NO20004312L - Fremgangsmåte for fremstilling av 5-lipoksygenase-inhibitorer med forskjellige heterocycliske ringsystemer - Google Patents

Fremgangsmåte for fremstilling av 5-lipoksygenase-inhibitorer med forskjellige heterocycliske ringsystemer

Info

Publication number: NO20004312L
Authority: NO; Norway
Prior art keywords: naoh; preparation; solvent; koh; formula
Prior art date: 1999-08-31

Application number

NO20004312A

Other languages

English (en)

Norwegian (no)

Other versions

NO20004312D0 (no

Inventor

Timothy Norris

Megan Elizabeth Hnatow

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-31

Filing date

2000-08-30

Publication date

2001-03-01

2000-08-30 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-08-30 Publication of NO20004312D0 publication Critical patent/NO20004312D0/no

2001-03-01 Publication of NO20004312L publication Critical patent/NO20004312L/no

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000000867 Lipoxygenase Inhibitor Substances 0.000 title 1
125000000623 heterocyclic group Chemical group 0.000 title 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 9
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 3
239000003444 phase transfer catalyst Substances 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical group [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 abstract 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
150000001491 aromatic compounds Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
239000012299 nitrogen atmosphere Substances 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
-1 palladium metal complex Chemical class 0.000 abstract 1
239000008188 pellet Substances 0.000 abstract 1
150000004714 phosphonium salts Chemical class 0.000 abstract 1
239000000843 powder Substances 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1
150000003624 transition metals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrane Compounds (AREA)
Pyridine Compounds (AREA)
Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

NO20004312A 1999-08-31 2000-08-30 Fremgangsmåte for fremstilling av 5-lipoksygenase-inhibitorer med forskjellige heterocycliske ringsystemer NO20004312L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US15161099P	1999-08-31	1999-08-31

Publications (2)

Publication Number	Publication Date
NO20004312D0 NO20004312D0 (no)	2000-08-30
NO20004312L true NO20004312L (no)	2001-03-01

Family

ID=22539510

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20004312A NO20004312L (no)	1999-08-31	2000-08-30	Fremgangsmåte for fremstilling av 5-lipoksygenase-inhibitorer med forskjellige heterocycliske ringsystemer

Country Status (33)

Country	Link
EP (1)	EP1081144A3 (is)
JP (1)	JP2001106686A (is)
KR (1)	KR20010050274A (is)
CN (1)	CN1286251A (is)
AP (1)	AP2000001909A0 (is)
AR (1)	AR022650A1 (is)
AU (1)	AU5370200A (is)
BG (1)	BG104730A (is)
BR (1)	BR0003888A (is)
CA (1)	CA2316748A1 (is)
CO (1)	CO5180623A1 (is)
CZ (1)	CZ20003159A3 (is)
EA (1)	EA200000803A3 (is)
EE (1)	EE200000513A (is)
GT (1)	GT200000144A (is)
HR (1)	HRP20000565A2 (is)
HU (1)	HUP0003437A3 (is)
ID (1)	ID27128A (is)
IL (1)	IL138089A0 (is)
IS (1)	IS5604A (is)
MA (1)	MA26750A1 (is)
NO (1)	NO20004312L (is)
NZ (1)	NZ506633A (is)
OA (1)	OA11451A (is)
PA (1)	PA8499601A1 (is)
PE (1)	PE20010523A1 (is)
PL (1)	PL342280A1 (is)
SG (1)	SG87145A1 (is)
SK (1)	SK12862000A3 (is)
SV (1)	SV2002000160A (is)
TN (1)	TNSN00176A1 (is)
TR (1)	TR200002530A2 (is)
UY (1)	UY26315A1 (is)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004112837A1 (ja) *	2003-05-23	2004-12-29	Hisamitsu Pharmaceutical Co., Inc.	非ステロイド系消炎鎮痛剤含有外用経皮製剤およびインターロイキン－１α生成抑制剤
EP1834953A1 (en) *	2006-03-14	2007-09-19	Ranbaxy Laboratories Limited	Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors
CN103980312B (zh) *	2014-05-27	2016-09-07	广州大学	一种n杂环双膦配体及其合成方法
WO2025038927A1 (en) *	2023-08-16	2025-02-20	Raythera, Inc.	Modulators of tnf alpha activity and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK281577B6 (sk) *	1994-10-18	2001-05-10	Pfizer Inc.	Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze

