NO20022470L - Pyrimidinderivater - Google Patents

Pyrimidinderivater

Info

Publication number: NO20022470L
Authority: NO; Norway
Prior art keywords: compounds; formula; pyrimidine; cox; fever
Prior art date: 1999-11-26

Application number

NO20022470A

Other languages

English (en)

Norwegian (no)

Other versions

NO20022470D0 (no

Inventor

Richard Howard Green

Charles David Hartley

Alan Naylor

Jeremy John Payne

Neil Anthony Pegg

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-26

Filing date

2002-05-24

Publication date

2002-07-18

2002-05-24 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2002-05-24 Publication of NO20022470D0 publication Critical patent/NO20022470D0/no

2002-07-18 Publication of NO20022470L publication Critical patent/NO20022470L/no

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 1
206010037660 Pyrexia Diseases 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001924 cycloalkanes Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/06—Antiabortive agents; Labour repressants
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Obesity (AREA)
Pregnancy & Childbirth (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Gynecology & Obstetrics (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)

NO20022470A 1999-11-26 2002-05-24 Pyrimidinderivater NO20022470L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9927844.2A GB9927844D0 (en)	1999-11-26	1999-11-26	Chemical compounds
PCT/EP2000/011673 WO2001038311A2 (en)	1999-11-26	2000-11-23	Pyrimidine derivatives as selective inhibitors of cox-2

Publications (2)

Publication Number	Publication Date
NO20022470D0 NO20022470D0 (no)	2002-05-24
NO20022470L true NO20022470L (no)	2002-07-18

Family

ID=10865107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20022470A NO20022470L (no)	1999-11-26	2002-05-24	Pyrimidinderivater

Country Status (21)

Country	Link
US (1)	US6780869B1 (de)
EP (1)	EP1235812B1 (de)
JP (1)	JP2003514898A (de)
KR (1)	KR20020063899A (de)
CN (1)	CN1399633A (de)
AT (1)	ATE316962T1 (de)
AU (1)	AU2508401A (de)
BR (1)	BR0015821A (de)
CA (1)	CA2395049A1 (de)
CO (1)	CO5271666A1 (de)
CZ (1)	CZ20021802A3 (de)
DE (1)	DE60025848T2 (de)
ES (1)	ES2256086T3 (de)
GB (1)	GB9927844D0 (de)
HU (1)	HUP0203385A3 (de)
IL (1)	IL149586A0 (de)
MX (1)	MXPA02005231A (de)
NO (1)	NO20022470L (de)
PE (1)	PE20011008A1 (de)
PL (1)	PL356237A1 (de)
WO (1)	WO2001038311A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9927844D0 (en)	1999-11-26	2000-01-26	Glaxo Group Ltd	Chemical compounds
GB0003224D0 (en)	2000-02-11	2000-04-05	Glaxo Group Ltd	Chemical compounds
GB0021494D0 (en)	2000-09-01	2000-10-18	Glaxo Group Ltd	Chemical comkpounds
GB0112803D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0112810D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0112802D0 (en) *	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0119477D0 (en) *	2001-08-09	2001-10-03	Glaxo Group Ltd	Pyrimidine derivatives
DE60233742D1 (de)	2001-10-10	2009-10-29	Hitachi High Tech Corp	Leuchtverbindungen und markierungsreagentien für die diese verwendet werden
PL372210A1 (en) *	2002-02-22	2005-07-11	Warner-Lambert Company Llc	Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
ATE325115T1 (de) *	2002-08-19	2006-06-15	Glaxo Group Ltd	Pyrimidinderivate als selektive cox-2-inhibitoren
UY27939A1 (es) *	2002-08-21	2004-03-31	Glaxo Group Ltd	Compuestos
GB0221443D0 (en) *	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
GB0227443D0 (en) *	2002-11-25	2002-12-31	Glaxo Group Ltd	Pyrimidine derivatives
WO2005000227A2 (en) *	2003-06-06	2005-01-06	Intermune, Inc.	Methods of treating tnf-mediated disorders
GB0319037D0 (en) *	2003-08-13	2003-09-17	Glaxo Group Ltd	7-Azaindole Derivatives
GB0813142D0 (en)	2008-07-17	2008-08-27	Glaxo Group Ltd	Novel compounds
MX2011012343A (es) *	2009-05-19	2011-12-14	Dow Agrosciences Llc	Compuestos y metodos para controlar hongos.
US9133123B2 (en)	2010-04-23	2015-09-15	Cytokinetics, Inc.	Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es)	2010-04-23	2012-10-10	Cytokinetics Inc	Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR081331A1 (es)	2010-04-23	2012-08-08	Cytokinetics Inc	Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
ES2529233T3 (es)	2010-07-09	2015-02-18	Convergence Pharmaceuticals Limited	Compuestos tetrazol como bloqueadores de canales de calcio
HUE059559T2 (hu)	2015-02-25	2022-12-28	Univ California	5HT agonisták az epilepsziás rendellenességek kezelésére

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6020343A (en)	1995-10-13	2000-02-01	Merck Frosst Canada, Inc.	(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
IL127441A (en)	1996-07-18	2003-02-12	Merck Frosst Canada Inc	Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors
TW520362B (en)	1996-12-05	2003-02-11	Amgen Inc	Substituted pyrimidine compounds and pharmaceutical composition comprising same
GB9927844D0 (en)	1999-11-26	2000-01-26	Glaxo Group Ltd	Chemical compounds
GB0003224D0 (en)	2000-02-11	2000-04-05	Glaxo Group Ltd	Chemical compounds

1999
- 1999-11-26 GB GBGB9927844.2A patent/GB9927844D0/en not_active Ceased
2000
- 2000-11-23 WO PCT/EP2000/011673 patent/WO2001038311A2/en not_active Ceased
- 2000-11-23 CZ CZ20021802A patent/CZ20021802A3/cs unknown
- 2000-11-23 BR BR0015821-6A patent/BR0015821A/pt not_active Application Discontinuation
- 2000-11-23 CA CA002395049A patent/CA2395049A1/en not_active Abandoned
- 2000-11-23 ES ES00988751T patent/ES2256086T3/es not_active Expired - Lifetime
- 2000-11-23 US US10/130,516 patent/US6780869B1/en not_active Expired - Fee Related
- 2000-11-23 EP EP00988751A patent/EP1235812B1/de not_active Expired - Lifetime
- 2000-11-23 AU AU25084/01A patent/AU2508401A/en not_active Abandoned
- 2000-11-23 DE DE60025848T patent/DE60025848T2/de not_active Expired - Fee Related
- 2000-11-23 MX MXPA02005231A patent/MXPA02005231A/es unknown
- 2000-11-23 CN CN00816293A patent/CN1399633A/zh active Pending
- 2000-11-23 KR KR1020027006732A patent/KR20020063899A/ko not_active Withdrawn
- 2000-11-23 HU HU0203385A patent/HUP0203385A3/hu unknown
- 2000-11-23 AT AT00988751T patent/ATE316962T1/de not_active IP Right Cessation
- 2000-11-23 IL IL14958600A patent/IL149586A0/xx unknown
- 2000-11-23 JP JP2001540074A patent/JP2003514898A/ja active Pending
- 2000-11-23 PE PE2000001249A patent/PE20011008A1/es not_active Application Discontinuation
- 2000-11-23 PL PL00356237A patent/PL356237A1/xx not_active Application Discontinuation
- 2000-11-24 CO CO00090138A patent/CO5271666A1/es not_active Application Discontinuation
2002
- 2002-05-24 NO NO20022470A patent/NO20022470L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2256086T3 (es)	2006-07-16
US6780869B1 (en)	2004-08-24
IL149586A0 (en)	2002-11-10
PL356237A1 (en)	2004-06-28
WO2001038311A3 (en)	2001-11-01
CZ20021802A3 (cs)	2002-10-16
KR20020063899A (ko)	2002-08-05
CA2395049A1 (en)	2001-05-31
EP1235812B1 (de)	2006-02-01
GB9927844D0 (en)	2000-01-26
BR0015821A (pt)	2002-07-30
DE60025848T2 (de)	2006-08-03
CO5271666A1 (es)	2003-04-30
NO20022470D0 (no)	2002-05-24
WO2001038311A2 (en)	2001-05-31
HUP0203385A2 (en)	2003-05-28
MXPA02005231A (es)	2002-11-07
CN1399633A (zh)	2003-02-26
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NO20022470L (no)	2002-07-18	Pyrimidinderivater
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HUP0300544A2 (hu)	2003-07-28	Integrin expresszálás inhibitorokat tartalmazó gyógyszerkészítmények
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DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
BR0015195A (pt)	2002-06-18	Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma condição associada com a transmissão reduzida de nicotina para o tratamento ou profilaxia de distúrbios psicóticos ou distúrbios de deterioração intelectual e para o tratamento ou profilaxia de doenças ou condições humanas
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AP2002002595A0 (en)	2002-09-30	Heterocyclic amide derivatives.