NO20005060L - Krystallinske former av 1S-[1<alfa>(2S,3R), 9<alfa>]6,10- diokso-N-(2-etoksy-5-okso-tetrahydro-3-furanyl)-9[[(1- isokinolyl)karbonyl]amino]oktahydro-6H-piridazino[1,2- a][1,2]diazepin-1-karboksamid - Google Patents

Krystallinske former av 1S-[1<alfa>(2S*,3R*), 9<alfa>]6,10- diokso-N-(2-etoksy-5-okso-tetrahydro-3-furanyl)-9[[(1- isokinolyl)karbonyl]amino]oktahydro-6H-piridazino[1,2- a][1,2]diazepin-1-karboksamid

Info

Publication number: NO20005060L
Authority: NO; Norway
Prior art keywords: alpha; pyridazino; diazepine; octahydro; isoquinolyl
Prior art date: 1998-04-08

Application number

NO20005060A

Other languages

English (en)

Other versions

NO20005060D0 (no

NO327995B1 (no

Inventor

Jean-Yves Godard

Valerie Rognon

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-08

Filing date

2000-10-06

Publication date

2000-10-06

2000-10-06 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

2000-10-06 Publication of NO20005060D0 publication Critical patent/NO20005060D0/no

2000-10-06 Publication of NO20005060L publication Critical patent/NO20005060L/no

2009-11-02 Publication of NO327995B1 publication Critical patent/NO327995B1/no

Links

-1 2-ethoxy-5-oxo-tetrahydro-3-furanyl Chemical group 0.000 title 1
PPIXVPFGMODPHO-UHFFFAOYSA-N N'-(isoquinoline-1-carbonyl)-2,3,4,6,7,8,9,10-octahydro-1H-pyridazino[1,2-a]diazepine-4-carbohydrazide Chemical compound C1(CCCN2N1CCCCC2)C(=O)NNC(=O)C1=NC=CC2=CC=CC=C12 PPIXVPFGMODPHO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Immunology (AREA)
Neurology (AREA)
Crystallography & Structural Chemistry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)

NO20005060A 1998-04-08 2000-10-06 Krystallinsk form av vannfritt 1S-[1alfa(2S*,3R*), 9alfa]6,10-diokso-N-(2-etoksy-5-okso-tetrahydro-3-furanyl)-9[[(1-isokinolyl)karbonyl]amino]oktahydro-6H-piridazino[1,2-a][1,2]diazepin-1-karboksamid (form A), fremgangsmate for fremstilling av denne, og anvendelse av den for fremstilling av et medikament NO327995B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9804367A FR2777279B1 (fr)	1998-04-08	1998-04-08	Nouvelles formes cristallines du 1s-[1alpha(2s,3r), 9 alpha] 6,10-dioxo-n-(2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9[[(1-isoquinolyl)carbonyl]amino]octohydro-6h-pyridazino [1,2-a][1,2]diazepine-1-carboxamide
PCT/FR1999/000799 WO1999052935A1 (fr)	1998-04-08	1999-04-07	Formes cristallines du 1s-[1alpha (2s,3r),9alpha]-6, 10-dioxo-n- (2-ethoxy-5 -oxo-tetrahydro-3 -furanyl) -9-[[(1-isoquinolyl) carbonyl]-amino] octahydro-6h -piridazino[1, 2-a][1,2] diazepine-1- carboxamide

Publications (3)

Publication Number	Publication Date
NO20005060D0 NO20005060D0 (no)	2000-10-06
NO20005060L true NO20005060L (no)	2000-10-06
NO327995B1 NO327995B1 (no)	2009-11-02

Family

ID=9524993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005060A NO327995B1 (no)	1998-04-08	2000-10-06	Krystallinsk form av vannfritt 1S-[1alfa(2S,3R), 9alfa]6,10-diokso-N-(2-etoksy-5-okso-tetrahydro-3-furanyl)-9[[(1-isokinolyl)karbonyl]amino]oktahydro-6H-piridazino[1,2-a][1,2]diazepin-1-karboksamid (form A), fremgangsmate for fremstilling av denne, og anvendelse av den for fremstilling av et medikament

Country Status (38)

Country	Link
US (2)	US6544977B1 (no)
EP (1)	EP1070083B1 (no)
JP (1)	JP2002511485A (no)
KR (1)	KR100582981B1 (no)
CN (1)	CN1202123C (no)
AP (1)	AP1734A (no)
AR (1)	AR018328A1 (no)
AT (1)	ATE315044T1 (no)
AU (1)	AU758042B2 (no)
BG (1)	BG64736B1 (no)
BR (1)	BR9909549A (no)
CA (1)	CA2325629C (no)
CU (1)	CU23055A3 (no)
CZ (1)	CZ299744B6 (no)
DE (1)	DE69929315T2 (no)
DK (1)	DK1070083T3 (no)
EA (1)	EA002761B1 (no)
EE (1)	EE04467B1 (no)
ES (1)	ES2253880T3 (no)
FR (1)	FR2777279B1 (no)
GE (1)	GEP20032974B (no)
HK (1)	HK1038575B (no)
HR (1)	HRP20000665B1 (no)
HU (1)	HU227561B1 (no)
ID (1)	ID26290A (no)
IL (2)	IL138818A (no)
ME (1)	ME01627B (no)
NO (1)	NO327995B1 (no)
NZ (1)	NZ507199A (no)
PL (1)	PL197016B1 (no)
RS (1)	RS49916B (no)
SI (1)	SI1070083T1 (no)
SK (1)	SK286267B6 (no)
TR (1)	TR200002914T2 (no)
TW (1)	TW522152B (no)
UA (1)	UA71563C2 (no)
WO (1)	WO1999052935A1 (no)
ZA (1)	ZA200005438B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0713951B8 (pt) *	2006-06-30	2021-05-25	Novartis Ag	derivados de quinazolina, e composição farmacêutica
AU2014277867B2 (en) *	2007-12-04	2016-11-03	Arbutus Biopharma Corporation	Targeting lipids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5552400A (en) *	1994-06-08	1996-09-03	Sterling Winthrop Inc.	Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors

1998
- 1998-04-08 FR FR9804367A patent/FR2777279B1/fr not_active Expired - Lifetime
1999
- 1999-03-15 TW TW088103966A patent/TW522152B/zh not_active IP Right Cessation
- 1999-03-30 AR ARP990101432A patent/AR018328A1/es active IP Right Grant
- 1999-04-07 HU HU0101586A patent/HU227561B1/hu not_active IP Right Cessation
- 1999-04-07 ME MEP-2000-608A patent/ME01627B/me unknown
- 1999-04-07 ID IDW20002015A patent/ID26290A/id unknown
- 1999-04-07 SI SI9930877T patent/SI1070083T1/sl unknown
- 1999-04-07 JP JP2000543491A patent/JP2002511485A/ja active Pending
- 1999-04-07 CZ CZ20003678A patent/CZ299744B6/cs not_active IP Right Cessation
- 1999-04-07 RS YUP-608/00A patent/RS49916B/sr unknown
- 1999-04-07 TR TR2000/02914T patent/TR200002914T2/xx unknown
- 1999-04-07 ES ES99911890T patent/ES2253880T3/es not_active Expired - Lifetime
- 1999-04-07 US US09/647,858 patent/US6544977B1/en not_active Expired - Lifetime
- 1999-04-07 EP EP99911890A patent/EP1070083B1/fr not_active Expired - Lifetime
- 1999-04-07 EE EEP200000586A patent/EE04467B1/xx unknown
- 1999-04-07 AU AU30416/99A patent/AU758042B2/en not_active Ceased
- 1999-04-07 BR BR9909549-1A patent/BR9909549A/pt not_active Application Discontinuation
- 1999-04-07 SK SK1488-2000A patent/SK286267B6/sk not_active IP Right Cessation
- 1999-04-07 EA EA200001047A patent/EA002761B1/ru not_active IP Right Cessation
- 1999-04-07 DK DK99911890T patent/DK1070083T3/da active
- 1999-04-07 CN CNB998071455A patent/CN1202123C/zh not_active Expired - Fee Related
- 1999-04-07 WO PCT/FR1999/000799 patent/WO1999052935A1/fr not_active Ceased
- 1999-04-07 DE DE69929315T patent/DE69929315T2/de not_active Expired - Lifetime
- 1999-04-07 KR KR1020007011159A patent/KR100582981B1/ko not_active Expired - Fee Related
- 1999-04-07 AT AT99911890T patent/ATE315044T1/de active
- 1999-04-07 NZ NZ507199A patent/NZ507199A/xx not_active IP Right Cessation
- 1999-04-07 CA CA2325629A patent/CA2325629C/fr not_active Expired - Fee Related
- 1999-04-07 PL PL343350A patent/PL197016B1/pl unknown
- 1999-04-07 AP APAP/P/2000/001939A patent/AP1734A/en active
- 1999-04-07 HR HR20000665A patent/HRP20000665B1/xx not_active IP Right Cessation
- 1999-04-07 HK HK02100107.8A patent/HK1038575B/zh not_active IP Right Cessation
- 1999-04-07 CU CU20000213A patent/CU23055A3/es unknown
- 1999-04-07 GE GEAP19995614A patent/GEP20032974B/en unknown
- 1999-07-04 UA UA2000116295A patent/UA71563C2/uk unknown
2000
- 2000-10-02 IL IL138818A patent/IL138818A/en not_active IP Right Cessation
- 2000-10-05 ZA ZA200005438A patent/ZA200005438B/en unknown
- 2000-10-06 BG BG104829A patent/BG64736B1/bg unknown
- 2000-10-06 NO NO20005060A patent/NO327995B1/no not_active IP Right Cessation
2002
- 2002-11-18 US US10/299,242 patent/US6946459B2/en not_active Expired - Lifetime
2005
- 2005-04-14 IL IL168047A patent/IL168047A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
BG64736B1 (bg)	2006-01-31
HRP20000665B1 (en)	2008-01-31
CZ20003678A3 (cs)	2001-02-14
UA71563C2 (uk)	2004-12-15
JP2002511485A (ja)	2002-04-16
EA002761B1 (ru)	2002-08-29
HRP20000665A2 (en)	2001-08-31
SK286267B6 (sk)	2008-06-06
CN1305491A (zh)	2001-07-25
NZ507199A (en)	2002-12-20
SI1070083T1 (sl)	2006-04-30
CN1202123C (zh)	2005-05-18
KR20010034759A (ko)	2001-04-25
US6544977B1 (en)	2003-04-08
WO1999052935A1 (fr)	1999-10-21
ATE315044T1 (de)	2006-02-15
EA200001047A1 (ru)	2001-04-23
EP1070083A1 (fr)	2001-01-24
YU60800A (sh)	2002-11-15
IL138818A (en)	2008-11-26
BG104829A (en)	2001-05-31
AU758042B2 (en)	2003-03-13
CZ299744B6 (cs)	2008-11-12
EE04467B1 (et)	2005-04-15
ZA200005438B (en)	2002-01-07
HK1038575B (zh)	2006-01-06
BR9909549A (pt)	2000-12-12
AP2000001939A0 (en)	2000-12-31
ME01627B (me)	2008-09-29
AP1734A (en)	2007-03-22
RS49916B (sr)	2008-09-29
PL197016B1 (pl)	2008-02-29
HU227561B1 (en)	2011-08-29
IL168047A (en)	2011-10-31
HUP0101586A3 (en)	2002-11-28
CA2325629C (fr)	2013-01-22
DK1070083T3 (da)	2006-05-15
FR2777279B1 (fr)	2004-08-13
ID26290A (id)	2000-12-14
DE69929315D1 (de)	2006-03-30
SK14882000A3 (sk)	2001-04-09
AU3041699A (en)	1999-11-01
HUP0101586A2 (hu)	2001-11-28
FR2777279A1 (fr)	1999-10-15
NO20005060D0 (no)	2000-10-06
CA2325629A1 (fr)	1999-10-21
US6946459B2 (en)	2005-09-20
US20030171365A1 (en)	2003-09-11
ES2253880T3 (es)	2006-06-01
EP1070083B1 (fr)	2006-01-04
HK1038575A1 (en)	2002-03-22
AR018328A1 (es)	2001-11-14
KR100582981B1 (ko)	2006-05-24
DE69929315T2 (de)	2006-08-17
TW522152B (en)	2003-03-01
TR200002914T2 (tr)	2001-02-21
GEP20032974B (en)	2003-05-27
EE200000586A (et)	2002-02-15
PL343350A1 (en)	2001-08-13
NO327995B1 (no)	2009-11-02
CU23055A3 (es)	2005-06-24

