NO20015901L - Robust autofokussystem for mikroskop - Google Patents

Robust autofokussystem for mikroskop

Info

Publication number
NO20015901L
NO20015901L NO20015901A NO20015901A NO20015901L NO 20015901 L NO20015901 L NO 20015901L NO 20015901 A NO20015901 A NO 20015901A NO 20015901 A NO20015901 A NO 20015901A NO 20015901 L NO20015901 L NO 20015901L
Authority
NO
Norway
Prior art keywords
filter
image
autofocusing
focus
elements
Prior art date
Application number
NO20015901A
Other languages
English (en)
Other versions
NO20015901D0 (no
Inventor
Jan-Mark Geusebroek
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20015901D0 publication Critical patent/NO20015901D0/no
Publication of NO20015901L publication Critical patent/NO20015901L/no

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/28—Systems for automatic generation of focusing signals
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/244—Devices for focusing using image analysis techniques
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Automatic Focus Adjustment (AREA)
  • Microscoopes, Condenser (AREA)
  • Eye Examination Apparatus (AREA)
  • Memory System Of A Hierarchy Structure (AREA)
  • Studio Devices (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en fremgangsmåte og apparat for autofokusering av et optisk instrument, spesielt et mikroskop (10). Autofokussystemet inkluderer et di-gitalt gradientfilter for å generere en fokusverdi fra hvert fanget bilde. Bilder kan fanges ved forskjellige po-sisjoner og fokusverdiene analyseres for å bestemme et fo-kusverdimaksimum. Posisjonen tilsvarende dette maksimum tas deretter som fokusposisjonen. Romomfanget av filteret er. fortrinnsvis innstillbart slik at det digitale filter innstillbart velger elementer av bildet avhengig av deres størrelse i bildet. Derved, er filtreringsprosessen kon-trollerbar slik at den påvirkes av elementer av bildet viss størrelse kan være spesifisert av operatøren indirekte ved hjelp av romomfanget av filteret. Dette tillater eksklude-ring av små eller store elementer av bildet fra autofokus-prosedyren som filteret fortrinnsvis bør ignorere. Autofokussystemet er spesielt nyttig for autofokusering av bio-logiske prøver.
NO20015901A 1999-06-04 2001-12-03 Robust autofokussystem for mikroskop NO20015901L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201795 1999-06-04
PCT/EP2000/004987 WO2000075709A1 (en) 1999-06-04 2000-05-30 Robust autofocus system for a microscope

Publications (2)

Publication Number Publication Date
NO20015901D0 NO20015901D0 (no) 2001-12-03
NO20015901L true NO20015901L (no) 2002-02-04

Family

ID=8240282

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20015901A NO20015901L (no) 1999-06-04 2001-12-03 Robust autofokussystem for mikroskop

Country Status (13)

Country Link
EP (1) EP1190271B1 (no)
JP (1) JP2003501693A (no)
KR (1) KR100699445B1 (no)
AT (1) ATE249057T1 (no)
AU (1) AU773652B2 (no)
CA (1) CA2374910C (no)
DE (1) DE60005007T2 (no)
DK (1) DK1190271T3 (no)
IL (1) IL146882A0 (no)
NO (1) NO20015901L (no)
NZ (1) NZ515390A (no)
WO (1) WO2000075709A1 (no)
ZA (1) ZA200109941B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002063367A1 (en) 2001-02-02 2002-08-15 Cellomics, Inc. Method for estimating the best initial focus position
DE10113084A1 (de) * 2001-03-17 2002-09-19 Leica Microsystems Autofokus-Mikroskopsystem
US7141773B2 (en) * 2001-08-06 2006-11-28 Bioview Ltd. Image focusing in fluorescent imaging
DE10217404A1 (de) 2002-04-18 2003-11-06 Leica Microsystems Autofokusverfahren für ein Mikroskop und System zum Einstellen des Fokus für ein Mikroskop
US7030351B2 (en) * 2003-11-24 2006-04-18 Mitutoyo Corporation Systems and methods for rapidly automatically focusing a machine vision inspection system
JP2006039315A (ja) * 2004-07-28 2006-02-09 Hamamatsu Photonics Kk 自動焦点装置及びそれを用いた顕微鏡装置
JP4774835B2 (ja) * 2005-07-04 2011-09-14 株式会社ニコン 顕微鏡
JP4663602B2 (ja) * 2006-08-14 2011-04-06 オリンパス株式会社 自動合焦装置、顕微鏡および自動合焦方法
US7769219B2 (en) * 2006-12-11 2010-08-03 Cytyc Corporation Method for assessing image focus quality
WO2008131225A1 (en) * 2007-04-20 2008-10-30 Interscopic Analysis, Llc Method, system and apparatus for capturing digital microscopic medical images for remote analysis via machine vision or distributed panels
WO2009107321A1 (ja) * 2008-02-28 2009-09-03 株式会社ニコン 顕微鏡装置および細胞培養装置
FR2931966A1 (fr) * 2008-05-30 2009-12-04 Novacyt Procede d'analyse cellulaire d'un prelevement au moyen d'une plaque d'analyse virtuelle
US8111938B2 (en) 2008-12-23 2012-02-07 Mitutoyo Corporation System and method for fast approximate focus
WO2011005238A1 (en) * 2009-07-08 2011-01-13 Freescale Semiconductor, Inc. Degree-of-focus determination module, position-of-best-focus selection modules, image processing module, imaging system, and corresponding method
DE102009045107A1 (de) * 2009-09-29 2011-03-31 Carl Zeiss Imaging Solutions Gmbh Automatisches Fokussierverfahren für ein optisches Instrument zum vergrößerten Betrachten eines Objektes
US8111905B2 (en) 2009-10-29 2012-02-07 Mitutoyo Corporation Autofocus video tool and method for precise dimensional inspection
US8786694B2 (en) * 2009-12-31 2014-07-22 Abbott Point Of Care, Inc. Method and apparatus for fast focus imaging biologic specimens
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
KR101302415B1 (ko) 2012-06-27 2013-09-06 주식회사 나무가 3Ｄ Ｄｅｐｔｈ렌즈의 초점을 자동으로 조절하는 3Ｄ 카메라 신호처리시스템
KR101409320B1 (ko) * 2013-04-04 2014-06-19 주식회사 제이엔옵틱 현미경을 이용한 샘플의 높이측정방법
EP3757648B1 (en) * 2019-06-28 2023-08-30 Associação Fraunhofer Portugal Optical system attachable to a mobile device for scanning biological sample slides and operating method thereof
CN117705775B (zh) * 2024-02-05 2024-04-26 中国科学院长春光学精密机械与物理研究所 多色荧光显微成像系统、成像方法、自动聚焦方法
CN120103597B (zh) * 2024-12-30 2025-11-21 苏州博致医疗科技有限公司 一种自动聚焦方法及显微镜图像获取设备

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53116852A (en) * 1977-03-23 1978-10-12 Olympus Optical Co Ltd Automatic focus adjusting system
JPS63200112A (ja) * 1987-02-16 1988-08-18 Olympus Optical Co Ltd オ−トフオ−カス装置
US5790710A (en) * 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
DK0834758T3 (da) * 1994-07-01 1999-12-13 Jeffrey H Price Kontinuerligt volumenafbildningssystem til scanningmikroskopi
US5647025A (en) * 1994-09-20 1997-07-08 Neopath, Inc. Automatic focusing of biomedical specimens apparatus
DE19726696A1 (de) * 1997-06-24 1999-01-07 Jenoptik Jena Gmbh Verfahren zur Fokussierung bei der Abbildung strukturierter Oberflächen von scheibenförmigen Objekten

Also Published As

Publication number Publication date
ATE249057T1 (de) 2003-09-15
NO20015901D0 (no) 2001-12-03
EP1190271B1 (en) 2003-09-03
KR100699445B1 (ko) 2007-03-26
CA2374910C (en) 2009-10-06
AU5399200A (en) 2000-12-28
EP1190271A1 (en) 2002-03-27
NZ515390A (en) 2002-10-25
DE60005007D1 (de) 2003-10-09
JP2003501693A (ja) 2003-01-14
DE60005007T2 (de) 2004-07-08
WO2000075709A1 (en) 2000-12-14
AU773652B2 (en) 2004-06-03
IL146882A0 (en) 2002-08-14
CA2374910A1 (en) 2000-12-14
ZA200109941B (en) 2003-03-03
DK1190271T3 (da) 2003-12-22
KR20020001883A (ko) 2002-01-09

Similar Documents

Publication Publication Date Title
NO20015901D0 (no) Robust autofokussystem for mikroskop
JP4136011B2 (ja) 焦点深度伸長装置
DE69704554D1 (de) Konfokales mikroskop
DE60230960D1 (de) Vorrichtung und Verfahren zur Erfassung digitaler Mikroskopbilder
ATE521006T1 (de) Verfahren, software und gerät zur fokussierung eines optischen systems mittels computerbildanalyse
ATE227434T1 (de) Verfahren und vorrichtung zur objektabbildung
ATE285590T1 (de) Methode und vorrichtung zur aufnahme dreidimensionaler abbildungen von schwebend gehaltenen mikroobjekten unter verwendung hochauflösender mikroskopie
DE69720458D1 (de) Programmierbares räumlich lichtmoduliertes Mikroskop und Mikroskopieverfahren
DE60023156D1 (de) Verfahren und gerät zur verminderung der trapezverzerrung und verbesserung der bildschärfe in einem optischen bilderfassungssystem
DE602004025298D1 (de) Mikroskop-System und Verfahren
DE60004227D1 (de) Vorrichtung und verfahren für infrarot-autofokus mit bildauswertung
US8508589B2 (en) Imaging systems and associated methods thereof
US20020186464A1 (en) Autofocus microscope system
DE69940697D1 (de) Verfahren und vorrichtung zur automatischen fokussierung eines dokuments währen berührungslosem abtasten
JP3267984B2 (ja) 自動合焦装置及び自動合焦装置における合焦調整方法
EP1255146A3 (de) Verfahren und Vorrichtung zum automatischen fokussieren eines optischen Gerätes
JP2008046305A (ja) 自動合焦装置、顕微鏡および自動合焦方法
CN109003228A (zh) 一种暗场显微大视场自动拼接成像方法
EP3223054A1 (en) Microscope system and specimen observation method
DE10297550D2 (de) Verfahren und Vorrichtung zur kontaktlosen Gewinnung von Bildern der Kornea
JP2005221368A (ja) 観察装置及びその観察方法
CN105301794B (zh) 用于快速运动物体的超高分辨成像装置
JP2007047228A (ja) 結像光学装置、及び光学ユニット
JPS63307652A (ja) 電子顕微鏡の焦点位置検出装置
EP3304049A1 (en) Systems and methods for generating a structured illumination image

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application