NO20014560L - Quinasoliner og terapautisk anvendelse derav - Google Patents

Quinasoliner og terapautisk anvendelse derav

Info

Publication number
NO20014560L
NO20014560L NO20014560A NO20014560A NO20014560L NO 20014560 L NO20014560 L NO 20014560L NO 20014560 A NO20014560 A NO 20014560A NO 20014560 A NO20014560 A NO 20014560A NO 20014560 L NO20014560 L NO 20014560L
Authority
NO
Norway
Prior art keywords
quinasolines
therapeutic use
treatment
cancer
methods
Prior art date
Application number
NO20014560A
Other languages
English (en)
Other versions
NO20014560D0 (no
Inventor
Fatih M Uckun
Xing-Ping Liu
Rama K Narla
Original Assignee
Parker Hughes Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parker Hughes Inst filed Critical Parker Hughes Inst
Publication of NO20014560L publication Critical patent/NO20014560L/no
Publication of NO20014560D0 publication Critical patent/NO20014560D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Quinazolinforbindelser og fremgangsmåter for behandlingen av kreft og for behandlingen av allergiske reaksjoner.
NO20014560A 1999-03-19 2001-09-19 Quinasoliner og terapautisk anvendelse derav NO20014560D0 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12514599P 1999-03-19 1999-03-19
US12517799P 1999-03-19 1999-03-19
US12533899P 1999-03-19 1999-03-19
US09/357,404 US6258820B1 (en) 1999-03-19 1999-07-20 Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
PCT/US2000/006902 WO2000056720A1 (en) 1999-03-19 2000-03-16 Quinazolines and therapeutic use thereof

Publications (2)

Publication Number Publication Date
NO20014560L true NO20014560L (no) 2001-09-19
NO20014560D0 NO20014560D0 (no) 2001-09-19

Family

ID=27494574

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014560A NO20014560D0 (no) 1999-03-19 2001-09-19 Quinasoliner og terapautisk anvendelse derav

Country Status (10)

Country Link
US (5) US6258820B1 (no)
EP (1) EP1163228A1 (no)
JP (1) JP2002540103A (no)
KR (1) KR20020011973A (no)
AU (1) AU4171900A (no)
CA (1) CA2367861A1 (no)
IL (1) IL144954A0 (no)
MX (1) MXPA01009453A (no)
NO (1) NO20014560D0 (no)
WO (1) WO2000056720A1 (no)

