NO20004668D0 - 1-(3-heteroarylpropyl- eller -prop-2-enyl)-4- benzylpiperidiner anvendt som NMDA-reseptorantagonister - Google Patents
1-(3-heteroarylpropyl- eller -prop-2-enyl)-4- benzylpiperidiner anvendt som NMDA-reseptorantagonisterInfo
- Publication number
- NO20004668D0 NO20004668D0 NO20004668A NO20004668A NO20004668D0 NO 20004668 D0 NO20004668 D0 NO 20004668D0 NO 20004668 A NO20004668 A NO 20004668A NO 20004668 A NO20004668 A NO 20004668A NO 20004668 D0 NO20004668 D0 NO 20004668D0
- Authority
- NO
- Norway
- Prior art keywords
- benzylpiperidines
- heteroarylpropyl
- enyl
- prop
- receptor antagonists
- Prior art date
Links
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19812331A DE19812331A1 (de) | 1998-03-20 | 1998-03-20 | Piperidinderivate |
| PCT/EP1999/001573 WO1999048891A1 (de) | 1998-03-20 | 1999-03-11 | 1-(3 -heteroarylpropyl- oder -prop -2-enyl) -4-benzylpiperidine als nmda-rezeptor-antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004668L NO20004668L (no) | 2000-09-19 |
| NO20004668D0 true NO20004668D0 (no) | 2000-09-19 |
Family
ID=7861717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004668A NO20004668D0 (no) | 1998-03-20 | 2000-09-19 | 1-(3-heteroarylpropyl- eller -prop-2-enyl)-4- benzylpiperidiner anvendt som NMDA-reseptorantagonister |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6548516B1 (pt) |
| EP (1) | EP1068202B1 (pt) |
| JP (1) | JP4451565B2 (pt) |
| KR (1) | KR20010042047A (pt) |
| CN (1) | CN1123571C (pt) |
| AR (1) | AR014747A1 (pt) |
| AT (1) | ATE416173T1 (pt) |
| AU (1) | AU747900B2 (pt) |
| BR (1) | BR9908902A (pt) |
| CA (1) | CA2324339C (pt) |
| DE (2) | DE19812331A1 (pt) |
| DK (1) | DK1068202T3 (pt) |
| ES (1) | ES2316184T3 (pt) |
| HU (1) | HUP0101220A3 (pt) |
| ID (1) | ID26125A (pt) |
| NO (1) | NO20004668D0 (pt) |
| PL (1) | PL342732A1 (pt) |
| PT (1) | PT1068202E (pt) |
| RU (1) | RU2217429C2 (pt) |
| SK (1) | SK13692000A3 (pt) |
| WO (1) | WO1999048891A1 (pt) |
| ZA (1) | ZA992191B (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE200200667A (et) | 2000-05-31 | 2004-06-15 | Warner-Lambert Company | Bitsüklilised tsükloheksüülamiinid ja nende kasutamine NMDA retseptori antagonistidena |
| AU2001263130A1 (en) | 2000-06-06 | 2001-12-17 | Warner Lambert Company | Bicyclic cyclohexylamines and their use as nmda receptor antagonists |
| MXPA03004652A (es) | 2000-12-21 | 2003-09-05 | Warner Lambert Co | Derivados de piperidina como antagonistas selectivos de subtipo de n-metil-d-aspartato. |
| MXPA02002749A (es) | 2001-03-27 | 2002-10-28 | Warner Lambert Co | Derivados de ciclohexilamina como antagonistas del subtipo selectivo del n-metil-d-aspartato. |
| DE10248067A1 (de) * | 2002-10-07 | 2004-04-15 | Proteosys Ag | Heteroarylpropyl-Piperazine und Heteroarylpropyl-Piperidine |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (en) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP2013514379A (ja) * | 2009-12-15 | 2013-04-25 | ニユーロツプ・インコーポレイテツド | 神経障害の治療のための化合物 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| CN102133198B (zh) * | 2011-03-09 | 2012-02-08 | 北京四环科宝制药有限公司 | 一种酒石酸艾芬地尔冻干粉针剂及其制备方法 |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| CN103965188A (zh) * | 2013-01-29 | 2014-08-06 | 中山大学 | 含硒多奈哌齐类似物 |
| KR20170141769A (ko) * | 2015-04-29 | 2017-12-26 | 얀센 파마슈티카 엔.브이. | 인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도 |
| ES2865330T3 (es) | 2015-04-29 | 2021-10-15 | Janssen Pharmaceutica Nv | Azabenzimidazoles y su uso como moduladores del receptor AMPA |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| JP3084729B2 (ja) * | 1990-06-15 | 2000-09-04 | 横河電機株式会社 | デジタルオシロスコープ |
| TW281670B (pt) | 1993-09-02 | 1996-07-21 | Hoffmann La Roche | |
| FR2717810B1 (fr) * | 1994-03-22 | 1996-04-26 | Adir | Nouvelles aminoalkyl benzoxazolinones et benzothiazolinones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| AU3138595A (en) | 1994-07-20 | 1996-02-16 | Acea Pharmaceuticals, Inc. | Haloperidol analogs and the use thereof |
| ATE174915T1 (de) * | 1994-10-31 | 1999-01-15 | Merck Patent Gmbh | Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| DE19643790A1 (de) | 1996-10-30 | 1998-05-07 | Merck Patent Gmbh | Benzoxazol-Derivat |
-
1998
- 1998-03-20 DE DE19812331A patent/DE19812331A1/de not_active Withdrawn
-
1999
- 1999-03-11 AU AU34105/99A patent/AU747900B2/en not_active Ceased
- 1999-03-11 RU RU2000126475/04A patent/RU2217429C2/ru not_active IP Right Cessation
- 1999-03-11 ID IDW20002091A patent/ID26125A/id unknown
- 1999-03-11 EP EP99915568A patent/EP1068202B1/de not_active Expired - Lifetime
- 1999-03-11 BR BR9908902-5A patent/BR9908902A/pt not_active IP Right Cessation
- 1999-03-11 JP JP2000537874A patent/JP4451565B2/ja not_active Expired - Fee Related
- 1999-03-11 HU HU0101220A patent/HUP0101220A3/hu unknown
- 1999-03-11 SK SK1369-2000A patent/SK13692000A3/sk unknown
- 1999-03-11 CA CA002324339A patent/CA2324339C/en not_active Expired - Fee Related
- 1999-03-11 KR KR1020007010387A patent/KR20010042047A/ko not_active Withdrawn
- 1999-03-11 PT PT99915568T patent/PT1068202E/pt unknown
- 1999-03-11 AT AT99915568T patent/ATE416173T1/de not_active IP Right Cessation
- 1999-03-11 DE DE59914921T patent/DE59914921D1/de not_active Expired - Lifetime
- 1999-03-11 ES ES99915568T patent/ES2316184T3/es not_active Expired - Lifetime
- 1999-03-11 WO PCT/EP1999/001573 patent/WO1999048891A1/de not_active Ceased
- 1999-03-11 PL PL99342732A patent/PL342732A1/xx not_active Application Discontinuation
- 1999-03-11 US US09/646,185 patent/US6548516B1/en not_active Expired - Fee Related
- 1999-03-11 DK DK99915568T patent/DK1068202T3/da active
- 1999-03-11 CN CN99804190A patent/CN1123571C/zh not_active Expired - Fee Related
- 1999-03-18 ZA ZA9902191A patent/ZA992191B/xx unknown
- 1999-03-19 AR ARP990101208A patent/AR014747A1/es not_active Application Discontinuation
-
2000
- 2000-09-19 NO NO20004668A patent/NO20004668D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU747900B2 (en) | 2002-05-30 |