Legal Events

Date	Code	Title	Description
2018-11-26	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
HUP9902136A3 (en)	2000-03-28	Novel substituted cyclic amino acid derivatives use as pharmaceutical agents
HUP0004310A3 (en)	2001-11-28	Cyclic amino acids, and derivatives thereof and pharmaceutical compositions comprising the said compounds as active agents
NO986208L (no)	1998-12-30	Vandige peptidformuleringer
DK0891978T3 (da)	2002-07-01	5H-Thiazol(3,2-a)pyrimidinderivativer
IT1282627B1 (it)	1998-03-31	Procedimento per la preparazione di perfluoropoliossialchileni perossidici
IT1272922B (it)	1997-07-01	Procedimento per la preparazione di composti metallocenici
NO20011664L (no)	2001-04-03	Sammensetning med höy renhet omfattende (7<alfa>, 17<alfa>)- 17-hydroksy-7-metyl-19-nor-17-pregn-5(10)-en-20-yn-3-on
ITMI931680A0 (it)	1993-07-28	Procedimento per la preparazione di alcansolfonammidi
IT1295934B1 (it)	1999-05-28	Procedimento migliorato per la sintesi di alchilpoliglucosidi
NO20005060D0 (no)	2000-10-06	Krystallinske former av 1S-[1<alfa>(2S,3R), 9<alfa>]6,10- diokso-N-(2-etoksy-5-okso-tetrahydro-3-furanyl)-9[[(1- isokinolyl)karbonyl]amino]oktahydro-6H-piridazino[1,2- a][1,2]diazepin-1-karboksamid
IT1292132B1 (it)	1999-01-25	Procedimento per la preparazione di diacereina
ITMI981796A0 (it)	1998-07-31	Procedimento per la preparazione di r-(-)-carnitina
IT1299630B1 (it)	2000-03-24	Dispositivo di connessione per la connessione di due corpi
IT1293819B1 (it)	1999-03-10	Procedimento per la preparazione di acarbosio
IT1267078B1 (it)	1997-01-24	Apparecchiatura per la preparazione di soluzioni
ITMI942485A0 (it)	1994-12-09	Procedimento per la preparazione di epibatidina
IT1286527B1 (it)	1998-07-15	Procedimento per la sintesi di 2-idrossi-4-alchilossi benzofenone
ITTO930667A0 (it)	1993-09-13	Procedimento per la preparazione di ethalfluralin
ITMI912520A1 (it)	1993-03-20	Procedimento per la preparazione di 1-/(2s)-3-merca-prometil-1- ossopropil-/l-prolina
ITMI930340A1 (it)	1994-08-23	Procedimento per la preparazione di 5-oxo-2-pirrolidoncarbossilato di piridossina
IT1283641B1 (it)	1998-04-23	Procedimento per la preparazione di cefalosporine
ITMI970682A1 (it)	1998-09-26	Procedimento per la preparazione di (s)-n-terbutil-1, 2, 3, 4- tetraidroisochinolin-3- carbossiammide
ITMI932694A0 (it)	1993-12-22	Procedimento per la preparazione di 2-idrossi-1-4-noftochinoni
IT1286498B1 (it)	1998-07-15	Procedimento per la preparazione di antibiotici beta-lattamici
ITMI20000810A0 (it)	2000-04-12	Procedimento per la preparazione di 5'-acetilstavudina

NO20005060L - Krystallinske former av 1S-[1<alfa>(2S*,3R*), 9<alfa>]6,10- diokso-N-(2-etoksy-5-okso-tetrahydro-3-furanyl)-9[[(1- isokinolyl)karbonyl]amino]oktahydro-6H-piridazino[1,2- a][1,2]diazepin-1-karboksamid - Google Patents