NO974595L - Imidazo£1,2-a|pyridin-derivater - Google Patents

Imidazo£1,2-a|pyridin-derivater

Info

Publication number
NO974595L
NO974595L NO974595A NO974595A NO974595L NO 974595 L NO974595 L NO 974595L NO 974595 A NO974595 A NO 974595A NO 974595 A NO974595 A NO 974595A NO 974595 L NO974595 L NO 974595L
Authority
NO
Norway
Prior art keywords
alkyl
derivatives
imidazo
pyridin
compounds
Prior art date
Application number
NO974595A
Other languages
English (en)
Other versions
NO974595D0 (no
Inventor
Paul John Beswick
Ian Baxter Campbell
Alan Naylor
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506965.4A external-priority patent/GB9506965D0/en
Priority claimed from GBGB9512099.4A external-priority patent/GB9512099D0/en
Priority claimed from GBGB9516117.0A external-priority patent/GB9516117D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO974595D0 publication Critical patent/NO974595D0/no
Publication of NO974595L publication Critical patent/NO974595L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Denne oppfinnelse tilveiebringer forbindelsene med formel (I) og farmasøytisk akseptable derivater derav hvori: R° representerer halogen; R1 og RJ uavhengig er valgt fra H, halogen, C^alkyl. CMalkyl substituert med ett eller flere fluoratomer. CMalkoksy. C^hydroksyalkyl. SCMalkyl. C(0)H eller C(0)C,.4alkyl; og R5 representerer C,.4alkyl. Forbindelser med formel (I) er potente og selektive inhibitorer av COX-2 og kan anvendes ved behandling av smerte, feber og betennelse ved flere forskjellige tilstander og sykdommer.
NO974595A 1995-04-04 1997-10-03 Imidazo£1,2-a|pyridin-derivater NO974595L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9506965.4A GB9506965D0 (en) 1995-04-04 1995-04-04 Chemical compounds
GBGB9512099.4A GB9512099D0 (en) 1995-06-14 1995-06-14 Chemical compounds
GBGB9516117.0A GB9516117D0 (en) 1995-08-05 1995-08-05 Chemical compounds
PCT/EP1996/001438 WO1996031509A1 (en) 1995-04-04 1996-04-02 IMIDAZO[1,2-a]PYRIDINE DERIVATIVES

Publications (2)

Publication Number Publication Date
NO974595D0 NO974595D0 (no) 1997-10-03
NO974595L true NO974595L (no) 1997-12-03

Family

ID=27267657

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974595A NO974595L (no) 1995-04-04 1997-10-03 Imidazo£1,2-a|pyridin-derivater

Country Status (17)

Country Link
EP (1) EP0819127A1 (no)
JP (1) JPH11501049A (no)
KR (1) KR19980703559A (no)
CN (1) CN1186492A (no)
AU (1) AU5276696A (no)
BG (1) BG101934A (no)
CA (1) CA2216809A1 (no)
CZ (1) CZ313397A3 (no)
EA (1) EA199700209A1 (no)
HU (1) HUP9801602A3 (no)
IS (1) IS4570A (no)
NO (1) NO974595L (no)
NZ (1) NZ304886A (no)
PL (1) PL322623A1 (no)
SK (1) SK133297A3 (no)
TR (1) TR199701105T1 (no)
WO (1) WO1996031509A1 (no)

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FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
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ATE275148T1 (de) * 1998-11-03 2004-09-15 Glaxo Group Ltd Pyrazolopyridin derivative als selektive cox-2 inhibitoren
WO2000052008A1 (en) * 1999-02-27 2000-09-08 Glaxo Group Limited Pyrazolopyridines
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GB9930358D0 (en) 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
JP2003523958A (ja) 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法
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PE20011333A1 (es) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
NZ524252A (en) 2000-07-20 2004-03-26 Lauras As Cox-2 inhibitors for treating HIV and AIDS
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0025449D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
ES2245380T3 (es) 2000-12-15 2006-01-01 Glaxo Group Limited Pirazolopiridinas.
EP1377573B1 (en) 2000-12-15 2005-07-27 Glaxo Group Limited Pyrazolopyridine derivatives
US7153855B2 (en) 2001-03-08 2006-12-26 Smithkline Beecham Corporation Pyrazolopyridinyl pyrimidine therapeutic compounds
EP1372643A1 (en) 2001-03-30 2004-01-02 Smithkline Beecham Corporation Pyrazolopyridines, process for their preparation and use as therapeutic compounds
PE20021017A1 (es) 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible
JP4219171B2 (ja) 2001-04-10 2009-02-04 スミスクライン ビーチャム コーポレーション 抗ウイルス性ピラゾロピリジン化合物
US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
AU2002305143A1 (en) 2001-04-27 2002-11-11 Smithkline Beecham Corporation Pyrazolo'1,5-a!pyridine derivatives
KR20040018281A (ko) 2001-06-21 2004-03-02 스미스클라인 비참 코포레이션 포진 바이러스 감염의 예방 및 치료를 위한 이미다조[1，２－α]피리딘 유도체
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
US7244740B2 (en) 2001-10-05 2007-07-17 Smithkline Beecham Corporation Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
WO2003050120A1 (en) 2001-12-11 2003-06-19 Smithkline Beecham Corporation Pyrazolo-pyridine derivatives as antiherpes agents
CN100369898C (zh) 2002-02-12 2008-02-20 史密丝克莱恩比彻姆公司 用作p38抑制剂的烟酰胺衍生物
JP2005535642A (ja) 2002-06-28 2005-11-24 ニトロメッド インコーポレーティッド オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
WO2004033454A1 (en) 2002-10-03 2004-04-22 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
KR20040072004A (ko) 2003-02-07 2004-08-16 삼성에스디아이 주식회사 유기 전계 발광 소자용 발광 화합물 및 그를 이용한 유기전계발광 소자
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
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CA2647859C (en) 2006-03-29 2016-01-05 Nitromed, Inc. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
US7750007B2 (en) 2006-11-06 2010-07-06 Supergen, Inc. Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors
DK2734205T3 (en) 2011-07-21 2018-06-14 Tolero Pharmaceuticals Inc Heterocyclic Protein Kinase Inhibitors
WO2016177776A1 (en) 2015-05-04 2016-11-10 Academisch Medisch Centrum Biomarkers for the detection of aspirin insensitivity
HUE072069T2 (hu) 2019-02-12 2025-10-28 Sumitomo Pharma America Inc 2-((1R,4R)-4-((3-(3-(trifluormetil)fenil)imidazo[1,2- b]piridazin-6-il)amino)ciklohexil)propán-2-ol sósavas sójának kristályos formája
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES

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US3455924A (en) * 1967-02-08 1969-07-15 Upjohn Co Dianisylimidazoles

Also Published As

Publication number Publication date
CN1186492A (zh) 1998-07-01
KR19980703559A (ko) 1998-11-05
CA2216809A1 (en) 1996-10-10
WO1996031509A1 (en) 1996-10-10
EP0819127A1 (en) 1998-01-21
CZ313397A3 (cs) 1998-03-18
EA199700209A1 (ru) 1998-04-30
NZ304886A (en) 1998-11-25
PL322623A1 (en) 1998-02-02
AU5276696A (en) 1996-10-23
HUP9801602A3 (en) 1999-01-28
NO974595D0 (no) 1997-10-03
MX9707379A (es) 1997-11-29
BG101934A (en) 1999-04-30
SK133297A3 (en) 1998-07-08
IS4570A (is) 1997-09-25
JPH11501049A (ja) 1999-01-26
TR199701105T1 (xx) 1998-02-21
HUP9801602A2 (hu) 1998-11-30

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