NO20004431L - Glysintransportinhibitorer - Google Patents

Glysintransportinhibitorer

Info

Publication number
NO20004431L
NO20004431L NO20004431A NO20004431A NO20004431L NO 20004431 L NO20004431 L NO 20004431L NO 20004431 A NO20004431 A NO 20004431A NO 20004431 A NO20004431 A NO 20004431A NO 20004431 L NO20004431 L NO 20004431L
Authority
NO
Norway
Prior art keywords
epsi
epilepsy
piperazinyl
piperidinyl
fluorophenyl
Prior art date
Application number
NO20004431A
Other languages
Norwegian (no)
Other versions
NO20004431D0 (en
Inventor
Walter Herman Maria Lou Luyten
Frans Eduard Janssens
Ludo Edmond Josephine Kennis
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20004431D0 publication Critical patent/NO20004431D0/en
Publication of NO20004431L publication Critical patent/NO20004431L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Den foreliggende oppfinnelse vedrører anvendelsen av glysintransportinhiberende 4,4-bis (4-fluorfenyl)butyl]-1-(piperazinyl og piperidinyl)-derivater ved fremstillingen av medikamenter for å behandle forstyrrelser i det sentrale og perifere nervesystem, spesielt psykoser, smerte, epil-epsi, nevrodegenerative sykdommer (Alzheimers sykdom),. slag, hodetraume, multippel sklerose og lignende. Opp-finnelsen omfatter videre nye forbindelser, deres frem-stilling og deres farmasøytisk former.The present invention relates to the use of glycine transport inhibiting 4,4-bis (4-fluorophenyl) butyl] -1- (piperazinyl and piperidinyl) derivatives in the manufacture of medicaments for the treatment of disorders of the central and peripheral nervous system, in particular psychoses, pain, epilepsy. -epsi, neurodegenerative diseases (Alzheimer's disease) ,. stroke, head trauma, multiple sclerosis and the like. The invention further encompasses novel compounds, their preparation and their pharmaceutical forms.

NO20004431A 1998-03-06 2000-09-05 Glysintransportinhibitorer NO20004431L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200701 1998-03-06
PCT/EP1999/001309 WO1999044596A2 (en) 1998-03-06 1999-02-26 Glycine transport inhibitors

Publications (2)

Publication Number Publication Date
NO20004431D0 NO20004431D0 (en) 2000-09-05
NO20004431L true NO20004431L (en) 2000-10-30

Family

ID=8233444

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004431A NO20004431L (en) 1998-03-06 2000-09-05 Glysintransportinhibitorer

Country Status (17)

