NO20005391L - Nye oktahydro-6,10-diokso-6H-pyridazino[1,2-a][1,2]diazepin-1- karboksylsyrederivater metyl, etyl, propyl, isopropyl, n-butyl, isobutyl eller terbutyl, eller benzyl eller naftyl - Google Patents

Nye oktahydro-6,10-diokso-6H-pyridazino[1,2-a][1,2]diazepin-1- karboksylsyrederivater metyl, etyl, propyl, isopropyl, n-butyl, isobutyl eller terbutyl, eller benzyl eller naftyl

Info

Publication number
NO20005391L
NO20005391L NO20005391A NO20005391A NO20005391L NO 20005391 L NO20005391 L NO 20005391L NO 20005391 A NO20005391 A NO 20005391A NO 20005391 A NO20005391 A NO 20005391A NO 20005391 L NO20005391 L NO 20005391L
Authority
NO
Norway
Prior art keywords
pyridazino
terbutyl
diazepine
dioxo
naphthyl
Prior art date
Application number
NO20005391A
Other languages
English (en)
Other versions
NO328864B1 (no
NO20005391D0 (no
Inventor
Colette Colladant
Veronique Crocq
John Patrick Larkin
Patrick Roussel
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO20005391D0 publication Critical patent/NO20005391D0/no
Publication of NO20005391L publication Critical patent/NO20005391L/no
Publication of NO328864B1 publication Critical patent/NO328864B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Forbindelser med formel (I) i SR-konfigurasjon eller i form av en SR + SS-blandktg, hvori R betegner et hydrogenatom et alkyl- eller aralkylradikal inneholdende opptil 18 karbonatomer, der arnirrfunksjonen er fri eller beskyttet. Forbindelsene kan anvendes for fremstilling av aktive prinsipper for medisiner.
NO20005391A 1998-04-27 2000-10-26 Oktahydro-6,10-diokso-6H-pyridazino[1,2-a][1,2]diazepin-1-karboksylsyrederivater, fremgangsmate for fremstilling derav og anvendelser derav NO328864B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9805243A FR2777889B1 (fr) 1998-04-27 1998-04-27 Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs
PCT/FR1999/000981 WO1999055724A1 (fr) 1998-04-27 1999-04-26 NOUVEAUX DERIVES DE L'ACIDE OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO[1,2-a] [1,2] DIAZEPINE-1-CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION A LA PREPARATION DE COMPOSES THERAPEUTIQUEMENT ACTIFS

Publications (3)

Publication Number Publication Date
NO20005391D0 NO20005391D0 (no) 2000-10-26
NO20005391L true NO20005391L (no) 2000-12-19
NO328864B1 NO328864B1 (no) 2010-05-31

Family

ID=9525705

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005391A NO328864B1 (no) 1998-04-27 2000-10-26 Oktahydro-6,10-diokso-6H-pyridazino[1,2-a][1,2]diazepin-1-karboksylsyrederivater, fremgangsmate for fremstilling derav og anvendelser derav

Country Status (37)

Country Link
US (3) US6548664B1 (no)
EP (1) EP1073673B1 (no)
JP (2) JP4332298B2 (no)
KR (1) KR100561582B1 (no)
CN (1) CN1167711C (no)
AP (1) AP1518A (no)
AR (1) AR016466A1 (no)
AU (1) AU755286B2 (no)
BG (1) BG65282B1 (no)
BR (1) BR9910020A (no)
CA (1) CA2330492C (no)
CU (1) CU23155A3 (no)
CY (1) CY1107599T1 (no)
DE (1) DE69934790T2 (no)
DK (1) DK1073673T3 (no)
EA (1) EA003280B1 (no)
EE (1) EE04682B1 (no)
ES (1) ES2279617T3 (no)
FR (1) FR2777889B1 (no)
GE (1) GEP20033119B (no)
HR (1) HRP20000733B1 (no)
HU (1) HU230060B1 (no)
ID (1) ID26292A (no)
IL (3) IL139102A0 (no)
ME (2) ME00300B (no)
NO (1) NO328864B1 (no)
NZ (1) NZ507618A (no)
PL (1) PL203762B1 (no)
PT (1) PT1073673E (no)
RS (1) RS50423B (no)
SI (1) SI1073673T1 (no)
SK (1) SK288050B6 (no)
TR (1) TR200003142T2 (no)
TW (1) TWI249537B (no)
UA (1) UA71913C2 (no)
WO (1) WO1999055724A1 (no)
ZA (1) ZA200006081B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177565B1 (en) 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6201118B1 (en) 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
FR2853901B1 (fr) 2003-04-16 2005-06-17 Isochem Sa Procede de preparation de derives de l'acide hexahydropyridazine-3-carboxylique
WO2005028449A1 (en) * 2003-06-26 2005-03-31 Honeywell Specialty Chemicals Seelze Gmbh Improved process for the manufacture of 1,2-disubstituted hexahydropyridazine-3-carboxylic acids and esters thereof
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法
WO2005122682A2 (en) 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Process for the preparation of esters of piperazic acid
WO2012049646A1 (en) 2010-10-12 2012-04-19 Ranbaxy Laboratories Limited Process for the preparation of an intermediate of cilazapril

