| FR2681320B1 (fr) | 1991-09-12 | 1994-01-14 | Synthelabo | Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique. |
| FR2681325B1 (fr) | 1991-09-16 | 1993-12-17 | Fabre Medicament Pierre | Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique. |
| DE69631058T2 (de) | 1995-09-15 | 2004-06-03 | Neurosearch A/S | Piperindinverbindungen als calcium-kanal-blocker |
| ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
-
1999
- 1999-02-01 US US09/241,816 patent/US6319920B1/en not_active Expired - Fee Related
- 1999-02-19 HU HU0100760A patent/HUP0100760A3/hu unknown
- 1999-02-19 PL PL99342692A patent/PL194037B1/pl unknown
- 1999-02-19 IL IL13793699A patent/IL137936A0/xx unknown
- 1999-02-19 JP JP2000533415A patent/JP3523198B2/ja not_active Expired - Fee Related
- 1999-02-19 CN CNB998045322A patent/CN1143848C/zh not_active Expired - Fee Related
- 1999-02-19 NZ NZ506317A patent/NZ506317A/en unknown
- 1999-02-19 DE DE69939053T patent/DE69939053D1/de not_active Expired - Lifetime
- 1999-02-19 AT AT99908933T patent/ATE400554T1/de not_active IP Right Cessation
- 1999-02-19 EP EP99908933A patent/EP1058680B1/en not_active Expired - Lifetime
- 1999-02-19 AU AU28353/99A patent/AU753255B2/en not_active Ceased
- 1999-02-19 KR KR10-2000-7009431A patent/KR100384906B1/ko not_active Expired - Fee Related
- 1999-02-19 YU YU53100A patent/YU53100A/sh unknown
- 1999-02-19 ES ES99908933T patent/ES2310032T3/es not_active Expired - Lifetime
- 1999-02-19 WO PCT/EP1999/001102 patent/WO1999043657A1/en not_active Ceased
- 1999-02-19 CA CA002321198A patent/CA2321198C/en not_active Expired - Fee Related
- 1999-02-19 RU RU2000124676/04A patent/RU2220138C2/ru not_active IP Right Cessation
- 1999-02-19 TR TR2000/02481T patent/TR200002481T2/xx unknown
- 1999-02-19 HR HR20000544A patent/HRP20000544A2/hr not_active Application Discontinuation
- 1999-02-19 BR BR9909253-0A patent/BR9909253A/pt not_active Application Discontinuation
- 1999-02-23 PE PE1999000155A patent/PE20000325A1/es not_active Application Discontinuation
- 1999-02-24 CO CO99011501A patent/CO4990939A1/es unknown
- 1999-02-24 AR ARP990100772A patent/AR015523A1/es not_active Application Discontinuation
- 1999-02-25 MY MYPI99000700A patent/MY133445A/en unknown
- 1999-02-25 MA MA25473A patent/MA26610A1/fr unknown
-
2000
- 2000-08-25 NO NO20004261A patent/NO317106B1/no unknown
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