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US6126917A (en) * 1999-06-01 2000-10-03 Hadasit Medical Research Services And Development Ltd. Epidermal growth factor receptor binding compounds for positron emission tomography
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WO2001036394A1 (en) * 1999-11-15 2001-05-25 Parker Hughes Institute 4-(4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline to prevent development of colorectal cancer
US6482828B1 (en) 1999-11-15 2002-11-19 Parker Hughes Institute 4-(4′-hydroxyphenyl) amino-6,7-dimethoxyquinazoline to prevent development of colorectal cancer
EP1294349A2 (en) * 2000-06-26 2003-03-26 The Regents Of The University Of Michigan Use of egf-r protein tyrosine kinase inhibitors for preventing photoaging in human skin
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
ES2400339T3 (es) 2002-07-15 2013-04-09 Symphony Evolution, Inc. Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer
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AU2003294142A1 (en) * 2002-12-24 2004-07-22 Astrazeneca Ab Therapeutic quinazoline derivatives
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GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
CA2744997A1 (en) 2003-09-26 2005-04-07 Exelixis, Inc. C-met modulators and method of use
JP4932495B2 (ja) 2004-01-23 2012-05-16 アムゲン インコーポレイテッド 化合物及び使用方法
CA2553433A1 (en) 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine compounds and their use in the treatment of inflammation angiogenesis and cancer
ATE413389T1 (de) 2004-02-03 2008-11-15 Astrazeneca Ab Chinazolinderivate
BRPI0400869B8 (pt) * 2004-03-02 2021-05-25 Univ Estadual Campinas Unicamp novos compostos derivados de 4-anilinoquinazolinas com propriedade inibidora de adenosinacinases
AU2005214373B2 (en) * 2004-02-19 2011-07-28 Rexahn Corporation Quinazoline derivatives and therapeutic use thereof
US7652009B2 (en) 2004-11-30 2010-01-26 Amgem Inc. Substituted heterocycles and methods of use
BRPI0607537A2 (pt) * 2005-04-12 2009-09-15 Elan Pharma Int Ltd formulações de derivado de quinazolina nanoparticulado
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
WO2008095847A1 (de) 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
CN101362719B (zh) * 2007-08-06 2012-04-18 北京师范大学 喹啉类衍生物以及包含其的组合物
EP2220078B1 (en) * 2007-10-29 2013-05-22 Amgen, Inc Benzomorpholine derivatives and methods of use
ES2734288T3 (es) 2007-11-28 2019-12-05 Dana Farber Cancer Inst Inc Inhibidores de miristato de moléculas pequeñas de Bcr-abl y métodos de uso
US8497369B2 (en) 2008-02-07 2013-07-30 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
NZ589883A (en) 2008-05-13 2012-06-29 Astrazeneca Ab Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy} quinazoline
EP2313397B1 (de) 2008-08-08 2016-04-20 Boehringer Ingelheim International GmbH Cyclohexyloxy-substituierte heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
CN101659658B (zh) * 2008-08-29 2014-04-02 北大方正集团有限公司 氰基取代的喹啉衍生物
EA038195B1 (ru) 2009-01-16 2021-07-22 Экселиксис, Инк. Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее применение для лечения рака почек и печени
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
US9193718B2 (en) 2012-03-26 2015-11-24 Fujian Institute Of Research On The Structure Of Matter, Chinese Academy Of Sciences Quinazoline derivative and application thereof
ES2818531T3 (es) 2015-12-17 2021-04-13 Biokine Therapeutics Ltd Moléculas pequeñas para inhibir la actividad de las quimiocinas y/o el crecimiento de células cancerosas
EP3390378B1 (en) * 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
WO2019235571A1 (ja) * 2018-06-06 2019-12-12 富士フイルム株式会社 血液がんの処置剤および医薬組成物
US20210113540A1 (en) * 2018-06-06 2021-04-22 National University Corporation Hokkaido University Treatment agent and pharmaceutical composition for glioma
WO2019235572A1 (ja) * 2018-06-06 2019-12-12 富士フイルム株式会社 固形がんの処置剤および医薬組成物
CA3107453A1 (en) * 2018-07-23 2020-01-30 Ohio State Innovation Foundation Derivatives of papaverine that are effective hypoxic tumor radiosensitizers
CN114096524B (zh) 2019-05-15 2025-03-04 阿龙拜欧有限公司 用于治疗癌症、抑制趋化因子活性和/或诱导细胞死亡的小分子
WO2022086622A1 (en) * 2020-10-21 2022-04-28 Ohio State Innovation Foundation Methods to sensitize tumors to treatment by immunotherapy

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Also Published As

Publication number Publication date
CA2367861A1 (en) 2000-09-28
US7038049B2 (en) 2006-05-02
JP2002540103A (ja) 2002-11-26
US20020137757A1 (en) 2002-09-26
US20010016588A1 (en) 2001-08-23
AU4171900A (en) 2000-10-09
WO2000056720A1 (en) 2000-09-28
KR20020011973A (ko) 2002-02-09
US20050075353A1 (en) 2005-04-07
US6638939B2 (en) 2003-10-28
US6258820B1 (en) 2001-07-10
MXPA01009453A (es) 2002-05-14
US20040039002A1 (en) 2004-02-26
IL144954A0 (en) 2002-06-30
US6358962B2 (en) 2002-03-19
EP1163228A1 (en) 2001-12-19
NO20014560D0 (no) 2001-09-19

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