NO20023577L - Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider - Google Patents

Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider

Info

Publication number: NO20023577L
Authority: NO; Norway
Prior art keywords: pyridinioalanine; amidinophenylalanyl; cyclohexylglycyl; amides; acetyl
Prior art date: 2000-01-28

Application number

NO20023577A

Other languages

English (en)

Norwegian (no)

Other versions

NO20023577D0 (no

Inventor

Gerhard Breipohl

Wolfgang Holla

Heiner Jendralla

Gerhard Beck

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-28

Filing date

2002-07-26

Publication date

2002-08-28

2002-07-26 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2002-07-26 Publication of NO20023577D0 publication Critical patent/NO20023577D0/no

2002-08-28 Publication of NO20023577L publication Critical patent/NO20023577L/no

Links

RIFFXNRHBJPOGV-RDPSFJRHSA-O (2S)-2-[acetyl(carbamimidoyl)amino]-N-[2-[[(2S)-1-amino-1-oxopropan-2-yl]-pyridin-1-ium-1-ylamino]-2-oxoethyl]-N-cyclohexyl-3-phenylpropanamide Chemical class C(C)(=O)N([C@@H](CC1=CC=CC=C1)C(=O)N(CC(=O)N([C@@H](C)C(=O)N)[N+]1=CC=CC=C1)C1CCCCC1)C(N)=N RIFFXNRHBJPOGV-RDPSFJRHSA-O 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO20023577A 2000-01-28 2002-07-26 Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider NO20023577L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10003586		2000-01-28
PCT/EP2001/000523 WO2001055175A2 (en)	2000-01-28	2001-01-18	Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides

Publications (2)

Publication Number	Publication Date
NO20023577D0 NO20023577D0 (no)	2002-07-26
NO20023577L true NO20023577L (no)	2002-08-28

Family

ID=7628946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20023577A NO20023577L (no)	2000-01-28	2002-07-26	Fremgangsmåte for fremstilling av acetyl-amidinofenylalanyl- cykloheksylglycyl-pyridinioalaninamider

Country Status (29)

Country	Link
US (2)	US20010031858A1 (es)
EP (1)	EP1254159B9 (es)
JP (1)	JP4778181B2 (es)
KR (1)	KR100758141B1 (es)
CN (1)	CN1176104C (es)
AR (1)	AR027246A1 (es)
AT (1)	ATE325810T1 (es)
AU (1)	AU779722B2 (es)
BR (1)	BR0107804A (es)
CA (1)	CA2398497C (es)
CZ (1)	CZ20022583A3 (es)
DE (1)	DE60119491T2 (es)
DK (1)	DK1254159T3 (es)
EE (1)	EE200200410A (es)
ES (1)	ES2262632T3 (es)
HR (1)	HRP20020631A2 (es)
HU (1)	HUP0301986A2 (es)
IL (2)	IL150897A0 (es)
MX (1)	MXPA02006762A (es)
NO (1)	NO20023577L (es)
NZ (1)	NZ520427A (es)
PL (1)	PL356801A1 (es)
PT (1)	PT1254159E (es)
RU (1)	RU2250212C2 (es)
SK (1)	SK10842002A3 (es)
TW (1)	TWI236481B (es)
WO (1)	WO2001055175A2 (es)
YU (1)	YU51202A (es)
ZA (1)	ZA200205990B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH695999A5 (de)	2002-02-28	2006-11-15	Wilex Ag	Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten.
CN101379077A (zh) *	2005-12-07	2009-03-04	夏洛特·豪泽	因子ⅷ和因子ⅷ-类似蛋白的小肽或者拟肽亲合性配体
CN101774942B (zh) *	2010-01-27	2012-08-22	宁波武盛化学有限公司	制备n-乙酰基-dl-环己基甘氨酸的方法
US8558023B2 (en) *	2010-04-20	2013-10-15	Chiral Quest, Inc.	Enantioselective process for cycloalkenyl β-substituted alanines
JP5913352B2 (ja) *	2010-11-29	2016-04-27	高砂香料工業株式会社	不斉水素化触媒、およびそれを用いた光学活性カルボニル化合物の製造方法
CN115068469B (zh) *	2022-07-08	2024-02-27	深圳市小分子新药创新中心有限公司	Tigit抑制剂及其应用
CN115612702A (zh) *	2022-10-09	2023-01-17	深圳市茵诺圣生物科技有限公司	L-丙氨酸类非天然氨基酸3-(3-吡啶基)-l-丙氨酸的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2916711A1 (de)	1979-04-25	1980-11-06	Behringwerke Ag	Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4623717A (en) *	1980-03-05	1986-11-18	Miles Laboratories, Inc.	Pasteurized therapeutically active protein compositions
US4440679A (en) *	1980-03-05	1984-04-03	Cutter Laboratories, Inc.	Pasteurized therapeutically active protein compositions
SE9301916D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
JP3032297B2 (ja) *	1993-10-15	2000-04-10	ローヌ‐プーランローラーファーマシューティカルズインコーポレイテッド	抗血栓性アザシクロアルキルアルカノイルペプチド及びプソイドペプチド
SI9520044B (sl) *	1994-04-26	2004-08-31	Aventis Pharmaceuticals Inc.	Inhibitorji Xa faktorja
US5849510A (en)	1994-04-26	1998-12-15	Selectide Corporation	Factor Xa inhibitors
TR199801107T2 (xx) *	1995-12-20	1998-10-21	Hoechst Marion Roussel Inc.	N-Asetil (L)-4-siyanofenilalanin Ac (L)-phe (4-CN)-OH ve N-Asetil-(L)-p-amidinofenilalanin-sikloheksil-glisin -�-(3-N-metilpiridinyum)-alanin Ac-(L)-pAph-Chg-PalMe (3) -NH2'nin haz�rlanmas� i�in yeni bir i�lem.
DE19856443A1 (de)	1998-12-08	2000-06-21	Centeon Pharma Gmbh	Stabilisiertes Antithrombin III-Präparat

2001
- 2001-01-18 SK SK1084-2002A patent/SK10842002A3/sk unknown
- 2001-01-18 EE EEP200200410A patent/EE200200410A/xx unknown
- 2001-01-18 JP JP2001561027A patent/JP4778181B2/ja not_active Expired - Fee Related
- 2001-01-18 AR ARP010100225A patent/AR027246A1/es unknown
- 2001-01-18 EP EP01911497A patent/EP1254159B9/en not_active Expired - Lifetime
- 2001-01-18 PL PL01356801A patent/PL356801A1/xx unknown
- 2001-01-18 HU HU0301986A patent/HUP0301986A2/hu unknown
- 2001-01-18 AT AT01911497T patent/ATE325810T1/de active
- 2001-01-18 RU RU2002123046/04A patent/RU2250212C2/ru not_active IP Right Cessation
- 2001-01-18 DK DK01911497T patent/DK1254159T3/da active
- 2001-01-18 AU AU40516/01A patent/AU779722B2/en not_active Ceased
- 2001-01-18 NZ NZ520427A patent/NZ520427A/en unknown
- 2001-01-18 CZ CZ20022583A patent/CZ20022583A3/cs unknown
- 2001-01-18 MX MXPA02006762A patent/MXPA02006762A/es active IP Right Grant
- 2001-01-18 KR KR1020027009583A patent/KR100758141B1/ko not_active Expired - Fee Related
- 2001-01-18 HR HRP20020631 patent/HRP20020631A2/hr not_active Application Discontinuation
- 2001-01-18 WO PCT/EP2001/000523 patent/WO2001055175A2/en not_active Ceased
- 2001-01-18 IL IL15089701A patent/IL150897A0/xx active IP Right Grant
- 2001-01-18 PT PT01911497T patent/PT1254159E/pt unknown
- 2001-01-18 ES ES01911497T patent/ES2262632T3/es not_active Expired - Lifetime
- 2001-01-18 CA CA2398497A patent/CA2398497C/en not_active Expired - Fee Related
- 2001-01-18 CN CNB018041523A patent/CN1176104C/zh not_active Expired - Fee Related
- 2001-01-18 DE DE60119491T patent/DE60119491T2/de not_active Expired - Lifetime
- 2001-01-18 BR BR0107804-6A patent/BR0107804A/pt not_active Application Discontinuation
- 2001-01-18 YU YU51202A patent/YU51202A/sh unknown
- 2001-01-26 US US09/769,487 patent/US20010031858A1/en not_active Abandoned
- 2001-03-07 TW TW090101207A patent/TWI236481B/zh not_active IP Right Cessation
2002
- 2002-07-24 IL IL150897A patent/IL150897A/en not_active IP Right Cessation
- 2002-07-26 ZA ZA200205990A patent/ZA200205990B/en unknown
- 2002-07-26 NO NO20023577A patent/NO20023577L/no unknown
2004
- 2004-06-17 US US10/869,076 patent/US7084250B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HRP20020631A2 (en)	2004-12-31
KR100758141B1 (ko)	2007-09-13
HK1051866A1 (en)	2003-08-22
AU4051601A (en)	2001-08-07
JP2003523364A (ja)	2003-08-05
ATE325810T1 (de)	2006-06-15
HUP0301986A2 (hu)	2003-09-29
DE60119491D1 (de)	2006-06-14
AU779722B2 (en)	2005-02-10
WO2001055175A3 (en)	2002-02-21
IL150897A0 (en)	2003-02-12
EE200200410A (et)	2003-12-15
EP1254159B1 (en)	2006-05-10
RU2002123046A (ru)	2004-01-10
DE60119491T2 (de)	2006-11-16
RU2250212C2 (ru)	2005-04-20
CA2398497C (en)	2011-04-26
DK1254159T3 (da)	2006-09-11
IL150897A (en)	2008-08-07
WO2001055175A2 (en)	2001-08-02
CN1396928A (zh)	2003-02-12
KR20030019306A (ko)	2003-03-06
SK10842002A3 (sk)	2003-04-01
JP4778181B2 (ja)	2011-09-21
NZ520427A (en)	2004-02-27
ZA200205990B (en)	2003-04-30
BR0107804A (pt)	2002-10-22
US20040225109A1 (en)	2004-11-11
YU51202A (sh)	2005-11-28
CZ20022583A3 (cs)	2002-10-16
US20010031858A1 (en)	2001-10-18
MXPA02006762A (es)	2002-10-23
PT1254159E (pt)	2006-07-31
AR027246A1 (es)	2003-03-19
NO20023577D0 (no)	2002-07-26
TWI236481B (en)	2005-07-21
US7084250B2 (en)	2006-08-01
ES2262632T3 (es)	2006-12-01
EP1254159A2 (en)	2002-11-06
EP1254159B9 (en)	2006-06-28
CN1176104C (zh)	2004-11-17
PL356801A1 (en)	2004-07-12
CA2398497A1 (en)	2001-08-02

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