NO20005841L - Pyrrolo[1,2-b]pyridazinderivater med sPLA2inhiberende effekt - Google Patents

Pyrrolo[1,2-b]pyridazinderivater med sPLA2inhiberende effekt

Info

Publication number
NO20005841L
NO20005841L NO20005841A NO20005841A NO20005841L NO 20005841 L NO20005841 L NO 20005841L NO 20005841 A NO20005841 A NO 20005841A NO 20005841 A NO20005841 A NO 20005841A NO 20005841 L NO20005841 L NO 20005841L
Authority
NO
Norway
Prior art keywords
inhibitory effect
pyrrolo
pyridazine derivatives
carbon ring
spla2
Prior art date
Application number
NO20005841A
Other languages
English (en)
Other versions
NO20005841D0 (no
Inventor
Mitsuaki Ohtani
Masahiro Fuji
Yoshikazu Fukui
Makoto Adachi
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of NO20005841D0 publication Critical patent/NO20005841D0/no
Publication of NO20005841L publication Critical patent/NO20005841L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Forbindelser med sPLiA2 inhiberende effekt ,som er representert ved den generelle formel (I), prodruger derav, farmasøytisk aksepterbare salter derav, eller solvater derav, og sPLAinhibitorer inneholdende de samme som aktiv bestanddel, hvor Rrepresenterer -(L1) -R6 (hvorrepresenterer en divalent koblingsgruppe med 1 til 18 atomer, osv., og Rrepresenterer en karbonring som har en eller flere ikke-interfererende substituenter, osv.), Rrepresenterer Cl til C3 alkyl, osv.,er -()-(sur gruppe), Rog Rrepresenterer hydrogen, en ikke-interfererende substituent, en karbonring, osv., X'ene representerer uavhengig hver oksygen eller svovel, og RA representerer -C(=X)-C(=X)-NH, osv.
NO20005841A 1998-05-21 2000-11-17 Pyrrolo[1,2-b]pyridazinderivater med sPLA2inhiberende effekt NO20005841L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13931998 1998-05-21
JP24473698 1998-08-31
PCT/JP1999/002630 WO1999059999A1 (en) 1998-05-21 1999-05-20 PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES HAVING sPLA2 INHIBITORY EFFECT

Publications (2)

Publication Number Publication Date
NO20005841D0 NO20005841D0 (no) 2000-11-17
NO20005841L true NO20005841L (no) 2001-01-22

Family

ID=26472156

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005841A NO20005841L (no) 1998-05-21 2000-11-17 Pyrrolo[1,2-b]pyridazinderivater med sPLA2inhiberende effekt

Country Status (11)

Country Link
US (1) US6472389B1 (no)
EP (1) EP1085021A4 (no)
JP (1) JP4544446B2 (no)
KR (1) KR20010034881A (no)
CN (1) CN1302300A (no)
AU (1) AU748787B2 (no)
BR (1) BR9911048A (no)
CA (1) CA2332528A1 (no)
HU (1) HUP0103546A3 (no)
NO (1) NO20005841L (no)
WO (1) WO1999059999A1 (no)