Country Link
EP (1) EP1059922A2 (en)
JP (1) JP2002505277A (en)
KR (1) KR20010032968A (en)
CN (1) CN1292698A (en)
AU (1) AU3408999A (en)
BG (1) BG104685A (en)
BR (1) BR9907951A (en)
CA (1) CA2322164A1 (en)
EE (1) EE200000482A (en)
HR (1) HRP20000523A2 (en)
HU (1) HUP0101048A2 (en)
IL (1) IL138228A0 (en)
NO (1) NO20004431L (en)
PL (1) PL343435A1 (en)
SK (1) SK13082000A3 (en)
TR (1) TR200002567T2 (en)
WO (1) WO1999044596A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20014573A3 (en) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Respiratory syncytial virus replication inhibitors
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
EP1296950A2 (en) * 2000-04-20 2003-04-02 NPS Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors
DE10040016A1 (en) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Novel beta-amyloid inhibitors, process for their preparation and their use as pharmaceuticals
US20020120149A1 (en) 2000-09-08 2002-08-29 Ali Syed M. Substituted hydrazine derivatives
US20020082283A1 (en) * 2000-09-14 2002-06-27 Gliatech, Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
AR032653A1 (en) 2001-02-09 2003-11-19 Telik Inc HYPERCYCLIC INHIBITORS OF THE GLICINE TRANSPORTER 2 PHARMACEUTICAL COMPOSITIONS, USE AND METHODS.
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
DK1663232T3 (en) * 2003-09-09 2008-02-04 Hoffmann La Roche Benzimidazole derivatives as human chymase inhibitors
JP4563387B2 (en) * 2003-09-09 2010-10-13 エフ．ホフマン−ラ ロシュ アーゲー 1-Benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychosis
WO2005058885A2 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Piperidine derivatives and their use as glycine transporter inhibitors
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
KR100880093B1 (en) * 2004-12-09 2009-01-23 에프. 호프만-라 로슈 아게 Phenyl-piperazine Methanone Derivatives
CA2590316A1 (en) * 2004-12-15 2006-06-22 F. Hoffmann-La Roche Ag Bi- and tricyclic substituted phenyl methanones as glycine transporter i (glyt-1) inhibitors for the treatment of alzheimer's disease
PE20061156A1 (en) 2004-12-23 2006-12-16 Glaxo Group Ltd BENZAMIDE DERIVATIVES AS INHIBITING AGENTS OF THE GLYCINE TRANSPORTER
GB0428233D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
KR20070094955A (en) * 2005-01-06 2007-09-27 에프. 호프만-라 로슈 아게 Sulfanyl-substituted phenylmethanones as glycine transporter 1 (XLVT-1) inhibitors for the treatment of neurological and neuropsychiatric diseases
RU2396270C2 (en) * 2005-01-07 2010-08-10 Ф.Хоффманн-Ля Рош Аг [4-(heteroaryl)piperazine-1-yl]-(2,5-substituted phenyl)methanone derivatives as glycine-1 (glyt-1) carrier inhibitors for treating neurologic and psychoneurological diseases
JP2008527016A (en) * 2005-01-18 2008-07-24 エフ．ホフマン−ラ ロシュ アーゲー 2,5-Disubstituted phenylmethanone derivatives as glycine transporter 1 (GlyT-1) inhibitors for the treatment of neurological and neuropsychiatric diseases
ES2332529T3 (en) 2005-01-26 2010-02-08 F. Hoffmann-La Roche Ag DERIVATIVES OF PHENYL-METANONE AND ITS EMPLOYMENT AS INHIBITORS OF GLICINE TRANSPORTER 1.
CN101119968B (en) * 2005-02-07 2011-08-31 弗·哈夫曼-拉罗切有限公司 Heterocyclic-substituted phenylphenone derivatives as inhibitors of glycine transporter 1
CN100341871C (en) * 2005-06-03 2007-10-10 复旦大学 Organic sulfur compound containing piperidine structure, its preparation and use
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
WO2007118853A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
ES2389456T3 (en) 2006-11-01 2012-10-26 Purdue Pharma Lp Phenylpropionamide compounds and their use
FR2910321B1 (en) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc CREAM GEL COMPRISING AT LEAST ONE RETINOID AND BENZOLE PEROXIDE
FR2910320B1 (en) * 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc EMULSION COMPRISING AT LEAST ONE RETINOID AND BENZOLE PEROXIDE
US8399486B2 (en) 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US8258306B2 (en) * 2007-12-12 2012-09-04 Amgen Inc. Glycine transporter-1 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
AU1041599A (en) * 1997-11-13 1999-06-07 Jose Luis Castro Pineiro Therapeutic uses of triazolo-pyridazine derivatives

Also Published As

Publication number Publication date
WO1999044596A2 (en) 1999-09-10
EP1059922A2 (en) 2000-12-20
IL138228A0 (en) 2001-10-31
TR200002567T2 (en) 2000-11-21
BG104685A (en) 2001-04-30
BR9907951A (en) 2001-01-30
CN1292698A (en) 2001-04-25
KR20010032968A (en) 2001-04-25
WO1999044596A3 (en) 2000-02-17
NO20004431D0 (en) 2000-09-05
PL343435A1 (en) 2001-08-13
CA2322164A1 (en) 1999-09-10
SK13082000A3 (en) 2001-03-12
AU3408999A (en) 1999-09-20
HUP0101048A2 (en) 2001-10-28
EE200000482A (en) 2002-02-15
HRP20000523A2 (en) 2001-02-28
JP2002505277A (en) 2002-02-19

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