NO20006320L - Cyclic somatostatin analogues - Google Patents
Cyclic somatostatin analoguesInfo
- Publication number
- NO20006320L NO20006320L NO20006320A NO20006320A NO20006320L NO 20006320 L NO20006320 L NO 20006320L NO 20006320 A NO20006320 A NO 20006320A NO 20006320 A NO20006320 A NO 20006320A NO 20006320 L NO20006320 L NO 20006320L
- Authority
- NO
- Norway
- Prior art keywords
- present
- somatostatin analogues
- relates
- cyclic somatostatin
- somatostatin
- Prior art date
Links
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- 108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
- 102000011096 Somatostatin receptor Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfinnelse angår cykliske derivater inneholdende en imidazol cis- amidbindingsetterlikning som binder selektivt til somatostatin reseptorundertyper og anvendelsen derav ved behandling av tilstander som kan behandles ved å frembringe en agonist- eller antagonist-effekt fra somatostatin-undertype-reseptorene. Foreliggende oppfinnelse angår også fremgangsmåter for fremstilling av forbindelsene ifølge foreliggende oppfinnelse.BACKGROUND OF THE INVENTION The present invention relates to cyclic derivatives containing an imidazole cis-amide binding mimic which selectively binds to somatostatin receptor subtypes and their use in treating conditions which can be treated by producing an agonist or antagonist effect from the somatostatin subtype receptors. The present invention also relates to processes for preparing the compounds of the present invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9818198A | 1998-06-16 | 1998-06-16 | |
| US8950398P | 1998-06-16 | 1998-06-16 | |
| PCT/US1999/013304 WO1999065942A1 (en) | 1998-06-16 | 1999-06-11 | Cyclic somatostatin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20006320D0 NO20006320D0 (en) | 2000-12-12 |
| NO20006320L true NO20006320L (en) | 2001-02-12 |
Family
ID=26780645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006320A NO20006320L (en) | 1998-06-16 | 2000-12-12 | Cyclic somatostatin analogues |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1086131A1 (en) |
| JP (1) | JP2002518409A (en) |
| CN (1) | CN1200000C (en) |
| AR (1) | AR021161A1 (en) |
| AU (1) | AU745493B2 (en) |
| CA (1) | CA2335184A1 (en) |
| HU (1) | HUP0102902A3 (en) |
| NO (1) | NO20006320L (en) |
| PL (1) | PL345037A1 (en) |
| RU (1) | RU2242481C2 (en) |
| TW (3) | TWI242442B (en) |
| WO (1) | WO1999065942A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1086086T3 (en) | 1998-06-12 | 2005-01-24 | Sod Conseils Rech Applic | Imidazolyl derivatives and their use as somatostatin receptor ligands |
| FR2796945B1 (en) * | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | NOVEL DERIVATIVES OF HYDANTOINS, THIOHYDANTOINS, PYRIMIDINEDIONES AND THIOXOPYRIMIDINONES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| ATE360620T1 (en) | 2000-08-01 | 2007-05-15 | Sod Conseils Rech Applic | IMIDAZOLE DERIVATIVES |
| WO2004071448A2 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma Inc. | Substituted azole derivatives as inhibitors of protein tyrosine phosphatases |
| WO2006063465A1 (en) * | 2004-12-15 | 2006-06-22 | Diamedica Inc. | Treatment of insulin resistance by modulating somatostatin using somatostatin receptor antagonists |
| CN101341129B (en) * | 2005-12-14 | 2011-12-14 | 布里斯托尔-迈尔斯斯奎布公司 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors |
| NZ568595A (en) * | 2005-12-14 | 2010-04-30 | Bristol Myers Squibb Co | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor Xla inhibitors |
| AU2009296267B2 (en) | 2008-09-26 | 2013-10-31 | Ambrx, Inc. | Non-natural amino acid replication-dependent microorganisms and vaccines |
| EP2168983A1 (en) * | 2008-09-30 | 2010-03-31 | Ipsen Pharma | New octapeptide compounds and their therapeutic use |
| WO2010050445A1 (en) * | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | Bicyclic compound |
| KR20250158818A (en) | 2016-02-09 | 2025-11-06 | 씨디알디 벤쳐스 인코포레이티드 | Somatostatin receptor antagonist compounds and methods of using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| GB9513224D0 (en) * | 1995-06-29 | 1995-09-06 | Sandoz Ltd | Organic compounds |