| EP1068202A1 (de) | 2001-01-17 |
| ATE416173T1 (de) | 2008-12-15 |
| PT1068202E (pt) | 2009-03-06 |
| ID26125A (id) | 2000-11-23 |
| NO20004668L (no) | 2000-09-19 |
| RU2217429C2 (ru) | 2003-11-27 |
| JP2002507613A (ja) | 2002-03-12 |
| SK13692000A3 (sk) | 2001-02-12 |
| ES2316184T3 (es) | 2009-04-01 |
| CN1293673A (zh) | 2001-05-02 |
| HUP0101220A2 (hu) | 2002-05-29 |
| BR9908902A (pt) | 2000-11-28 |
| WO1999048891A1 (de) | 1999-09-30 |
| JP4451565B2 (ja) | 2010-04-14 |
| AR014747A1 (es) | 2001-03-28 |
| CA2324339A1 (en) | 1999-09-30 |
| PL342732A1 (en) | 2001-07-02 |
| DK1068202T3 (da) | 2009-03-16 |
| AU3410599A (en) | 1999-10-18 |
| DE59914921D1 (de) | 2009-01-15 |
| DE19812331A1 (de) | 1999-09-23 |
| EP1068202B1 (de) | 2008-12-03 |
| US6548516B1 (en) | 2003-04-15 |
| HUP0101220A3 (en) | 2003-08-28 |
| CN1123571C (zh) | 2003-10-08 |
| ZA992191B (en) | 1999-09-29 |
| CA2324339C (en) | 2010-01-12 |
| KR20010042047A (ko) | 2001-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20004668D0 (no) | 1-(3-heteroarylpropyl- eller -prop-2-enyl)-4- benzylpiperidiner anvendt som NMDA-reseptorantagonister | |
| DK1009732T3 (da) | 1-Amino-alkylcyclohexan NMDA receptor antagonister | |
| NO20012948L (no) | Hydroksydifenylureasulfonamider som IL-8 reseptor antagonister | |
| NO20012411D0 (no) | Pyrrolidin-derivater-CCR-3-reseptorantagonister | |
| NO985225L (no) | Indolderivater nyttige som endotelinreseptorantagonister | |
| ATE280157T1 (de) | 4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii | |
| NO20023485D0 (no) | 1,3-disubstituerte pyrrolidiner som alfa-2- adrenoceptorantagonister | |
| DE69812096D1 (de) | Neuropeptid y rezeptorantagonisten | |
| IS5706A (is) | Adenosín A3 viðtakastillar | |
| FI971026A7 (fi) | Kinoksaliinidioni-NMDA-reseptoriantagonisteja | |
| ID24726A (id) | Antagonis-antagonis reseptor trombin | |
| ID26223A (id) | Antagonis reseptor vitronektin | |
| ID24162A (id) | Antagonis-antagonis reseptor vitronektin | |
| DK0854867T3 (da) | Tetrahydroquinoliner som NMDA-antagonister | |
| TR199501389A2 (tr) | Adesyon reseptörü antagonistleri (karsitlari). | |
| ID26086A (id) | Ligan-ligan reseptor 5ht1 azabisiklik | |
| DK0964863T3 (da) | Oxazolidinoner som 5-HT2A-antagonister | |
| NO20020578D0 (no) | Substituerte pyrrolidin-2,3,4-trion-3-oskimderivater som er nyttige som NMDA-reseptorantagonister | |
| ID28811A (id) | Antagonis reseptor vitronektin | |
| DK0912556T3 (da) | Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister | |
| NO985972L (no) | Indolinderivater anvendelige som 5-HT-2C reseptorantagonister | |
| NO20002575D0 (no) | Substituerte oksimer som neurokininantagonister | |
| NO963775D0 (no) | Indol-derivater som CCK-reseptorantagonister | |
| DK1200400T3 (da) | Substituerede pyrrolidin-2,3,4-trion derivater, der er anvendelse som NMDA-receptorantagonister | |
| DK1207159T3 (da) | Heteroaromatiske derivater som dopamin-D4-receptorantagonister |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |