NO20021999D0 - Spaltning av intermediater i syntesen av hovedsakelig rent bicalutamid - Google Patents

Spaltning av intermediater i syntesen av hovedsakelig rent bicalutamid

Info

Publication number: NO20021999D0
Authority: NO; Norway
Prior art keywords: intermediates; cleavage; synthesis; substantially pure; pure bicalutamide
Prior art date: 1999-10-27

Application number

NO20021999A

Other languages

English (en)

Other versions

NO20021999L (no

Inventor

Nnochiri N Ekwuribe

Kenneth D James

Original Assignee

Nobex Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-27

Filing date

2002-04-26

Publication date

2002-04-26

2002-04-26 Application filed by Nobex Corp filed Critical Nobex Corp

2002-04-26 Publication of NO20021999D0 publication Critical patent/NO20021999D0/no

2002-06-20 Publication of NO20021999L publication Critical patent/NO20021999L/no

Links

LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 title 1
229960000997 bicalutamide Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003776 cleavage reaction Methods 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
230000007017 scission Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/06—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20021999A 1999-10-27 2002-04-26 Spaltning av intermediater i syntesen av hovedsakelig rent bicalutamid NO20021999L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16188499P	1999-10-27	1999-10-27
PCT/US2000/041609 WO2001034563A1 (en)	1999-10-27	2000-10-25	Resolution of intermediates in the synthesis of substantially pure bicalutamide

Publications (2)

Publication Number	Publication Date
NO20021999D0 true NO20021999D0 (no)	2002-04-26
NO20021999L NO20021999L (no)	2002-06-20

Family

ID=22583193

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20021999A NO20021999L (no)	1999-10-27	2002-04-26	Spaltning av intermediater i syntesen av hovedsakelig rent bicalutamid

Country Status (19)

Country	Link
US (1)	US6593492B1 (no)
EP (1)	EP1224167A1 (no)
JP (1)	JP4778178B2 (no)
KR (1)	KR20020067509A (no)
CN (1)	CN1413188A (no)
AU (1)	AU2619501A (no)
BR (1)	BR0015124A (no)
CA (1)	CA2389100A1 (no)
CZ (1)	CZ20021434A3 (no)
HK (1)	HK1048299A1 (no)
HU (1)	HUP0203186A2 (no)
IL (2)	IL149256A0 (no)
MX (1)	MXPA02004225A (no)
NO (1)	NO20021999L (no)
NZ (1)	NZ518552A (no)
PL (1)	PL360059A1 (no)
TW (1)	TWI271397B (no)
WO (1)	WO2001034563A1 (no)
ZA (1)	ZA200203228B (no)

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US6995284B2 (en)	2000-08-24	2006-02-07	The University Of Tennessee Research Foundation	Synthesis of selective androgen receptor modulators
US6071957A (en)	1996-11-27	2000-06-06	The University Of Tennessee Research Corporation	Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
US6998500B2 (en)	2000-08-24	2006-02-14	University Of Tennessee Research Foundation	Selective androgen receptor modulators and methods of use thereof
US6838484B2 (en)	2000-08-24	2005-01-04	University Of Tennessee Research Foundation	Formulations comprising selective androgen receptor modulators
US8008348B2 (en)	2001-12-06	2011-08-30	University Of Tennessee Research Foundation	Treating muscle wasting with selective androgen receptor modulators
US8445534B2 (en)	2000-08-24	2013-05-21	University Of Tennessee Research Foundation	Treating androgen decline in aging male (ADAM)-associated conditions with SARMs
US7622503B2 (en)	2000-08-24	2009-11-24	University Of Tennessee Research Foundation	Selective androgen receptor modulators and methods of use thereof
US7026500B2 (en)	2000-08-24	2006-04-11	University Of Tennessee Research Foundation	Halogenated selective androgen receptor modulators and methods of use thereof
US6737550B2 (en) *	2001-06-13	2004-05-18	Biogal Gryogyszergyar Rt.	Process for preparing rac-bicalutamide and its intermediates
PT1463497E (pt)	2001-12-06	2011-12-20	Gtx Inc	Tratamento do desgaste muscular com moduladores selectivos do receptor de androgénios
US8853266B2 (en)	2001-12-06	2014-10-07	University Of Tennessee Research Foundation	Selective androgen receptor modulators for treating diabetes
US6740770B2 (en) *	2001-12-13	2004-05-25	Sumika Fine Chemicals Co., Ltd.	Crystal of bicalutamide and production method thereof
CA2689080C (en)	2002-02-07	2011-07-05	University Of Tennessee Research Foundation	Treating benign prostate hyperplasia with sarms
JP5113979B2 (ja)	2002-02-28	2013-01-09	ユニバーシティオブテネシーリサーチファウンデーション	複数置換の選択的アンドロゲンレセプタ修飾因子及びその使用方法
WO2003074450A2 (en)	2002-02-28	2003-09-12	The University Of Tennessee Research Corporation	Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy
US7772433B2 (en)	2002-02-28	2010-08-10	University Of Tennessee Research Foundation	SARMS and method of use thereof
US7803970B2 (en)	2002-02-28	2010-09-28	University Of Tennessee Research Foundation	Multi-substitued selective androgen receptor modulators and methods of use thereof
AU2003241583B2 (en)	2002-06-17	2009-05-21	University Of Tennessee Research Foundation	N-bridged selective androgen receptor modulators and methods of use thereof
US7741371B2 (en)	2002-06-17	2010-06-22	University Of Tennessee Research Foundation	Selective androgen receptor modulators and methods of use thereof
US6818766B2 (en)	2002-10-02	2004-11-16	Synthon Bv	Process for making bicalutamide and intermediates thereof
US8309603B2 (en)	2004-06-07	2012-11-13	University Of Tennessee Research Foundation	SARMs and method of use thereof
US9884038B2 (en)	2004-06-07	2018-02-06	University Of Tennessee Research Foundation	Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en)	2004-06-07	2018-02-13	University Of Tennessee Research Foundation	Selective androgen receptor modulator for treating hormone-related conditions
EP1669347A1 (en) *	2004-12-10	2006-06-14	Helm AG	Process for the preparation of 3-¬(4-fluorophenyl) sulfonyl\|-2-hydroxy-2-methyl propionic acid
US20060269596A1 (en) *	2005-01-12	2006-11-30	Gary Liversidge	Controlled release compositions comprising an acylanilide
KR20070114343A (ko) *	2005-03-29	2007-12-03	유에스브이 리미티드	비칼루타미드의 제조 방법
WO2008013791A2 (en) *	2006-07-24	2008-01-31	University Of Delaware	Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
US9844528B2 (en)	2006-08-24	2017-12-19	University Of Tennessee Research Foundation	SARMs and method of use thereof
AU2007287070C1 (en)	2006-08-24	2013-02-14	University Of Tennessee Research Foundation	Substituted acylanilides and methods of use thereof
US10010521B2 (en)	2006-08-24	2018-07-03	University Of Tennessee Research Foundation	SARMs and method of use thereof
US9730908B2 (en)	2006-08-24	2017-08-15	University Of Tennessee Research Foundation	SARMs and method of use thereof
US7968603B2 (en)	2007-09-11	2011-06-28	University Of Tennessee Research Foundation	Solid forms of selective androgen receptor modulators
WO2011008543A2 (en) *	2009-06-29	2011-01-20	University Of Delaware	Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
JP2013544768A (ja)	2010-09-29	2013-12-19	シルパメディケアリミテッド	ビカルタミドの調製方法
CN103539710A (zh) *	2012-07-02	2014-01-29	国药一心制药有限公司	一种（r）-比卡鲁胺的合成方法
US9969683B2 (en)	2012-07-13	2018-05-15	Gtx, Inc.	Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
EP3733170A1 (en)	2012-07-13	2020-11-04	Oncternal Therapeutics, Inc.	A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms)
US10987334B2 (en)	2012-07-13	2021-04-27	University Of Tennessee Research Foundation	Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10314807B2 (en)	2012-07-13	2019-06-11	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en)	2012-07-13	2017-08-29	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en)	2012-07-13	2019-04-16	Gtx, Inc.	Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en)	2012-07-13	2017-04-18	Gtx, Inc.	Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US12685719B2 (en)	2012-07-13	2026-07-21	University Of Tennessee Research Foundation	Treatment of breast cancer with selective androgen receptor modulators and cyclin-dependent kinase 4/6 inhibitors
CN104897818A (zh) *	2015-06-19	2015-09-09	重庆医药高等专科学校	一种同时测定比卡鲁胺中6种有关物质的uplc方法
CN108069887B (zh) *	2016-11-17	2021-04-20	山西振东制药股份有限公司	一种(r)-比卡鲁胺中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58183669A (ja) *	1982-04-19	1983-10-26	Teikoku Chem Ind Corp Ltd	光学活性なプロピオン酸誘導体の製造方法
DE3372965D1 (en) *	1982-07-23	1987-09-17	Ici Plc	Amide derivatives
GB8617652D0 (en) *	1986-07-18	1986-08-28	Ici Plc	Acylanilide derivatives
CA2146005A1 (en) *	1992-10-21	1994-04-28	Charles W. Murtiashaw, Iii	Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl)benzoic acids
CA2181358A1 (en)	1994-01-21	1995-07-27	Nancy M. Gray	Methods and compositions for treating androgen-dependent diseases using optically pure r-(-)-casodex
WO1998055153A1 (en)	1997-06-04	1998-12-10	The University Of Tennessee Research Corporation	Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging

2000
- 2000-10-25 NZ NZ518552A patent/NZ518552A/en unknown
- 2000-10-25 CZ CZ20021434A patent/CZ20021434A3/cs unknown
- 2000-10-25 KR KR1020027005357A patent/KR20020067509A/ko not_active Withdrawn
- 2000-10-25 AU AU26195/01A patent/AU2619501A/en not_active Abandoned
- 2000-10-25 WO PCT/US2000/041609 patent/WO2001034563A1/en not_active Ceased
- 2000-10-25 CA CA002389100A patent/CA2389100A1/en not_active Abandoned
- 2000-10-25 MX MXPA02004225A patent/MXPA02004225A/es not_active Application Discontinuation
- 2000-10-25 HU HU0203186A patent/HUP0203186A2/hu unknown
- 2000-10-25 BR BR0015124-6A patent/BR0015124A/pt not_active Application Discontinuation
- 2000-10-25 CN CN00817760A patent/CN1413188A/zh active Pending
- 2000-10-25 EP EP00989719A patent/EP1224167A1/en not_active Withdrawn
- 2000-10-25 PL PL36005900A patent/PL360059A1/xx unknown
- 2000-10-25 JP JP2001536512A patent/JP4778178B2/ja not_active Expired - Fee Related
- 2000-10-25 US US09/695,884 patent/US6593492B1/en not_active Expired - Lifetime
- 2000-10-25 HK HK03100398.5A patent/HK1048299A1/zh unknown
- 2000-10-25 IL IL14925600A patent/IL149256A0/xx unknown
- 2000-10-26 TW TW089122556A patent/TWI271397B/zh not_active IP Right Cessation
2002
- 2002-04-22 IL IL149256A patent/IL149256A/en not_active IP Right Cessation
- 2002-04-23 ZA ZA200203228A patent/ZA200203228B/en unknown
- 2002-04-26 NO NO20021999A patent/NO20021999L/no unknown

Also Published As

Publication number	Publication date
HK1048299A1 (zh)	2003-03-28
JP2003513955A (ja)	2003-04-15
WO2001034563A1 (en)	2001-05-17
NZ518552A (en)	2003-10-31
BR0015124A (pt)	2002-07-02
IL149256A (en)	2011-05-31
JP4778178B2 (ja)	2011-09-21
TWI271397B (en)	2007-01-21
EP1224167A1 (en)	2002-07-24
MXPA02004225A (es)	2002-10-17
PL360059A1 (en)	2004-09-06
KR20020067509A (ko)	2002-08-22
CA2389100A1 (en)	2001-05-17
CZ20021434A3 (cs)	2002-11-13
NO20021999L (no)	2002-06-20
IL149256A0 (en)	2002-11-10
HUP0203186A2 (hu)	2003-01-28
AU2619501A (en)	2001-06-06
CN1413188A (zh)	2003-04-23
US6593492B1 (en)	2003-07-15
ZA200203228B (en)	2003-07-23

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IT1312551B1 (it)	2002-04-22	Processo per la sintesi di 5-alchilbenzodiossoli
ITMI20020052A0 (it)	2002-01-14	Procedimento per l'idrolisi selettiva di nucleosidi poliesteri
EP1498139A4 (en)	2007-03-07	NEW THROMBOMODULIN EXPRESSION MOTORS
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DE60009048D1 (de)	2004-04-22	Herstellung von norlabdanoxid
IT1291728B1 (it)	1999-01-21	Procedimento migliorato per la sintesi di acqua ossigenata
AU2003217354A8 (en)	2003-09-02	Synthesis of sulfamidates
UA3824S (uk)	2000-10-16	Комплект етикеток "горілка "посольська"
IT1303770B1 (it)	2001-02-23	Procedimento per la sintesi di polioli polieteri
UA3749S (uk)	2000-10-16	Комплект етикеток для горілки особливої "замкова"
UA3748S (uk)	2000-10-16	Комплект етикеток для горілки особливої "поліська"
UA3752S (uk)	2000-10-16	Комплект етикеток для горілки особливої "волинська"