NO20006320L - Cyclic somatostatin analogues - Google Patents
Cyclic somatostatin analoguesInfo
- Publication number
- NO20006320L NO20006320L NO20006320A NO20006320A NO20006320L NO 20006320 L NO20006320 L NO 20006320L NO 20006320 A NO20006320 A NO 20006320A NO 20006320 A NO20006320 A NO 20006320A NO 20006320 L NO20006320 L NO 20006320L
- Authority
- NO
- Norway
- Prior art keywords
- present
- somatostatin analogues
- relates
- cyclic somatostatin
- somatostatin
- Prior art date
Links
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- 108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
- 102000011096 Somatostatin receptor Human genes 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfinnelse angår cykliske derivater inneholdende en imidazol cis- amidbindingsetterlikning som binder selektivt til somatostatin reseptorundertyper og anvendelsen derav ved behandling av tilstander som kan behandles ved å frembringe en agonist- eller antagonist-effekt fra somatostatin-undertype-reseptorene. Foreliggende oppfinnelse angår også fremgangsmåter for fremstilling av forbindelsene ifølge foreliggende oppfinnelse.BACKGROUND OF THE INVENTION The present invention relates to cyclic derivatives containing an imidazole cis-amide binding mimic which selectively binds to somatostatin receptor subtypes and their use in treating conditions which can be treated by producing an agonist or antagonist effect from the somatostatin subtype receptors. The present invention also relates to processes for preparing the compounds of the present invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9818198A | 1998-06-16 | 1998-06-16 | |
| US8950398P | 1998-06-16 | 1998-06-16 | |
| PCT/US1999/013304 WO1999065942A1 (en) | 1998-06-16 | 1999-06-11 | Cyclic somatostatin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20006320D0 NO20006320D0 (en) | 2000-12-12 |
| NO20006320L true NO20006320L (en) | 2001-02-12 |
Family
ID=26780645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006320A NO20006320L (en) | 1998-06-16 | 2000-12-12 | Cyclic somatostatin analogues |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1086131A1 (en) |
| JP (1) | JP2002518409A (en) |
| CN (1) | CN1200000C (en) |
| AR (1) | AR021161A1 (en) |
| AU (1) | AU745493B2 (en) |
| CA (1) | CA2335184A1 (en) |
| HU (1) | HUP0102902A3 (en) |
| NO (1) | NO20006320L (en) |
| PL (1) | PL345037A1 (en) |
| RU (1) | RU2242481C2 (en) |
| TW (3) | TW527361B (en) |
| WO (1) | WO1999065942A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0202648A3 (en) | 1998-06-12 | 2003-02-28 | Sod Conseils Rech Applic | Imidazolyl derivatives, pharmaceutical compositions containing them and their use |
| FR2796945B1 (en) | 1999-07-30 | 2002-06-28 | Sod Conseils Rech Applic | NOVEL DERIVATIVES OF HYDANTOINS, THIOHYDANTOINS, PYRIMIDINEDIONES AND THIOXOPYRIMIDINONES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| US7566734B2 (en) * | 2000-08-01 | 2009-07-28 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Imidazolyl derivatives |
| US20040186151A1 (en) * | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
| US8017575B2 (en) | 2004-12-15 | 2011-09-13 | Wilfred Wayne Lautt | Treatment of insulin resistance by modulating somatostatin using somatostatin receptor antagonists |
| JP5225098B2 (en) | 2005-12-14 | 2013-07-03 | ブリストル−マイヤーズ スクイブ カンパニー | Arylpropionamide, arylacrylamide, arylpropinamide, or arylmethylurea analogs as factor XIa inhibitors |
| ES2365815T3 (en) * | 2005-12-14 | 2011-10-11 | Bristol-Myers Squibb Company | ANALOGS OF ARILPROPIONAMIDA, ARILACRILAMIDA, ARILPROPINAMIDA OR ARILMETILUREA AS INHIBITORS OF THE XIA FACTOR. |
| PE20110480A1 (en) | 2008-09-26 | 2011-07-01 | Ambrx Inc | MICROORGANISMS AND VACCINES DEPENDENT ON REPLICATION OF NON-NATURAL AMINO ACIDS |
| EP2168983A1 (en) * | 2008-09-30 | 2010-03-31 | Ipsen Pharma | New octapeptide compounds and their therapeutic use |
| JP5535931B2 (en) * | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | Bicyclic compound |
| AU2017217271C1 (en) * | 2016-02-09 | 2021-08-05 | Cdrd Ventures Inc. | Somatostatin receptor antagonist compounds and methods of using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
| GB9513224D0 (en) * | 1995-06-29 | 1995-09-06 | Sandoz Ltd | Organic compounds |
| US6673927B2 (en) * | 1996-02-16 | 2004-01-06 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Farnesyl transferase inhibitors |
-
1999
- 1999-06-11 HU HU0102902A patent/HUP0102902A3/en unknown
- 1999-06-11 EP EP99931793A patent/EP1086131A1/en not_active Withdrawn
- 1999-06-11 RU RU2001101530/04A patent/RU2242481C2/en not_active IP Right Cessation
- 1999-06-11 CA CA002335184A patent/CA2335184A1/en not_active Abandoned
- 1999-06-11 AU AU48223/99A patent/AU745493B2/en not_active Ceased
- 1999-06-11 CN CNB998075027A patent/CN1200000C/en not_active Expired - Fee Related
- 1999-06-11 JP JP2000554767A patent/JP2002518409A/en active Pending
- 1999-06-11 PL PL99345037A patent/PL345037A1/en not_active Application Discontinuation
- 1999-06-11 WO PCT/US1999/013304 patent/WO1999065942A1/en not_active Ceased
- 1999-06-15 TW TW088110016A patent/TW527361B/en not_active IP Right Cessation
- 1999-06-15 TW TW091115003A patent/TWI242441B/en active
- 1999-06-15 TW TW093100348A patent/TWI242442B/en active
- 1999-06-15 AR ARP990102857A patent/AR021161A1/en unknown
-
2000
- 2000-12-12 NO NO20006320A patent/NO20006320L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1305496A (en) | 2001-07-25 |
| TWI242441B (en) | 2005-11-01 |
| HUP0102902A3 (en) | 2002-02-28 |
| JP2002518409A (en) | 2002-06-25 |
| HUP0102902A2 (en) | 2002-01-28 |
| TW200410986A (en) | 2004-07-01 |
| CA2335184A1 (en) | 1999-12-23 |
| AR021161A1 (en) | 2002-07-03 |
| TW527361B (en) | 2003-04-11 |
| CN1200000C (en) | 2005-05-04 |
| PL345037A1 (en) | 2001-11-19 |
| AU4822399A (en) | 2000-01-05 |
| WO1999065942A8 (en) | 2000-02-17 |
| WO1999065942A1 (en) | 1999-12-23 |
| NO20006320D0 (en) | 2000-12-12 |
| RU2242481C2 (en) | 2004-12-20 |
| EP1086131A1 (en) | 2001-03-28 |
| TWI242442B (en) | 2005-11-01 |
| AU745493B2 (en) | 2002-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |