DK0912556T3 - Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister - Google Patents

Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister

Info

Publication number: DK0912556T3
Authority: DK; Denmark
Prior art keywords: receptor antagonists; derivatives useful; indoline derivatives; indoline; useful
Prior art date: 1996-06-20

Application number

DK97929202T

Other languages

English (en)

Inventor

Steven M Bromidge

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-20

Filing date

1997-06-16

Publication date

2001-01-22

1997-06-16 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2001-01-22 Application granted granted Critical

2001-01-22 Publication of DK0912556T3 publication Critical patent/DK0912556T3/da

Links

102000006902 5-HT2C Serotonin Receptor Human genes 0.000 title 1
108010072553 5-HT2C Serotonin Receptor Proteins 0.000 title 1
125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK97929202T 1996-06-20 1997-06-16 Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister DK0912556T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9612885.5A GB9612885D0 (en)	1996-06-20	1996-06-20	Novel compounds
PCT/EP1997/003157 WO1997048700A1 (en)	1996-06-20	1997-06-16	Indoline derivatives useful as 5-ht-2c receptor antagonists

Publications (1)

Publication Number	Publication Date
DK0912556T3 true DK0912556T3 (da)	2001-01-22

Family

ID=10795577

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97929202T DK0912556T3 (da)	1996-06-20	1997-06-16	Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister

Country Status (27)

Country	Link
US (2)	US6313145B1 (da)
EP (1)	EP0912556B1 (da)
JP (1)	JP2000512644A (da)
KR (1)	KR20040101563A (da)
CN (1)	CN1147485C (da)
AR (1)	AR008244A1 (da)
AT (1)	ATE196766T1 (da)
AU (1)	AU718000B2 (da)
BR (1)	BR9709982A (da)
CA (1)	CA2258559A1 (da)
CO (1)	CO4870758A1 (da)
CZ (1)	CZ289799B6 (da)
DE (1)	DE69703242T2 (da)
DK (1)	DK0912556T3 (da)
ES (1)	ES2152682T3 (da)
GB (1)	GB9612885D0 (da)
GR (1)	GR3034847T3 (da)
HU (1)	HUP9903480A3 (da)
IL (1)	IL127304A (da)
NO (1)	NO316756B1 (da)
NZ (1)	NZ332840A (da)
PL (1)	PL186885B1 (da)
PT (1)	PT912556E (da)
TR (1)	TR199802552T2 (da)
TW (1)	TW360650B (da)
WO (1)	WO1997048700A1 (da)
ZA (1)	ZA975416B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9710523D0 (en) *	1997-05-23	1997-07-16	Smithkline Beecham Plc	Novel compounds
WO1999043650A2 (en) *	1998-02-25	1999-09-02	Smithkline Beecham Plc	Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) *	2000-08-12	2000-09-27	Smithkline Beecham Plc	Compounds
US20030008880A1 (en) *	2001-05-02	2003-01-09	Pfizer Inc.	4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
JP2005535560A (ja)	2001-11-28	2005-11-24	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	治療用の化合物
GB0200283D0 (en) *	2002-01-08	2002-02-20	Smithkline Beecham Plc	Compounds
MXPA04008517A (es)	2002-03-04	2005-08-19	Pharmacia & Upjohn Co Llc	Compuestos terapeuticos.
ATE423094T1 (de) *	2002-04-19	2009-03-15	Glaxo Group Ltd	Verbindungen mit affinität zum 5ht2c-rezeptor und deren therapeutische verwendung
GB0305024D0 (en) *	2003-03-05	2003-04-09	Glaxo Group Ltd	Compounds
GB0305553D0 (en) *	2003-03-11	2003-04-16	Glaxo Group Ltd	Compounds
KR101062376B1 (ko) *	2008-04-10	2011-09-06	한국화학연구원	신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
CN102348798A (zh)	2009-01-16	2012-02-08	麻省理工学院	孤独症谱系障碍的诊断和治疗

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2142721A1 (en)	1992-08-20	1994-03-03	Ian T. Forbes	Condensed indole derivatives as 5ht and 5ht antagonists
GB9313913D0 (en)	1993-07-06	1993-08-18	Smithkline Beecham Plc	Novel compounds
WO1996023769A2 (en)	1995-02-02	1996-08-08	Smithkline Beecham Plc	Heterocyclic compounds possessing 5ht2c receptor antagonist activity
NZ301265A (en) *	1995-02-02	1998-12-23	Smithkline Beecham Plc	Indole derivatives as 5ht receptor antagonists, preparation and pharmaceutical compositions thereof
GB9607219D0 (en)	1996-04-04	1996-06-12	Smithkline Beecham Plc	Novel compounds
US6028055A (en)	1996-10-22	2000-02-22	Genetech, Inc.	Receptor selective BNP

1996
- 1996-06-20 GB GBGB9612885.5A patent/GB9612885D0/en active Pending
1997
- 1997-06-16 IL IL12730497A patent/IL127304A/xx not_active IP Right Cessation
- 1997-06-16 JP JP10502260A patent/JP2000512644A/ja not_active Ceased
- 1997-06-16 NZ NZ332840A patent/NZ332840A/xx unknown
- 1997-06-16 TR TR1998/02552T patent/TR199802552T2/xx unknown
- 1997-06-16 PL PL97330708A patent/PL186885B1/pl not_active IP Right Cessation
- 1997-06-16 CA CA002258559A patent/CA2258559A1/en not_active Abandoned
- 1997-06-16 AU AU33396/97A patent/AU718000B2/en not_active Ceased
- 1997-06-16 BR BR9709982A patent/BR9709982A/pt not_active Application Discontinuation
- 1997-06-16 HU HU9903480A patent/HUP9903480A3/hu not_active Application Discontinuation
- 1997-06-16 US US09/202,772 patent/US6313145B1/en not_active Expired - Fee Related
- 1997-06-16 KR KR10-2004-7017304A patent/KR20040101563A/ko not_active Abandoned
- 1997-06-16 PT PT97929202T patent/PT912556E/pt unknown
- 1997-06-16 CZ CZ19984204A patent/CZ289799B6/cs not_active IP Right Cessation
- 1997-06-16 DK DK97929202T patent/DK0912556T3/da active
- 1997-06-16 CN CNB971955395A patent/CN1147485C/zh not_active Expired - Fee Related
- 1997-06-16 AT AT97929202T patent/ATE196766T1/de not_active IP Right Cessation
- 1997-06-16 ES ES97929202T patent/ES2152682T3/es not_active Expired - Lifetime
- 1997-06-16 WO PCT/EP1997/003157 patent/WO1997048700A1/en not_active Ceased
- 1997-06-16 DE DE69703242T patent/DE69703242T2/de not_active Expired - Fee Related
- 1997-06-16 EP EP97929202A patent/EP0912556B1/en not_active Expired - Lifetime
- 1997-06-18 AR ARP970102675A patent/AR008244A1/es active IP Right Grant
- 1997-06-19 ZA ZA975416A patent/ZA975416B/xx unknown
- 1997-06-19 TW TW086108550A patent/TW360650B/zh active
- 1997-06-20 CO CO97034433A patent/CO4870758A1/es unknown
1998
- 1998-12-18 NO NO19985970A patent/NO316756B1/no unknown
2000
- 2000-11-14 GR GR20000402536T patent/GR3034847T3/el not_active IP Right Cessation
2001
- 2001-09-06 US US09/948,289 patent/US20020035134A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US6313145B1 (en)	2001-11-06
NO985970D0 (no)	1998-12-18
GB9612885D0 (en)	1996-08-21
ZA975416B (en)	1999-01-25
US20020035134A1 (en)	2002-03-21
EP0912556B1 (en)	2000-10-04
CO4870758A1 (es)	1999-12-27
NO985970L (no)	1998-12-18
GR3034847T3 (en)	2001-02-28
CZ420498A3 (cs)	1999-05-12
BR9709982A (pt)	1999-08-10
AU3339697A (en)	1998-01-07
NZ332840A (en)	2000-05-26
AU718000B2 (en)	2000-04-06
DE69703242T2 (de)	2001-03-08
HUP9903480A3 (en)	2002-12-28
JP2000512644A (ja)	2000-09-26
ES2152682T3 (es)	2001-02-01
NO316756B1 (no)	2004-04-26
CZ289799B6 (cs)	2002-04-17
EP0912556A1 (en)	1999-05-06
PT912556E (pt)	2001-02-28
KR20040101563A (ko)	2004-12-02
DE69703242D1 (de)	2000-11-09
AR008244A1 (es)	1999-12-29
HUP9903480A2 (en)	2000-07-28
CA2258559A1 (en)	1997-12-24
IL127304A (en)	2003-07-06
WO1997048700A1 (en)	1997-12-24
CN1147485C (zh)	2004-04-28
PL186885B1 (pl)	2004-03-31
TW360650B (en)	1999-06-11
HK1019744A1 (en)	2000-02-25
ATE196766T1 (de)	2000-10-15
TR199802552T2 (xx)	1999-02-22
CN1222152A (zh)	1999-07-07
PL330708A1 (en)	1999-05-24
IL127304A0 (en)	1999-09-22

Publication	Publication Date	Title
NO985225L (no)	1998-11-09	Indolderivater nyttige som endotelinreseptorantagonister
NO943348L (no)	1994-11-09	Kondenserte indolderivater som 5HT4-reseptorantagonister
FI973205L (fi)	1997-10-01	Indolijohdannaisia 5-HT-reseptoriantagonisteina
DK0856001T3 (da)	2002-12-30	Pyrimidinderivater som 5-HT2C-receptor-antagonister
DE69809755D1 (de)	2003-01-09	Substituierte 1,2,3,4-tetrahydronaphthalin derivate
NO974043L (no)	1997-11-03	Indolderivater som EAA-antagonister
NO20002036D0 (no)	2000-04-18	Cyklopentenderivater nyttig som antagonister for motilinreseptoren
NO20020578D0 (no)	2002-02-05	Substituerte pyrrolidin-2,3,4-trion-3-oskimderivater som er nyttige som NMDA-reseptorantagonister
NO985970L (no)	1998-12-18	Indolinderivater anvendelige som 5_HT-2C-reseptor-antagonister
FI951798A0 (fi)	1995-04-13	Bentsofuraanijohdannaiset 5-HT1-kaltaisina reseptoriantagonisteina
NO985972L (no)	1998-12-18	Indolinderivater anvendelige som 5-HT-2C reseptorantagonister
DK0885222T3 (da)	2001-08-27	Heterocycliske ergolinderivater som 5HT1A-receptorligander
NO963775L (no)	1996-09-09	Indol-derivater som CCK-reseptorantagonister
DK1207159T3 (da)	2004-07-19	Heteroaromatiske derivater som dopamin-D4-receptorantagonister
SI0912556T1 (en)	2001-02-28	Indoline derivatives useful as 5-ht-2c receptor antagonists
HK1019747A (en)	2000-02-25	Indoline derivatives useful as 5-ht-2c receptor antagonists