BR0014459A - Polìmeros de n-metil-n- (3-{3-[2-tienilcarbonil]-pirazol-[1,5-"alfa"]-pirimidin-7-il } fenil) acetamida e composições e métodos relacionados aos mesmos - Google Patents

Polìmeros de n-metil-n- (3-{3-[2-tienilcarbonil]-pirazol-[1,5-"alfa"]-pirimidin-7-il } fenil) acetamida e composições e métodos relacionados aos mesmos

Info

Publication number
BR0014459A
BR0014459A BR0014459-2A BR0014459A BR0014459A BR 0014459 A BR0014459 A BR 0014459A BR 0014459 A BR0014459 A BR 0014459A BR 0014459 A BR0014459 A BR 0014459A
Authority
BR
Brazil
Prior art keywords
methyl
methods
thienylcarbonyl
pyrazol
pyrimidin
Prior art date
Application number
BR0014459-2A
Other languages
English (en)
Inventor
William J Thiele
Patrick B O'donnell
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of BR0014459A publication Critical patent/BR0014459A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"POLìMEROS DE N-METIL-N-(3-{3-[2-TIENILCARBONILI]PIRAZOL-[1,5-<244>]-PIRI MIDIN-7-IL}FENIL)ACETAMIDA E COMPOSIçõES E MéTODOS RELACIONADOS AOS MESMOS". Polimorfos de N-metil-N-(3-{3-[2- tienilcarbonil]pirazol - [1,5-<244>- pirimidin -7-il} fenil) acetamida (Composto (1)), e uso dos mesmos como um agente sedativo- hipnótico, ansiolítico, anticonvulsivo e relaxante do músculo esqueletal. Processos para preparar os mesmos, bem como métodos e composições relacionadas também são descritos, particularmente com relação ao tratamento de insónia. Provê-se um polimorfo de forma I possuindo exceção física e estabilidade em calor. Um polimorfo de forma II.
BR0014459-2A 1999-09-02 2000-09-01 Polìmeros de n-metil-n- (3-{3-[2-tienilcarbonil]-pirazol-[1,5-"alfa"]-pirimidin-7-il } fenil) acetamida e composições e métodos relacionados aos mesmos BR0014459A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38952499A 1999-09-02 1999-09-02
US42162099A 1999-10-19 1999-10-19
PCT/US2000/024051 WO2001015700A1 (en) 1999-09-02 2000-09-01 POLYMORPHS OF N-METHYL-N-(3-{3-[2-THIENYLCARBONYL]-PYRAZOL-[1,5-α]-PYRIMIDIN -7-YL }PHENYL )ACETAMIDE AND COMPOSITIONS AND METHODS RELATED THERETO

Publications (1)

Publication Number Publication Date
BR0014459A true BR0014459A (pt) 2002-07-16

Family

ID=27012737

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014459-2A BR0014459A (pt) 1999-09-02 2000-09-01 Polìmeros de n-metil-n- (3-{3-[2-tienilcarbonil]-pirazol-[1,5-"alfa"]-pirimidin-7-il } fenil) acetamida e composições e métodos relacionados aos mesmos

Country Status (26)

Country Link
EP (2) EP1214075B1 (pt)
JP (1) JP4592241B2 (pt)
KR (1) KR20020035585A (pt)
CN (2) CN1331865C (pt)
AP (1) AP1631A (pt)
AT (1) ATE269082T1 (pt)
AU (2) AU769856B2 (pt)
BR (1) BR0014459A (pt)
CA (1) CA2382588C (pt)
CZ (1) CZ2002783A3 (pt)
DE (1) DE60011638T2 (pt)
DK (1) DK1214075T3 (pt)
EA (1) EA004706B1 (pt)
ES (1) ES2222920T3 (pt)
HK (1) HK1047407B (pt)
HU (1) HUP0202698A3 (pt)
IL (2) IL148242A0 (pt)
MX (1) MXPA02002314A (pt)
NO (1) NO322752B1 (pt)
NZ (1) NZ517298A (pt)
OA (1) OA12200A (pt)
PL (1) PL353362A1 (pt)
PT (1) PT1214075E (pt)
SK (1) SK2782002A3 (pt)
TR (1) TR200200534T2 (pt)
WO (1) WO2001015700A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532152B1 (en) * 2002-08-26 2006-10-25 Neurocrine Biosciences, Inc. Novel polymorph of n-methyl-n-(3- 3- 2-thienylcarbonyl|-pyrazol- 1,5-alpha|-pyrimidin-7-yl phenyl)acetamide and compositions and methods related thereto
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
EP1918290A1 (en) * 2006-10-11 2008-05-07 Ferrer Internacional, S.A. Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
EP1956021A1 (en) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
WO2010109480A2 (en) * 2009-03-24 2010-09-30 Glenmark Generics Limited Processes for the preparation of indiplon and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
SG30590G (en) * 1985-05-13 1995-09-18 American Cyanamid Co D7-(3-disubstituted amino) phenylaepyrazolod 1,5-aaepyrimidines
US5421422A (en) * 1993-11-19 1995-06-06 Boretec Inc Roller cutter mount for tunneling machine

Also Published As

Publication number Publication date
NO20021041L (no) 2002-04-03
CA2382588A1 (en) 2001-03-08
DK1214075T3 (da) 2004-10-25
EP1214075B1 (en) 2004-06-16
NO322752B1 (no) 2006-12-04
IL148242A0 (en) 2002-09-12
HUP0202698A3 (en) 2004-12-28
JP4592241B2 (ja) 2010-12-01
MXPA02002314A (es) 2002-08-12
CN1331865C (zh) 2007-08-15
EA200200320A1 (ru) 2002-08-29
SK2782002A3 (en) 2003-04-01
JP2003508440A (ja) 2003-03-04
OA12200A (en) 2006-05-09
DE60011638D1 (de) 2004-07-22
CZ2002783A3 (cs) 2004-01-14
ES2222920T3 (es) 2005-02-16
CN1198824C (zh) 2005-04-27
EA004706B1 (ru) 2004-06-24
NO20021041D0 (no) 2002-03-01
HK1047407B (en) 2004-12-24
PL353362A1 (en) 2003-11-17
EP1477169A1 (en) 2004-11-17
DE60011638T2 (de) 2004-10-21
AU2004201356A1 (en) 2004-04-29
AP1631A (en) 2006-07-12
HK1047407A1 (en) 2003-02-21
ATE269082T1 (de) 2004-07-15
WO2001015700A9 (en) 2002-09-12
PT1214075E (pt) 2004-11-30
IL148242A (en) 2006-12-10
KR20020035585A (ko) 2002-05-11
EP1214075A4 (en) 2003-05-02
CN1680376A (zh) 2005-10-12
EP1214075A1 (en) 2002-06-19
AU6949100A (en) 2001-03-26
WO2001015700A1 (en) 2001-03-08
NZ517298A (en) 2004-01-30
AP2002002428A0 (en) 2002-03-31
CA2382588C (en) 2008-11-25
TR200200534T2 (tr) 2002-06-21
CN1374866A (zh) 2002-10-16
HUP0202698A2 (hu) 2002-12-28
AU769856B2 (en) 2004-02-05

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