2000
- 2000-08-01 SG SG200004340A patent/SG87145A1/en unknown
- 2000-08-10 PA PA20008499601A patent/PA8499601A1/es unknown
- 2000-08-11 CO CO00060138A patent/CO5180623A1/es not_active Application Discontinuation
- 2000-08-17 EP EP00307046A patent/EP1081144A3/en not_active Withdrawn
- 2000-08-18 OA OA1200000224A patent/OA11451A/en unknown
- 2000-08-24 TN TNTNSN00176A patent/TNSN00176A1/fr unknown
- 2000-08-24 IL IL13808900A patent/IL138089A0/xx unknown
- 2000-08-25 SK SK1286-2000A patent/SK12862000A3/sk unknown
- 2000-08-25 IS IS5604A patent/IS5604A/is unknown
- 2000-08-28 UY UY26315A patent/UY26315A1/es not_active Application Discontinuation
- 2000-08-28 ID IDP20000710A patent/ID27128A/id unknown
- 2000-08-29 AU AU53702/00A patent/AU5370200A/en not_active Abandoned
- 2000-08-29 AR ARP000104489A patent/AR022650A1/es not_active Application Discontinuation
- 2000-08-29 BG BG104730A patent/BG104730A/xx unknown
- 2000-08-29 CA CA002316748A patent/CA2316748A1/en not_active Abandoned
- 2000-08-29 GT GT200000144A patent/GT200000144A/es unknown
- 2000-08-29 PE PE2000000886A patent/PE20010523A1/es not_active Application Discontinuation
- 2000-08-30 HU HU0003437A patent/HUP0003437A3/hu unknown
- 2000-08-30 NZ NZ506633A patent/NZ506633A/en unknown
- 2000-08-30 BR BR0003888-1A patent/BR0003888A/pt not_active IP Right Cessation
- 2000-08-30 SV SV2000000160A patent/SV2002000160A/es unknown
- 2000-08-30 NO NO20004312A patent/NO20004312L/no not_active Application Discontinuation
- 2000-08-30 HR HR20000565A patent/HRP20000565A2/hr not_active Application Discontinuation
- 2000-08-30 MA MA26053A patent/MA26750A1/fr unknown
- 2000-08-30 CZ CZ20003159A patent/CZ20003159A3/cs unknown
- 2000-08-30 KR KR1020000050877A patent/KR20010050274A/ko not_active Abandoned
- 2000-08-30 CN CN00126409A patent/CN1286251A/zh active Pending
- 2000-08-31 EE EEP200000513A patent/EE200000513A/xx unknown
- 2000-08-31 EA EA200000803A patent/EA200000803A3/ru unknown
- 2000-08-31 AP APAP/P/2000/001909A patent/AP2000001909A0/en unknown
- 2000-08-31 PL PL00342280A patent/PL342280A1/xx not_active Application Discontinuation
- 2000-08-31 TR TR2000/02530A patent/TR200002530A2/xx unknown
- 2000-08-31 JP JP2000262200A patent/JP2001106686A/ja active Pending

Also Published As

Publication number	Publication date
TNSN00176A1 (fr)	2005-11-10
SV2002000160A (es)	2002-01-23
PE20010523A1 (es)	2001-04-28
OA11451A (en)	2003-12-08
TR200002530A2 (tr)	2001-04-20
NO20004312D0 (no)	2000-08-30
CZ20003159A3 (cs)	2001-12-12
NZ506633A (en)	2001-12-21
ID27128A (id)	2001-03-01
AR022650A1 (es)	2002-09-04
HUP0003437A2 (hu)	2001-06-28
AP2000001909A0 (en)	2000-09-30
KR20010050274A (ko)	2001-06-15
EP1081144A3 (en)	2001-04-11
GT200000144A (es)	2002-02-20
SK12862000A3 (sk)	2002-02-05
UY26315A1 (es)	2001-04-30
EA200000803A2 (ru)	2001-04-23
PA8499601A1 (es)	2002-02-21
BG104730A (en)	2001-09-28
BR0003888A (pt)	2001-12-11
CN1286251A (zh)	2001-03-07
IL138089A0 (en)	2001-10-31
MA26750A1 (fr)	2004-12-20
CA2316748A1 (en)	2001-02-28
HUP0003437A3 (en)	2002-08-28
JP2001106686A (ja)	2001-04-17
EP1081144A2 (en)	2001-03-07
EE200000513A (et)	2001-04-16
SG87145A1 (en)	2002-03-19
HRP20000565A2 (en)	2001-06-30
CO5180623A1 (es)	2002-07-30
PL342280A1 (en)	2001-03-12
AU5370200A (en)	2001-03-08
EA200000803A3 (ru)	2001-06-25
HU0003437D0 (en)	2000-08-30
IS5604A (is)	2001-03-01

Legal Events

Date	Code	Title	Description
2002-04-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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NO20004312L (no)	2001-03-01	Fremgangsmåte for fremstilling av 5-lipoksygenase-inhibitorer med forskjellige heterocycliske ringsystemer
IL133814A (en)	2005-07-25	Process for the preparation of 1-aryl-3-cyclopropyl-1,3-propanediones
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TW306923B (is)	1997-06-01
JPS54145632A (en)	1979-11-14	Preparation of 2-cyanophenol derivative