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
AU669364B2 (en) * 1992-05-15 1996-06-06 Merrell Pharmaceuticals Inc. Novel mercaptoacetylamido pyridazo(1,2)pyridazine, pyrazolo(1,2)pyridazine, pyridazo(1,2-a)(1,2)diazepine and pyrazolo(1,2-a)(1,2)diazepine derivatives useful as inhibitors of enkephalinase and ace
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6201118B1 (en) * 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor

Also Published As

Publication number Publication date
KR100561582B1 (ko) 2006-03-20
NO328864B1 (no) 2010-05-31
CN1167711C (zh) 2004-09-22
AP1518A (en) 2005-12-12
IL190120A (en) 2011-10-31
MEP40808A (en) 2011-02-10
US20020128473A1 (en) 2002-09-12
HU230060B1 (hu) 2015-06-29
ZA200006081B (en) 2001-10-29
CY1107599T1 (el) 2013-03-13
TR200003142T2 (tr) 2001-03-21
WO1999055724A1 (fr) 1999-11-04
ID26292A (id) 2000-12-14
EE04682B1 (et) 2006-08-15
CA2330492A1 (fr) 1999-11-04
YU65800A (sh) 2003-01-31
PL203762B1 (pl) 2009-11-30
BR9910020A (pt) 2001-01-09
HUP0102447A3 (en) 2003-05-28
UA71913C2 (uk) 2005-01-17
FR2777889A1 (fr) 1999-10-29
BG65282B1 (bg) 2007-11-30
AU3427499A (en) 1999-11-16
AR016466A1 (es) 2001-07-04
IL139102A (en) 2008-06-05
SK16002000A3 (sk) 2001-09-11
IL190120A0 (en) 2008-08-07
AU755286B2 (en) 2002-12-05
US20030130269A1 (en) 2003-07-10
CA2330492C (fr) 2012-03-13
NZ507618A (en) 2003-07-25
BG104891A (en) 2001-10-31
PT1073673E (pt) 2007-03-30
EA200001107A1 (ru) 2001-04-23
AP2000001973A0 (en) 2000-12-31
DE69934790T2 (de) 2007-10-31
JP5101558B2 (ja) 2012-12-19
SI1073673T1 (sl) 2007-04-30
TWI249537B (en) 2006-02-21
HRP20000733A2 (en) 2001-02-28
DE69934790D1 (de) 2007-02-22
PL343720A1 (en) 2001-09-10
EA003280B1 (ru) 2003-04-24
DK1073673T3 (da) 2007-05-07
ME00300B (me) 2011-05-10
JP2009155343A (ja) 2009-07-16
ES2279617T3 (es) 2007-08-16
NO20005391D0 (no) 2000-10-26
US6548664B1 (en) 2003-04-15
HK1039131A1 (en) 2002-04-12
JP2002513030A (ja) 2002-05-08
US6570012B2 (en) 2003-05-27
KR20010043033A (ko) 2001-05-25
EP1073673B1 (fr) 2007-01-10
HRP20000733B1 (hr) 2009-06-30
IL139102A0 (en) 2001-11-25
HUP0102447A2 (hu) 2001-11-28
CN1306539A (zh) 2001-08-01
FR2777889B1 (fr) 2004-07-09
JP4332298B2 (ja) 2009-09-16
SK288050B6 (sk) 2013-03-01
CU23155A3 (es) 2006-07-18
RS50423B (sr) 2009-12-31
EE200000619A (et) 2002-06-17
GEP20033119B (en) 2003-11-25
EP1073673A1 (fr) 2001-02-07

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