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JP2001513555A (ja) * 1997-08-28 2001-09-04 イーライ・リリー・アンド・カンパニー 非リウマチ様関節炎の処置方法
CA2346334A1 (en) 1998-10-14 2000-04-20 Shionogi & Co., Ltd. Composition for treating or preventing ischemia reperfusion injury
JP4636521B2 (ja) 1999-07-19 2011-02-23 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有する三環系化合物
JP4636522B2 (ja) 1999-08-02 2011-02-23 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有する三環式化合物
US6787545B1 (en) 1999-08-23 2004-09-07 Shiongi & Co., Ltd. Pyrrolotriazine derivatives having spla2-inhibitory activities
AU2001267823A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Compounds exhibiting x-type spla2 inhibiting effect
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
WO2002012249A2 (en) * 2000-08-04 2002-02-14 Eli Lilly And Company Substituted pyrrole compounds and their use as spla2 inhibitors
TWI314457B (no) * 2001-03-19 2009-09-11 Shionogi & Co
US6730694B1 (en) 2001-07-20 2004-05-04 Eli Lilly And Company sPLA2 inhibitors
KR20040053125A (ko) 2001-09-13 2004-06-23 신타 파마슈티칼스 코프. 암 치료용 1-글리옥실일아미드 인돌리진
US6900208B2 (en) * 2002-03-28 2005-05-31 Bristol Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
AR041470A1 (es) * 2002-10-17 2005-05-18 Upjohn Co Compuestos de pirrolo (1,2 - b) piridazina y sus usos
DK1581535T5 (da) * 2003-01-09 2009-12-21 Astellas Pharma Inc Pyrrolopyridazinderivater
WO2004082606A2 (en) * 2003-03-13 2004-09-30 Synta Pharmaceuticals Corp. Fused pyrrole compounds
US7030112B2 (en) * 2003-03-25 2006-04-18 Bristol-Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
US7041671B2 (en) 2003-04-02 2006-05-09 Pfizer Inc Pyrrolo[1,2-b]pyridazine compounds and their uses
US7034023B2 (en) 2003-04-04 2006-04-25 Pfizer Inc Pyrrolo[1,2-B]pyridazine compounds and their uses
US7056920B2 (en) 2003-04-04 2006-06-06 Pfizer Inc Pyrrolo[1,2-B]pyridazine compounds and their uses
EP1615929A1 (en) * 2003-04-15 2006-01-18 Pharmacia & Upjohn Company LLC Pyrrolo [1,2-b] pyridazine compounds and their uses
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
CA2523072A1 (en) * 2003-05-07 2004-11-18 Pharmacia & Upjohn Company Llc Pyrrolo (1,2-b) pyridazine compounds and their use as crf-1 receptor antagonists
WO2005013907A2 (en) * 2003-08-07 2005-02-17 Japan Tobacco Inc. Pyrrolo[1,2-b]pyridazine derivatives
AU2005209115A1 (en) * 2004-01-30 2005-08-11 Japan Tobacco Inc. Anorectic compounds
WO2008133660A2 (en) * 2006-11-21 2008-11-06 Qd Vision, Inc. Nanocrystals including a group iiia element and a group va element, method, composition, device and other prodcucts
US8048880B2 (en) * 2007-05-03 2011-11-01 Anthera Pharmaceuticals, Inc. Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies
CN102325449A (zh) * 2008-12-19 2012-01-18 安塞拉制药有限公司 用分泌磷脂酶A2(sPLA2)抑制剂或sPLA2抑制剂组合疗法处理主要不良心血管事件和急性冠状动脉综合症的方法
SG175390A1 (en) 2009-04-29 2011-12-29 Amarin Corp Plc Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
CA2822357A1 (en) 2010-12-22 2012-06-28 Abbvie Inc. Hepatitis c inhibitors and uses thereof
WO2013028253A1 (en) 2011-08-19 2013-02-28 Qd Vision, Inc. Semiconductor nanocrystals and methods
MA55556A (fr) 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5

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Publication number Priority date Publication date Assignee Title
JPH06501918A (ja) * 1990-05-25 1994-03-03 藤沢薬品工業株式会社 ピロロピリダジン化合物
DE4224165A1 (de) * 1992-07-22 1994-01-27 Bayer Ag Imidazolinyl-pyrrolo-pyridazine
IL109311A0 (en) 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
PL180523B1 (pl) 1994-04-01 2001-02-28 Eli Lilly & Co Nowy zwiazek, pochodna 1H-indolo-3-glioksylamidu i srodek farmaceutyczny PL PL PL PL PL PL PL PL PL PL
US6214876B1 (en) 1994-07-21 2001-04-10 Eli Lilly And Company Indene-1-acetamide sPLA2 inhibitors
JPH10505584A (ja) 1994-07-21 1998-06-02 イーライ・リリー・アンド・カンパニー インドリジンｓＰＬＡ▲下２▼インヒビター
US5641800A (en) 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
KR19990072111A (ko) 1995-12-13 1999-09-27 피터 지. 스트링거 Spla2 억제제인 나프틸 글리옥스아미드
AU1289797A (en) 1995-12-13 1997-07-03 Eli Lilly And Company Naphthyl acetamides as spla2 inhibitors
JP2001503055A (ja) 1996-10-30 2001-03-06 イーライ・リリー・アンド・カンパニー 置換三環化合物群
US6353128B1 (en) 1996-12-03 2002-03-05 Eli Lilly And Company Phenyl acetamides as sPLA2 inhibitors
US5916922A (en) 1996-12-03 1999-06-29 Eli Lilly And Company Phenyl glyoxamides as SPLA2 inhibitors
ID18983A (id) 1996-12-04 1998-05-28 Lilly Co Eli Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
US5919774A (en) 1996-12-10 1999-07-06 Eli Lilly And Company Pyrroles as sPLA2 inhibitors
TW455581B (en) 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides

Also Published As

Publication number Publication date
CA2332528A1 (en) 1999-11-25
US6472389B1 (en) 2002-10-29
HUP0103546A3 (en) 2002-12-28
JP4544446B2 (ja) 2010-09-15
EP1085021A4 (en) 2003-01-08
KR20010034881A (ko) 2001-04-25
WO1999059999A1 (en) 1999-11-25
HUP0103546A2 (hu) 2002-02-28
AU748787B2 (en) 2002-06-13
AU3732799A (en) 1999-12-06
CN1302300A (zh) 2001-07-04
EP1085021A1 (en) 2001-03-21
BR9911048A (pt) 2001-02-06
NO20005841D0 (no) 2000-11-17

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