| US6673927B2 (en) * | 1996-02-16 | 2004-01-06 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farnesyl transferase inhibitors |
-
1999
- 1999-06-11 PL PL99345037A patent/PL345037A1/en not_active Application Discontinuation
- 1999-06-11 CA CA002335184A patent/CA2335184A1/en not_active Abandoned
- 1999-06-11 EP EP99931793A patent/EP1086131A1/en not_active Withdrawn
- 1999-06-11 HU HU0102902A patent/HUP0102902A3/en unknown
- 1999-06-11 RU RU2001101530/04A patent/RU2242481C2/en not_active IP Right Cessation
- 1999-06-11 WO PCT/US1999/013304 patent/WO1999065942A1/en not_active Ceased
- 1999-06-11 CN CNB998075027A patent/CN1200000C/en not_active Expired - Fee Related
- 1999-06-11 AU AU48223/99A patent/AU745493B2/en not_active Ceased
- 1999-06-11 JP JP2000554767A patent/JP2002518409A/en active Pending
- 1999-06-15 TW TW093100348A patent/TWI242442B/en active
- 1999-06-15 TW TW088110016A patent/TW527361B/en not_active IP Right Cessation
- 1999-06-15 AR ARP990102857A patent/AR021161A1/en unknown
- 1999-06-15 TW TW091115003A patent/TWI242441B/en active
-
2000
- 2000-12-12 NO NO20006320A patent/NO20006320L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI242442B (en) | 2005-11-01 |
| AU745493B2 (en) | 2002-03-21 |
| CN1305496A (en) | 2001-07-25 |
| TW200410986A (en) | 2004-07-01 |
| HUP0102902A2 (en) | 2002-01-28 |
| NO20006320D0 (en) | 2000-12-12 |
| TWI242441B (en) | 2005-11-01 |
| HUP0102902A3 (en) | 2002-02-28 |
| AR021161A1 (en) | 2002-07-03 |
| AU4822399A (en) | 2000-01-05 |
| TW527361B (en) | 2003-04-11 |
| CA2335184A1 (en) | 1999-12-23 |
| EP1086131A1 (en) | 2001-03-28 |
| WO1999065942A8 (en) | 2000-02-17 |
| WO1999065942A1 (en) | 1999-12-23 |
| JP2002518409A (en) | 2002-06-25 |
| PL345037A1 (en) | 2001-11-19 |
| RU2242481C2 (en) | 2004-12-20 |
| CN1200000C (en) | 2005-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602005021494D1 (en) | SUBSTITUTED PYRAZOLE, SUCH COMPOUNDS AND COMPOSITIONS AND METHOD OF USE THEREOF | |
| DE69835225D1 (en) | METHOD FOR THE TREATMENT OF PSYCHOSES CAUSED BY GLYCOCORTICOIDAL DISORDER | |
| TW200745031A (en) | Acyl indoles, compositions containing such compounds and methods of use | |
| NO20006320L (en) | Cyclic somatostatin analogues | |
| YU34898A (en) | Ccr-3 receptor antagonists | |
| AUPO755097A0 (en) | Receptor agonist and antagonist | |
| WO2004100875A3 (en) | Benzimidazoles, compositions containing such compounds and methods of use | |
| WO2004069158A3 (en) | Substituted pyrazoles, compositions containing such compounds and methods of use | |
| ATE144773T1 (en) | INDOLE DERIVATIVES AS 5-HT1-LIKE ANTAGONISTS FOR THE TREATMENT OF MIGRAINES | |
| EA200501724A1 (en) | CONNECTIONS SPECIFIC TO MELANOCORTIN RECEPTORS | |
| ATE506065T1 (en) | METHOD FOR TREATING OR PREVENTING SYMPTOMS OF HORMONAL CHANGES | |
| IL138345A0 (en) | Novel compositions of epropsartan | |
| IS8377A (en) | Arylindenopyridine and arylindenopyrimidine and their use as antagonists of the A2A adenosine receptor | |
| PL364358A1 (en) | Receptor in the edb fibronectin domain (ii) | |
| MX2007004661A (en) | 1-(hetero)aryl-3-amino-pyrollidine derivatives for use as mglur3 receptor antagonists. | |
| ATE266660T1 (en) | PIPERIDINE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR ANTAGONISTS | |
| MXPA05013256A (en) | 1- (alkylaminoalkyl-pyrolidin-/piperidinyl) -2, 2-diphenylacetamide derivatives as muscarinic receptor antagonists. | |
| DE69809242D1 (en) | NEW PYRIMID DERIVATIVES | |
| WO2007001466A3 (en) | Peptidomimetic somatostatin receptor subtype 2 ligands and pet imaging agents | |
| BR0206844A (en) | Use of gal3 receptor antagonists for the treatment of depression and / or anxiety and compounds used in such methods. | |
| DE60135773D1 (en) | Assays | |
| ATE380048T1 (en) | TREATING MALE SEXUAL DYSFUNCTION | |
| DE602005019090D1 (en) | Pyrrolidin-2-one derivatives for use as DP1 receptor agonists | |
| BRPI0408979A (en) | use of an angiotensin ii type 1 antagonist and receptor alone or in combination with a metabolically neutral antihypertensive substance, and method for the treatment and / or prevention of metabolic syndrome | |
| ATE320005T1 (en) | TESTING METHODS FOR AGONISTS OR ANTAGONISTS OF BINDING OF DYNORPHIN A TO THE MAS RECEPTOR |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |