NO20021041L - Polymorfismer av N-metyl-N-(3{3-[2-tienylkarbonyl]pyrazol- [1,5-alfa]-pyrimidin-7-yl}fenyl)acetamid og blandinger ogfremgangsmåter relatert dertil - Google Patents

Polymorfismer av N-metyl-N-(3{3-[2-tienylkarbonyl]pyrazol- [1,5-alfa]-pyrimidin-7-yl}fenyl)acetamid og blandinger ogfremgangsmåter relatert dertil

Info

Publication number
NO20021041L
NO20021041L NO20021041A NO20021041A NO20021041L NO 20021041 L NO20021041 L NO 20021041L NO 20021041 A NO20021041 A NO 20021041A NO 20021041 A NO20021041 A NO 20021041A NO 20021041 L NO20021041 L NO 20021041L
Authority
NO
Norway
Prior art keywords
thienylcarbonyl
pyrimidin
acetamide
phenyl
methyl
Prior art date
Application number
NO20021041A
Other languages
English (en)
Other versions
NO322752B1 (no
NO20021041D0 (no
Inventor
William J Thiele
Patrick B O'donnell
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of NO20021041D0 publication Critical patent/NO20021041D0/no
Publication of NO20021041L publication Critical patent/NO20021041L/no
Publication of NO322752B1 publication Critical patent/NO322752B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Polymorfer av N-metyl-N-(3-{3-[2-tienylkarbonyl]pyrazol-[1,5-a]-pyrimidin-7-yl}fenyl)acetamid (forbindelse (1)), samt anvendelse av disse som et sedativt hypnotisk middel, et anxiolytisk middel, et antikonvulsivt middel og et skjelett-muskelavslappende middel. Fremgangsmåter for fremstilling av slike, så vel som beslektede preparater og metoder beskrives også, spesielt med hensyn til behandling av søvnløshet. En polymorf form I som er i besittelse av eksepsjonell fysikalsk og varmestabilitet tilveiebringes. En polymorf form II.
NO20021041A 1999-09-02 2002-03-01 Polymorfismer av N-metyl-N-(3{3-[2-tienylkarbonyl]pyrazol-[1,5-alfa]-pyrimidin-7-yl}fenyl)acetamid og blandinger og fremgangsmater relatert dertil NO322752B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38952499A 1999-09-02 1999-09-02
US42162099A 1999-10-19 1999-10-19
PCT/US2000/024051 WO2001015700A1 (en) 1999-09-02 2000-09-01 POLYMORPHS OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5-α]-PYRIMIDIN -7-YL }PHENYL )ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO

Publications (3)

Publication Number Publication Date
NO20021041D0 NO20021041D0 (no) 2002-03-01
NO20021041L true NO20021041L (no) 2002-04-03
NO322752B1 NO322752B1 (no) 2006-12-04

Family

ID=27012737

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021041A NO322752B1 (no) 1999-09-02 2002-03-01 Polymorfismer av N-metyl-N-(3{3-[2-tienylkarbonyl]pyrazol-[1,5-alfa]-pyrimidin-7-yl}fenyl)acetamid og blandinger og fremgangsmater relatert dertil

Country Status (26)

Country Link
EP (2) EP1214075B1 (no)
JP (1) JP4592241B2 (no)
KR (1) KR20020035585A (no)
CN (2) CN1331865C (no)
AP (1) AP1631A (no)
AT (1) ATE269082T1 (no)
AU (2) AU769856B2 (no)
BR (1) BR0014459A (no)
CA (1) CA2382588C (no)
CZ (1) CZ2002783A3 (no)
DE (1) DE60011638T2 (no)
DK (1) DK1214075T3 (no)
EA (1) EA004706B1 (no)
ES (1) ES2222920T3 (no)
HK (1) HK1047407B (no)
HU (1) HUP0202698A3 (no)
IL (2) IL148242A0 (no)
MX (1) MXPA02002314A (no)
NO (1) NO322752B1 (no)
NZ (1) NZ517298A (no)
OA (1) OA12200A (no)
PL (1) PL353362A1 (no)
PT (1) PT1214075E (no)
SK (1) SK2782002A3 (no)
TR (1) TR200200534T2 (no)
WO (1) WO2001015700A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532152B1 (en) * 2002-08-26 2006-10-25 Neurocrine Biosciences, Inc. Novel polymorph of n-methyl-n-(3- 3- 2-thienylcarbonyl|-pyrazol- 1,5-alpha|-pyrimidin-7-yl phenyl)acetamide and compositions and methods related thereto
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
EP1918290A1 (en) * 2006-10-11 2008-05-07 Ferrer Internacional, S.A. Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
EP1956021A1 (en) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
WO2010109480A2 (en) * 2009-03-24 2010-09-30 Glenmark Generics Limited Processes for the preparation of indiplon and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
SG30590G (en) * 1985-05-13 1995-09-18 American Cyanamid Co D7-(3-disubstituted amino) phenylaepyrazolod 1,5-aaepyrimidines
US5421422A (en) * 1993-11-19 1995-06-06 Boretec Inc Roller cutter mount for tunneling machine

Also Published As

Publication number Publication date
CA2382588A1 (en) 2001-03-08
DK1214075T3 (da) 2004-10-25
EP1214075B1 (en) 2004-06-16
NO322752B1 (no) 2006-12-04
IL148242A0 (en) 2002-09-12
HUP0202698A3 (en) 2004-12-28
JP4592241B2 (ja) 2010-12-01
MXPA02002314A (es) 2002-08-12
CN1331865C (zh) 2007-08-15
EA200200320A1 (ru) 2002-08-29
SK2782002A3 (en) 2003-04-01
JP2003508440A (ja) 2003-03-04
OA12200A (en) 2006-05-09
DE60011638D1 (de) 2004-07-22
CZ2002783A3 (cs) 2004-01-14
ES2222920T3 (es) 2005-02-16
CN1198824C (zh) 2005-04-27
EA004706B1 (ru) 2004-06-24
NO20021041D0 (no) 2002-03-01
HK1047407B (en) 2004-12-24
PL353362A1 (en) 2003-11-17
EP1477169A1 (en) 2004-11-17
DE60011638T2 (de) 2004-10-21
AU2004201356A1 (en) 2004-04-29
AP1631A (en) 2006-07-12
HK1047407A1 (en) 2003-02-21
ATE269082T1 (de) 2004-07-15
WO2001015700A9 (en) 2002-09-12
PT1214075E (pt) 2004-11-30
BR0014459A (pt) 2002-07-16
IL148242A (en) 2006-12-10
KR20020035585A (ko) 2002-05-11
EP1214075A4 (en) 2003-05-02
CN1680376A (zh) 2005-10-12
EP1214075A1 (en) 2002-06-19
AU6949100A (en) 2001-03-26
WO2001015700A1 (en) 2001-03-08
NZ517298A (en) 2004-01-30
AP2002002428A0 (en) 2002-03-31
CA2382588C (en) 2008-11-25
TR200200534T2 (tr) 2002-06-21
CN1374866A (zh) 2002-10-16
HUP0202698A2 (hu) 2002-12-28
AU769856B2 (en) 2004-02-05

Similar Documents

Publication Publication Date Title
BR0313695A (pt) Polimorfo de n-metil-n-(3-{3-[2-tienil carbonil]pirazol-[1,5-alfa]pirimidin-7-il}fenil) acetamida e composições e processos relacionados ao mesmo
NO934103D0 (no) Forbedringer i benzodiazepinbehandling med cholinesterase- inhibitorer
NO934104D0 (no) Behandling av tretthetssyndrom med cholinesterase-inhibitorer
NO307181B1 (no) Fremgangsmåte for fremstilling av N-[3(3-cyanopyrazol[1,5- a]pyrimidin-7-yl)fenyl]-N-etylacetamid
NO20021041L (no) Polymorfismer av N-metyl-N-(3{3-[2-tienylkarbonyl]pyrazol- [1,5-alfa]-pyrimidin-7-yl}fenyl)acetamid og blandinger ogfremgangsmåter relatert dertil
BR0013138A (pt) Sìntese de pirazolopirimidinas substituìdas
IL160076A0 (en) Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
ES533654A0 (es) Procedimiento para preparar pirazol (1,5-a)pirimidin-metanonas
MXPA03001048A (es) Polimorfos de zaleplon y metodos para la preparacion de los mismos.
DK160097C (da) Fremgangsmaade til fremstilling af 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl-6-oxo-4h-imidazo(1,5-a)(1,4)benzodiazepin samt 3-cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazol til anvendelse som udgangsmateriale ved fremgangsmaaden
ATE413407T1 (de) Pyrrolo(2,1-c)(1,4)benzodiazepin-dimere als antitumormittel und verfahren dafür
Kim et al. Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues
BR0304837A (pt) Processo para a preparação de n-[3-(3-ciano-pirazol[1,5-a]pirimidin-7-il)fenil]-n-etilace tamida) (zaleplon)
ES2182541T3 (es) Pyrazolo(3,4-d)pirimidinas con actividad anticonvulsiva y antialergica /aniasmatica.
EP0462468A3 (en) 9-amino-2-phenylbicyclo(3.3.1)nonane and 9-amino-2-phenylbicyclo(3.3.1)-non-2-ene and therapeutic agents containing them

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees